Understanding Suicide Risk Within the Research Domain Criteria (RDoC) Framework: Insights, Challenges, and Future Research Considerations
Open accessAbstract
Suicide is a leading cause of death worldwide. Prior research has focused primarily on sociodemographic and psychiatric risk factors with little improvement in the prediction or prevention of suicidal behavior over time. The Research Domain Criteria (RDoC) may be an especially useful framework for advancing research in this area. This article provides a brief and broad overview of research on suicidal behavior relating to each of the RDoC domains—highlighting the RDoC construct(s) where research has focused, the construct(s) where research is lacking, and suggestions for future research directions. We also discuss major challenges for suicide research within the RDoC framework, including the intersection of RDoC domains, interaction of domains with the environment, incorporation of developmental stage, integration of distal and proximal processes, and inclusion of suicide-specific constructs. We conclude by underscoring important considerations for future research aimed at using the RDoC framework to study suicidal behavior and other forms of psychopathology.
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This study had strengths including prospective evaluation of suicidal outcomes, measurement at multiple RDoC levels in a transdiagnostic sample, and a dynamic, multilevel statistical approach allowing for prospective modeling of diathesis and stress interplay.
“This study had many strengths, including prospective evaluation of suicidal outcomes, measurement at multiple Research Domain Criteria (RDoC) levels in a transdiagnostic sample [48], and the dynamic, multilevel statistical approach allowing for prospective modeling of diathesis and stress interplay.”
From HPA axis response and psychosocial stress as interactive predictors of suicidal ideation and behavior in adolescent females: a multilevel diathesis-stress framework (2018) · cites this paper as [48]
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Experimental — accuracy not yet measuredChronic or relatively stable processes and characteristics are likely more relevant to long-term or general risk, and their low temporal variance makes them less able to predict short-term risk robustly.
“This is an important consideration because chronic or relatively stable processes and characteristics are likely more relevant to understanding long-term or general risk (Glenn et al., 2017), and their relatively low temporal variance means they lack the temporal sensitivity required to be robust predictors of short-term risk.”
From Sleep and suicide: A systematic review and meta-analysis of longitudinal studies (2020) · cites this paper as Glenn et al., 2017
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Ballard, E. D., Ionescu, D. F., Voort, J. L. V., Slonena, E. E., Franco-Chaves, J. A., Zarate, C. A., & Grillon, C. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.03.027 · Cited by 33 · see citing works
Bruffaerts, R., Kessler, R. C., Demyttenaere, K., Bonnewyn, A., & Nock, M. K. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.07.042 · Cited by 32 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- NIMH Arousal and Regulatory Systems: Workshop Proceedings Research Domain Criteria Workshop Proceedings 2012 Retrieved from http://www.nimh.nih.gov/research-priorities/rdoc/arousal-and-regulatory-systems-workshop-proceedings.shtml
Cited by
Sorted by citations
Sleep and suicide: A systematic review and meta-analysis of longitudinal studies
Liu, R. T., Steele, S. J., Hamilton, J. L., Do, Q. B. P., Furbish, K., Burke, T. A., Martinez, A. P., & Gerlus, N. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101895 · Cited by 239 · see citing works
“This is an important consideration because chronic or relatively stable processes and characteristics are likely more relevant to understanding long-term or general risk (Glenn et al., 2017), and their relatively low temporal variance means they lack the temporal sensitivity required to be robust predictors of short-t…”
BackgroundAdolescent Suicide as a Failure of Acute Stress-Response Systems.
Miller, A. B., & Prinstein, M. J. (2019) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095625 · Cited by 235 · see citing works
“Notably, the prevalence of suicidal ideation, suicidal behavior, and death by suicide all increase dramatically during the adolescent transition, a unique period of developmental vulnerability for suicidal ideation and behaviors (Curtin et al. 2016, Glenn et al. 2017b, Kõlves & de Leo 2017).”
BackgroundHigh-frequency repetitive TMS for suicidal ideation in adolescents with depression
Croarkin, P. E., Nakonezny, P. A., Deng, Z.-D., Romanowicz, M., Voort, J. L. V., Camsari, D. D., Schak, K. M., Port, J. D., & Lewis, C. P. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.06.048 · Cited by 95 · see citing works
Eisenlohr-Moul, T. A., Miller, A. B., Giletta, M., Hastings, P. D., Rudolph, K. D., Nock, M. K., & Prinstein, M. J. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0206-6 · Cited by 87 · see citing works
Self-citationBecker, S. P., & Willcutt, E. G. (2019) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-018-1136-x · Cited by 85 · see citing works
- Authors
- Glenn, C. R., Cha, C. B., Kleiman, E. M., & Nock, M. K.
- Affiliations
- University of Rochester (US)
- Columbia University (US)
- Harvard University (US)
- Corresponding author
- Glenn, Catherine R.
- Venue
- Clinical Psychological Science
- Publisher
- SAGE Publications
- Published
- 2017-04-26
- Volume
- 5
- Issue
- 3
- Pages
- 568-592
- ISSN
- 2167-7026 (ISSN-L)
- 2167-7034
- PMC
- PMC5487002
- OpenAlex
- W2608797004
- Semantic Scholar
- 113da42c30bbb0cf6f986e8d40828904ed4a8879
- Cited by
- 113
- References
- 210
- Citations by year
- 2026: 4 · 2025: 15 · 2024: 7 · 2023: 10 · 2022: 12 · 2021: 17 · 2020: 17 · 2019: 14 · 2018: 12 · 2017: 5
- FWCI
- 16.28
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Clinical Psychological Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- Chet and Will Griswold Suicide Prevention Fund
- John T. and Catherine D. MacArthur Foundation
- National Institute of Mental Health (HHSN271201500513P)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- suicide risk, suicidal behavior, Research Domain Criteria, suicide prevention, suicide risk prediction, risk factors, developmental stages, psychopathology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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