Physiological, Pharmacokinetic, and Pharmacodynamic Changes in Space

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Cardiac atrophy after bed rest and spaceflight

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Functional and structural adaptations of skeletal muscle to microgravity

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Space Physiology and Medicine

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Regulation of body fluid compartments during short-term spaceflight

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Biomedical Results of Apollo

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Space Physiology and Medicine

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Control of red blood cell mass in spaceflight

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The Regulation of Extracellular Fluid Volume

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Subnormal norepinephrine release relates to presyncope in astronauts after spaceflight

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Glucocorticoids inhibit the production of IL 6 from monocytes, endothelial cells and fibroblasts

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Dose Effects of Recombinant Human lnterleukin-6 on Pituitary Hormone Secretion and Energy Expenditure

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‘Investigation of space flight effects on Escherichia coli and a proposed model of underlying physical mechanisms’.

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Renal effects of head-out water immersion in humans: a 15-year update

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Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space

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Vascular adaptation to microgravity: what have we learned?

Zhang, L. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.6.2415 · Cited by 180 · see citing works

Simulated microgravity alters differentiation and increases apoptosis in human follicular thyroid carcinoma cells

Grimm, D. G., Bauer, J. W., Kossmehl, P. P., Shakibaei, M., Schönberger, J., Pickenhahn, H., Schulze-Tanzil, G. G., Vetter, R., Eilles, C., Paul, M., et al. (2002) · The FASEB Journal · doi:10.1096/fj.01-0673fje · Cited by 167 · see citing works

Bacterial growth in space flight: logistic growth curve parameters for Escherichia coli and Bacillus subtilis

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Biomedical Results from Skylab. NASA SP-377

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Pulmonary diffusing capacity, capillary blood volume, and cardiac output during sustained microgravity

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Immunological analyses of U.S. Space Shuttle crewmembers.

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Neurohormonal control of plasma volume.

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Space Flight Is Associated with Rapid Decreases of Undercarboxylated Osteocalcin and Increases of Markers of Bone Resorption without Changes in Their Circadian Variation: Observations in Two Cosmonauts

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Study of minimal inhibitory concentration of antibiotics on bacteria cultivated in vitro in space (Cytos 2 experiment).

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Space Flight: A Challenge for Normal Bone Homeostasis

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Endocrine and molecular responses to surgical stress

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Effects of head-down-tilt bed rest on cerebral hemodynamics during orthostatic stress

Zhang, R., Zuckerman, J. H., Pawelczyk, J. A., & Levine, B. D. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.6.2139 · Cited by 120 · see citing works

Invited Review: Gender issues related to spaceflight: a NASA perspective

Harm, D. L., Jennings, R. T., Meck, J. V., Powell, M. R., Putcha, L., Sams, C. F., Schneider, S. M., Shackelford, L. C., Smith, S. M., & Whitson, P. A. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.5.2374 · Cited by 119 · see citing works

Chromosome aberrations in the blood lymphocytes of astronauts after space flight

George, K., Durante, M., Wu, H., Willingham, V., Badhwar, G., & Cucinotta, F. A. (2001) · Radiation Research · doi:10.1667/0033-7587(2001)156[0731:caitbl]2.0.co;2 · Cited by 119 · see citing works

cDNA microarray reveals altered cytoskeletal gene expression in space‐flown leukemic T lymphocytes (Jurkat)

Lewis, M. L., Cubano, L. A., Zhao, B., Dinh, H.-K., Pabalan, J. G., Piepmeier, E. H., & Bowman, P. D. (2001) · The FASEB Journal · doi:10.1096/fj.00-0820fje · Cited by 116 · see citing works

Gravity effects on regional lung ventilation determined by functional EIT during parabolic flights

Frerichs, I., Dudykevych, T., Hinz, J. M., Bodenstein, M., Hahn, G., & Hellige, G. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.1.39 · Cited by 115 · see citing works

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Human physiology in space

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Inhomogeneity of pulmonary perfusion during sustained microgravity on SLS-1

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Lung volumes during sustained microgravity on Spacelab SLS-1

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Cardiovascular Adaptation to Spaceflight

Charles, J. B., & Lathers, C. M. (1991) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1991.tb03665.x · Cited by 106 · see citing works

Association of sex and age with responses to lower-body negative pressure

Frey, M., & Hoffler, G. W. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.65.4.1752 · Cited by 104 · see citing works

Analysis of sleep on Shuttle missions.

