Dental Research Waste in Design, Analysis, and Reporting: A Scoping Review
Open accessAbstract
Research waste is highly prevalent across biomedical investigations. We aimed to assess the evidence on the extent of research waste in dental research. We performed a scoping review of empirical evaluations of dental studies assessing the prevalence and impact of limitations in design, conduct, analysis, and reporting of research. PubMed was searched using specific terms to retrieve studies dealing with design, conduct, analysis, and reporting of studies in dentistry, with no year or language restrictions. Of the 1,807 publications identified from the search and from manual searches, 71 were included in this review. The topic and article selection was based on the expert opinion of the authors. The existing evidence suggests that, although there are improvements over time, substantial deficiencies in all areas (design, conduct, analysis, reporting) were prevalent in dental research publications. Waste in research is a multifaceted problem without a simple solution. However, an appreciation of optimal research design and execution is a prerequisite and should be underpinned by policies that include appropriate training in research methods and properly aligned incentives.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Rayyan-a web and mobile app for systematic reviews.
Ouzzani, M., Hammady, H., Fedorowicz, Z., & Elmagarmid, A. (2016) · Systematic Reviews · doi:10.1186/s13643-016-0384-4 · Cited by 26,092 · see citing works
Increasing value and reducing waste in research design, conduct, and analysis
Ioannidis, J. P. A., Greenland, S., Hlatky, M. A., Khoury, M. J., Macleod, M. R., Moher, D., Schulz, K. F., & Tibshirani, R. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62227-8 · Cited by 1,597 · see citing works
Self-citationWhy Most Clinical Research Is Not Useful
Ioannidis, J. P. A. (2016) · PLOS Medicine · doi:10.1371/journal.pmed.1002049 · Cited by 655 · see citing works
Self-citationThe prevalence of statistical reporting errors in psychology (1985–2013)
Nuijten, M. B., Hartgerink, C. H. J., van Assen, M. A. L. M., Epskamp, S., & Wicherts, J. M. (2016) · Behavior Research Methods · doi:10.3758/s13428-015-0664-2 · Cited by 510 · see citing works
Røttingen, J.-A., Regmi, S., Eide, M., Young, A. J., Viergever, R. F., Årdal, C., Guzman, J., Edwards, D., Matlin, S. A., & Terry, R. F. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61046-6 · Cited by 477 · see citing works
Comparisons against baseline within randomised groups are often used and can be highly misleading
Bland, M., & Altman, D. G. (2011) · Trials · doi:10.1186/1745-6215-12-264 · Cited by 251 · see citing works
Rice, D. B., Raffoul, H., Ioannidis, J. P. A., & Moher, D. (2020) · BMJ · doi:10.1136/bmj.m2081 · Cited by 241 · see citing works
Self-citationGargon, E., Gorst, S. L., Harman, N., Smith, V. A., Matvienko‐Sikar, K., & Williamson, P. R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0209869 · Cited by 112 · see citing works
An assessment of quality characteristics of randomised control trials published in dental journals
Pandis, N., Polychronopoulou, A., & Eliades, T. (2010) · Journal of Dentistry · doi:10.1016/j.jdent.2010.05.014 · Cited by 94 · see citing works
Self-citationNieminen, P. A., Sipilä, K., Takkinen, H., et al. (2007) · BMC Medical Education · doi:10.1186/1472-6920-7-51 · Cited by 93 · see citing works
Relationship between sponsorship and failure rate of dental implants: a systematic approach
Popelut, A., Valet, F., Fromentin, O., Thomas, A., & Bouchard, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010274 · Cited by 86 · see citing works
Development of a core outcome set for use in routine orthodontic clinical trials
Tsichlaki, A., O'Brien, K. D., Benson, P. E., Marshman, Z., Johal, A., Colonio-Salazar, F. B., Harman, N., & Fleming, P. S. (2020) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2020.05.010 · Cited by 74 · see citing works
Self-citationAttitudes, awareness, and barriers toward evidence-based practice in orthodontics
Madhavji, A., Araújo, E., Kim, K. B., & Buschang, P. H. (2011) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2010.05.023 · Cited by 72 · see citing works
Needleman, I. G., Chin, S., O'Brien, T., Petrie, A., & Donos, N. (2012) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2011.01836.x · Cited by 72 · see citing works
Fleming, P., Buckley, N., Seehra, J., Polychronopoulou, A., & Pandis, N. (2012) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2012.05.013 · Cited by 68 · see citing works
Self-citationAre studies reporting significant results more likely to be published?
Koletsi, D., Karagianni, A., Pandis, N., Makou, M., Polychronopoulou, A., & Eliades, T. (2009) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2009.02.024 · Cited by 68 · see citing works
Self-citationAre clustering effects accounted for in statistical analysis in leading dental specialty journals?
