Cited by 47Psychotherapy Techniques and ApplicationsPsychoanalysis and Psychopathology ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

A study demonstrating efficacy of a psychoanalytic psychotherapy for panic disorder: Implications for psychoanalytic research, theory, and practice

Open access
Busch, Fredric N., Milrod, Barbara L., Sandberg, Larry S.·2009·Journal of the American Psychoanalytic Association

Abstract

Systematic research on psychoanalytic treatments has been limited by several factors, including a belief that clinical experience can demonstrate the effectiveness of psychoanalysis, rendering systematic research unnecessary, the view that psychoanalytic research would be difficult or impossible to accomplish, and a concern that research would distort the treatment being delivered. In recent years, however, many psychoanalysts have recognized the necessity of research in order to obtain a more balanced assessment of the role of psychodynamic psychotherapy and psychoanalysis in a contemporary treatment armamentarium, as well as to allow appropriate evaluation and potentially greater acceptance by the broader mental health and medical communities. In this context, studies were conducted of a psychodynamic treatment, Panic-Focused Psychodynamic Psychotherapy (PFPP), initially in an open trial and then in a randomized controlled trial (RCT) in comparison with a less active treatment, Applied Relaxation Training (ART; Cerny et al. 1984), for adults with primary DSM-IV panic disorder. The results of the RCT demonstrated the efficacy of PFPP in treating panic disorder, and also demonstrated that a psychoanalytic treatment can be systematically evaluated in a mode consistent with the principles of evidence-based medicine. Two specific features of the methodology, the development of the treatment manual and the operationalization of the adherence instrument, both core building blocks of contemporary psychotherapy outcome research, and their implications for psychoanalytic research are discussed in greater depth. The theoretical, clinical, and educational implications of the PFPP studies are elaborated, and suggestions are made for pursuing further outcome research of psychoanalytic treatments.

Integrity signals

Registry

Crossref · 10.1177/0003065108329677

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

0 of 28 cited sources checked · 0 supported · 0 flagged

  • Findingcitation

    PFPP yielded a significantly higher response rate than applied relaxation training (73% vs 39%, p = .017) in the randomized controlled trial.

    “PFPP demonstrated a significantly higher rate of response compared with ART: 73% vs. 39% (p = .017).”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Barlow et al. 2000 source
  • Findingown data

    PFPP produced significantly greater improvement in psychosocial function than applied relaxation training on the Sheehan Disability Scale (p = .014).

    “PFPP also led to significantly greater improvement in psychosocial function, as measured on the Sheehan Disability Scale (SDS; Sheehan 1983): p = .014.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Sheehan 1983

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Findingown data

    In a randomized controlled trial, Panic-Focused Psychodynamic Psychotherapy was more efficacious than applied relaxation training for adults with primary DSM-IV panic disorder.

    “The results of the RCT demonstrated the efficacy of PFPP in treating panic disorder, and also demonstrated that a psychoanalytic treatment can be systematically evaluated in a mode consistent with the principles of evidence-based medicine.”
    • Also stated in: § Description of Studies and Results · plain
      “PFPP was found to be more efficacious than ART in forty-nine subjects with primary DSM-IV panic disorder.”
    • Also stated in: § Description of Studies and Results · boosted
      “a significantly greater reduction in a broad range of panic symptoms was observed after PFPP, compared with ART, as assessed by the Panic Disorder Severity Scale, the primary outcome measure.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Milrod et al. 2007 source
  • Findingown data

    Comorbid major depression, present in 8 of 21 open-trial patients, remitted with PFPP.

    “Notably, comorbid major depression, present in eight of twenty-one patients, remitted with PFPP as well.”
    Quote in the paperNot a substantial claim
  • Findingcitation

    In the open trial, 16 of the 17 remaining patients met response criteria, defined as greater than 40% reduction on the Panic Disorder Severity Scale, after 24 sessions of PFPP over 12 weeks.

    “Four patients dropped out, and at termination sixteen of the remaining seventeen met “response” criteria (Barlow et al. 2000), a greater than 40 percent reduction in the Panic Disorder Severity Scale (PDSS; Shear et al. 1997).”
    Quote in the paperSubstantial claim0 of 2 sources checked
    • cites Barlow et al. 2000 source
    • cites Shear et al. 1997 source
  • Classified as probably not a substantial claim. 21
  • May combine two claims. 20
  • Not yet classified. 1
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    The therapists' concern about adherence standards decreased once their treatments were found to be highly adherent.

    “Their concern about meeting adherence standards eased as their treatments were found in fact to have a high degree of adherence.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingnone given

    Therapists without psychoanalytic training have since learned PFPP, participated in a subsequent study, and conducted the treatment well.

