Cited by 211Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchDementia and Cognitive Impairment Research

Towards a Better Understanding of GABAergic Remodeling in Alzheimer’s Disease

Open access
Govindpani, Karan, Calvo-Flores Guzmán, Beatriz, Vinnakota, Chitra, Waldvogel, Henry, Faull, Richard, Kwakowsky, Andrea·2017·International Journal of Molecular Sciences

Abstract

γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the vertebrate brain. In the past, there has been a major research drive focused on the dysfunction of the glutamatergic and cholinergic neurotransmitter systems in Alzheimer’s disease (AD). However, there is now growing evidence in support of a GABAergic contribution to the pathogenesis of this neurodegenerative disease. Previous studies paint a complex, convoluted and often inconsistent picture of AD-associated GABAergic remodeling. Given the importance of the GABAergic system in neuronal function and homeostasis, in the maintenance of the excitatory/inhibitory balance, and in the processes of learning and memory, such changes in GABAergic function could be an important factor in both early and later stages of AD pathogenesis. Given the limited scope of currently available therapies in modifying the course of the disease, a better understanding of GABAergic remodeling in AD could open up innovative and novel therapeutic opportunities.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/ijms18081813

Cites

348 of 348 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

5 of the 353 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Govindpani, K., Calvo-Flores Guzmán, B., Vinnakota, C., Waldvogel, H., Faull, R., & Kwakowsky, A.
Affiliations
  • University of Auckland (NZ)
  • Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New Zealand
Corresponding author
Kwakowsky, Andrea
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2017-08-21
Volume
18
Issue
8
Pages
1813
ISSN
1422-0067 (ISSN-L)
OpenAlex
W2746415584
Cited by
208
References
353
Citations by year
2026: 20 · 2025: 14 · 2024: 25 · 2023: 26 · 2022: 16 · 2021: 41 · 2020: 29 · 2019: 29 · 2018: 5 · 2017: 2 · 2012: 1
FWCI
2.18
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • ResearchSpace (University of Auckland) (submittedVersion, cc-by)
Funders
  • Aotearoa Foundation (3705579)
  • Brain Research New Zealand (3710638)
  • Health Research Council of New Zealand (3627373)
  • Maurice and Phyllis Paykel Trust (3713650)
  • Auckland Medical Research Foundation (3712563)
  • University of Otago (110089.01)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, GABAergic system, inhibitory neurotransmission, excitation-inhibition balance, neurodegeneration, AD pathogenesis, therapeutic target
MeSH terms
Alzheimer Disease, Brain, gamma-Aminobutyric Acid, Humans, Neurotransmitter Agents, GABAergic Neurons

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review