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Tau Immunotherapies for Alzheimer’s Disease and Related Tauopathies: Progress and Potential Pitfalls1

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Striatal Blood–Brain Barrier Opening in Parkinson's Disease Dementia: A Pilot Exploratory Study

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Receptor specific, stimuli responsive and subcellular targeted approaches for effective therapy of Alzheimer: Role of surface engineered nanocarriers

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Blood–brain barrier opening by intracarotid artery hyperosmolar mannitol induces sterile inflammatory and innate immune responses

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MRI and histological evaluation of pulsed focused ultrasound and microbubbles treatment effects in the brain

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Focused Ultrasound Combined with Microbubbles in Central Nervous System Applications

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Tau Immunotherapies for Alzheimer’s Disease and Related Tauopathies: Progress and Potential Pitfalls

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A Multifaceted Approach to Optimizing AAV Delivery to the Brain for the Treatment of Neurodegenerative Diseases

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Protection of MCC950 against Alzheimer's disease via inhibiting neuronal pyroptosis in SAMP8 mice

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Safety and Efficacy of Scanning Ultrasound Treatment of Aged APP23 Mice

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Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling

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Reconsidering the role of blood-brain barrier in Alzheimer’s disease: From delivery to target

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Current and emerging brain applications of MR-guided focused ultrasound

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Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventions

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“Focused Ultrasound-mediated Drug Delivery in Humans – a Path Towards Translation in Neurodegenerative Diseases”

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Blood–brain barrier opening with low intensity pulsed ultrasound for immune modulation and immune therapeutic delivery to CNS tumors

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Blood–brain barrier opening with focused ultrasound in experimental models of Parkinson's disease

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Current and Emerging Strategies for Enhancing Antibody Delivery to the Brain

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Efficacy of gene delivery to the brain using AAV and ultrasound depends on serotypes and brain areas

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ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma

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Amyloid-β and Tau in Alzheimer’s Disease: Novel Pathomechanisms and Non-Pharmacological Treatment Strategies

Nisbet, R. M., & Götz, J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179907 · Cited by 55 · see citing works

The Applications of Focused Ultrasound (FUS) in Alzheimer’s Disease Treatment: A Systematic Review on Both Animal and Human Studies

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Advances in acoustic monitoring and control of focused ultrasound-mediated increases in blood-brain barrier permeability

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Ultrasonic technologies in imaging and drug delivery

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The blood-brain barrier, a key bridge to treat neurodegenerative diseases

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Multimodal analysis of aged wild-type mice exposed to repeated scanning ultrasound treatments demonstrates long-term safety

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Rapid and Effective Generation of Nanobody Based CARs using PCR and Gibson Assembly

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Single-chain variable fragment antibody-based immunochromatographic strip for rapid detection of fumonisin B1 in maize samples

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Exosomes and ultrasound: The future of theranostic applications

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Focused ultrasound mitigates pathology and improves spatial memory in Alzheimer's mice and patients

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Focused ultrasound in Parkinson's disease: A twofold path toward disease modification

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Tau secretion and propagation: Perspectives for potential preventive interventions in Alzheimer's disease and other tauopathies

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A sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies

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Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model

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Focused ultrasound gene delivery for the treatment of neurological disorders

Kofoed, R. H., & Aubert, I. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.12.006 · Cited by 40 · see citing works

Recent trends in treatment strategies for Alzheimer's disease and the challenges: A topical advancement

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Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology

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Drug delivery strategies to cross the blood-brain barrier in Alzheimer’s disease: a comprehensive review on three promising strategies

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Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ25–35-Induced Mice by Inhibiting the NLRP3 Inflammasome

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Adeno‐associated virus‐based Alzheimer's disease mouse models and potential new therapeutic avenues

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The Blood-Brain Barrier in Alzheimer’s Disease

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Scanning ultrasound in the absence of blood-brain barrier opening is not sufficient to clear β-amyloid plaques in the APP23 mouse model of Alzheimer's disease

Leinenga, G., Koh, W. K., & Götz, J. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.08.002 · Cited by 31 · see citing works

