The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Nonpharmacological Interventions to Improve Depression, Anxiety, and Quality of Life (QoL) in People With Dementia: An Overview of Systematic Reviews
Open accessAbstract
This overview aimed to systematically synthesize evidence from existing systematic reviews to signpost practitioners to the current evidence base on nonpharmacological interventions to improve depression, anxiety, and quality of life (QoL) in people with dementia and to discuss priorities for future research. The databases MEDLINE, PsycINFO, Scopus, and Cochrane Central Register of Controlled Trials were searched in August 2017 with an updated search in January 2019. Fourteen systematic reviews of randomized controlled trials of nonpharmacological interventions were identified. Dementia stage was rated moderate or severe in the majority of the reviews and type of dementia varied. Interventions reported to be effective were cognitive stimulation (QoL: standardized mean difference [SMD] = 0.38), music-based therapeutic interventions (depression: SMD = -0.27, anxiety: SMD = -0.43, QoL: SMD = 0.32), and psychological treatments (mainly cognitive behavior therapy; depression: SMD = -0.22, anxiety: MD = -4.57). Although health-care professionals are recommended to continue using these approaches, future research needs to focus on the type and form of interventions that are most effective for different stages and types of dementia.
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“Memantine can be used in conjunction with an AChEI because their modes of action are complimentary. The said combinatorial therapy is usually beneficial to patients, with cumulative results and no rise in side effects (Kishita et al., 2020).”
From An update on the novel and approved drugs for Alzheimer disease (2022) · cites this paper as Kishita et al., 2020
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“Memantine can be administered in combination with an AChEI, as they have complementary mechanisms of action.”
From Current and Future Treatments in Alzheimer Disease: An Update (2020) · cites this paper as [15]
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“Their combination benefits patients with usually additive effects, without any increase in adverse effects.14,15”
From Current and Future Treatments in Alzheimer Disease: An Update (2020) · cites this paper as [15]
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Citations
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
Higgins, J. P. T., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A. C., et al. (2011) · BMJ · doi:10.1136/bmj.d5928 · Cited by 33,817
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39489.470347.ad · Cited by 23,305 · cited 1×
“For each included review, information was recorded depending on (a) date of last search; (b) the number of RCTs included in the review; (c) participant characteristics (mean age, dementia diagnosis, dementia severity); (d) intervention and comparator characteristics; (e) pooled effect sizes (the mean difference [MD] o…”
MethodShea, B. J., Reeves, B. C., Wells, G., Thuku, M., Hamel, C., Moran, J., Moher, D., Tugwell, P., Welch, V., Kristjansson, E., et al. (2017) · BMJ · doi:10.1136/bmj.j4008 · Cited by 10,636
Cognitive Therapy for Depression
(2012) · PsycEXTRA Dataset · doi:10.1037/e675542012-001 · Cited by 9,678
The global prevalence of dementia: a systematic review and metaanalysis.
Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., & Ferri, C. P. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.11.007 · Cited by 4,941
Cognitive Therapy of Depression
HOLLON, S. D., & BECK, A. T. (1979) · Cognitive-Behavioral Interventions · doi:10.1016/b978-0-12-404480-7.50012-5 · Cited by 4,685
The Efficacy of Cognitive Behavioral Therapy: A Review of Meta-analyses
Hofmann, S. G., Asnaani, A., Vonk, I. J. J., Sawyer, A. T., & Fang, A. (2012) · Cognitive Therapy and Research · doi:10.1007/s10608-012-9476-1 · Cited by 3,445 · cited 1×
“CBT has established itself as an efficacious and appropriate psychological treatment for use with individuals with anxiety disorders across the life span.(46) CBT approaches used in RCTs included in the analysis utilized techniques from conventional CBT, such as challenging dysfunctional thoughts, developing positive…”
MethodAromataris, E., Fernandez, R., Godfrey, C. M., Holly, C., Khalil, H., & Tungpunkom, P. (2015) · International Journal of Evidence-Based Healthcare · doi:10.1097/xeb.0000000000000055 · Cited by 2,587
How Many Studies Do You Need?: A Primer on Statistical Power for Meta-Analysis
Valentine, J. C., Pigott, T. D., & Rothstein, H. R. (2010) · Journal of Educational and Behavioral Statistics · doi:10.3102/1076998609346961 · Cited by 1,294
