Cited by 199Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

GABAergic Function in Alzheimer's Disease: Evidence for Dysfunction and Potential as a Therapeutic Target for the Treatment of Behavioural and Psychological Symptoms of Dementia

Open access
Lanctôt, Krista L, Herrmann, Nathan, Mazzotta, Paolo, Khan, Lyla R, Ingber, Neil·2004·The Canadian Journal of Psychiatry

Abstract

Alzheimer's disease (AD) is characterized by disruptions in multiple major neurotransmitters. While many studies have attempted to establish whether GABA is disrupted in AD patients, findings have varied. We review evidence for disruptions in GABA among patients with AD and suggest that the variable findings reflect subtypes of the disease that are possibly manifested clinically by differing behavioural symptoms. GABA, the major inhibitory neurotransmitter, has long been a target for anxiolytics, hypnotic sedatives, and anticonvulsants. We review the clinical use of GABAergic agents in treating persons with AD symptoms. While newer generation GABAergic medications are now available, they have yet to be evaluated among patients with AD.

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Crossref · 10.1177/070674370404900705

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147 of 147 references verified0 citation errors · 0 not checkable

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Authors
Lanctôt, K. L., Herrmann, N., Mazzotta, P., Khan, L. R., & Ingber, N.
Affiliations
Sunnybrook Health Science Centre (CA)
Corresponding author
Lanctôt, Krista L
Venue
The Canadian Journal of Psychiatry
Published
2004-07
Volume
49
Issue
7
Pages
439-453
ISSN
  • 0706-7437 (ISSN-L)
  • 1497-0015
OpenAlex
W2184602814
Cited by
191
References
146
Citations by year
2025: 7 · 2024: 6 · 2023: 6 · 2022: 11 · 2021: 14 · 2020: 12 · 2019: 13 · 2018: 19 · 2017: 15 · 2016: 11 · 2015: 9 · 2014: 8 · 2013: 9 · 2012: 6
FWCI
3.09
Type
journal article
Language
en
Open access
Locations
  • The Canadian Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Alzheimer's Society
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
Alzheimer's disease, GABA, GABAergic dysfunction, behavioral and psychological symptoms of dementia, inhibitory neurotransmitter, GABAergic drugs, anxiolytics, antiepileptic drugs, disease subtypes
MeSH terms
Aged, Alzheimer Disease, Benzodiazepines, Binding Sites, Brain, Frontal Lobe, gamma-Aminobutyric Acid, Humans, Limbic System, Parietal Lobe, Temporal Lobe, Tomography, Emission-Computed, Tomography, Emission-Computed, Single-Photon, Receptors, GABA, GABA Agonists

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