The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Progesterone Inhibits Mast Cell Secretion
Abstract
Mast cells are involved in allergic reactions, where they secrete numerous vasoactive, inflammatory and nociceptive mediators in response to immunoglobulin E (IgE) and antigen. However, they have also been implicated in inflammatory conditions, such as painful bladder syndrome/interstitial cystitis (PBS/IC), irritable bowel syndrome (IBS) and migraines, all of which occur more often in women and are exacerbated during ovulation, but are suppressed during pregnancy. Mast cells express high affinity estrogen receptors and estradiol augments their secretion, while tamoxifen inhibits it. Here we report that progesterone (100 nM), but not the structurally related cholesterol, inhibits histamine secretion from purified rat peritoneal mast cells stimulated immunologically or by substance P (SP), an effect also documented by electron microscopy. These results suggest that mast cell secretion may be regulated by progesterone and may explain the reduced symptoms of certain inflammatory conditions during pregnancy.
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“A number of in vivo and in vitro studies suggest that sexual hormones regulate MCs functionality and distribution in several tissues [10–14].”
From Gender-Related Effects of Sex Steroids on Histamine Release and Fc ε RI Expression in Rat Peritoneal Mast Cells (2015) · cites this paper as [14]
In the citing paper
“This is consistent with previous studies reporting that progesterone (100 nM) inhibits histamine secretion from PMCs purified from male rats stimulated immunologically [14].”
From Gender-Related Effects of Sex Steroids on Histamine Release and Fc ε RI Expression in Rat Peritoneal Mast Cells (2015) · cites this paper as [14]
Citations
Cites
Mast cells in the development of adaptive immune responses
Galli, S. J., Nakae, S., & Tsai, M. M. (2005) · Nature Immunology · doi:10.1038/ni1158 · Cited by 1,280
Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action.
Ahmed, S. A., Penhale, W. J., & Talal, N. (1985) · PubMed · Cited by 815
Regulation of the Immune System by Sex Steroids*
Grossman, C. J. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-3-435 · Cited by 671
Effects of gender and sex steroids on the immune response
Schuurs, A. H. W. M., & Verheul, H. A. M. (1990) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(90)90270-3 · Cited by 587
Mast cells are closely apposed to nerves in the human gastrointestinal mucosa
Stead, R. H., Dixon, M. F., Bramwell, N. H., Riddell, R. H., & Bienenstock, J. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90627-6 · Cited by 445
Critical role of mast cells in inflammatory diseases and the effect of acute stress
Theoharides, T. C., & Cochrane, D. E. (2003) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.10.041 · Cited by 438
Self-citationThe Natural History of Interstitial Cystitis: A Survey of 374 Patients
Koziol, J. A., Clark, D. C., Gittes, R. F., & Tan, E. M. (1993) · The Journal of Urology · doi:10.1016/s0022-5347(17)36120-7 · Cited by 351
Identification of mast cell progenitors in adult mice
Chen, C., Grimbaldeston, M. A., Tsai, M. M., Weissman, I. L., & Galli, S. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504197102 · Cited by 312
Selective dysfunction of mechanosensitive intestinal afferents in irritable bowel syndrome
Accarino, A. M., Azpiroz, F., & Malagelada, J. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90434-4 · Cited by 282
Mast cell involvement in interstitial cystitis: a review of human and experimental evidence
Theoharides, T. C., Kempuraj, D., & Sant, G. R. (2001) · Urology · doi:10.1016/s0090-4295(01)01129-3 · Cited by 277
Self-citationDimtriadou, V., Buzzi, M. G., Moskowitz, M. A., & Theoharides, T. C. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90253-k · Cited by 275
Self-citationIncreased number of substance P positive nerve fibres in interstitial cystitis
Pang, X., Marchand, J. E., Sant, G. R., Kream, R. M., Theoharides, T. C., & J. (1995) · British Journal of Urology · doi:10.1111/j.1464-410x.1995.tb07384.x · Cited by 248
Self-citationDifferential release of serotonin and histamine from mast cells
Theoharides, T. C., Bondy, P. K., Tsakalos, N. D., & Askenase, P. W. (1982) · Nature · doi:10.1038/297229a0 · Cited by 244
Self-citationSuggestive evidence for a direct innervation of mucosal mast cells
Newson, B., Dahlström, A. B., Enerbäck, L., & Ahlman, H. K. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90153-7 · Cited by 235
Homology of the rat basophilic leukemia cell and the rat mucosal mast cell.
