Language and behavior domains enhance the value of the clinical dementia rating scale
Open accessAbstract
Background: The six domain standard Clinical Dementia Rating Scale (CDRstd) has been successful for staging patients with the clinical syndrome of probable Alzheimer's disease (AD). The CDRstd does not specifically address language dysfunction or alteration in personality and social behaviors which are prominent in behavioral variant frontotemporal dementia (bvFTD) and primary progressive aphasia (PPA). Objective: To determine the value of adding domains of Language (LANG), and Behavior, Comportment, and Personality (BEHAV) to the CDRstd for the evaluation of patients with bvFTD and PPA. Methods: Two new domains, LANG and BEHAV, were constructed to parallel the six domains sampled in the CDRstd. Clinical and neuropsychological test data were obtained from the National Alzheimer's Coordinating Center. The dataset contained information on 2550 probable AD, 88 vascular dementia, 281 dementia with Lewy body, 234 bvFTD, and 137 PPA patients. Results: There were 76.5% of bvFTD and 99.3% of PPA patients with abnormal ratings (>0) on the LANG domain; 90.2% of bvFTD and 63.5% of PPA had abnormal ratings on the BEHAV domain. In patients with a CDRstd sum of boxes score of <4, 53.7% of bvFTD had BEHAV domain and 78.6% of PPA patients had LANG domain scores >1. Among probable AD patients, 3.7% had LANG ratings that were ≥1 and 3.8% had BEHAV ratings that were ≥1. Logistic regression analyses showed that adding either the LANG or BEHAV domains to the CDRstd sum of boxes score significantly improved the discrimination between probable AD, bvFTD, and PPA. Conclusions: The new LANG and BEHAV domains add value to the CDRstd for the characterization of the nonamnestic symptoms that are prominent in patients with bvFTD and PPA but that also occur in those with probable AD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The FTLD-modified Clinical Dementia Rating scale added domains of language and behavior to the original CDR, accounting for the most prominent symptoms in bvFTD.
“The adapted version of the CDR, FTLD-modified Clinical Dementia Rating scale (FTLD-CDR); (Knopman et al., 2008), added domains of language and behavior to the original scale, accounting for the most prominent symptoms in bvFTD (Knopman et al., 2011).”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Knopman et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069 · see citing works
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047 · see citing works
Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921 · see citing works
Berti, A. (1992) · Neuropsychologia · doi:10.1016/0028-3932(92)90076-x · Cited by 4,190 · see citing works
J Neuropsychiatry Clin Neurosci
Yudofsky, S. C., & Hales, R. E. (1992) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.4.4.359 · Cited by 3,818 · see citing works
Weıntraub, S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120075013 · Cited by 3,012 · see citing works
Measurement of Functional Activities in Older Adults in the Community
PFEFFER, R. I., Kurosaki, T., Harrah, C. H., Chance, J. M., & Filos, S. (1982) · Journal of Gerontology · doi:10.1093/geronj/37.3.323 · Cited by 2,978 · see citing works
Melnick, V. L., & Dubler, N. N. (1985) · Contemporary Issues in Biomedicine, Ethics, and Society · doi:10.1007/978-1-4612-5174-3 · Cited by 1,986 · see citing works
Validation of the NPI-Q, a Brief Clinical Form of the Neuropsychiatric Inventory
Kaufer, D., Cummings, J. L., Ketchel, P., Smith, V. M., MacMillan, A., Shelley, T., López, O. L., & DeKosky, S. T. (2000) · Journal of Neuropsychiatry · doi:10.1176/jnp.12.2.233 · Cited by 1,978 · see citing works
Eling, P. (1993) · Acta Psychologica · doi:10.1016/0001-6918(93)90027-o · Cited by 1,198 · see citing works
Mesulam, M. ‐. (2001) · Annals of Neurology · doi:10.1002/ana.91 · Cited by 1,001 · see citing works