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Central cardiovascular pressures during graded water immersion in humans

Gabrielsen, A., Johansen, L. B., & Norsk, P. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.2.581 · Cited by 103 · see citing works

Characterization of the osteoblast-like cell phenotype under microgravity conditions in the NASA-approved rotating wall vessel bioreactor (RWV)

Rucci, N., Migliaccio, S., ZANI, B. M., Taranta, A., & Teti, A. M. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10120 · Cited by 100 · see citing works

An Episode of Ventricular Tachycardia During Long-Duration Spaceflight

Fritsch-Yelle, J. M., Leuenberger, U. A., D’Aunno, D. S., Rossum, A. C., Brown, T. E., Wood, M. L., Josephson, M. E., & Goldberger, A. L. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00179-9 · Cited by 97 · see citing works

Renal and endocrine responses in humans to isotonic saline infusion during microgravity

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Acute and delayed effects of a single-dose injection of interleukin-6 on thyroid function in healthy humans

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Quantitation of tissue loss during prolonged space flight

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AN ENZYME-LINKED IMMUNOSORBENT ASSAY FOR CORTISOL IN THE SALIVA OF MAN AND DOMESTIC FARM ANIMALS

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Spaceflight alters immune cell function and distribution

Sonnenfeld, G., Mandel, A. D., Konstantinova, I., Berry, W. D., TAYLOR, G. R., Lesnyak, A. T., Fuchs, B. B., & Rakhmilevich, A. L. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.2.s191 · Cited by 89 · see citing works

Modulation of Hypothalamic–Pituitary–Adrenal Function by Transgenic Expression of Interleukin-6 in the CNS of Mice

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Fluid volume control during short-term space flight and implications for human performance

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Effects of Gravity on Gastric Emptying, Intestinal Transit, and Drug Absorption

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Water and sodium balances and their relation to body mass changes in microgravity

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The Risk of Renal Stone Formation during and after Long Duration Space Flight

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Long-term exposure to spaceflight conditions affects bacterial response to antibiotics.

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Cardiovascular Responses to Postural Changes: Differences with Age for Women and Men

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Changes in Total Body Water During Spaceflight

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Skeletal muscle disuse induces fibre type-dependent enhancement of Na+ channel expression

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Antibiotic activity in space.

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Chapter 6 Regulation of Body Fluid Volume and Electrolyte Concentrations in Spaceflight

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Journal of Bone and Mineral Research

Grigoriev, A. I., Morukov, B. V., Oganov, V. S., Rakhmanov, A. S., & Buravkova, L. B. (1992) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650071416 · Cited by 72 · see citing works

The Sympathetic Nervous System and the Physiologic Consequences of Spaceflight: A Hypothesis

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Effect of adenosine on the expression of β2 integrins and L-selectin of human polymorphonuclear leukocytes in vitro

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Effect of microgravity and hypergravity on deposition of 0.5- to 3-μm-diameter aerosol in the human lung

Darquenne, C., Paiva, M., West, J. B., & Prisk, G. K. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.6.2029 · Cited by 67 · see citing works

Effects of spaceflight on levels and activity of immune cells.

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The endocrine system in space flight

Leach, C. S., Johnson, P., & Cintrón, N. M. (1988) · Acta Astronautica · doi:10.1016/0094-5765(88)90017-3 · Cited by 65 · see citing works

Human cellular immune responsiveness following space flight.

