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Meta-analytical Comparison of Voxel-Based Morphometry Studies in Obsessive-Compulsive Disorder vs Other Anxiety Disorders
Abstract
CONTEXT: Whether obsessive-compulsive disorder (OCD) is adequately classified as an anxiety disorder is a matter of considerable debate. OBJECTIVES: To quantitatively compare structural brain changes in OCD and other anxiety disorders using novel voxel-based meta-analytical methods and to generate an online database to facilitate replication and further analyses by other researchers. DATA SOURCES: The PubMed, ScienceDirect, and Scopus databases were searched between 2001 (the date of the first voxel-based morphometry study in any anxiety disorder) and 2009. All voxel-based morphometry studies comparing patients with any anxiety disorder and healthy controls were retrieved. Manual searches were also conducted. Authors were contacted soliciting additional data. STUDY SELECTION: Thirty-seven data sets were identified, of which 26 (including 639 patients with anxiety disorders and 737 healthy controls) met inclusion criteria. DATA EXTRACTION: Coordinates were extracted from clusters of significant gray matter difference between patients and controls. Demographic, clinical, and methodological variables were extracted from each study or obtained from the authors. DATA SYNTHESIS: Patients with anxiety disorders (including OCD) showed decreased bilateral gray matter volumes in the dorsomedial frontal/anterior cingulate gyri. Individuals with OCD had increased bilateral gray matter volumes (vs healthy controls and vs individuals with other anxiety disorders) in the lenticular/caudate nuclei, while patients with other anxiety disorders (mainly panic and posttraumatic stress disorders) had decreased gray matter volumes in the left lenticular nucleus. The findings remained largely unchanged in quartile and jackknife sensitivity analyses. Controlling for potential confounders such as age or antidepressant medication had little impact on the results. CONCLUSIONS: The meta-analysis consistently revealed common as well as distinct neural substrates in OCD and other anxiety disorders. These results have implications for the current debate surrounding the classification of OCD in the DSM-V.
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Too few studies met eligibility criteria to perform meta-regressions exploring heterogeneity between disorders, concomitant medication status or therapy type.
“Too few studies met our eligibility criteria to perform meta-regressions to explore heterogeneity between disorders, concomitant medication status or therapy type (Radua et al., 2010).”
From Meta-analyses of the neural mechanisms and predictors of response to psychotherapy in depression and anxiety (2018) · cites this paper as Radua et al., 2010
There were too few studies meeting eligibility criteria to perform meta-regressions to study heterogeneity between disorders, therapies or methodologies.
“There were too few studies that met our eligibility criteria to perform meta-regressions (Radua et al., 2010) to study heterogeneity between disorders, therapies or methodologies (all but one study was task-based).”
From Meta-analyses of the neural mechanisms and predictors of response to psychotherapy in depression and anxiety (2018) · cites this paper as Radua et al., 2010
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Gilbert, A. R., Keshavan, M. S., Diwadkar, V., Nutche, J., MacMaster, F., Easter, P. C., Buhagiar, C. J., & Rosenberg, D. R. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.02.011 · Cited by 70
Chen, S., Li, L., Xu, B., & Liu, J. (2009) · BMC Psychiatry · doi:10.1186/1471-244x-9-39 · Cited by 68
Christian, C. J., Lencz, T., Robinson, D. G., Burdick, K. E., Ashtari, M., Malhotra, A. K., Betensky, J. D., & Szeszko, P. R. (2008) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2008.03.005 · Cited by 67
Kopřivová, J., Horáček, J., Tintěra, J., Praško, J., Raszka, M., Ibrahim, I., & Höschl, C. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.08.012 · Cited by 65
Li, L., Chen, S., Liu, J., Zhang, J., He, Z., & Lin, X. (2006) · The Canadian Journal of Psychiatry · doi:10.1177/070674370605100704 · Cited by 63
Brain structural correlates of depressive comorbidity in obsessive–compulsive disorder
Cardoner, N., Soriano‐Mas, C., Pujol, J., Alonso, P., Harrison, B. J., Deus, J., Hernández‐Ribas, R., Menchón, J. M., & Vallejo, J. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.039 · Cited by 62
Emdad, R., Bonekamp, D., Söndergaard, H. P., Björklund, T., Agartz, I., Ingvar, M., & Theorell, T. (2006) · Psychotherapy and Psychosomatics · doi:10.1159/000090897 · Cited by 56
Emotional responses to subcortical electrical stimulation in psychiatric patients
Laitinen, L. (1979) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(79)90002-7 · Cited by 51
A parametric approach to voxel-based meta-analysis
Costafreda, S. G., David, A. S., & Brammer, M. J. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.01.031 · Cited by 44
Cecconi, J. P., Lopes, A. C., Duran, F., Santos, L. C., Hoexter, M. Q., Gentil, A. F., Canteras, M. M., de Castro, C. C., Norén, G., Greenberg, B. D., et al. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.09.061 · Cited by 37
Obsessive compulsive disorder—Five clinical questions and a suggested approach
Insel, T. R. (1982) · Comprehensive Psychiatry · doi:10.1016/0010-440x(82)90072-4 · Cited by 32
Uchida, R. R., Del‐Ben, C. M., Araújo, D., Busatto, G. F., Duran, F., Crippa, J. A., & Graeff, F. G. (2008) · Anais da Academia Brasileira de Ciências · doi:10.1590/s0001-37652008000100010 · Cited by 28
Lesion Topography in Capsulotomy for Refractory Anxiety – Is the Right Side the Right Side?