Morris, J. C., Weintraub, S., Chui, H. C., Cummings, J., DeCarli, C., Ferris, S., Foster, N. L., Galasko, D., Graff-Radford, N., Peskind, E. R., et al. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000213865.09806.92 · Cited by 950 · see citing works
The Alzheimer's Disease Centers' Uniform Data Set (UDS)
Weıntraub, S., Salmon, D. P., Mercaldo, N. D., Ferris, S. H., Graff‐Radford, N. R., Chui, H. C., Cummings, J. L., DeCarli, C. S., Foster, N. L., Galasko, D. R., et al. (2009) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e318191c7dd · Cited by 885 · see citing works
Lee, K. L., & Mark, D. B. (1996) · Cited by 485 · see citing works
Primary Progressive Aphasia — A Language-Based Dementia
Mesulam, M. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022435 · Cited by 471 · see citing works
Development of methodology for conducting clinical trials in frontotemporal lobar degeneration
Knopman, D. S., Kramer, J. H., Boeve, B. F., Caselli, R. J., Graff-Radford, N. R., Mendez, M. F., Miller, B. L., & Mercaldo, N. (2008) · Brain · doi:10.1093/brain/awn234 · Cited by 442 · see citing works
Self-citationMRI and CSF biomarkers in normal, MCI, and AD subjects
Vemuri, P., Wiste, H. J., Weigand, S. D., Shaw, L. M. J., Trojanowski, J. Q., Weiner, M. W., Knopman, D. S., Petersen, R. C., & Jack, C. R. (2009) · Neurology · doi:10.1212/wnl.0b013e3181af79fb · Cited by 398 · see citing works
Self-citationThe frontal behavioral inventory in the differential diagnosis of frontotemporal dementia
KERTESZ, A., NADKARNI, N., DAVIDSON, W., & THOMAS, A. W. (2000) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617700644041 · Cited by 317 · see citing works
Thompson, P. M., Hayashi, K. M., Dutton, R. A., Chiang, M., Leow, A., Sowell, E. R., de Zubicaray, G. I., Becker, J. T., López, O. L., Aizenstein, H. J., et al. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.017 · Cited by 250 · see citing works
Cognitive Test Performance in Detecting, Staging, and Tracking Alzheimer's Disease
Locascio, J. J., Growdon, J. H., & Corkin, S. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540350081020 · Cited by 228 · see citing works
Donepezil treatment of patients with MCI
Doody, R. S., Ferris, S. H., Salloway, S., Sun, Y., Goldman, R. S., Watkins, W. E., Xu, Y., & Murthy, A. K. (2009) · Neurology · doi:10.1212/01.wnl.0000344650.95823.03 · Cited by 212 · see citing works
DONEPEZIL TREATMENT OF PATIENTS WITH MCI: A 48-WEEK RANDOMIZED, PLACEBO- CONTROLLED TRIAL
Crane, P. K. (2009) · Neurology · doi:10.1212/wnl.0b013e3181bd6c25 · Cited by 194 · see citing works
Cortical neuroanatomic correlates of symptom severity in primary progressive aphasia
Sapolsky, D., Bakkour, A., Negreira, A. M., Nalipinski, P., Weıntraub, S., Mesulam, M. M., Caplan, D. N., & Dickerson, B. C. (2010) · Neurology · doi:10.1212/wnl.0b013e3181ea15e8 · Cited by 113 · see citing works
Deyn, P. P. D., Engelborghs, S., Saerens, J., Goeman, J., Mariën, P., Maertens, K., Nagels, G., Martin, J., & Pickut, B. A. (2004) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1249 · Cited by 85 · see citing works
Brain and ventricular volumetric changes in frontotemporal lobar degeneration over 1 year
Knopman, D. S., Jack, C. R., Kramer, J. H., Boeve, B. F., Caselli, R. J., Graff-Radford, N. R., Mendez, M. F., Miller, B. L., & Mercaldo, N. D. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a71236 · Cited by 85 · see citing works
Self-citationBorroni, B., Agosti, C., Premi, E., Cerini, C., Cosseddu, M., Paghera, B., Bellelli, G., & Padovani, A. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02911.x · Cited by 65 · see citing works
The Cambridge behavioral inventory: validation and application in a memory clinic
Nagahama, Y., Okina, T., Suzuki, N., & Matsuda, M. (2006) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988706286545 · Cited by 45 · see citing works
Harrell, F., Jr. (1996) · doi:10.1002/(sici)1097-0258(19960229)15:4