Fleming, P. S., Koletsi, D., Polychronopoulou, A., Eliades, T., & Pandis, N. (2012) · Journal of Dentistry · doi:10.1016/j.jdent.2012.11.012 · Cited by 65 · see citing works
Self-citationAre Sample Sizes Clear and Justified in RCTs Published in Dental Journals?
Koletsi, D., Fleming, P. S., Seehra, J., Bagos, P. G., & Pandis, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085949 · Cited by 53 · see citing works
Self-citationSurveys on Reporting Guideline Usage in Dental Journals
Hua, F., Walsh, T., Glenny, A., & Worthington, H. V. (2016) · Journal of Dental Research · doi:10.1177/0022034516657803 · Cited by 53 · see citing works
Assessment of errors and misused statistics in dental research
Kim, J. S., Kim, D., & Hong, S. J. (2011) · International Dental Journal · doi:10.1111/j.1875-595x.2011.00037.x · Cited by 50 · see citing works
Reporting quality of systematic review abstracts in leading oral implantology journals
Kiriakou, J., Pandis, N., Fleming, P. S., Madianos, P., & Polychronopoulou, A. (2013) · Journal of Dentistry · doi:10.1016/j.jdent.2013.09.006 · Cited by 49 · see citing works
Self-citationKoufatzidou, M., Koletsi, D., Fleming, P. S., Polychronopoulou, A., & Pandis, N. (2019) · European Journal of Orthodontics · doi:10.1093/ejo/cjy046 · Cited by 44 · see citing works
Self-citationSaltaji, H., Armijo-Olivo, S., Cummings, G. G., Amin, M., & Flores-Mir, C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0190089 · Cited by 43 · see citing works
Does published orthodontic research account for clustering effects during statistical data analysis?
Koletsi, D., Pandis, N., Polychronopoulou, A., & Eliades, T. (2011) · European Journal of Orthodontics · doi:10.1093/ejo/cjr122 · Cited by 42 · see citing works
Self-citationMethods, transparency and reporting of clinical trials in orthodontics and periodontics
Papageorgiou, S. N., Antonoglou, G. N., Martin, C., & Eliades, T. (2019) · Journal of Orthodontics · doi:10.1177/1465312519842315 · Cited by 40 · see citing works
Koletsi, D., Pandis, N., Polychronopoulou, A., & Eliades, T. (2012) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2011.12.020 · Cited by 37 · see citing works
Self-citationKoletsi, D., Fleming, P. S., Behrents, R. G., Lynch, C. D., & Pandis, N. (2017) · Journal of Dentistry · doi:10.1016/j.jdent.2017.09.009 · Cited by 36 · see citing works
Self-citationLieber, R., Pandis, N., & Faggion, C. M. (2019) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13222 · Cited by 34 · see citing works
Self-citationPapageorgiou, S. N., Xavier, G. M., Cobourne, M. T., & Eliades, T. (2018) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2018.04.017 · Cited by 34 · see citing works
Pandis, N., Polychronopoulou, A., Madianos, P., Makou, M., & Eliades, T. (2011) · Journal of Evidence Based Dental Practice · doi:10.1016/j.jebdp.2010.11.026 · Cited by 33 · see citing works
Self-citationSample size in orthodontic randomized controlled trials: are numbers justified?
Koletsi, D., Pandis, N., & Fleming, P. S. (2013) · European Journal of Orthodontics · doi:10.1093/ejo/cjt005 · Cited by 31 · see citing works
Self-citationDelay and failure to publish dental research
Scholey, J., & Harrison, J. E. (2005) · Evidence-Based Dentistry · doi:10.1038/sj.ebd.6400347 · Cited by 31 · see citing works
Sarkis‐Onofre, R., Poletto-Neto, V., Cenci, M. S., Pereira‐Cenci, T., & Moher, D. (2017) · Journal of Dentistry · doi:10.1016/j.jdent.2017.01.009 · Cited by 30 · see citing works
Full-text publication of abstracts presented at European Orthodontic Society congresses
Livas, C., Pandis, N., & Ren, Y. (2013) · European Journal of Orthodontics · doi:10.1093/ejo/cjt089 · Cited by 30 · see citing works
Self-citationBrignardello-Petersen, R., Carrasco-Labra, A., Yanine, N., Ulloa, C., Araya, I., Pintor, F., Villanueva, J., & Cornejo-Ovalle, M. (2013) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2013.0035 · Cited by 29 · see citing works
dos Santos, M. B. F., Agostini, B. A., Moraes, R. R., Schwendicke, F., & Sarkis‐Onofre, R. (2019) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13100 · Cited by 29 · see citing works
Control of bias in randomized controlled trials published in prosthodontic journals
Dumbrigue, H. B., Jones, J. S., & Esquivel, J. F. (2001) · Journal of Prosthetic Dentistry · doi:10.1067/mpr.2001.119980 · Cited by 28 · see citing works
Papageorgiou, S. N., Kloukos, D., Petridis, H. P., & Pandis, N. (2015) · The International Journal of Prosthodontics · doi:10.11607/ijp.4357 · Cited by 26 · see citing works
Self-citationHua, F., Walsh, T., Glenny, A., & Worthington, H. V. (2016) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2016.01.029 · Cited by 24 · see citing works
Publication bias in five dental implant journals: an observation from 2005 to 2009.