Opportunities and challenges in delivering biologics for Alzheimer’s disease by low-intensity ultrasound

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Novel models for Parkinson’s disease and their impact on future drug discovery

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Targeted protein degradation using intracellular antibodies and its application to neurodegenerative disease

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Focused ultrasound and Alzheimer’s disease A systematic review

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Selective targeting of 3 repeat Tau with brain penetrating single chain antibodies for the treatment of neurodegenerative disorders

Spencer, B. J., Brüschweiler, S., Sealey‐Cardona, M., Rockenstein, E. M., Adame, A., Florio, J. B., Mante, M., Trinh, I., Rissman, R. A., Konrat, R., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1869-0 · Cited by 28 · see citing works

Clinical relevance of animal models in aging-related dementia research

Padmanabhan, P., & Götz, J. (2023) · Nature Aging · doi:10.1038/s43587-023-00402-4 · Cited by 28 · see citing works

MR-guided focused ultrasound in movement disorders and beyond: Lessons learned and new frontiers.

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Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction

Leinenga, G., To, X. V., Bodea, L., Yousef, J. M., Richter-Stretton, G. L., Palliyaguru, T., Chicoteau, A., Dagley, L. F., Nasrallah, F. A., & Götz, J. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02509-5 · Cited by 27 · see citing works

Ultrasound-Mediated Diagnosis and Therapy based on Ultrasound Contrast Agents

Yoon, Y. I., Tang, W., & Chen, X. S. (2017) · Small Methods · doi:10.1002/smtd.201700173 · Cited by 27 · see citing works

Extended detrended fluctuation analysis of electroencephalograms signals during sleep and the opening of the blood–brain barrier

Павлов, А. Н., Dubrovsky, A. I., Koronovskii, A. A., Pavlova, O. N., SEMYACHKINA-GLUSHKOVSKAYA, O. V., & Kurths, J. (2020) · Chaos An Interdisciplinary Journal of Nonlinear Science · doi:10.1063/5.0011823 · Cited by 27 · see citing works

Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy

Bajracharya, R., Cruz, E., Götz, J., & Nisbet, R. M. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.07.026 · Cited by 24 · see citing works

Neuronally expressed anti-tau scFv prevents tauopathy-induced phenotypes in Drosophila models

Krishnaswamy, S., Huang, H.-W., Marchal, I. S., Ryoo, H. D., & Sigurdsson, E. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104770 · Cited by 23 · see citing works

Systemic AAV6-synapsin-GFP administration results in lower liver biodistribution, compared to AAV1&2 and AAV9, with neuronal expression following ultrasound-mediated brain delivery

Weber‐Adrian, D., Kofoed, R. H., Silburt, J., Noroozian, Z., Shah, K., Burgess, A., Rideout, S., Kügler, S., Hynynen, K., & Aubert, I. (2021) · Scientific Reports · doi:10.1038/s41598-021-81046-5 · Cited by 25 · see citing works

Synaptic vulnerability to amyloid-β and tau pathologies differentially disrupts emotional and memory neural circuits

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Recent advances in tau-directed immunotherapy against Alzheimer’s disease: an overview of pre-clinical and clinical development

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Disease-Modifying Effects of Non-Invasive Electroceuticals on β-Amyloid Plaques and Tau Tangles for Alzheimer’s Disease

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Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy

Bajracharya, R., Cruz, E., Götz, J., & Nisbet, R. M. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.07.026 · Cited by 24 · see citing works

O5‐06‐04: CHARACTERIZATION OF NOVEL TAU‐SPECIFIC ANTIBODIES AND ENHANCEMENT OF THEIR DELIVERY INTO THE BRAIN USING FOCUSED SCANNING ULTRASOUND

Nisbet, R. M., Brici, D., Janowicz, P. W., & Götz, J. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.06.4867

Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody

Janowicz, P. W., Leinenga, G., Götz, J., & Nisbet, R. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-45577-2 · Cited by 76 · see citing works

Ultrasound Delivery of an Anti-Aβ Therapeutic Agent to the Brain in a Mouse Model of Alzheimer’s Disease

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Translational Research with FUS BBBO and Neuromodulation for AD

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