Flagged first, then by citations
Cited by
Sorted by citations
The epidemiology of frontotemporal dementia
Onyike, C. U., & Diehl-Schmid, J. (2013) · International Review of Psychiatry · doi:10.3109/09540261.2013.776523 · Cited by 543 · see citing works
Miyagawa, T., Brushaber, D. E., Syrjanen, J. A., Kremers, W. K., Fields, J. A., Forsberg, L. K., Heuer, H. W., Knopman, D. S., Kornak, J., Boxer, A. L., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12033 · Cited by 162 · see citing works
Self-citationPredictive Modeling of the Progression of Alzheimer’s Disease with Recurrent Neural Networks
Wang, T., Qiu, R. G., & Yu, M. Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-27337-w · Cited by 138 · see citing works
Lifestyle and neurocognition in older adults with cognitive impairments
Blumenthal, J. A., Smith, P. J., Mabe, S., Hinderliter, A. L., Lin, P., Liao, L., Welsh-Bohmer, K. A., Browndyke, J. N., Kraus, W. E., Doraiswamy, P. M., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000006784 · Cited by 134 · see citing works
GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition
Murley, A. G., Rouse, M. A., Jones, P. S., Ye, R., Hezemans, F. H., O’Callaghan, C., Frangou, P., Kourtzi, Z., Rua, C., Carpenter, T. A., et al. (2020) · Brain · doi:10.1093/brain/awaa305 · Cited by 101 · see citing works
Use of the Progressive Aphasia Severity Scale (PASS) in monitoring speech and language status in PPA
Sapolsky, D., Domoto‐Reilly, K., & Dickerson, B. C. (2014) · Aphasiology · doi:10.1080/02687038.2014.931563 · Cited by 96 · see citing works
Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium
Miyagawa, T., Brushaber, D., Syrjanen, J., Kremers, W., Fields, J., Forsberg, L. K., Heuer, H. W., Knopman, D., Kornak, J., Boxer, A., et al. (2020) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.05.013 · Cited by 92 · see citing works
Self-citationAmyloid, tau and metabolic PET correlates of cognition in early and late-onset Alzheimer’s disease
Tanner, J. A., Iaccarino, L., Edwards, L., Asken, B. M., Gorno‐Tempini, M. L., Kramer, J. H., Pham, J. Q., Perry, D. C., Possin, K. L., Malpetti, M., et al. (2022) · Brain · doi:10.1093/brain/awac229 · Cited by 88 · see citing works
Khodabakhsh, A., Yeşil, F., Güner, E., & Demiroğlu, C. (2015) · EURASIP Journal on Audio Speech and Music Processing · doi:10.1186/s13636-015-0052-y · Cited by 81 · see citing works
Assessment of individuals with primary progressive aphasia
Grasso, S., & Henry, M. (2018) · Seminars in Speech and Language · doi:10.1055/s-0038-1660782 · Cited by 78 · see citing works
Loss of emotional insight in behavioral variant frontotemporal dementia or “frontal anosodiaphoria”
Mendez, M. F., & Shapira, J. S. (2011) · Consciousness and Cognition · doi:10.1016/j.concog.2011.09.005 · Cited by 77 · see citing works
Boeve, B., Bove, J., Brannelly, P., Brushaber, D., Coppola, G., Dever, R., Dheel, C., Dickerson, B., Dickinson, S., Faber, K., et al. (2020) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.06.4947 · Cited by 61 · see citing works
Self-citationDivergent Patterns of TDP-43 and Tau Pathologies in Primary Progressive Aphasia
Giannini, L. A. A., Xie, S. X., McMillan, C., Liang, M., Williams, A., Jester, C., Rascovsky, K., Wolk, D., Ash, S., Lee, E. B., et al. (2019) · Annals of Neurology · doi:10.1002/ana.25465 · Cited by 46 · see citing works
Symptom‐led staging for semantic and non‐fluent/agrammatic variants of primary progressive aphasia
Hardy, C. J. D., Taylor‐Rubin, C., Taylor, B., Harding, E., Gonzalez, A. S., Jiang, J., Thompson, L. M., Kingma, R. M., Chokesuwattanaskul, A., Walker, F., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13415 · Cited by 59 · see citing works
Observation of Social Behavior in Frontotemporal Dementia
Mendez, M. F., Fong, S. S., Shapira, J. S., Jimenez, E. E., Kaiser, N. C., Kremen, S. A., & Tsai, P. (2013) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317513517035 · Cited by 50 · see citing works