Rück, C., Svanborg, P., & Meyerson, B. A. (2005) · Stereotactic and Functional Neurosurgery · doi:10.1159/000089988 · Cited by 12
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Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective
Grupe, D. W., & Nitschke, J. B. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3524 · Cited by 2,007
Activation Likelihood Estimation meta-analysis revisited
Eickhoff, S., Bzdok, D., Laird, A., Kurth, F., & Fox, P. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.09.017 · Cited by 1,448
“Apart from the integration of fMRI and PET data, ALE (Nickl- Jockschat et al., in press-a,b; Schroeter et al., 2007) and SDM (Radua and Mataix-Cols, 2009; Radua et al., 2010) have also been repeatedly used to summarise findings from voxel-based morphometry (VBM) studies.”
BackgroundMethodInfluentialIdentification of a Common Neurobiological Substrate for Mental Illness
Goodkind, M., Eickhoff, S. B., Oathes, D. J., Jiang, Y., Chang, A., Jones-Hagata, L. B., Ortega, B. N., Zaiko, Y. V., Roach, E. L., Korgaonkar, M. S., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2206 · Cited by 1,404
Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways
Milad, M. R., & Rauch, S. L. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.11.003 · Cited by 847
Stein, D. J., Costa, D. L. C., Lochner, C., Miguel, E. C., Reddy, Y. C. J., Shavitt, R. G., van den Heuvel, O. A., & Simpson, H. B. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0102-3 · Cited by 895
Radua, J., Mataix-Cols, D., Phillips, M. L., El-Hage, W., Kronhaus, D. M., Cardoner, N., & Surguladze, S. (2012) · European Psychiatry · doi:10.1016/j.eurpsy.2011.04.001 · Cited by 765
“We have recently developed a signed-differences method called signed differential mapping (SDM) [16,19], which is based and improves upon the many positive features of existing peakprobability methods.”
BackgroundMethodInfluentialSelf-citationEickhoff, S. B., Nichols, T. E., Laird, A. R., Hoffstaedter, F., Amunts, K., Fox, P. T., Bzdok, D., & Eickhoff, C. R. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.04.072 · Cited by 683
“…contribution of individual studies Empirically, it has repeatedly been noted that significant effects may be largely driven by even a single experiment if the total number of experiments is relatively low (Bzdok et al., 2011; Raemaekers et al., 2007; Turkeltaub et al., 2012; Wager et al., 2007).”
Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies
Fullana, M. A., Harrison, B. J., Soriano-Mas, C., Vervliet, B., Cardoner, N., Àvila-Parcet, A., & Radua, J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.88 · Cited by 702
Nakao, T., Radua, J., Rubia, K., & Mataix-Cols, D. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020281 · Cited by 588
Self-citationFusar-Poli, P., Nelson, B., Valmaggia, L., Yung, A. R., & McGuire, P. K. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs136 · Cited by 589
Frodl, T., & Skokauskas, N. (2012) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01786.x · Cited by 530
Arnsten, A. F. T., & Rubia, K. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.01.008 · Cited by 568
Norman, L. J., Carlisi, C., Lukito, S., Hart, H., Mataix-Cols, D., Radua, J., & Rubia, K. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.0700 · Cited by 426
Self-citationBrühl, A. B., Delsignore, A., Komossa, K., & Weidt, S. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.003 · Cited by 439
“…pattern in SAD, in OCD which has also been regrouped into a category of its own, the most consistent findings until now are in the field of structural differences, both white and grey matter (Radua et al., 2014, Piras et al., 2013; Radua et al., 2010, de Wit et al., 2014, Rotge et al., 2010).”
Bora, E., Fornito, A., Raduà, J., Walterfang, M., Seal, M. L., Wood, S. J., Yücel, M., Velakoulis, D., & Pantelis, C. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2010.12.020 · Cited by 440
Pittenger, C., Bloch, M. H., & Williams, K. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.09.006 · Cited by 426
“Morphometric studies have found abnormalities in the same group of brain regions (Menzies et al., 2008; Radua & Mataix-Cols, 2009); increased gray matter volume of the caudate nucleus may be particularly specific for OCD, as opposed to anxiety disorders more generally (Radua et al., 2009).”
