The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Comparative Human Salivary and Plasma Proteomes
Open accessAbstract
The protein compositions, or the proteomes, found in human salivary and plasma fluids are compared. From recent experimental work by many laboratories, a catalogue of 2290 proteins found in whole saliva has been compiled. This list of salivary proteins is compared with the 2698 proteins found in plasma. Approximately 27% of the whole-saliva proteins are found in plasma. However, despite this apparent low degree of overlap, the distribution found across Gene Ontological categories, such as molecular function, biological processes, and cellular components, shows significant similarities. Moreover, nearly 40% of the proteins that have been suggested to be candidate markers for diseases such as cancer, cardiovascular disease, and stroke can be found in whole saliva. These comparisons and correlations should encourage researchers to consider the use of saliva to discover new protein markers of disease and as a diagnostic non-proximal fluid to detect early signs of disease throughout the body.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Addona, T. A., Abbatiello, S. E., Schilling, B., Skates, S. J., Mani, D. R., Bunk, D. M., Spiegelman, C. H., Zimmerman, L. J., Ham, A.-J. L., Keshishian, H., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1546 · Cited by 1,037
Anderson, N. L., Polanski, M., Pieper, R., Gatlin, T., Tirumalai, R. S., Conrads, T. P., Veenstra, T. D., Adkins, J. N., Pounds, J. G., Fagan, R., et al. (2004) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m300127-mcp200 · Cited by 1,006
T he D iagnostic A pplications of S aliva — A R eview
Kaufman, E., & Lamster, I. B. (2002) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130201300209 · Cited by 887
Characterization of the Low Molecular Weight Human Serum Proteome
Tirumalai, R. S., Chan, K. C., Prieto, D. A., Issaq, H. J., Conrads, T. P., & Veenstra, T. D. (2003) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m300031-mcp200 · Cited by 860
Toward a Human Blood Serum Proteome
Adkins, J. N., Varnum, S. M., Auberry, K. J., Moore, R. J., Angell, N. H., Smith, R. D., Springer, D. L., & Pounds, J. G. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m200066-mcp200 · Cited by 793
Omenn, G. S., States, D. J., Adamski, M., Blackwell, T. W., Menon, R., Hermjakob, H., Apweiler, R., Haab, B. B., Simpson, R. J., Eddes, J. S., et al. (2005) · PROTEOMICS · doi:10.1002/pmic.200500358 · Cited by 787
The Clinical Plasma Proteome: A Survey of Clinical Assays for Proteins in Plasma and Serum
Anderson, N. L. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2009.126706 · Cited by 562
Salivary Proteomics for Oral Cancer Biomarker Discovery
Hu, S., Arellano, M., Boontheung, P., Wang, J., Zhou, H., Jiang, J., Elashoff, D., Wei, R., Loo, J. A., & Wong, D. T. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-5037 · Cited by 542
Self-citationPieper, R., Gatlin, C. L., Makusky, A. J., Russo, P. S., Schatz, C. R., Miller, S. S., Su, Q., McGrath, A. M., Estock, M. A., Parmar, P. P., et al. (2003) · PROTEOMICS · doi:10.1002/pmic.200300449 · Cited by 518
Denny, P., Hagen, F. K., Hardt, M., Liao, L., Yan, W., Arellanno, M., Bassilian, S., Bedi, G. S., Boontheung, P., Cociorva, D., et al. (2008) · Journal of Proteome Research · doi:10.1021/pr700764j · Cited by 445
Self-citation
Cited by
The physiology of salivary secretion
Proctor, G. B. (2016) · Periodontology 2000 · doi:10.1111/prd.12116 · Cited by 583
Application of Metabolomics in Alzheimer’s Disease
Wilkins, J. M., & Trushina, E. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2017.00719 · Cited by 268
Role of Saliva and Salivary Diagnostics in the Advancement of Oral Health
Dawes, C., & Wong, D. T. W. (2019) · Journal of Dental Research · doi:10.1177/0022034518816961 · Cited by 218
Self-citationSalivary Biomarkers for Detection of Oral Squamous Cell Carcinoma: Current State and Recent Advances
Yakob, M., Fuentes, L., Wang, M. B., Abemayor, E., & Wong, D. T. W. (2014) · Current Oral Health Reports · doi:10.1007/s40496-014-0014-y · Cited by 148
Self-citationPateel, D. G. S., Gunjal, S., Math, S. Y., Murugeshappa, D. G., & Nair, S. M. (2017) · International Journal of Dentistry · doi:10.1155/2017/2857629 · Cited by 22
“Saliva is composed of a variety of electrolytes, immunoglobulins, proteins, and enzymes and plays some important functions in the maintenance of oral health such as lubrication of the oral mucosa, defence from infections, protection against demineralization [1].”
Background
Metadata
- Authors
- Loo, J. A., Yan, W., Ramachandran, P., & Wong, D. T.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2010-08-25
- Volume
- 89
- Issue
- 10
- Pages
- 1016-1023
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2081030362
- Cited by
- 444
- References
- 56
- FWCI
- 11.60
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Comparative Human Salivary and Plasma Proteomes. https://app.cochat.ai/papers/10.1177/0022034510380414
- The paper
- Loo, J. A., Yan, W., Ramachandran, P., & Wong, D. T. (2010). Comparative Human Salivary and Plasma Proteomes. Journal of Dental Research. https://doi.org/10.1177/0022034510380414
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