Depression—Clinical, Experimental, and Theoretical Aspects
Strasburger, L. H. (1968) · Psychosomatic Medicine · doi:10.1097/00006842-196811000-00018 · Cited by 595
Abraha, I., Rimland, J. M., Trotta, F. M., Dell'Aquila, G., Cruz-Jentoft, A., Petrovic, M., Gudmundsson, A., Soiza, R., O'Mahony, D., Guaita, A., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-012759 · Cited by 557
Effectiveness of person-centered care on people with dementia: a systematic review and meta-analysis
Kim, S. K., & Park, M. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s117637 · Cited by 429
Banerjee, S. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.072983 · Cited by 363
Anxiety in dementia: A critical review
Seignourel, P. J., Kunik, M. E., Snow, L., WILSON, N. L., & Stanley, M. A. (2008) · Clinical Psychology Review · doi:10.1016/j.cpr.2008.02.008 · Cited by 339
Hunt, H., Pollock, A., Campbell, P., Estcourt, L., & Brunton, G. (2018) · Systematic Reviews · doi:10.1186/s13643-018-0695-8 · Cited by 314
Psychosocial interventions for people with dementia: a synthesis of systematic reviews
McDermott, O., Charlesworth, G. M., Hogervorst, E., Stoner, C. R., Moniz-Cook, E. D., Spector, A. E., Csipke, E., & Orrell, M. W. (2018) · Aging & Mental Health · doi:10.1080/13607863.2017.1423031 · Cited by 300
Quality of Life in Alzheimer Disease
Lawton, M. P. (1994) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199404000-00015 · Cited by 293
Quality of life of people with dementia in residential care homes
Hoe, J., Hancock, G. A., Livingston, G., & Orrell, M. W. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.104.007658 · Cited by 282
Ready, R. E., Ott, B. R., & Grace, J. (2004) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1075 · Cited by 259
Quality of Life in Alzheimer Disease
Lawton, M. P. (1994) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199424004-00015 · Cited by 247
Burns, A. S., & Iliffe, S. (2009) · BMJ · doi:10.1136/bmj.b75 · Cited by 230
Orgeta, V., Qazi, A., Spector, A. E., & Orrell, M. W. (2015) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.114.148130 · Cited by 210
Sands, L. P., Ferreira, P., Stewart, A. L., Brod, M. I., & Yaffe, K. S. (2004) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200405000-00006 · Cited by 208
Quality of Life measures for dementia.
Ready, R. E., & Ott, B. R. (2003) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-1-11 · Cited by 204
A review of quality of life instruments used in dementia
Ettema, T. P., Dröes, R., de Lange, J., Mellenbergh, G. J., & Ribbe, M. W. (2005) · Quality of Life Research · doi:10.1007/s11136-004-1258-0 · Cited by 197
Spector, A. E., Orrell, M. W., & Woods, B. T. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2464 · Cited by 196
Activities of daily living in frontotemporal dementia and Alzheimer disease
Mioshi, E., Kipps, C. M., Dawson, K., Mitchell, J., Graham, A., & Hodges, J. R. (2007) · Neurology · doi:10.1212/01.wnl.0000264897.13722.53 · Cited by 188 · cited 1×
“Cognitive impairments and functional abilities differ between typical Alzheimer disease and other types of dementia such as frontotemporal dementia.(52,53) Future research needs to explore whether interventions that found to be most effective are equally beneficial to those who do not fall into the typical population…”
BackgroundLaver, K., Dyer, S. M., Whitehead, C., Clemson, L. M., & Crotty, M. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-010767 · Cited by 179
Barreto, P. D. S., Demougeot, L., Pillard, F., Lapeyre‐Mestre, M., & Rolland, Y. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.09.001 · Cited by 123
Cognitive stimulation for the treatment of Alzheimer’s disease
Spector, A. E., Woods, B. T., & Orrell, M. W. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.5.751 · Cited by 114
Ritchie, C. W., Terrera, G. M., & Quinn, T. J. (2015) · Alzheimer s Research & Therapy · doi:10.1186/s13195-015-0113-6 · Cited by 106
The Construct of Generalized Anxiety Disorder in Alzheimer Disease
STARKSTEIN, S. E., Jorge, R. E., Petracca, G., & Robinson, R. G. (2006) · American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000229664.11306.b9 · Cited by 103
Outcomes measures in a decade of dementia and mild cognitive impairment trials
Harrison, J. K., Noel-Storr, A. H., Demeyere, N., Reynish, E. L., & Quinn, T. J. (2016) · Alzheimer s Research & Therapy · doi:10.1186/s13195-016-0216-8 · Cited by 103
Cognitive stimulation therapy (CST): neuropsychological mechanisms of change
Hall, L., Orrell, M. W., Stott, J. C. H., & Spector, A. E. (2012) · International Psychogeriatrics · doi:10.1017/s1041610212001822 · Cited by 79
Kim, S.-Y., Yoo, E.-Y., Jung, M.-Y., Park, S.-H., & Park, J.-H. (2012) · NeuroRehabilitation: An International, Interdisciplinary Journal · doi:10.3233/nre-2012-0779 · Cited by 70