    “Although the therapists in the studies reported here were all psychoanalysts, therapists without psychoanalytic training have since learned PFPP, have participated in a subsequent study, and have been able to conduct the treatment well.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingcitation

    The study's psychoanalytic therapists initially worried that using a manual would restrict flexibility and that they might not meet adherence standards.

    “The psychoanalytic therapists in our study initially expressed concern over whether use of a manual would limit their flexibility and whether they could meet adherence standards (Busch et al. 2001).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Busch et al. 2001 source
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    Four independent expert psychoanalysts judged the manual to closely match their own clinical work.

    “All four felt the manual closely approximated their own psychoanalytic clinical work, suggesting that operationalizing these approaches need not create a rigid or nonpsychoanalytic treatment.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    The therapists' clinical impression was that manualization and adherence standards did not disrupt the psychoanalytic process.

    “However, once they were engaged in study therapies, their clinical impression was that neither manualization nor adherence standards were disruptive of the psychoanalytic psychotherapeutic process.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingown data

    In the open trial, patients also showed significant improvement in psychosocial function, non-panic anxiety, and depression.

    “In addition to a significant reduction in symptoms of panic disorder, the patients demonstrated significant improvement in measures of psychosocial function, anxiety unrelated to panic, and depression.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingown data

    The therapists viewed their study participation positively, and many experienced a research 'cathexis' that they felt improved their treatments.

    “Despite their initial concerns, the therapists regarded their participation in the study in a positive light. Indeed, many experienced a research “cathexis,” an intensity of focus on their work that they felt improved their treatments.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingown data

    A 24-session course of PFPP reduced panic disorder symptoms and improved psychosocial functioning.

    “Our study found that a course of twenty-four sessions of PFPP was effective in treating panic disorder and improving psychosocial function.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    In those interviews, patients described their parents as variously temperamental, critical, frightening, demanding, and controlling, and reported difficulty acknowledging and expressing angry feelings.

    “They described their parents as variously temperamental, critical, frightening, demanding, and controlling, and they reported difficulty acknowledging and expressing angry feelings.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    A widespread view held that psychoanalytic concepts and interventions are too complex to study systematically, and this view contributed to limiting research.

    “a widespread view that psychoanalytic concepts and interventions are too complex to study in a systematic manner (Green 1996, 2000)”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Green 1996, 2000

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • May combine two claims.

    Premisecitation

    Many psychoanalysts believed that clinical experience already sufficiently demonstrated the effectiveness of psychoanalytic treatments, and this belief contributed to limiting systematic research.

    “a belief that clinical experience can demonstrate the effectiveness of psychoanalysis, rendering systematic research unnecessary”
    • Also stated in: § Abstract · plain
      “a belief among many psychoanalysts that psychoanalytic treatments have already adequately demonstrated effectiveness based on clinical experience (Busch 2006; Kernberg 2006b)”
    Quote in the paperSubstantial claim0 of 2 sources checked
    • cites Busch 2006

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites Kernberg 2006b

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing). May combine two claims.

    Premisecitation

    Focusing on psychiatric symptoms can yield rich information about patients' unconscious lives and can be a fruitful way to understand the patient.

    “The manual describes, as Freud (Breuer and Freud 1895) did, that focusing on psychiatric symptoms, as opposed to the more contemporary psychoanalytic focus on character, can provide a wealth of information about patients’ unconscious lives, and can be a fruitful route to understanding the patient.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Breuer and Freud 1895

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    The defense of undoing is considered an important mechanism by which many panic patients modulate conflicted anger.

    “the defense of “undoing,” which is considered an important mechanism whereby many panic patients modulate conflicted anger”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Milrod et al. 1997

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • May combine two claims.

    Premisecitation

    Bailey et al. (1998) found that process notes from taped sessions contained only one third of the material, with analyst comments omitted more often.

    “For example, Bailey et al. (1998) found that supposedly exhaustive process notes taken from sessions that were also tape-recordred contained only a third of the material, with a greater rate of omission of the analyst’s comments (Bucci 2001).”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites Bailey et al. (1998)

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites Bucci 2001 source
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Study design and conductown data

    All study therapists received a twelve-hour training course on conducting PFPP according to the manual, initial cases were closely supervised, monthly group supervision with videotape review occurred, and all therapists had additional individual supervision.

    “All study therapists were given a twelve-hour therapist training course that focused on how to conduct PFPP in accord with the treatment manual. Initial cases were closely supervised. Monthly group supervisory meetings were held that included discussion of particular cases, with review of videotapes. All the therapists availed themselves of additional, individual supervision.”
    Quote in the paperNot a substantial claim
  • Not yet classified.