BackgroundAnisotropic kernels for coordinate-based meta-analyses of neuroimaging studies
Radua, J., Rubia, K., Canales-Rodríguez, E. J., Pomarol-Clotet, E., Fusar-Poli, P., & Mataix-Cols, D. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00013 · Cited by 406
“D = √ (1− α) · D2 real + α · 2σ 2 · log ( ρ−1 ) (7)”
Regional brain volume in depression and anxiety disorders
van Tol, M.-J., van der Wee, N. J. A., van den Heuvel, O. A., Nielen, M. M. A., Demenescu, L. R., Aleman, A., Renken, R., van Buchem, M. A., Zitman, F. G., & Veltman, D. J. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.121 · Cited by 370
“Importantly, only few studies have explicitly controlled for anxiety comorbidity, although morphometric changes have also been identified in anxiety disorders.(36,37) Whereas volumetric studies in SAD and GAD have been rare, studies in PD have fairly consistently found altered volumes in the amygdala,(38-40) insular c…”
BackgroundPicó-Pérez, M., Radua, J., Steward, T., Menchón, J. M., & Soriano-Mas, C. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.06.001 · Cited by 367
“controls) of each study (either from SPMs or from peak information) and afterwards conducts a voxel-wise random-effects meta-analysis (weighing the studies for sample size, intra-study variance and between-study heterogeneity) (Radua and Mataix-Cols, 2009; Radua et al., 2010; Radua et al., 2012; Radua et al., 2014) (s…”
Goal-directed learning and obsessive-compulsive disorder
Gillan, C. M., & Robbins, T. W. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0475 · Cited by 348
Martin, A., Schurz, M., Kronbichler, M., & Richlan, F. (2015) · Human Brain Mapping · doi:10.1002/hbm.22749 · Cited by 378
“For the present coordinate-based meta-analysis, Anisotropic Effect-Size Signed Differential Mapping (ES-SDM) software (http://www.sdmproject.com), version 4.13 was used [Radua and Mataix-Cols, 2009; Radua et al., 2010, 2012, 2014].”
MethodInfluentialGong, J., Wang, J., Qiu, S., Chen, P., Luo, Z., Wang, J., Huang, L., & Wang, Y. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01036-5 · Cited by 348
Cognitive functioning in obsessive-compulsive disorder: A meta-analysis
Shin, N. Y., Lee, T. Y., Kim, E., & Kwon, J. S. (2014) · Psychological Medicine · doi:10.1017/s0033291713001803 · Cited by 334
“OCD has been reported to be associated with neurobiological abnormalities that are distinct from those associated with other anxiety disorders (Radua et al. 2010).”
Boedhoe, P. S. W., Schmaal, L., Abe, Y., Ameis, S. H., Arnold, P. D., Batistuzzo, M. C., Benedetti, F., Beucke, J. C., Bollettini, I., Bose, A., et al. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16020201 · Cited by 335
“Since repetitive behaviors differentiate OCD from other anxiety disorders, the increased lenticular volume in OCD may reflect these unique symptoms (13).”
Self-citationRaduà, J., Borgwardt, S., Crescini, A., Mataix‐Cols, D., Meyer‐Lindenberg, A., McGuire, P. K., & Fusar‐Poli, P. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.012 · Cited by 338
Self-citationBohrn, I. C., Altmann, U., & Jacobs, A. M. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.07.021 · Cited by 324
Rubia, K., Alegria, A. A., Cubillo, A. I., Smith, A. B., Brammer, M. J., & Radua, J. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.016 · Cited by 315
Fettes, P., Schulze, L., & Downar, J. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00025 · Cited by 299
“It is important to note that the literature implicates a number of corticostriatal pathways in OCD pathology other than the OFC—most prominently, pathways through the dACC and dmPFC (Radua et al., 2010), and pathways from the amygdala to orbital andmedial prefrontal cortex (Milad and Rauch, 2012).”
BackgroundThe search for imaging biomarkers in psychiatric disorders
Abi-Dargham, A., & Horga, G. (2016) · Nature Medicine · doi:10.1038/nm.4190 · Cited by 311
Wise, T., Raduà, J., Nortje, G., Cleare, A. J., Young, A. H., & Arnone, D. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.004 · Cited by 306
“Importantly, AES-SDM also allows meta-analytic group comparisons, which provides an indication of where computed effect sizes differ significantly between groups (21).”
BackgroundBoedhoe, P. S. W., Schmaal, L., Abe, Y., Alonso, P., Ameis, S. H., Anticevic, A., Arnold, P. D., Batistuzzo, M. C., Benedetti, F., Beucke, J. C., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17050485 · Cited by 271
Self-citationNeuroanatomical Maps of Psychosis Onset: Voxel-wise Meta-Analysis of Antipsychotic-Naive VBM Studies
Fusar‐Poli, P., Raduà, J., McGuire, P. K., & Borgwardt, S. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr134 · Cited by 291
“05 corrected for multiple comparisonsunderdifferent conditions.(27)Additionally,we applied an extent threshold of Ke > 20 voxels.”
