Cited by 107Mast cells and histamineAsthma and respiratory diseasesEstrogen and related hormone effects

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Progesterone Inhibits Mast Cell Secretion

Vasiadi, M., Kempuraj, D., Boucher, W., Kalogeromitros, D., Theoharides, T.C.·2006·International Journal of Immunopathology and Pharmacology

DOI 10.1177/039463200601900408

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Abstract

Mast cells are involved in allergic reactions, where they secrete numerous vasoactive, inflammatory and nociceptive mediators in response to immunoglobulin E (IgE) and antigen. However, they have also been implicated in inflammatory conditions, such as painful bladder syndrome/interstitial cystitis (PBS/IC), irritable bowel syndrome (IBS) and migraines, all of which occur more often in women and are exacerbated during ovulation, but are suppressed during pregnancy. Mast cells express high affinity estrogen receptors and estradiol augments their secretion, while tamoxifen inhibits it. Here we report that progesterone (100 nM), but not the structurally related cholesterol, inhibits histamine secretion from purified rat peritoneal mast cells stimulated immunologically or by substance P (SP), an effect also documented by electron microscopy. These results suggest that mast cell secretion may be regulated by progesterone and may explain the reduced symptoms of certain inflammatory conditions during pregnancy.

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Authors: Vasiadi, M., Kempuraj, D., Boucher, W., Kalogeromitros, D., & Theoharides, T. C.
Affiliations: Tufts Medical Center (US)
National and Kapodistrian University of Athens (GR)
Tufts University (US)
Corresponding author: Theoharides, T.C.
ORCID: Kempuraj, D.
Theoharides, T.C.
Venue: International Journal of Immunopathology and Pharmacology
Publisher: SAGE Publications
Published: 2006-10
Volume: 19
Issue: 4
Pages: 787-794
ISSN: 0394-6320 (ISSN-L)
2058-7384
DOI: 10.1177/039463200601900408
OpenAlex: W2142403829
Cited by: 107
References: 42
Citations by year: 2026: 2 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 9 · 2015: 11 · 2014: 3 · 2013: 1 · 2012: 3
FWCI: 2.14
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: International Journal of Immunopathology and Pharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01dk042409-03)
National Institute of Diabetes and Digestive and Kidney Diseases (DK42409)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: progesterone, mast cells, histamine release, substance P, estrogen receptor, estradiol, tamoxifen, peritoneal mast cells, pregnancy, inflammatory diseases, irritable bowel syndrome, interstitial cystitis, migraine, allergic reactions
MeSH terms: Animals, Male, Mast Cells, Progesterone, Rats, Sprague-Dawley, Rats

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Progesterone Inhibits Mast Cell Secretion

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