The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Infection, Inflammation, and Bone Regeneration: a Paradoxical Relationship
Open accessAbstract
Various strategies have been developed to promote bone regeneration in the craniofacial region. Most of these interventions utilize implantable materials or devices. Infections resulting from colonization of these implants may result in local tissue destruction in a manner analogous to periodontitis. This destruction is mediated via the expression of various inflammatory mediators and tissue-destructive enzymes. Given the well-documented association among microbial biofilms, inflammatory mediators, and tissue destruction, it seems reasonable to assume that inflammation may interfere with bone healing and regeneration. Paradoxically, recent evidence also suggests that the presence of certain pro-inflammatory mediators is actually required for bone healing. Bone injury (e.g., subsequent to a fracture or surgical intervention) is followed by a choreographed cascade of events, some of which are dependent upon the presence of pro-inflammatory mediators. If inflammation resolves promptly, then proper bone healing may occur. However, if inflammation persists (which might occur in the presence of an infected implant or graft material), then the continued inflammatory response may result in suboptimal bone formation. Thus, the effect of a given mediator is dependent upon the temporal context in which it is expressed. Better understanding of this temporal sequence may be used to optimize regenerative outcomes.
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Cites
IL-17 family cytokines and the expanding diversity of effector T cell lineages
Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141557 · Cited by 1,842
Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
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Gaffen, S. L., & Hajishengallis, G. (2008) · Journal of Dental Research · doi:10.1177/154405910808700908 · Cited by 334
Harder, A. T., & An, Y. H. (2003) · The Journal of Clinical Pharmacology · doi:10.1177/0091270003256061 · Cited by 155
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Ma, Q.-L., Zhao, L.-Z., Liu, R.-R., Jin, B.-Q., Song, W., Wang, Y., Zhang, Y.-S., Chen, L.-H., & Zhang, Y.-M. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.08.025 · Cited by 319
The Role of the Immune Cells in Fracture Healing
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Local delivery of nitric oxide: Targeted delivery of therapeutics to bone and connective tissues
Nichols, S. P., Storm, W. L., Koh, A., & Schoenfisch, M. H. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.03.002 · Cited by 148
Inflammation, ageing, and bone regeneration
Gibon, E., Lu, L. Y., Nathan, K., & Goodman, S. B. (2017) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2017.04.002 · Cited by 144
Cytokines during periodontal wound healing: potential application for new therapeutic approach
Morand, D., Davideau, J., Clauss, F., Jessel, N., Tenenbaum, H., & Huck, O. (2017) · Oral Diseases · doi:10.1111/odi.12469 · Cited by 80
Tuning Dual-Drug Release from Composite Scaffolds for Bone Regeneration
Paris, J. L., Román, J., Manzano, M., Cabañas, M. V., & Vallet-Regí, M. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.03.048 · Cited by 41
Lee, J. S., Jin, Y., Park, H., Yang, K., Lee, M. S., Yang, H. S., & Cho, S. (2017) · Biotechnology Journal · doi:10.1002/biot.201700062 · Cited by 40
Metadata
- Authors
- Thomas, M. V., & Puleo, D. A.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2011-01-19
- Volume
- 90
- Issue
- 9
- Pages
- 1052-1061
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2159314490
- Cited by
- 329
- References
- 4
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- green
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