MethodAbnormally high degree connectivity of the orbitofrontal cortex in obsessive-compulsive disorder
Beucke, J. C., Sepulcre, J., Talukdar, T., Linnman, C., Zschenderlein, K., Endrass, T., Kaufmann, C., & Kathmann, N. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.173 · Cited by 280
“In addition to consistencies with previous resting metabolism studies in OCD, the present findings converge with structural local alterations identified in this patient group.(48,49) More precisely, recent meta-analyses(49) revealed greater bilateral striatal volume in patients with OCD, which is consistent with a gre…”
de Wit, S. J., Alonso, P., Schweren, L., Mataix-Cols, D., Lochner, C., Menchón, J. M., Stein, D. J., Fouche, J.-P., Soriano-Mas, C., Sato, J. R., et al. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13040574 · Cited by 278
“Smaller medial frontal gray matter volume has been reported in anxiety and depression (3, 24), and in our sample it was more pronounced in patients with additional comorbid anxiety and/ or depression, which may thus be indicative of a common pathophysiological mechanism across affective disorders…”
Self-citationAnticevic, A., Hu, S., Zhang, S., Savic, A., Billingslea, E., Wasylink, S., Repovs, G., Cole, M. W., Bednarski, S., Krystal, J. H., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.021 · Cited by 268
“The right caudate and putamen have emerged as loci of pathology in many previous studies, using a variety of functional and structural imaging methods(11,13,15,73).”
MR Spectroscopic Studies of the Brain in Psychiatric Disorders
Maddock, R. J., & Buonocore, M. H. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_197 · Cited by 277
Worbe, Y., Marrakchi‐Kacem, L., Lecomte, S., Valabrègue, R., Poupon, F., Guevara, P., Tucholka, A., Mangin, J., Vidailhet, M., Lehéricy, S., et al. (2014) · Brain · doi:10.1093/brain/awu311 · Cited by 257
Marwood, L., Wise, T., Perkins, A. M., & Cleare, A. J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.022 · Cited by 251
Meta-analytic methods for neuroimaging data explained
Raduà, J., & Mataix‐Cols, D. (2012) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-2-6 · Cited by 250
Self-citationCompulsivity in obsessive–compulsive disorder and addictions
Figee, M., Pattij, T., Willuhn, I., Luigjes, J., van den Brink, W., Goudriaan, A. E., Potenza, M. N., Robbins, T. W., & Denys, D. A. J. P. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.12.003 · Cited by 256
“…OCD after brain injuries have often failed to demonstrate clear pathology of the limbic system such as found in anxiety disorders, but rather indicate that compulsivity may primarily stem from basal ganglia-prefrontal dysfunction (Whiteside et al., 2004; Radua et al., 2010; Figee et al., 2013).”
BackgroundResultNakao, T., Okada, K., & Kanba, S. (2014) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12195 · Cited by 231
“strated the biological independency of OCD from other anxiety disorders by showing that individuals with OCD had increased bilateral GM volumes in the lenticular/caudate nuclei, while patients with other anxiety disorders had decreased gray matter volumes in the left lenticular nucleus.(93)”
Modinos, G., Costafreda, S. G., van Tol, M., McGuire, P. K., Aleman, A., & Allen, P. (2012) · Cortex · doi:10.1016/j.cortex.2012.01.009 · Cited by 230
“The van Tol et al. dataset was identified as it is from one of our research groups (University of Groningen), and was included following the meta-analysis’ goal to include all relevant studies in this particular topic, as in previousmeta-analysis of neuroimaging data (Radua et al., 2010).”
Ersche, K. D., Williams, G. B., Robbins, T. W., & Bullmore, E. T. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.02.017 · Cited by 205
“By contrast, familial vulnerability for stimulant drug dependence, as seen in the first-degree relatives of stimulant-dependent individuals, seems to be associated with subcortical abnormalities such as the enlargement of the putamen [37] and compulsive traits [52,53], resembling the neuroimaging and cognitive abnorma…”
ResultSelective dysfunction of basal ganglia subterritories: From movement to behavioral disorders
Tremblay, L., Worbe, Y., Thobois, S., Sgambato, V., & Féger, J. (2015) · Movement Disorders · doi:10.1002/mds.26199 · Cited by 212
“1) can also explain the high association of motor and behavioral symptoms in disorders such as PD and GTS. GTS is a neurodevelopmental disorder characterized by simple and complex motor tics often associated with AD/HD and OCDs.37,38 In PD, degeneration of dopamine neurons39 results in a triad of motor symptoms (akine…”
BackgroundInfluentialAckermann, H., Hage, S. R., & Ziegler, W. (2014) · Behavioral and Brain Sciences · doi:10.1017/s0140525x13003099 · Cited by 223
Schurz, M., Aichhorn, M., Martin, A., & Perner, J. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00712 · Cited by 201
“We used Effect-Size Signed Differential Mapping (ES-SDM) software, version 2.31 for meta-analysis (Radua et al., 2010, 2012; http://www.sdmproject.com).”
