Cited by 969Long-Term Effects of COVID-19COVID-19 Clinical Research StudiesCOVID-19 and Mental Health

Symptoms, complications and management of long COVID: a review

Open access
Aiyegbusi, Olalekan Lee, Hughes, Sarah E, Turner, Grace, Rivera, Samantha Cruz, McMullan, Christel, Chandan, Joht Singh, Haroon, Shamil, Price, Gary +5 more·2021·Journal of the Royal Society of Medicine

Abstract

Globally, there are now over 160 million confirmed cases of COVID-19 and more than 3 million deaths. While the majority of infected individuals recover, a significant proportion continue to experience symptoms and complications after their acute illness. Patients with ‘long COVID’ experience a wide range of physical and mental/psychological symptoms. Pooled prevalence data showed the 10 most prevalent reported symptoms were fatigue, shortness of breath, muscle pain, joint pain, headache, cough, chest pain, altered smell, altered taste and diarrhoea. Other common symptoms were cognitive impairment, memory loss, anxiety and sleep disorders. Beyond symptoms and complications, people with long COVID often reported impaired quality of life, mental health and employment issues. These individuals may require multidisciplinary care involving the long-term monitoring of symptoms, to identify potential complications, physical rehabilitation, mental health and social services support. Resilient healthcare systems are needed to ensure efficient and effective responses to future health challenges.

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Crossref · 10.1177/01410768211032850

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  • Social and financial effects of COVID-19 contribute to issues surrounding long COVID, including mental ill health.

    “The social and financial effects of COVID-19 also contribute to the issues surrounding long COVID, including mental ill health.”
  • People with long COVID often report impaired quality of life and issues with education and employment.

    “People with long COVID often report impaired quality of life and issues with education and employment.”
  • Reported long COVID symptoms include fatigue, cough, chest tightness or pain, shortness of breath, sore throat, taste or smell abnormalities, palpitations, myalgia, joint pain, numbness or tingling, skin rashes, hair loss, diarrhoea, urological problems, headache, neurocognitive issues, insomnia, impaired balance or gait, and mental health problems; symptoms can be continuous or relapsing and remm

    “Reported symptoms of long COVID include fatigue, cough, chest tightness, chest pain, shortness of breath, sore throat, abnormalities of taste and smell, palpitations, myalgia, joint pain, numbness or tingling, skin rashes, hair loss, diarrhoea, urological problems, headache, neurocognitive issues including altered memory and concentration, cognitive blunting (known as brain fog), insomnia, im”

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Authors
Aiyegbusi, O. L., Hughes, S. E., Turner, G., Rivera, S. C., McMullan, C., Chandan, J. S., Haroon, S., Price, G., Davies, E. H., Nirantharakumar, K., Sapey, E., Calvert, M. J., & on behalf of the TLC Study Group
Affiliations
  • National Institute for Health and Care Research (GB)
  • University of Birmingham (GB)
  • Aparito Limited (United Kingdom) (GB)
  • Health Data Research UK (GB)
  • University Hospitals Birmingham NHS Foundation Trust (GB)
Corresponding author
Aiyegbusi, Olalekan Lee
Venue
Journal of the Royal Society of Medicine
Published
2021-07-15
Volume
114
Issue
9
Pages
428-442
ISSN
  • 0141-0768 (ISSN-L)
  • 1758-1095
OpenAlex
W3174599482
Cited by
969
References
84
Citations by year
2026: 65 · 2025: 128 · 2024: 212 · 2023: 314 · 2022: 226 · 2021: 23
FWCI
24.77
Type
journal article
Language
en
Open access
Locations
  • Journal of the Royal Society of Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion, cc-by)
Funders
NIHR (COV-LT-0013)
Topics
  • Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
Keywords
long COVID, fatigue, cognitive impairment, mental health, quality of life, physical rehabilitation, multidisciplinary care, symptom management, health system resilience
MeSH terms
COVID-19, SARS-CoV-2, Post-Acute COVID-19 Syndrome, Mental Disorders, Delivery of Health Care, Diarrhea, Employment, Fatigue, Headache, Humans, Mental Health, Pain, Quality of Life, Respiratory Tract Diseases, Sensation Disorders

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