Familial Aggregation of Suicidal Behavior: A Family Study of Male Suicide Completers From the General Population
Abstract
OBJECTIVE: This study compared suicidality in families of adult male suicide completers and community comparison subjects. METHOD: Two hundred forty-seven relatives of 25 male suicide completers and 171 relatives of 25 matched comparison subjects were assessed for recurrent risk of suicidal and related behaviors. Analyses were performed on a subgroup of relatives of suicide completers with cluster B personality disorders. RESULTS: Relatives of suicide completers were over 10 times more likely than relatives of comparison subjects to attempt or complete suicide after the authors controlled for psychopathology. Relatives of suicide completers were not more likely to exhibit suicidal ideation but had more severe suicidal ideation than relatives of comparison subjects. These findings were stronger for the suicide completers diagnosed with cluster B personality disorders. CONCLUSIONS: Suicide has a familial component independent of psychopathology that may be mediated by a combination of factors, including more severe suicidal ideation and aggressive behavior.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Convincing evidence for the heritability of suicidal behaviour has been provided in the past decade from large cohort studies, including evidence that suicide and suicide attempts are transmitted independently of psychopathologies.
“convincing evidence for the heritability of suicidal behaviour has been provided only in the past decade from large cohort studies, including evidence that suicide and suicide attempts are transmitted independently of psychopathologies 31,32,34,35 .”
From Suicide and suicide risk (2019) · cites this paper as [35]
Relatives of individuals who died by suicide are more likely to have increased impulsivity and aggression, and have an increased risk of suicidal behaviour compared to individuals without first-degree relatives who died by suicide.
“relatives of individuals who died by suicide are more likely to have increased impulsivity and aggression, and have an increased risk of suicidal behaviour compared to individuals without first-degree relatves who died by suicide 32,35 .”
From Suicide and suicide risk (2019) · cites this paper as [35]
Cites
Qin, P., Agerbo, E., & Mortensen, P. B. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.765 · Cited by 954 · see citing works
Suicidal behaviour: an epidemiological and genetic study
STATHAM, D. J., HEATH, A. C., MADDEN, P. A. F., BUCHOLZ, K. K., BIERUT, L., DINWIDDIE, S. H., SLUTSKE, W. S., DUNNE, M. P., & MARTIN, N. G. (1998) · Psychological Medicine · doi:10.1017/s0033291798006916 · Cited by 471 · see citing works
Family history of suicide among suicide victims.
Runeson, B., & Åsberg, M. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1525 · Cited by 250 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The interpersonal theory of suicide.
Van Orden, K. A., Witte, T. K., Cukrowicz, K. C., Braithwaite, S. R., Selby, E. A., & Joiner, T. E. (2010) · Psychological Review · doi:10.1037/a0018697 · Cited by 5,292 · see citing works
Suicide and suicidal behaviour
Turecki, G., & Brent, D. A. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00234-2 · Cited by 2,338 · see citing works
Self-citationTurecki, G., Brent, D. A., Gunnell, D., O’Connor, R. C., Oquendo, M. A., Pirkis, J., & Stanley, B. H. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0121-0 · Cited by 1,074 · see citing works
Self-citationDeep brain stimulation for treatment-resistant depression: follow-up after 3 to 6 years
Kennedy, S. H., Giacobbe, P., Rizvi, S. J., Placenza, F. M., Nishikawa, Y., Mayberg, H. S., & Lozano, A. M. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10081187 · Cited by 481 · see citing works
Candidate endophenotypes for genetic studies of suicidal behavior
Mann, J. J., Arango, V. A., Avenevoli, S., Brent, D. A., Champagne, F. A., Clayton, P., Currier, D., Dougherty, D. M., Haghighi, F., Hodge, S. E., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.021 · Cited by 398 · see citing works
Sequeira, A., Mamdani, F., Ernst, C., Vawter, M. P., Bunney, W. E., Lebel, V., Rehal, S., Klempan, T., Gratton, A., Benkelfat, C., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006585 · Cited by 388 · see citing works
Self-citationMcGirr, A., Renaud, J., Bureau, A., Seguin, M., Lesage, A., & Turecki, G. (2008) · Psychological Medicine · doi:10.1017/s0033291707001419 · Cited by 332 · see citing works