MethodInfluentialBrain anatomy alterations associated with social networking site (SNS) addiction
He, Q., Turel, O., & Bechara, A. (2017) · Scientific Reports · doi:10.1038/srep45064 · Cited by 200
Norman, L. J., Taylor, S. F., Liu, Y., Radua, J., Chye, Y., De Wit, S. J., Huyser, C., Karahanoglu, F. I., Luks, T., Manoach, D., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.11.010 · Cited by 189
“Moreover, many resting-state, structural and functional abnormalities within these regions are shared with unaffected relatives of patients with OCD (26, 65, 66, 69, 72, 75, 76), and are OCD-specific relative to disorders such as attention deficit/hyperactivity disorder, autism spectrum disorders and anxiety disorders…”
BackgroundMethodInfluentialPosner, J., Marsh, R., Maia, T. V., Peterson, B. S., Gruber, A., & Simpson, H. B. (2014) · Human Brain Mapping · doi:10.1002/hbm.22371 · Cited by 197
“Volumetric and gray-matter-density abnormalities have also been reported in these structures in patients with OCD [Maia et al., 2008; Radua et al., 2010].”
BackgroundGray matter volume in major depressive disorder: A meta-analysis of voxel-based morphometry studies
Lai, C.-H. (2013) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2012.06.006 · Cited by 191
MTAC, Wilson, R. P., Colizzi, M., Bossong, M. G., Allen, P., Kempton, M. J., & Bhattacharyya, S. (2018) · Neuropsychology Review · doi:10.1007/s11065-018-9385-5 · Cited by 196
“Meta-analysis was carried out using the seed-based d mapping software employing previously described methods (Radua et al. 2014; Radua and Mataix-Cols 2009; Radua et al. 2012, 2010).”
Carlisi, C. O., Norman, L. J., Lukito, S. S., Radua, J., Mataix-Cols, D., & Rubia, K. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.10.006 · Cited by 176
“While the vACC/MPFC is associated with affect control(61,62), more dorsal parts, in particular dACC, are crucial for inhibitory control(12,13,63,64) as well as for controlling affective VMPFC-limbic systems(65).”
BackgroundResultInfluentialSelf-citationMeta-analysis of Gray Matter Abnormalities in Autism Spectrum Disorder
Via, E., Raduà, J., Cardoner, N., Happe, F. G. E., & Mataix‐Cols, D. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.27 · Cited by 187
“The main strengths of this study are the unbiased inclusion of published and unpublished studies, even if their results were negative (ie, when no significant differences between participants with ASD and controls were found) and the use of novel voxel-wise meta-analytic methods.(27,28) The online database containing…”
BackgroundMethodSelf-citationZhou, M., Hu, X., Lu, L., Zhang, L., Chen, L., Gong, Q., & Huang, X. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.02.001 · Cited by 185
“To directly contrast the brain intrinsic activity of treated and untreated patients, we conducted two meta-analytic group comparisons for ALFF and fALFF studies using AES-SDM, which provided an indication of where the computed effect sizes differed significantly between groups (Radua et al., 2010).”
Won, E., & Kim, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186546 · Cited by 192
“For panic disorder, changes in volumes of the frontal and orbitofrontal cortices [109–114], anterior cingulate cortex [109,112,115,116], amygdala [109,117–120], temporal lobe [110,111,120,121], parahippocampal gyrus [122], insula [109], basal ganglia [111,118], caudate [123,124], and brainstem [112,116,125] have been…”
BackgroundWigton, R., Radua, J., Allen, P., Averbeck, B., Meyer-Lindenberg, A., McGuire, P., Shergill, S. S., & Fusar-Poli, P. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130289 · Cited by 179
“001 1182 Left BA 13 (222) Left BA 22 (219) Left BA 38 (174) Left BA 6 (165) Left BA 21 (120) Left BA 43 (70) Left BA 44 (39) Left BA 4 (37) Left BA 47 (31) Left BA 42 (26) Left BA 9 (19) Left BA 20 (12)”
Revise the revised? New dimensions of the neuroanatomical hypothesis of panic disorder
Dresler, T., Guhn, A., Tupak, S. V., Ehlis, A., Herrmann, M. J., Fallgatter, A. J., Deckert, J., & Domschke, K. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0811-1 · Cited by 182
“Another recent metaanalysis comprising almost the same studies as in Lai (2011) also points towards involvement of the right caudate (Radua et al. 2010).”
BackgroundResultInfluentialTang, S., Lu, L., Zhang, L., Hu, X., Bu, X., Li, H., Hu, X., Gao, Y., Zeng, Z., Gong, Q., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.09.010 · Cited by 187
“Subsequently, a quantitative comparison of amygdala rsFC abnormalities between adult MDD and adolescent MDD was performed by calculating the difference between each MDD group in each voxel, and then standard randomization tests were used to establish statistical significance [27].”