A syntax–lexicon trade-off in language production
Rezaii, N., Mahowald, K., Ryskin, R. A., Dickerson, B. C., & Gibson, E. A. F. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2120203119 · Cited by 41 · see citing works
Primary progressive aphasia: six questions in search of an answer
Belder, C. R. S., Marshall, C. R., Jiang, J., Mazzeo, S., Chokesuwattanaskul, A., Rohrer, J. D., Volkmer, A., Hardy, C. J. D., & Warren, J. D. (2023) · Journal of Neurology · doi:10.1007/s00415-023-12030-4 · Cited by 47 · see citing works
Olney, N. T., Ong, E., Goh, S. M., Bajorek, L., Dever, R., Staffaroni, A. M., Cobigo, Y., Bock, M., Chiang, K., Ljubenkov, P., et al. (2020) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.08.196 · Cited by 46 · see citing works
Self-citationHeuer, H. W., Wang, P., Rascovsky, K., Wolf, A., Appleby, B., Bove, J., Bordelon, Y., Brannelly, P., Brushaber, D. E., Caso, C., et al. (2020) · Alzheimer's & Dementia · doi:10.1002/alz.12046 · Cited by 43 · see citing works
Self-citationLonger Term Effects of Diet and Exercise on Neurocognition: 1‐Year Follow‐up of the ENLIGHTEN Trial
Blumenthal, J. A., Smith, P. J., Mabe, S., Hinderliter, A. L., Welsh-Bohmer, K. A., Browndyke, J. N., Doraiswamy, P. M., Lin, P., Kraus, W. E., Burke, J. R., et al. (2019) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16252 · Cited by 46 · see citing works
Personalized Repetitive Transcranial Magnetic Stimulation for Primary Progressive Aphasia
Pytel, V., Cabrera‐Martín, M. N., Delgado‐Álvarez, A., Ayala, J. L., Balugo, P., Delgado‐Alonso, C., Yus, M., Carreras, M. T., Carreras, J. L., Matías‐Guiu, J., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210566 · Cited by 48 · see citing works
Nelson, R. S., Abner, E. L., Jicha, G. A., Schmitt, F. A., Di, J., Wilcock, D. M., Barber, J. M., Eldik, L. J. V., Katsumata, Y., Fardo, D. W., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01576-z · Cited by 44 · see citing works
Modirrousta, M., Price, B., & Dickerson, B. (2013) · Neurodegenerative Disease Management · doi:10.2217/nmt.13.6 · Cited by 43 · see citing works
Revised Self-Monitoring Scale: A potential endpoint for frontotemporal dementia clinical trials
Toller, G., Ranasinghe, K., Cobigo, Y., Staffaroni, A., Appleby, B., Brushaber, D., Coppola, G., Dickerson, B., Domoto-Reilly, K., Fields, J., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000009451 · Cited by 40 · see citing works
Self-citationCabral-Pinto, M. M. S., Reis, A. P. M., Almeida, A. A., Freitas, S., Simões, M. R., Diniz, M. L., Pinto, E., Ramos, P., da Silva, E. F., & Moreira, P. I. (2018) · Exposure and Health · doi:10.1007/s12403-018-0274-1 · Cited by 39 · see citing works
Matías‐Guiu, J. A., Suárez‐Coalla, P., Yus, M., Pytel, V., Hernández‐Lorenzo, L., Delgado‐Alonso, C., Delgado‐Álvarez, A., Gómez‐Ruiz, N., Polidura, C., Cabrera‐Martín, M. N., et al. (2021) · Cortex · doi:10.1016/j.cortex.2021.10.010 · Cited by 39 · see citing works
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring
Staffaroni, A. M., Weintraub, S., Rascovsky, K., Rankin, K. P., Taylor, J., Fields, J. A., Casaletto, K. B., Hillis, A. E., Lukic, S., Gorno‐Tempini, M. L., et al. (2021) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1002/dad2.12148 · Cited by 33 · see citing works
Cheran, G., Silverman, H., Manoochehri, M., Goldman, J., Lee, S., Wu, L., Cines, S., Fallon, E., Kelly, B. D., Olszewska, D. A., et al. (2018) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-317263 · Cited by 32 · see citing works
Detecting clinical change with the CDR-FTLD: differences between FTLD and AD dementia
Mioshi, E., Flanagan, E., & Knopman, D. (2017) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4556 · Cited by 29 · see citing works
“This study went beyond prior analyses (Knopman et al., 2011) and confirmed the utility of the CDR-FTLD in detecting changes in FTLD and AD dementia over time using Rasch analysis.”
