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Measurement of Malondialdehyde in Plasma by High Performance Liquid Chromatography with Fluorimetric Detection
Abstract
The thiobarbituric acid test for malondialdehyde is widely used as an indicator of lipid peroxidation and free radical activity. We describe a simple and sensitive high performance liquid chromatographic (HPLC) method for measuring the malondialdehyde-thiobarbituric acid adduct using fluorimetric detection. Extraction into organic solvent or other complex sample preparation is not required and the assay is sensitive to <0 · 05 μmol/L. This method could easily be applied to any setting where a measure of lipid peroxidation is required.
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Sarandol, A., Sarandol, E., Eker, S. S., Erdinc, S., Vatansever, E., & Kirli, S. (2007) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.829 · Cited by 486
Hollman, P. C. H., Cassidy, A., Comte, B., Heinonen, M., Richelle, M., Richling, E., Serafini, M., Scalbert, A., Sies, H., & Vidry, S. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.131490 · Cited by 406
REQUENA, J. R., FU, M. X., AHMED, M. U., JENKINS, A. J., LYONS, T. J., BAYNES, J. W., & THORPE, S. R. (1997) · Biochemical Journal · doi:10.1042/bj3220317 · Cited by 293
Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders
Ansarin, K., Khoubnasabjafari, M., & Jouyban, A. (2017) · BioImpacts · doi:10.15171/bi.2015.20 · Cited by 270
Shvedova, A. A., Kisin, E. R., Murray, A. R., Gorelik, O., Arepalli, S., Castranova, V., Young, S.-H., Gao, F., Tyurina, Y. Y., Oury, T. D., et al. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.03.018 · Cited by 163
Relations of glycemic index and glycemic load with plasma oxidative stress markers
Hu, Y., Block, G., Norkus, E. P., Morrow, J. D., Dietrich, M., & Hudes, M. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.70 · Cited by 154
Kotan, V. O., Sarandol, E., Kirhan, E., Ozkaya, G., & Kirli, S. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.03.021 · Cited by 149
Thiele, J. J., Traber, M. G., Tsang, K., Cross, C. E., & Packer, L. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00617-x · Cited by 138
Inder, T., Mocatta, T., Darlow, B., Spencer, C., Volpe, J. J., & Winterbourn, C. (2002) · Pediatric Research · doi:10.1203/00006450-200208000-00013 · Cited by 125
Ozone-exposure depletes vitamin E and induces lipid peroxidation in murine stratum corneum
Thiele, J. J., Traber, M. G., Polefka, T. G., Cross, C. E., & Packer, L. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12292144 · Cited by 123
Mannitol in cardioplegia as an oxygen free radical scavenger measured by malondialdehyde
Larsen, M., Webb, G., Kennington, S., Kelleher, N., Sheppard, J., Kuo, J., & Unsworth-White, J. (2002) · Perfusion · doi:10.1191/0267659102pf528oa · Cited by 49
Hermans, N., Cos, P., Berghe, D. V., Vlietinck, A. J., & de Bruyne, T. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.05.040 · Cited by 34
Metadata
- Authors
- Young, I. S., & Trimble, E. R.
- Venue
- Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
- Publisher
- SAGE Publications
- Published
- 1991-09
- Volume
- 28
- Issue
- 5
- Pages
- 504-508
- ISSN
- 0004-5632 (ISSN-L)
- 1758-1001
- OpenAlex
- W1967678385
- Cited by
- 271
- References
- 0
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
