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Cited by 81Personality Disorders and PsychopathologyTreatment of Major DepressionPsychotherapy Techniques and Applications

Combined treatment of major depression in patients with borderline personality disorder: a comparison with pharmacotherapy

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Bellino, Silvio, Zizza, Monica, Rinaldi, Camilla, Bogetto, Filippo·2006·The Canadian Journal of Psychiatry
DOI 10.1177/070674370605100707
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Abstract

Objective: Combined treatment with psychotherapy and antidepressants is more effective than monotherapies. Recent data show that combined therapy has better results in patients with depression and Axis II codiagnosis. The aim of this study was to compare combined treatment using interpersonal psychotherapy (IPT) with pharmacotherapy alone in patients with depression and borderline personality disorder (BPD). Methods: There were 39 consecutive outpatients diagnosed with BPD who presented with a major depressive episode enrolled in this study. They were randomly assigned to 1 of 2 treatment groups: fluoxetine 20 mg to 40 mg daily or fluoxetine 20 mg to 40 mg daily plus IPT 1 session weekly. Owing to noncompliance, 7 patients dropped out. We assessed the 32 patients who completed the 24 weeks of treatment at baseline, Week 12, and Week 24, using a semistructured interview for clinical characteristics, the Clinical Global Impression Scale (CGI), the Hamilton Depression Rating Scale (HDRS), and the Hamilton Anxiety Rating Scale (HARS), and 2 self-report questionnaires, that is, the Satisfaction Profile (SAT-P) for quality of life and the 64-item Inventory for Interpersonal Problems (IIP-64). We performed statistical analysis, using univariate general linear models with 2 factors: duration and type of treatment. Results: Changes in remission rates, CGI, and HARS score did not differ between treatments. According to changes in the HDRS scores; changes in psychological functioning and social functioning scores on the SAT-P; and changes in vindictive or self-centred, cold or distant, intrusive or needy, and socially inhibited scores on the IIP-64, combined therapy was superior to fluoxetine alone. Conclusions: Combined therapy with IPT is more effective than antidepressant therapy alone, both in treating symptoms of major depression and in improving dimensions of quality of life and interpersonal functioning.

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Crossref · 10.1177/070674370605100707

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  • Some studies concentrated on participants with distinct comorbid conditions, such as alcohol abuse or dependence, post-traumatic stress disorder, or major depressive disorder episodes.

    “Some studies, however, concentrated on participants with distinct comorbid conditions, such as alcohol abuse or dependence (Gregory 2008), post-traumatic stress disorder (Steil 2010) or major depressive disorder episodes (Bellino 2006;Bellino 2007).”

    From Psychological therapies for people with borderline personality disorder. (2012) · cites this paper as Bellino 2006

  • In the IPT-BPD trial (Bellino 2010), allegiance effect was improbable at low risk because the working group seemed experienced in but not associated with IPT.

    “Allegiance effect improbable? Low risk The working group seems to be experienced in but not to be associated with IPT (cf. Bellino 2006;Bellino 2007).”

    From Psychological therapies for people with borderline personality disorder. (2012) · cites this paper as Bellino 2006

  • The two trials included in this review that tested drug treatment plus psychotherapy against drug treatment plus clinical management only indicated superior results for participants who received additional psychotherapy.

    “the two trials included here testing drug treatment plus psychotherapy against drug treatment plus clinical management only (Bellino 2006;Bellino 2010), indicated superior results for those participants who received additional psychotherapy.”

    From Psychological therapies for people with borderline personality disorder. (2012) · cites this paper as Bellino 2006

  • Bellino 2006 had low risk of an allegiance effect.

    “Allegiance effect improbable?Low risk The authors seem not to be associated with IPT.”

    From Psychological therapies for people with borderline personality disorder. (2012) · cites this paper as Bellino 2006

  • Bellino 2006 had high risk of attention bias because more attention was paid to the experimental group.

    “Attention bias: equal amounts of attention to all groups (obligatory treatment components)?High risk More attention paid to EG participants.”

    From Psychological therapies for people with borderline personality disorder. (2012) · cites this paper as Bellino 2006

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Authors
Bellino, S., Zizza, M., Rinaldi, C., & Bogetto, F.
Affiliations
University of Turin (IT)
Corresponding author
Bellino, Silvio
ORCID
Bellino, Silvio
Venue
The Canadian Journal of Psychiatry
Publisher
SAGE Publications
Published
2006-06
Volume
51
Issue
7
Pages
453-460
ISSN
  • 0706-7437 (ISSN-L)
  • 1497-0015
DOI
10.1177/070674370605100707
OpenAlex
W2167048560
Cited by
81
References
56
Citations by year
2026: 1 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 10 · 2013: 5 · 2012: 3
FWCI
6.65
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • The Canadian Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
  • INFM-OAR (INFN Catania) (submittedVersion, other-oa)
  • Zenodo (CERN European Organization for Nuclear Research) (other-oa)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Keywords
major depressive disorder, borderline personality disorder, interpersonal psychotherapy, fluoxetine, combined psychotherapy and pharmacotherapy, antidepressant monotherapy, remission, quality of life, interpersonal functioning, medication adherence
MeSH terms
Adult, Borderline Personality Disorder, Combined Modality Therapy, Depressive Disorder, Major, Major Depressive Disorder, Female, Fluoxetine, Humans, Male, Personality Inventory, Psychotherapy, Antidepressive Agents, Second-Generation

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