Seldin, D. C., Adelman, S., Austen, K. F., Stevens, R. L., Hein, A., CAULFIELD, J. P., & Woodbury, R. G. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.11.3871 · Cited by 230
Premenstrual exacerbation of asthma.
Gibbs, C. J., Coutts, I. I., Lock, R. B., Finnegan, O. C., & White, R. J. (1984) · Thorax · doi:10.1136/thx.39.11.833 · Cited by 218
Sex steroid regulation of autoimmunity
Grossman, C. J., Roselle, G. A., & Mendenhall, C. L. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90287-f · Cited by 203
Activation of Bladder Mast Cells in Interstitial Cystitis: A Light and Electron Microscopic Study
Theoharides, T. C., Sant, G. R., El-Mansoury, M., Létourneau, R., Ucci, A. A., & Meares, E. M. (1995) · The Journal of Urology · doi:10.1016/s0022-5347(01)67669-9 · Cited by 183
Self-citationLétourneau, R., Pang, X., Sant, G. R., & Theoharides, T. C. (1996) · British Journal of Urology · doi:10.1046/j.1464-410x.1996.08178.x · Cited by 160
Self-citationEstradiol Augments while Tamoxifen Inhibits Rat Mast Cell Secretion
Vliagoftis, H., Dimitriadou, V., Boucher, W., Rozniecki, J. J., Correia, I., Raam, S., & Theoharides, T. C. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000236217 · Cited by 158
Self-citationPLASMA LEVELS OF PROGESTERONE IN PREGNANCY MEASURED BY A RAPID COMPETITIVE PROTEIN BINDING TECHNIQUE
Johansson, E. D. B. (1969) · European Journal of Endocrinology · doi:10.1530/acta.0.0610607 · Cited by 155
Interstitial Cystitis: A Neuroimmunoendocrine Disorder a
THEOHARIDES, T. C., PANG, X., LETOURNEAU, R., & SANT, G. R. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09601.x · Cited by 139
Self-citationDaëron, M., Sterk, A. R., Hirata, F., & Ishizaka, T. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.129.3.1212 · Cited by 104
Pang, X., Cotreau‐Bibbo, M. M., Sant, G. R., & Theoharides, T. C. (1995) · British Journal of Urology · doi:10.1111/j.1464-410x.1995.tb07303.x · Cited by 103
Self-citationInterstitial Cystitis: Correlation with Nerve Fibres, Mast Cells and Histamine
Lundeberg, T., Liedberg, H., Nordling, L., Theodorsson, E., OWZARSKI, A., & Ekman, P. (1993) · British Journal of Urology · doi:10.1111/j.1464-410x.1993.tb15986.x · Cited by 94
(1990) · PubMed · Cited by 85
MENSTRUAL CYCLE AFFECTS BLADDER PAIN SENSATION IN SUBJECTS WITH INTERSTITIAL CYSTITIS
Powell, T., Ness, T. J., Cannon, R., Lloyd, L. K., Weigent, D. A., & Fillingim, R. B. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000176747.40242.3d · Cited by 77
Spanos, C. P., El-Mansoury, M., Létourneau, R., Minogiannis, P., Greenwood, J., Siri, P., Sant, G. R., & Theoharides, T. C. (1996) · Urology · doi:10.1016/s0090-4295(96)00239-7 · Cited by 53
Self-citationTakei, M., Burgoyne, D. L., & Andersen, R. J. (1994) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600830909 · Cited by 50
Daily plasma progesterone levels during the menstrual cycle
Woolever, C. A. (1963) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(16)35633-2 · Cited by 37
Immunomodulators for treatment of interstitial cystitis
Theoharides, T. C., & Sant, G. R. (2005) · Urology · doi:10.1016/j.urology.2004.08.052 · Cited by 33
Self-citationHormonal pattern in women affected by rheumatoid arthritis
Valentino, R., Savastano, S., Tommaselli, A. P., Riccio, A., Mariniello, P., Pronesti, G., Divitiis, P. M. D., & Lombardi, G. (1993) · Journal of Endocrinological Investigation · doi:10.1007/bf03347683 · Cited by 29
Histamine Releasing Activity of Natural Estrogens.