Yuan, J. C., Shyamsunder, N., Barao, V. A. R., Lee, D. J., & Sukotjo, C. (2011) · PubMed · Cited by 23 · see citing works
Alamri, H. M., & Alharbi, F. (2018) · Journal of Endodontics · doi:10.1016/j.joen.2018.05.011 · Cited by 22 · see citing works
Bondemark, L., & Abdulraheem, S. (2018) · European Journal of Orthodontics · doi:10.1093/ejo/cjx084 · Cited by 21 · see citing works
Assessment of Publication Bias in Dental Specialty Journals
Polychronopoulou, A., Pandis, N., & Eliades, T. (2010) · Journal of Evidence Based Dental Practice · doi:10.1016/j.jebdp.2010.09.014 · Cited by 19 · see citing works
Self-citationAssessment of Bias in Methodology for Randomized Controlled Trials Published on Implant Dentistry
Dumbrigue, H. B., Al‐Bayat, M. I., Ng, C. C. H., & Wakefield, C. W. (2006) · Journal of Prosthodontics · doi:10.1111/j.1532-849x.2006.00115.x · Cited by 19 · see citing works
Koletsi, D., Pandis, N., Polychronopoulou, A., & Eliades, T. (2012) · Journal of Evidence Based Dental Practice · doi:10.1016/j.jebdp.2012.05.002 · Cited by 18 · see citing works
Self-citationSmaïl‐Faugeron, V., Chabouis, H. F., & Courson, F. (2014) · BMC Oral Health · doi:10.1186/1472-6831-14-35 · Cited by 18 · see citing works
Papageorgiou, S. N., Antonoglou, G. N., Sándor, G. K. B., & Eliades, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182785 · Cited by 17 · see citing works
Koletsi, D., Karagianni, A., Pandis, N., et al. (2009) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2009.06.002 · Cited by 16 · see citing works
Self-citationChen, J., Li, Z., Liu, B., Gan, X., Li, C., & Yu, H. (2018) · Journal of Dentistry · doi:10.1016/j.jdent.2018.04.025 · Cited by 16 · see citing works
Statistical testing against baseline was common in dental research
Koletsi, D., Arun, M., Fleming, P. S., & Pandis, N. (2015) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2015.01.005 · Cited by 15 · see citing works
Self-citationStatistical analysis in orthodontic journals: are we ignoring confounding?
Spanou, A., Koletsi, D., Fleming, P. S., et al. (2015) · European Journal of Orthodontics · doi:10.1093/ejo/cjv004 · Cited by 14 · see citing works
Self-citationConflict of Interest Reporting in Dentistry Randomized Controlled Trials: A Systematic Review
Beyari, M. M., Hak, A., Li, C. S., & Lamfon, H. A. (2014) · Journal of Evidence Based Dental Practice · doi:10.1016/j.jebdp.2014.06.002 · Cited by 14 · see citing works
Rushing, D. C., Rushing, C. J., Ospina, A., et al. (2018) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2018.06.004 · Cited by 12 · see citing works
Statistical testing against baseline in orthodontic research: a meta-epidemiologic study
Gratsia, S., Koletsi, D., Fleming, P. S., & Pandis, N. (2018) · European Journal of Orthodontics · doi:10.1093/ejo/cjy029 · Cited by 11 · see citing works
Self-citationDumbrigue, H. B., Dumbrigue, E. C., Dumbrigue, D. C., & Chingbingyong, M. I. (2018) · Journal of Prosthodontics · doi:10.1111/jopr.13010 · Cited by 11 · see citing works
Significance bias: an empirical evaluation of the oral health literature
Kagereki, E., Gakonyo, J., & Simila, H. O. (2016) · BMC Oral Health · doi:10.1186/s12903-016-0208-x · Cited by 10 · see citing works
Elangovan, S., Prakasam, S., Gajendrareddy, P. K., & Allareddy, V. (2016) · Journal of Evidence Based Dental Practice · doi:10.1016/j.jebdp.2015.03.016 · Cited by 9 · see citing works
A priori power considerations in orthodontic research: a 3 year meta-epidemiologic study
Gratsia, S., Koletsi, D., Fleming, P. S., & Pandis, N. (2019) · European Journal of Orthodontics · doi:10.1093/ejo/cjz061 · Cited by 9 · see citing works
Self-citationFerreira, C. A., Loureiro, C. A., Saconato, H., & Atallah, Á. N. (2011) · Sao Paulo Medical Journal · doi:10.1590/s1516-31802011000200006 · Cited by 8 · see citing works
Are claims made in orthodontic journal advertisements evidence-supported?