MethodThe neural crossroads of psychiatric illness: an emerging target for brain stimulation
Downar, J., Blumberger, D. M., & Daskalakis, Z. J. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.10.007 · Cited by 166
Bandelow, B., Baldwin, D. S., Abelli, M., Altamura, C. A., Dell’Osso, B. M., Domschke, K., Fineberg, N. A., Grünblatt, E., Jarema, M., Maron, E., et al. (2016) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1181783 · Cited by 174
“(2013) 49 CBT fMRI Response to CBT in panic patients was associated with an inhibitory functional coupling between the ACC and the amygdala Reinecke et al. (2014) 14 CBT fMRI Response to brief CBT predicted by increased pre-treatment activation in bilateral insula and left dorsolateral prefrontal cortex during threat…”
MethodResultShang, J., Fu, Y., Ren, Z., Zhang, T., Du, M., Gong, Q., Lui, S., & Zhang, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093432 · Cited by 164
Zarei, M., Mataix-Cols, D., Heyman, I., Hough, M., Doherty, J., Burge, L., Winmill, L., Nijhawan, S., Matthews, P. M., & James, A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.032 · Cited by 160
Self-citationStructural correlates of auditory hallucinations in schizophrenia: a meta-analysis.
Palaniyappan, L., Balain, V., Radua, J., & Liddle, P. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.01.038 · Cited by 156
Obsessive–compulsive disorder comorbidity: Clinical assessment and therapeutic implications
Pallanti, S., Grassi, G., Sarrecchia, E. D., Cantisani, A., & Pellegrini, M. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00070 · Cited by 158
“However, the growing evidence that OCD has much in common with other anxiety disorders despite its specific features (Storch et al., 2008; Radua et al., 2010; Stein et al., 2010) has led to the realization that it would be inappropriate to remove it from the group of anxiety disorders in DSM-5.”
BackgroundMultimodal Voxel-Based Meta-Analysis of White Matter Abnormalities in Obsessive–Compulsive Disorder
Raduà, J., Grau, M., van den Heuvel, O. A., de Schotten, M. T., Stein, D. J., Canales-Rodríguez, E. J., Catani, M., & Mataix-Cols, D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.5 · Cited by 160
“…with the superior parietal lobule, the results of our meta-analysis also support a growing body of evidence that other regions outside the traditional cortico- striatal loops, such as parietal cortex, may be involved in OCD (Menzies et al, 2008a; Radua and Mataix-Cols, 2009; Radua et al, 2010).”
InfluentialSelf-citationDunlop, K., Woodside, B., Olmsted, M., Colton, P., Giacobbe, P., & Downar, J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.292 · Cited by 147
Martin, A., Kronbichler, M., & Richlan, F. (2016) · Human Brain Mapping · doi:10.1002/hbm.23202 · Cited by 167
“For the present coordinate-based meta-analysis, we used Seed-based d Mapping (SDM; formerly Signed Differential Mapping) software (http://www.sdmproject.com), version 4.31 [Radua et al., 2010, 2012, 2014; Radua and MataixCols, 2009].”
MethodInfluentialLisofsky, N., Kazzer, P., Heekeren, H. R., & Prehn, K. (2014) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2014.06.001 · Cited by 158
Cortical Thickness Abnormalities at Different Stages of the Illness Course in Schizophrenia
Zhao, Y., Zhang, Q., Shah, C., Li, Q., Sweeney, J. A., Li, F. Y., & Gong, Q. (2022) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2022.0799 · Cited by 149
Brandl, F., Weise, B., Bratec, S. M., Jassim, N., Ayala, D. H., Bertram, T., Ploner, M., & Sorg, C. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01271-y · Cited by 158
“First, our study extends previous singledisorder meta-analyses of GMV-changes in MDD [8], ANX [9], and CP [10]: via conjunction analysis, we showed directly, for the first time to our knowledge, an overlap between disorder-individual GMV-decreases in medial PFC/ACC and insula, which had already been shown individually…”
ResultRadua, J., Via, E., Catani, M., & Mataix-Cols, D. (2011) · Psychological Medicine · doi:10.1017/s0033291710002187 · Cited by 183
“Comparison of global and regional white-matter volumes Meta-analytical differences in global white-matter volumes were calculated using standard randomeffects models with the ‘globals ’ procedure in SDM software (www.sdmproject.com/), which uses restricted maximum-likelihood estimation of the variance, a fitting metho…”
MethodInfluentialSelf-citationA Critical Review of Magnetic Resonance Spectroscopy Studies of Obsessive-Compulsive Disorder
Brennan, B. P., Rauch, S. L., Jensen, J. E., & Pope, H. G. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.023 · Cited by 148
“However, 1H-MRS also suggests reduced tNAA in caudate—yet these same meta-analyses found caudate volume equal (51) or increased (50, 52) in OCD across studies collectively—though some individual studies reported reduced caudate volume in OCD (53, 54).”
ResultBora, E., Fornito, A., Yücel, M., & Pantelis, C. (2011) · Psychological Medicine · doi:10.1017/s0033291711001450 · Cited by 138
“To compare schizophrenia and bipolar disorder findings, we contrasted the control–schizophrenia and control– bipolar disorder maps using the omnibus test (Q statistic), correcting for age (dichotomized as 0 and 1 based on themean) (Radua et al. 2010).”