Shelesnyak, M. C. (1959) · Experimental Biology and Medicine · doi:10.3181/00379727-100-24762 · Cited by 28
Histamine Metabolism During the Menstrual Cycle
Jonassen, F., Granérus, G., & Wetterqvist, H. (1976) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016347609158501 · Cited by 27
Inhibition of murine cytotoxic T cell responses by progesterone
Männel, D. N., Falk, W., & Yron, I. (1990) · Immunology Letters · doi:10.1016/0165-2478(90)90181-o · Cited by 27
Age–sex incidence in symptomatic allergies: an excess of females in the child-bearing years
Wormald, P. J. (1977) · Journal of Hygiene · doi:10.1017/s0022172400052827 · Cited by 26
Settipane, R. A., & Simon, R. A. (1989) · PubMed · Cited by 24
Effect of Pregnancy on Airway Responsiveness and Asthma Severity: Relationship to Serum Progesterone
Juniper, E. F., Daniel, E. E., Roberts, R. S., Kline, P. A., HARGREAVE, F. E., & Newhouse, M. T. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/143.3_pt_2.s78 · Cited by 19
Uchida, H., Mizuno, K., Yoshida, A., & Ueda, H. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(02)00135-3 · Cited by 17
Neuroimmune Connections and Regulation of Function in the Urinary Bladder
Theoharides, T. C., & Sant, G. R. (2003) · CRC Press eBooks · doi:10.3109/9780203008966-20 · Cited by 14
Self-citationNeuroimmune Interactions in the Lung
Undem, B. J., & Weinreich, D. M. (2003) · CRC Press eBooks · doi:10.3109/9780203008966-17 · Cited by 11
Kita, E., Hamuro, A., Oku, D., Nishikawa, F., Yasui, K., Emoto, M., Katsui, N., & Kashiba, S. (1990) · Cellular Immunology · doi:10.1016/0008-8749(90)90164-m · Cited by 5
Research works printed but not linked: 7
- Ahmed S.A., 1985, Am. J. Pathol., 121, 531
- Padilla L., 1990, Cell. Mol. Biol., 36, 93
- Kouretas D., 1991, Clin. Res., 39, 320
- Settipane R.A., 1989, Ann. Allergy, 63, 373
- Conrad M.J., 1974, Physiol. Chem. Phys., 6, 11
- Patra P.B., Tibbitts F.D., Westfall D.P., 1995. Endocrine status and urinary mast cells: Possible relationship to interstitial cystitis. NIH IC Symposium Jan.9–11 .
- Popova L.A., 1989, Fiziol. ZH (Kiev), 35, 75
Cited by
Sorted by citations
Sex differences and sex steroids in lung health and disease
Townsend, E. A., Miller, V. M., & Prakash, Y. S. (2012) · Endocrine Reviews · doi:10.1210/er.2010-0031 · Cited by 395
Gender difference, sex hormones, and immediate type hypersensitivity reactions
Chen, W., Mempel, M., Schober, W., Behrendt, H., & Ring, J. (2008) · Allergy · doi:10.1111/j.1398-9995.2008.01880.x · Cited by 370
Roved, J., Westerdahl, H., & Hasselquist, D. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.11.017 · Cited by 348
Cremon, C., Gargano, L., Morselli-Labate, A. M., Santini, D., Cogliandro, R. F., De Giorgio, R., Stanghellini, V., Corinaldesi, R., & Barbara, G. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.94 · Cited by 342
Sex hormones in the modulation of irritable bowel syndrome
Mulak, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i10.2433 · Cited by 287
Metadata
- Authors
- Vasiadi, M., Kempuraj, D., Boucher, W., Kalogeromitros, D., & Theoharides, T. C.
- Affiliations
- Tufts Medical Center (US)
- National and Kapodistrian University of Athens (GR)
- Tufts University (US)
- Corresponding author
- Theoharides, T.C.
- Venue
- International Journal of Immunopathology and Pharmacology
- Publisher
- SAGE Publications
- Published
- 2006-10
- Volume
- 19
- Issue
- 4
- Pages
- 787-794
- ISSN
- 0394-6320 (ISSN-L)
- 2058-7384
- OpenAlex
- W2142403829
- Cited by
- 107
- References
- 42
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 9 · 2015: 11 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Immunopathology and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk042409-03)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK42409)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- progesterone, mast cells, histamine release, substance P, estrogen receptor, estradiol, tamoxifen, peritoneal mast cells, pregnancy, inflammatory diseases, irritable bowel syndrome, interstitial cystitis, migraine, allergic reactions
- MeSH terms
- Animals, Male, Mast Cells, Progesterone, Rats, Sprague-Dawley, Rats
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