    Premise

    Vinnars et al. (2005) found no significant outcome difference between manualized time-limited supportive-expressive psychotherapy and nonmanualized community-delivered psychodynamic psychotherapy for personality disorder patients; both reduced the number meeting personality disorder criteria and the severity of personality disorders and psychiatric symptoms.

    “The authors did not find a significant difference in outcome between the two treatment conditions, and both led to reductions in the number of patients who met the criteria for personality disorder diagnoses, and in the severity of personality disorders and psychiatric symptoms.”
    Quote in the paperNot yet classified0 of 1 sources checked
    • cites Vinnars et al. 2005 source
  • May combine two claims.

    Study design and conductreasoning

    In the efficacy study, treatments were matched in number and frequency of sessions and in therapist experience, making the trial conservative and less likely to show differences between conditions.

    “In the efficacy study, treatments were designed to match in number and frequency of sessions and in the degree of therapist experience, making this treatment trial a conservative one, less likely to show differences between treatment conditions.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S2 (checkable).

    Premisereasoning

    With anxious patients, a comparison psychotherapy group is needed to determine whether improvement results from therapist care and attention rather than the specific therapeutic intervention.

    “Particularly with anxious patients, it is important to determine whether they improve simply as a result of the therapist’s care and attention, rather than as a result of the specific therapeutic intervention—hence the need for a comparison psychotherapy group.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Interpretationown data

    PFPP is efficacious for panic disorder, a DSM-IV Axis I condition.

    “adherents of evidence-based medicine must recognize that psychoanalytic treatment is efficacious with panic disorder.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Interpretationreasoning

    The treatment's 'music' did not appear to be impaired by using a manual, though this was not systematically studied.

    “Thus, while this question was not systematically studied, the “music” of the treatment did not appear to be impaired by use of a manual.”
    Quote in the paperNot a substantial claim
  • Classified as probably not a substantial claim.

    Premisereasoning

    Successful adherence rating requires a simple, operationalized description of psychoanalytic psychotherapy that lets independent raters obtain similar results for the same session.

    “Successful adherence rating entails the development of a simple, operationalized description of psychoanalytic psychotherapy, the use of which allows independent raters to obtain similar results when rating the same session (see below).”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing), S4 (based). May combine two claims.

    Interpretationnone given

    The authors' clinical impression was that time-limited psychoanalytic psychotherapy may intensify the transference and thereby lead to faster symptom improvement.

    “Our clinical impression is that time-limited psychoanalytic psychotherapy may have intensified the transference, potentially leading to more rapid symptomatic gains.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable).

    Premisecitation

    Adherence rating instruments are essential in contemporary psychotherapy outcome research.

    “Adherence rating instruments are essential tools in contemporary psychotherapy outcome research (Gerber et al. 2006).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Gerber et al. 2006

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Classified as probably not a substantial claim.

    Premisereasoning

    Adherence rating instruments concretely show that clinicians are delivering the treatment being studied.

    “They provide concrete demonstration that treating clinicians are actually delivering the treatment being studied.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Premisereasoning

    Head-to-head trials of therapies presumed equally active, such as CBT and PFPP, require enough subjects to provide statistical power to distinguish between them, each with a high response rate; because expected response rates are high, the needed number of subjects would be unfeasibly large.

    “Head-to-head trials of therapies presumed to be equally active, such as CBT and PFPP, require enough subjects to provide the statistical power to distinguish between the two therapies, each with a high response rate. Because of the high response rates expected with CBT and PFPP, the number of subjects needed would be unfeasibly large.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Premisecitation

    Applied relaxation training was chosen as the comparison because it is a credible and efficacious treatment for panic disorder but is less efficacious than CBT.

    “ART was chosen as a comparison therapy because it has been shown to be a credible and efficacious treatment for panic disorder (Öst and Westling 1995), yet it is less efficacious than CBT (Beck et al. 1994; Craske, Brown, and Barlow 1991).”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites Öst and Westling 1995 source
    • cites Beck et al. 1994 source
    • cites Craske, Brown, and Barlow 1991 source
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Study design and conductown data

    No concurrent treatments were permitted during the open trial, and patients on ineffective anti-panic medications were tapered off to gain study access.

    “No concurrent treatments were permitted during this clinical trial, and patients who presented on ineffective anti-panic medications (i.e., who met symptomatic study entrance criteria while taking pharmacological agents) were tapered off of their medication regimens in order to gain access to the study.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Interpretationown data

    Although brief psychotherapy restricts exploration of conflicts, this limitation does not reduce its usefulness for these patients.