BackgroundSelf-citationSymptom‐based staging for logopenic variant primary progressive aphasia
Hardy, C. J. D., Taylor‐Rubin, C., Taylor, B., Harding, E., Gonzalez, A. S., Jiang, J., Thompson, L., Kingma, R. M., Chokesuwattanaskul, A., Walker, F., et al. (2024) · European Journal of Neurology · doi:10.1111/ene.16304 · Cited by 29 · see citing works
Slachevsky, A., Pedro Zitko, M., Martínez‐Pernía, D., Forno, G., Court, F. A., Lillo, P., Villagra, R., Duran-Aniotz, C. A., Parrao, T., Assar, R., et al. (2020) · BMC Geriatrics · doi:10.1186/s12877-020-01866-4 · Cited by 27 · see citing works
A scale of socioemotional dysfunction in frontotemporal dementia.
Barsuglia, J. P., Kaiser, N., Wilkins, S., Joshi, A., Barrows, R., Paholpak, P., Panchal, H., Jimenez, E. E., Mather, M. J., & Mendez, M. (2014) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acu050 · Cited by 23 · see citing works
Familial language network vulnerability in primary progressive aphasia
Weıntraub, S., Rader, B. M., Coventry, C., Sridhar, J., Wood, J. L., Guillaume, K. A., Coppola, G., Ramos, E. M., Bonakdarpour, B., Rogalski, E. J., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000009842 · Cited by 23 · see citing works
Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia
Gallée, J., Cordella, C., Fedorenko, E. G., Hochberg, D., Touroutoglou, A., Quimby, M., & Dickerson, B. C. (2021) · Brain Sciences · doi:10.3390/brainsci11020130 · Cited by 24 · see citing works
A multivariate metabolic imaging marker for behavioral variant frontotemporal dementia
Nazem, A., Tang, C. C., Spetsieris, P. G., Dresel, C., Gordon, M. L., Diehl‐Schmid, J., Grimmer, T., Yakushev, I. Y., Mattis, P. J., Ma, Y., et al. (2018) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2018.07.009 · Cited by 24 · see citing works
Chanteloup, G., Cordonnier, M., Moreno‐Ramos, T., Pytel, V., Matías‐Guiu, J., Gobbo, J., Cabrera‐Martín, M. N., Gómez‐Pinedo, U., Garrido, C., & Matías‐Guiu, J. A. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190545 · Cited by 24 · see citing works
Semantic knowledge of social interactions is mediated by the hedonic evaluation system in the brain
Rijpma, M. G., Montembeault, M., Shdo, S. M., Kramer, J. H., Miller, B. L., & Rankin, K. P. (2023) · Cortex · doi:10.1016/j.cortex.2022.12.015 · Cited by 19 · see citing works
Lowe, D. A., Balsis, S. M., Miller, T. M., Benge, J. F., & Doody, R. S. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000341731 · Cited by 22 · see citing works
Functional decline in the aphasic variant of Alzheimer's disease
Moeller, S., Sridhar, J., Martersteck, A., Coventry, C., Kuang, A., Zhang, H., Weıntraub, S., Mesulam, M. M., & Rogalski, E. J. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12331 · Cited by 20 · see citing works
Are we comparing frontotemporal dementia and Alzheimer disease patients with the right measures?