TAYLOR, G. R., & Dardano, J. R. (1983) · PubMed · Cited by 65 · see citing works

Secondary metabolism in simulated microgravity

Demain, A. L., & Fang, A. (2001) · The Chemical Record · doi:10.1002/tcr.1018 · Cited by 64 · see citing works

Destruction of newly released red blood cells in space flight

Alfrey, C. P., Udden, M. M., Huntoon, C. L., & Driscoll, T. B. (1996) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199610000-00032 · Cited by 62 · see citing works

Inhibited interferon-gamma but normal interleukin-3 production from rats flown on the space shuttle.

Gould, C. L., Lyte, M., Williams, J. V., Mandel, A. D., & Sonnenfeld, G. (1987) · PubMed · Cited by 62 · see citing works

Behavior of bacteria and antibiotics under space conditions.

Tixador, R., Gasset, G., Eche, B., Moatti, N., Lapchine, L., Woldringh, C. L., Toorop, P. E., Moatti, J. P., Delmotte, F., & Tap, G. (1994) · PubMed · Cited by 62 · see citing works

Reduced natriuresis during weightlessness

Drummer, C., Heer, M. A., Dressend�rfer, R. A., Strasburger, C. J., & Gerzer, R. (1993) · Journal of Molecular Medicine · doi:10.1007/bf00209720 · Cited by 60 · see citing works

Simulated microgravity, psychic stress, and immune cells in men: observations during 120-day 6° HDT

Choukèr, A., Thiel, M., Баранов, В. М., Meshkov, D., Kotov, A. N., Peter, K., Messmer, K., & Christ, F. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.5.1736 · Cited by 59 · see citing works

Microgravity modifies protein kinase C isoform translocation in the human monocytic cell line U937 and human peripheral blood T‐cells

Hatton, J. P., Gaubert, F., Cazenave, J., & Schmitt, D. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10273 · Cited by 59 · see citing works

Erythropoietin under real and simulated microgravity conditions in humans

Gunga, H.-C., Kirsch, K., Baartz, F.-J., Maillet, A., Gharib, C., Nalishiti, W., Rich, I. N., & Röcker, L. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.2.761 · Cited by 59 · see citing works

Cytogenetic studies of blood lymphocytes from cosmonauts after long-term space flights on MIR station

Fedorenko, B. S., Druzhinin, S., Yudaeva, L., Petrov, V. M., Akatov, Y. A., Snigiryova, G. P., Novitskaya, N., Shevchenko, V. A., & Rubanovich, A. V. (2001) · Advances in Space Research · doi:10.1016/s0273-1177(01)00011-4 · Cited by 58 · see citing works

Analyses of plasma for metabolic and hormonal changes in rats flown aboard COSMOS 2044

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Haematocrit, plasma volume and noradrenaline in humans during simulated weightlessness for 42 days

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Water and sodium balance in space

Drummer, C., Norsk, P., & Heer, M. A. (2001) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2001.27765 · Cited by 57 · see citing works

Altered carbohydrate, lipid, and xenobiotic metabolism by liver from rats flown on Cosmos 1887

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Simulated microgravity enhances vasoconstrictor responsiveness of rat basilar artery

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Dispersion of 0.5- to 2-μm aerosol in μG and hypergravity as a probe of convective inhomogeneity in the lung

Darquenne, C., West, J. B., & Prisk, G. K. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.4.1402 · Cited by 55 · see citing works

Factors Affecting Drug Bioavailability in Space

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Altered thermoregulatory responses after 15 days of head-down tilt

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Simulated weightlessness-induced attenuation of testosterone production may be responsible for bone loss

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Shear stress enhances microcin B17 production in a rotating wall bioreactor, but ethanol stress does not

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Body fluid regulation in µ-gravity differs from that on Earth: an overview

Drummer, C., Gerzer, R., Baisch, F. J., & Heer, M. A. (2000) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240000335 · Cited by 54 · see citing works

Regional lung function in man during immersion with the head above water.

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Unexpected renal responses in space

Norsk, P., CHRISTENSEN, N. J., Bie, P., Gabrielsen, A., Heer, M. A., & Drummer, C. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03135-4 · Cited by 54 · see citing works

Effect of a 22-day space flight on the lymphoid organs of rats.

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Preliminary medical results of the Mir year-long mission

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Ion channel are sensitive to gravity changes

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