    “Although brief psychotherapy limits the exploration of conflicts, this does not detract from the utility of this approach for these patients.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    The PFPP manual was constructed around a psychodynamic formulation of panic disorder that incorporated psychoanalytic theorists and clinicians and information from psychological studies of panic patients, including parental perceptions, premorbid personality traits, and defense mechanisms.

    “The formulation incorporated the work of psychoanalytic theorists and clinicians (e.g., Freud 1926; Deutsch 1929), as well as information derived from psychological studies of patients with panic disorder—e.g., parental perceptions, premorbid personality traits, defense mechanisms (Arrindell et al. 1983; Parker 1979; Kleiner and Marshall 1987; Busch et al. 1995).”
    Quote in the paperNot a substantial claim0 of 3 sources checked
    • cites Busch et al. 1991 source
    • cites Shear et al. 1993 source
    • cites Milrod 1995 source
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Interpretationown data

    In the authors' studies, symptom focus may have helped relieve panic, but this was not specifically evaluated.

    “Yet in our studies, symptom focus may have contributed to panic relief, though this was not specifically evaluated.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: Focus on panic symptoms is a crucial component of PFPP's effectiveness.
  • Classified as probably not a substantial claim.

    Premisereasoning

    To accomplish adherence rating, the therapy's specific essential components must be clearly articulated.

    “To accomplish this, specific essential components of the therapy must be clearly articulated.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S2 (checkable).

    Interpretationreasoning

    The PFPP studies demonstrate the value of research on psychoanalytic treatments.

    “The studies of Panic-Focused Psychoanalytic Psychotherapy described below provide a demonstration of the value of such research.”
    Quote in the paperNot a substantial claim
32 of 32
  • The paper relies on this without support.

    Focus on panic symptoms is a crucial component of PFPP's effectiveness.

    “Based on our clinical experience, we consider this focus on panic symptoms to be a crucial component of what makes PFPP effective, though this has not been systematically assessed.”
  • The paper relies on this without support.

    In nonpsychoanalytically based psychotherapies, therapists have preset agendas that determine session content, whereas in psychoanalytic psychotherapy the therapist permits the patient to guide the session.

    “In nonpsychoanalytically based psychotherapies, therapists have preset agendas that determine the content of the session. In psychoanalytic psychotherapy, the therapist necessarily permits the patient to guide the session by following the patient’s themes and associations.”
  • The paper relies on this without support.

    Individual dynamics and defense mechanisms can contribute to the onset and continuation of panic disorder.

    “It illustrates how individual sets of dynamics and defense mechanisms can contribute to the onset and continuation of panic disorder, and contains descriptions of psychodynamic techniques and approaches to these dynamics.”
3 of 3

Cites

Flagged first, then by citations

Research works printed but not linked: 11

  1. Bailey, K.E., Paper presented to the American Psychoanalytic Association
  2. Busch, F.N., 2006, Bulletin of the Association of Psychoanalytic Medicine, 40, 81
  3. Cerny, J.A., 1984, Anxiety treatment project relaxation treatment manual
  4. 2007, American Journal of Psychiatry, 64, 922
  5. Deutsch, H., 1929, International Journal of Psychoanalysis, 10, 51
  6. Freud, S., 1926, Standard Edition, 20, 75
  7. Gabbard, G.O., 1997, International Journal of Psychoanalysis, 78, 15
  8. Knekt, P., 2004, Studies in Social Security & Health, 77
  9. Leon, A.C., 2001, Journal of Psychotherapy Practice & Research, 10, 1
  10. Rutherford, B., 2007, Bulletin of the Association of Psychoanalytic Medicine, 41, 4
  11. Shedler J., 2006, International Journal of Psychoanalysis Online Discussion Group Bulletin, No. 736 (September 15)

Cited by

Sorted by citations

Authors
Busch, F. N., Milrod, B. L., & Sandberg, L. S.
Affiliations
Cornell University (US)
Venue
Journal of the American Psychoanalytic Association
Published
2009-02
Volume
57
Issue
1
Pages
131-148
ISSN
  • 0003-0651 (ISSN-L)
  • 1941-2460
OpenAlex
W2165344724
Cited by
47
References
54
Citations by year
2026: 1 · 2024: 3 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 3
FWCI
7.05
Type
journal article
Language
en
Open access
Locations
  • Journal of the American Psychoanalytic Association (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R01MH070918, K23-MH01849-01/05, K23MH001849)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
panic disorder, psychodynamic psychotherapy, medication adherence, treatment manual development, psychotherapy outcome research, evidence-based medicine, psychoanalytic research methodology
MeSH terms
Adult, Humans, Manuals as Topic, Psychoanalytic Theory, Psychoanalytic Therapy, Relaxation Therapy, Research, Randomized Controlled Trials as Topic, Panic Disorder, Treatment Outcome, Evidence-Based Medicine

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