Livas, C., Kouskoura, T., Ren, Y., et al. (2014) · The Angle Orthodontist · doi:10.2319/040814-258.1 · Cited by 8 · see citing works
The reporting of blinding in orthodontic randomized controlled trials: where do we stand?
Abdulraheem, S., & Bondemark, L. (2019) · European Journal of Orthodontics · doi:10.1093/ejo/cjy021 · Cited by 8 · see citing works
Conflict of interest reporting in dentistry meta-analyses: A systematic review
Beyari, M., Strain, D., Li, C., & Lamfon, H. (2014) · Journal of Clinical and Experimental Dentistry · doi:10.4317/jced.51225 · Cited by 7 · see citing works
Research in prosthodontics: a 10-year observation of trends in topics, collaboration, and funding.
Lee, D. J., Yuan, J. C., Knoernschild, K. L., et al. (2011) · PubMed · Cited by 5 · see citing works
Bias: A 30‐Year Review of Randomized Controlled Trials Published in Three Prosthodontic Journals
Dumbrigue, H. B., Dumbrigue, D. C., Dumbrigue, E. C., & Chingbingyong, M. I. (2019) · Journal of Prosthodontics · doi:10.1111/jopr.13072 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [23]23. Holden ACL, Spallek H. 2018. Looking Gift-horses in the Mouth: Gift-giving, Incentives and Conflict of Interest in the Dental Profession. J Law Med. 25(3):794-799.
- [41]41. Lee KC, Chuang S-K. 2020. Financial conflicts of interest in dentistry: how much money do providers receive from industry? Gen Dent. 68(1):56-60.
- [64]64. Smaïl-Faugeron V, Fron-Chabouis H, Durieux P. 2015. Clinical trial registration in oral health journals. J Dent Res. 94(3):8S-13S.
Cited by
Sorted by citations
Research transparency in dental research: A programmatic analysis
Raittio, E., Sofi‐Mahmudi, A., & Uribe, S. E. (2023) · European Journal of Oral Sciences · doi:10.1111/eos.12908 · Cited by 15 · see citing works
Elagami, R. A., Reis, T. M., Hassan, M. A., Tedesco, T. K., Braga, M. M., Mendes, F. M., Cenci, M. S., Huysmans, M.-C., & Raggio, D. P. (2024) · BMC Oral Health · doi:10.1186/s12903-024-04417-0 · Cited by 14 · see citing works
Do randomised clinical trials on dental caries adopt Open Science practices?
Acosta, C. D. P., Cenci, J., Brondani, B., Elagami, R. A., Pereira-Cenci, T., Cenci, M. S., Huysmans, M.-C. D. N. J. M., Raggio, D. P., Braga, M. M., & Mendes, F. M. (2024) · BMC Oral Health · doi:10.1186/s12903-024-05218-1 · Cited by 4 · see citing works
“In dentistry, although most journals endorse OSPs, such as the use of reporting guidelines and recommendations for data sharing [18], very few articles have made their crude data available [19–22], and most studies have not registered the research protocol prospectively [19].”
- Authors
- Pandis, N., Fleming, P. S., Katsaros, C., & Ioannidis, J. P. A.
- Affiliations
- University of Bern (CH)
- Queen Mary University of London (GB)
- Stanford University (US)
- Corresponding author
- Pandis, N.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2020-10-15
- Volume
- 100
- Issue
- 3
- Pages
- 245-252
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W3092659595
- Semantic Scholar
- 8a7c9ed50dfed16f39de72c62b5ac195a859e719
- Cited by
- 58
- References
- 64
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 19 · 2023: 7 · 2022: 9 · 2021: 6 · 2020: 1
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- green
- qmro.qmul.ac.uk
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed (publishedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion)
- Topics
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Health Sciences › Health Professions › Health Information Management › Methodologies in Health Research and Practice
- Social Sciences › Safety Research › Academic integrity and plagiarism
- Keywords
- research waste, dental research, study design flaws, research conduct, reporting quality, research methodology training, research incentives, research quality
- MeSH terms
- Research Design, Dental Research
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review