Wu, J., Wang, Y., & Wang, Z. (2017) · Journal of Advanced Nursing · doi:10.1111/jan.13311 · Cited by 62
Regan, B., & Varanelli, L. (2013) · International Psychogeriatrics · doi:10.1017/s104161021300152x · Cited by 60
Cooper, C., Mukadam, N., Katona, C., Lyketsos, C. G., Blazer, D. G., Ames, D. J., Rabins, P. V., Brodaty, H., Lima, C. D. M., & Livingston, G. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2012.10.018 · Cited by 53
Richardson, A., Pedley, G., Pelone, F., Akhtar, F., Chang, J., Muleya, W., & Greenwood, N. (2016) · International Psychogeriatrics · doi:10.1017/s1041610216000132 · Cited by 53
A Review of Diagnostic Process and Postdiagnostic Support for People With Dementia in Rural Areas
Szymczyńska, P., Innes, A., Mason, A., & Stark, C. R. (2011) · Journal of Primary Care & Community Health · doi:10.1177/2150131911404705 · Cited by 47
Ojagbemi, A., & Akin-Ojagbemi, N. (2017) · Journal of Applied Gerontology · doi:10.1177/0733464817693374 · Cited by 47
Emotional Well-Being in a Person with Dementia
Kolanowski, A. M., Litaker, M. S., Catalano, P. A., Higgins, P. A., & Heineken, J. (2002) · Western Journal of Nursing Research · doi:10.1177/01939450222045699 · Cited by 39
Legge, A. W. (2015) · Music Therapy Perspectives · doi:10.1093/mtp/miv025 · Cited by 31
Jang, J., Cushing, N., Clemson, L. M., Hodges, J. R., & Mioshi, E. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000339670 · Cited by 30
Psychosocial interventions for people with moderate to severe dementia: A systematic review
Boote, J. D., Lewin, V., Beverley, C., & Bates, J. (2006) · Clinical Effectiveness in Nursing · doi:10.1016/j.cein.2006.06.002 · Cited by 18
Ojagbemi, A., & Owolabi, M. O. (2016) · Psychogeriatrics · doi:10.1111/psyg.12201 · Cited by 14
Research works printed but not linked: 10
- Logsdon RG, 2007, Alzheimer Care Today, 8, 309
- Reilly S, 2015, Cochrane Database Syst Rev, 1, CD008345
- Bahar-Fuchs A, 2013, Cochrane Database Syst Rev, CD003260
- Woods B, 2012, Cochrane Database Syst Rev, CD005562
- Forbes D, 2015, Cochrane Database Syst Rev, CD006489
- Forbes D, 2014, Cochrane Database Syst Rev, CD003946
- van der Steen JT, 2018, Cochrane Database Syst Rev, 7, CD003477
- Woods B, 2018, Cochrane Database Syst Rev, 3, CD001120
- Aplaon M, 2017, J Aging Res Clin Practice, 6, 28
- Kirkham JG, 2016, Cochrane Database Syst Rev, CD012312
Cited by
Sorted by citations
2020 Alzheimer's disease facts and figures
(2020) · Alzheimer's & Dementia · doi:10.1002/alz.12068 · Cited by 2,353
2021 Alzheimer's disease facts and figures
Anonymous (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12328 · Cited by 2,339
Current and Future Treatments in Alzheimer Disease: An Update
Yiannopoulou, K. G., & Papageorgiou, S. G. (2020) · Journal of Central Nervous System Disease · doi:10.1177/1179573520907397 · Cited by 966
Effects of music therapy on depression: A meta-analysis of randomized controlled trials
Tang, Q., Huang, Z., Zhou, H., & Ye, P. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240862 · Cited by 184
“Prior meta-analyses have reported an obvious effect of music therapy on improving depression [4, 5].”
BackgroundAn update on the novel and approved drugs for Alzheimer disease
Alhazmi, H. A., & Albratty, M. (2022) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2022.10.004 · Cited by 122
“The said combinatorial therapy is usually beneficial to patients, with cumulative results and no rise in side effects (Kishita et al., 2020).”
Metadata
- Authors
- Kishita, N., Backhouse, T., & Mioshi, E.
- Affiliations
- University of East Anglia (GB)
- Corresponding author
- Kishita, Naoko
- Venue
- Journal of Geriatric Psychiatry and Neurology
- Publisher
- SAGE Publications
- Published
- 2019-06-16
- Volume
- 33
- Issue
- 1
- Pages
- 28-41
- ISSN
- 0891-9887 (ISSN-L)
- 1552-5708
- OpenAlex
- W2952466078
- Cited by
- 103
- References
- 47
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 21 · 2023: 26 · 2022: 16 · 2021: 13 · 2020: 11 · 2019: 1
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- green
- ueaeprints.uea.ac.uk
- Locations
- Journal of Geriatric Psychiatry and Neurology (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (acceptedVersion)
- Funders
- Alzheimer's Society
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Social Psychology › Music Therapy and Health
- Social Sciences › Psychology › Clinical Psychology › Art Therapy and Mental Health
- Keywords
- dementia, non-pharmacological treatment, depression, anxiety, quality of life, cognitive stimulation, music therapy, cognitive behavioral therapy, psychological intervention, dementia stages, dementia types
- MeSH terms
- Anxiety, Dementia, Depression, Humans, Quality of Life
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