Double-blind, placebo-controlled study of dialectical behavior therapy plus olanzapine for borderline personality disorder
Abstract
OBJECTIVE: The aim of this study was to determine the efficacy and safety of dialectical behavior therapy plus olanzapine compared with dialectical behavior therapy plus placebo in patients with borderline personality disorder. METHOD: Sixty patients with borderline personality disorder were included in a 12-week, double-blind, placebo-controlled study. All patients received dialectical behavior therapy and were randomly assigned to receive either olanzapine or placebo following a 1-month baseline period. RESULTS: Seventy percent of the patients completed the 4-month trial. Combined treatment showed an overall improvement in most symptoms studied in both groups. Olanzapine was associated with a statistically significant improvement over placebo in depression, anxiety, and impulsivity/aggressive behavior. The mean dose of olanzapine was 8.83 mg/day. CONCLUSIONS: A combined psychotherapeutic plus pharmacological approach appears to lower dropout rates and constitutes an effective treatment for borderline personality disorder.
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The pharmacotherapy review (Stoffers 2010) included three trials testing psychotherapy plus drug against psychotherapy plus placebo.
“the pharmacotherapy review (Stoffers 2010) included three trials testing psychotherapy plus drug against psychotherapy plus placebo (Simpson 2004;Soler 2005;Linehan 2008).”
From Psychological therapies for people with borderline personality disorder. (2012) · cites this paper as Soler 2005
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- Authors
- Soler, J., Pascual, J. C., Campins, J., Barrachina, J., Puigdemont, D., Alvarez, E., & Pérez, V.
- Affiliations
- Hospital de Sant Pau (ES)
- Venue
- American Journal of Psychiatry
- Published
- 2005-06-01
- Volume
- 162
- Issue
- 6
- Pages
- 1221-1224
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2149470409
- Cited by
- 224
- References
- 6
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 10 · 2023: 4 · 2022: 2 · 2021: 8 · 2020: 4 · 2019: 11 · 2018: 2 · 2017: 12 · 2016: 9 · 2015: 6 · 2014: 13 · 2013: 10 · 2012: 18
- FWCI
- 21.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- borderline personality disorder, dialectical behavior therapy, olanzapine, combined psychotherapy and pharmacotherapy, depression, anxiety, impulsivity, aggression, treatment discontinuation
- MeSH terms
- Olanzapine, Adult, Behavior Therapy, Benzodiazepines, Borderline Personality Disorder, Combined Modality Therapy, Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Placebos, Antipsychotic Agents, Treatment Outcome
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