Self-citationThe molecular bases of the suicidal brain
Turecki, G. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3839 · Cited by 281 · see citing works
Self-citationMcGirr, A., Alda, M., Séguin, M., Cabot, S., Lesage, A., & Turecki, G. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.08111744 · Cited by 185 · see citing works
Self-citationNeuropathology of suicide: Recent findings and future directions
Lutz, P.-E., Mechawar, N., & Turecki, G. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.141 · Cited by 158 · see citing works
Self-citationMcGirr, A. (2010) · Journal of Psychiatry & Neuroscience · doi:10.1503/jpn.090121 · Cited by 147 · see citing works
Familial Pathways to Early-Onset Suicide Attempt: A 5.6-Year Prospective Study
Brent, D. A., Melhem, N. M., Oquendo, M., Burke, A., Birmaher, B., Stanley, B., Biernesser, C., Keilp, J., Kolko, D., Ellis, S., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2141 · Cited by 138 · see citing works
The Genetics of Suicide: A Critical Review of Molecular Studies
Brezo, J., Klempan, T., & Turecki, G. (2008) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2008.01.008 · Cited by 133 · see citing works
Self-citationMeyer, R. E., Salzman, C., Youngstrom, E. A., Clayton, P. J., Goodwin, F. K., Mann, J. J., Alphs, L. D., Broich, K., Goodman, W. K., Greden, J. F., et al. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10cs06070blu · Cited by 129 · see citing works
Self-citationGlenn, C. R., Cha, C. B., Kleiman, E. M., & Nock, M. K. (2017) · Clinical Psychological Science · doi:10.1177/2167702616686854 · Cited by 113 · see citing works
Brezo, J., Bureau, A., Mérette, C., Jomphe, V, Barker, E. D., Vitaro, F., Hébert, M., Carbonneau, R., Tremblay, R. E., & Turecki, G. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.19 · Cited by 109 · see citing works
Self-citationStress, cortisol and suicide risk
(2020) · International Review of Neurobiology · doi:10.1016/bs.irn.2019.11.006 · Cited by 108 · see citing works
Can Cholesterol Metabolism Modulation Affect Brain Function and Behavior?
Cartocci, V., Servadio, M., Trezza, V., & Pallottini, V. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25488 · Cited by 77 · see citing works
Zhang, H., Chen, Z., Jia, Z., & Gong, Q. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.03.002 · Cited by 72 · see citing works
Coon, H., Darlington, T. M., DiBlasi, E., Callor, W. B., Ferris, E., Fraser, A., Yu, Z., William, N., Das, S. C., Crowell, S. E., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0282-3 · Cited by 64 · see citing works
Fanelli, G., & Serretti, A. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.08.007 · Cited by 52 · see citing works
Segatto, M., Tonini, C., Pfrieger, F. W., Trezza, V., & Pallottini, V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133317 · Cited by 51 · see citing works
The narrative‐crisis model of suicide and its prediction of near‐term suicide risk
Cohen, L. J., Mokhtar, R., Richards, J., Hernandez, M., Bloch‐Elkouby, S., & Galynker, I. (2022) · Suicide and Life-Threatening Behavior · doi:10.1111/sltb.12816 · Cited by 51 · see citing works
de Groot, M., Neeleman, J., van der Meer, K., & Burger, H. (2010) · Suicide and Life-Threatening Behavior · doi:10.1521/suli.2010.40.5.425 · Cited by 34 · see citing works
- Authors
- Kim, C. D., Seguin, M., Therrien, N., Riopel, G., Chawky, N., Lesage, A. D., & Turecki, G.
- Affiliations
- Douglas Mental Health University Institute (CA)
- Venue
- American Journal of Psychiatry
- Published
- 2005-05-01
- Volume
- 162
- Issue
- 5
- Pages
- 1017-1019
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2140981442
- Cited by
- 178
- References
- 3
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 2 · 2023: 7 · 2022: 2 · 2021: 8 · 2020: 6 · 2019: 9 · 2018: 10 · 2017: 10 · 2016: 10 · 2015: 7 · 2014: 8 · 2013: 13 · 2012: 15
- FWCI
- 9.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Sociology and Political Science › Homicide, Infanticide, and Child Abuse
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- suicide, familial aggregation, relatives of suicide victims, suicide attempts, suicidal ideation, cluster B personality disorders, aggression
- MeSH terms
- Adult, Aggression, Alcoholism, Child, Family, Humans, Male, Pedigree, Personality Disorders, Psychiatric Status Rating Scales, Quebec, Risk Factors, Sex Factors, Suicide, Comorbidity, Child of Impaired Parents, Substance-Related Disorders, Genetic Predisposition to Disease, Diagnostic and Statistical Manual of Mental Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review