CoChat
Sign Up
Cited by 174Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular DisturbancesCognitive Functions and Memory

The Effect of Major Depression on Subjective and Objective Cognitive Deficits in Mild to Moderate Traumatic Brain Injury

Open access
Chamelian, Laury, Feinstein, Anthony·2006·The Journal of Neuropsychiatry and Clinical Neurosciences
DOI 10.1176/jnp.18.1.33
Open this paper in CoChat — free accountOpen PDF

Abstract

The effect of major depression on subjective and objective cognitive deficits 6 months following mild to moderate traumatic brain injury (TBI) was assessed in 63 subjects. Patients with subjective cognitive complaints (n=63) were more likely to be women, with higher Glasgow Coma Scale (GCS) scores and have a diagnosis of major depression. They also performed significantly more poorly on various measures of memory, attention and executive functioning. Group differences on most but not all cognitive measures disappeared in a multivariate analysis when controlling for depression. In mild to moderate TBI, subjective cognitive deficits are linked in large measure to comorbid major depression. However, other mechanisms may also account for these deficits.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1176/jnp.18.1.33

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Anxiety and depressive symptoms negatively influence patient rehabilitation and increase the severity and number of reported health problems such as fatigue, memory, headaches, and concentration problems.

    “Moreover, anxiety and depressive symptoms have a negative influence on patient rehabilitation [5] and they increase the severity and number of reported health problems such as fatigue, memory, headaches, and concentration problems [6, 7].”

    From The BrainACT study: acceptance and commitment therapy for depressive and anxiety symptoms following acquired brain injury: study protocol for a randomized controlled trial. (2019) · cites this paper as [7]

    The Major Depression and Conclusion sections (article pp. 33–38) link major depression with subjective cognitive complaints after mild-to-moderate traumatic brain injury. The paper does not establish that anxiety or depression increases the number or severity of reported health problems, including fatigue and headaches. The rehabilitation clause is cited to [5], not to this source. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 6

  1. McCullagh S, Feinstein A: Cognitive Changes, in Textbook of Traumatic Brain Injury, first edition. Silver JM, McAllister TW, Yudofsky SC (eds.), Washington, DC American Psychiatric Pub- lishing, Inc. 2005
  2. Sunderland A, Harris JE, Baddeley AD: Do laboratory test pre- dict everyday memory? A neuropsychological study. J Verbal Learn Verbal Behav 1983; 22:341-357
  3. Jorge RE, Robinson RG, Moser D, et al: Major depression follow- ing traumatic brain injury. Arch Gen Psychiatry 2004; 61:42-50
  4. Williams DH, Levin HS, Eisenberg HM: Mild head injury clas- sification. Neurosurgery 1990; 27:422-428
  5. McAllister TW, Sparling MB, Flashman LA, et al: Differential working memory load effects after a mild TBI. Neuroimage 2001; 14:1004-1012
  6. McAllister TW, Sparling MB, Flashman LA, et al: Reduction in episodic memory circuitry is related to traumatic brain injury severity. J Neuropsychiatry Clin Neurosci 2001; 13:141

Cited by

Sorted by citations

Related

Authors
Chamelian, L., & Feinstein, A.
Affiliations
Sunnybrook Health Science Centre (CA)
Corresponding author
Feinstein, Anthony
ORCID
Feinstein, Anthony
Venue
The Journal of Neuropsychiatry and Clinical Neurosciences
Publisher
American Psychiatric Association Publishing
Published
2006-02
Volume
18
Issue
1
Pages
33-38
ISSN
  • 0895-0172 (ISSN-L)
  • 1545-7222
DOI
10.1176/jnp.18.1.33
OpenAlex
W2137174078
Cited by
174
References
37
Citations by year
2026: 1 · 2025: 5 · 2024: 2 · 2022: 7 · 2021: 6 · 2020: 4 · 2019: 11 · 2018: 16 · 2017: 10 · 2016: 9 · 2015: 8 · 2014: 8 · 2013: 15 · 2012: 13
FWCI
8.82
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuropsychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
major depressive disorder, traumatic brain injury, mild to moderate TBI, subjective cognitive complaints, memory, attention, executive function, comorbidities, Glasgow Coma Scale, sex differences
MeSH terms
Adolescent, Adult, Cognition Disorders, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychometrics, Risk Factors, Reproducibility of Results, Glasgow Coma Scale, Post-Concussion Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review