The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Progesterone Inhibits Mast Cell Secretion
Abstract
Mast cells are involved in allergic reactions, where they secrete numerous vasoactive, inflammatory and nociceptive mediators in response to immunoglobulin E (IgE) and antigen. However, they have also been implicated in inflammatory conditions, such as painful bladder syndrome/interstitial cystitis (PBS/IC), irritable bowel syndrome (IBS) and migraines, all of which occur more often in women and are exacerbated during ovulation, but are suppressed during pregnancy. Mast cells express high affinity estrogen receptors and estradiol augments their secretion, while tamoxifen inhibits it. Here we report that progesterone (100 nM), but not the structurally related cholesterol, inhibits histamine secretion from purified rat peritoneal mast cells stimulated immunologically or by substance P (SP), an effect also documented by electron microscopy. These results suggest that mast cell secretion may be regulated by progesterone and may explain the reduced symptoms of certain inflammatory conditions during pregnancy.
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In the citing paper
“A number of in vivo and in vitro studies suggest that sexual hormones regulate MCs functionality and distribution in several tissues [10–14].”
From Gender-Related Effects of Sex Steroids on Histamine Release and Fc ε RI Expression in Rat Peritoneal Mast Cells (2015) · cites this paper as [14]
In the citing paper
“This is consistent with previous studies reporting that progesterone (100 nM) inhibits histamine secretion from PMCs purified from male rats stimulated immunologically [14].”
From Gender-Related Effects of Sex Steroids on Histamine Release and Fc ε RI Expression in Rat Peritoneal Mast Cells (2015) · cites this paper as [14]
Citations
Cites
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Cited by
Sorted by citations
Sex differences and sex steroids in lung health and disease
Townsend, E. A., Miller, V. M., & Prakash, Y. S. (2012) · Endocrine Reviews · doi:10.1210/er.2010-0031 · Cited by 395
Gender difference, sex hormones, and immediate type hypersensitivity reactions
Chen, W., Mempel, M., Schober, W., Behrendt, H., & Ring, J. (2008) · Allergy · doi:10.1111/j.1398-9995.2008.01880.x · Cited by 370
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Cremon, C., Gargano, L., Morselli-Labate, A. M., Santini, D., Cogliandro, R. F., De Giorgio, R., Stanghellini, V., Corinaldesi, R., & Barbara, G. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.94 · Cited by 342
Sex hormones in the modulation of irritable bowel syndrome
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Metadata
- Authors
- Vasiadi, M., Kempuraj, D., Boucher, W., Kalogeromitros, D., & Theoharides, T. C.
- Affiliations
- Tufts Medical Center (US)
- National and Kapodistrian University of Athens (GR)
- Tufts University (US)
- Corresponding author
- Theoharides, T.C.
- Venue
- International Journal of Immunopathology and Pharmacology
- Publisher
- SAGE Publications
- Published
- 2006-10
- Volume
- 19
- Issue
- 4
- Pages
- 787-794
- ISSN
- 0394-6320 (ISSN-L)
- 2058-7384
- OpenAlex
- W2142403829
- Cited by
- 107
- References
- 42
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 9 · 2015: 11 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Immunopathology and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk042409-03)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK42409)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- progesterone, mast cells, histamine release, substance P, estrogen receptor, estradiol, tamoxifen, peritoneal mast cells, pregnancy, inflammatory diseases, irritable bowel syndrome, interstitial cystitis, migraine, allergic reactions
- MeSH terms
- Animals, Male, Mast Cells, Progesterone, Rats, Sprague-Dawley, Rats
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