MethodA systematic review of the neural bases of psychotherapy for anxiety and related disorders
Brooks, S. J., & Stein, D. J. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.3/sbrooks · Cited by 134
Van den Eynde, F., Suda, M., Broadbent, H., Guillaume, S., Van den Eynde, M., Steiger, H., Israel, M., Berlim, M., Giampietro, V., Simmons, A., et al. (2012) · European Eating Disorders Review · doi:10.1002/erv.1163 · Cited by 132
Hattingh, C. J., Ipser, J., Tromp, S. A., Syal, S., Lochner, C., Brooks, S. J., & Stein, D. J. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00347 · Cited by 129
“Finally, alterations in gray matter volumes have recently been associated with anxiety disorders, especially in the ACC region (Radua et al., 2010), however, it is still unclear how structural differences relate to functional aberrations in this region.”
BackgroundRemijnse, P. L., van den Heuvel, O. A., Nielen, M. M. A., Vriend, C., Hendriks, G.-J., Hoogendijk, W. J. G., Uylings, H. B. M., & Veltman, D. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059600 · Cited by 123
Jung, W. H., Kang, D.-H., Kim, E., Shin, K. S., Jang, J. H., & Kwon, J. S. (2013) · NeuroImage: Clinical · doi:10.1016/j.nicl.2013.06.013 · Cited by 125
“…imaging using positron emission tomography, single photon emission computed tomography (Whiteside et al., 2004), and voxel-based morphometry studies (Radua et al., 2010) found reliable differences in radiotracer uptake and gray matter volume in the VS of OCD patients compared with controls.”
MethodResultRiederer, F., Marti, M., Luechinger, R., Lanzenberger, R. R., von Meyenburg, J., Gantenbein, A. R., Pirrotta, R., Gaul, C., Kollias, S. S., & Sándor, P. S. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2012.665175 · Cited by 125
“Also in obsessive-compulsive disorder a grey matter increase in the anterior striatum was found in a meta-analysis of VBM-studies (Radua et al. 2010).”
BackgroundHoexter, M. Q., de Souza Duran, F. L., D'Alcante, C. C., Dougherty, D. D., Shavitt, R. G., Lopes, A. C., Diniz, J. B., Deckersbach, T., Batistuzzo, M. C., Bressan, R. A., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.250 · Cited by 123
“Another recent VBM meta-analysis demonstrated that OCD was associated with greater putaminal volume, whereas the opposite was observed in other anxiety disorders (such as posttraumatic stress disorder and panic disorder) (Radua et al, 2010).”
Fouche, J.-P., du Plessis, S., Hattingh, C., Roos, A., Lochner, C., Soriano-Mas, C., Sato, J. R., Nakamae, T., Nishida, S., Kwon, J. S., et al. (2017) · British Journal of Psychiatry · doi:10.1192/bjp.bp.115.164020 · Cited by 110
“7,16 Similar to our present cortical thickness findings, associations of temporal and occipital regional volumes with the harm/checking and symmetry/order dimensions have been shown before, 22 as well as positive associations of the sexual/religious dimension and hoarding dimensions with prefrontal…”
InfluentialSelf-citationAbnormal Brain Activation During Theory of Mind Tasks in Schizophrenia: A Meta-Analysis
Kronbichler, L., Tschernegg, M., Martin, A., Schurz, M., & Kronbichler, M. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx073 · Cited by 120
Alterations in brain structure in adults with anorexia nervosa and the impact of illness duration
Fonville, L., Giampietro, V., Williams, S., Simmons, A., & Tchanturia, K. (2013) · Psychological Medicine · doi:10.1017/s0033291713002389 · Cited by 117
“As co-morbidity is the rule rather than the exception, brain abnormalities found in people with AN may, at least in part, reflect the influence of comorbid disorders, such as anxiety or depression (Lorenzetti et al. 2009; Bellani et al. 2010, 2011; Martin et al. 2010; Radua et al. 2010; Bora et al. 2012).”
BackgroundObsessive-Compulsive Disorder and Autism Spectrum Disorders: Longitudinal and Offspring Risk
Meier, S. M., Petersen, L. V., Schendel, D., Mattheisen, M., Mortensen, P. B., & Mors, O. N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141703 · Cited by 127
“In contrast to patients with other anxiety disorders patients with OCD displayed increased gray matter volumes in the caudate nuclei [15, 16].”
ResultValidity of modulation and optimal settings for advanced voxel-based morphometry
Raduà, J., Canales-Rodríguez, E. J., Pomarol-Clotet, E., & Salvador, R. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.07.084 · Cited by 122
“…is the study of brain volumetric abnormalities using voxel-basedmorphometry (VBM) (Bora et al., 2011; Cooper et al., 2014; Fusar-Poli et al., 2012; Lansley et al., 2013; Nakao et al., 2011; Palaniyappan et al., 2012; Radua and Mataix-Cols, 2009; Radua et al., 2010, 2011, 2012a; Via et al., 2011).”
MethodNeuroplasticity in response to cognitive behavior therapy for social anxiety disorder
Månsson, K. N. T., Salami, A., Frick, A., Carlbring, P., Andersson, G., Furmark, T., & Boraxbekk, C. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.218 · Cited by 124
Serra-Blasco, M., Raduà, J., Soriano‐Mas, C., Gómez‐Benlloch, A., Casteràs, D. P., Carulla‐Roig, M., Albajes‐Eizagirre, A., Arnone, D., Klauser, P., Canales-Rodríguez, E. J., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.002 · Cited by 105
“In any case, what they do report as common neurobiological substrates are bilateral insulae and dorsal ACC.”
BackgroundInfluentialSelf-citationSchulze, L., Schulze, A., Renneberg, B., Schmahl, C., & Niedtfeld, I. (2019) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.11.004 · Cited by 102
Zheng, H., Hu, Y.-B., Wang, Z.-L., Wang, M., Du, X.-X., & Dong, G. (2019) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109656 · Cited by 100
Gray Matter Abnormalities in Social Anxiety Disorder: Primary, Replication, and Specificity Studies
Talati, A., Pantazatos, S. P., Schneier, F. R., Weissman, M. M., & Joy Hirsch, C. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.022 · Cited by 108
Picó‐Pérez, M., Alemany-Navarro, M., Dunsmoor, J. E., Raduà, J., Albajes‐Eizagirre, A., Vervliet, B., Cardoner, N., Benet, O., Harrison, B. J., Soriano‐Mas, C., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.06.029 · Cited by 98
Liu, J., Li, Y., Zhang, W., Xiao, Y., Liu, L., Gao, X., Shah, C., Li, S., Bo, T., Gong, Q., et al. (2017) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-017-0964-4 · Cited by 108
From compulsivity to compulsion: the neural basis of compulsive disorders
Robbins, T. W., Banca, P., & Belin, D. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00807-z · Cited by 107
“Despite notable differences among these three compulsive syndromes, OCD and SUD shared dysregulation in the anterior insula, consistent with other evidence based on reduced GMV 127 .”
InfluentialEmotional arousal and multiple memory systems in the mammalian brain
Packard, M. G., & Goodman, J. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00014 · Cited by 102
“In addition, there is evidence that people with PTSD or obsessive-compulsive disorder (OCD) have enlarged caudate nuclei (Looi et al., 2009; Radua et al., 2010).”
BackgroundFusar‐Poli, P., Smieskova, R., Serafini, G., Politi, P., & Borgwardt, S. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.630408 · Cited by 96
“Additionally, we applied an extent threshold of Ke 20 voxels (Radua et al. 2009; Radua et al. 2010).”
MethodNeural correlates during working memory processing in major depressive disorder
Wang, X.-L., Du, M.-Y., Chen, T.-L., Chen, Z.-Q., Huang, X.-Q., Luo, Y., Zhao, Y.-J., Kumar, P., & Gong, Q.-Y. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.08.011 · Cited by 89
van den Heuvel, O. A., Boedhoe, P. S. W., Bertolín, S., Bruin, W. B., Francks, C., Ivanov, I., Jahanshad, N., Kong, X., Kwon, J. S., O’Neill, J., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.24972 · Cited by 91
“Based on the literature, future cross-disorder comparisons between OCD and other anxiety disorders, as previously done by Radua et al. (2010), as well as comparison with schizophrenia, which is also characterized by a bigger pallidum (Van Erp et al., 2016) may be useful.”
BackgroundResultInfluentialSelf-citationLi, X., & Wang, J. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00299-2 · Cited by 89
Tang, W., Zhu, Q., Gong, X., Zhu, C., Wang, Y., & Chen, S. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.07.004 · Cited by 90
Shaw, P., Sharp, W. S., Sudre, G. P., Wharton, A., GREENSTEIN, D. K., Raznahan, A., Evans, A. C., Chakravarty, M. M., Lerch, J. P., & Rapoport, J. L. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.3 · Cited by 89
“31, 65 There are limitations to the study.”
Metadata
- Authors
- Radua, J., van den Heuvel, O. A., Surguladze, S., & Mataix-Cols, D.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2010-07-01
- Volume
- 67
- Issue
- 7
- Pages
- 701-11
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2111531007
- Cited by
- 400
- References
- 104
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 21 · 2023: 21 · 2022: 31 · 2021: 18 · 2020: 22 · 2019: 21 · 2018: 20 · 2017: 33 · 2016: 25 · 2015: 30 · 2014: 30 · 2013: 34 · 2012: 33
- FWCI
- 33.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- obsessive-compulsive disorder, anxiety disorders, gray matter volume, brain structural changes, dorsomedial frontal cortex, anterior cingulate cortex, caudate nucleus, lentiform nucleus, panic disorder, post-traumatic stress disorder, DSM-V, voxel-based morphometry
- MeSH terms
- Adult, Anxiety Disorders, Brain, Brain Mapping, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Functional Laterality, Male, Obsessive-Compulsive Disorder, Online Systems, Psychiatric Status Rating Scales, Psychometrics, Diagnostic and Statistical Manual of Mental Disorders
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