Deutsch, M. B., Liang, L.-J. F., Jimenez, E. E., Mather, M. J., & Mendez, M. F. (2016) · International Psychogeriatrics · doi:10.1017/s1041610216000582 · Cited by 20 · see citing works
Lima-Silva, T. B., Mioshi, E., Bahia, V. S., Cecchini, M. A., Cassimiro, L., Guimarães, H. C., Gambogi, L. B., Caramelli, P., Balthazar, M., Damasceno, B., et al. (2021) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988720944239 · Cited by 18 · see citing works
Russo, G., Russo, M. J., Buyatti, D., Chrem, P., Bagnati, P., Suarez, M. F., Campos, J., Cohen, G., Amengual, A., Allegri, R., et al. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.06.024 · Cited by 19 · see citing works
Self-citationMatías‐Guiu, J. A., Pytel, V., Hernández‐Lorenzo, L., Patel, N., Peterson, K. A., Matías‐Guiu, J., Garrard, P., & Cuetos, F. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210668 · Cited by 18 · see citing works
Saloner, R., Staffaroni, A. M., Dammer, E. B., Johnson, E. C. B., Paolillo, E. W., Wise, A. B., Heuer, H. W., Forsberg, L. K., Lario‐Lago, A., Webb, J. D., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00878-2 · Cited by 18 · see citing works
Matías‐Guiu, J. A., Gómez‐Pinedo, U., Forero, L., Pytel, V., Cano-Cano, F., Moreno‐Ramos, T., Cabrera‐Martín, M. N., Matías‐Guiu, J., & González-Rosa, J. J. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190838 · Cited by 17 · see citing works
Asken, B. M., Ljubenkov, P. A., Staffaroni, A. M., Casaletto, K. B., Vandevrede, L., Cobigo, Y., Rojas-Rodriguez, J. C., Rankin, K. P., Kornak, J., Heuer, H., et al. (2023) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2022-330866 · Cited by 16 · see citing works
Paolillo, E. W., Casaletto, K. B., Clark, A. L., Taylor, J. C., Heuer, H. W., Wise, A. B., Dhanam, S., Sanderson-Cimino, M., Saloner, R., Kramer, J. H., et al. (2024) · JMIR Aging · doi:10.2196/52831 · Cited by 16 · see citing works
Comparison of clinical rating scales in genetic frontotemporal dementia within the GENFI cohort
Peakman, G., Russell, L. L., Convery, R. S., Nicholas, J. M., Swieten, J. C. V., Jiskoot, L. C., Moreno, F., Sánchez‐Valle, R., Laforce, R. J., Graff, C., et al. (2021) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2021-326868 · Cited by 15 · see citing works
da Silva, T. B. L., Ordonez, T. N., Brígola, A. G., Bahia, V. S., Cecchini, M. A., Guimarães, H. C., Gambogi, L. B., Caramelli, P., Balthazar, M. L. F., Damasceno, B. P., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.728108 · Cited by 15 · see citing works
Samra, K., MacDougall, A. M., Peakman, G., Bouzigues, A., Bocchetta, M., Cash, D. M., Greaves, C. V., Convery, R. S., Swieten, J. C. V., Jiskoot, L. C., et al. (2023) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2022-330152 · Cited by 15 · see citing works
Ranasinghe, K. G., Toller, G., Cobigo, Y., Chiang, K., Callahan, P., Eliazer, C., Kramer, J. H., Rosen, H. J., Miller, B. L., & Rankin, K. P. (2021) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1002/dad2.12183 · Cited by 13 · see citing works
da Silva, T. B. L., Bahia, V. S., Cecchini, M. A., Cassimiro, L., Guimarães, H. C., Gambogi, L. B., Caramelli, P., Balthazar, M. L. F., Damasceno, B. P., Brucki, S. M. D., et al. (2018) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000246 · Cited by 12 · see citing works
Kim, B. J., Grossman, M., Alemán, T. S., Song, D., Cousins, K. A. Q., McMillan, C. T., Saludades, A., Yu, Y., Lee, E. B., Wolk, D. A., et al. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.01.015 · Cited by 11 · see citing works
González, D. A., Finley, J. A., Patel, S. E. S., & Soble, J. R. (2024) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2024.10.014 · Cited by 10 · see citing works
Hüper, L., Steinacker, P., Polyakova, M., Mueller, K., Godulla, J., Herzig, S., Danek, A., Engel, A., Diehl‐Schmid, J., Claßen, J., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13863 · Cited by 10 · see citing works
Toller, G., Cobigo, Y., Callahan, P. M., Appleby, B. S., Brushaber, D. E., Domoto‐Reilly, K., Forsberg, L. K., Ghoshal, N., Graff‐Radford, J., Graff‐Radford, N. R., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.12898 · Cited by 10 · see citing works
Symptom-led staging for primary progressive aphasiaPreprint
Hardy, C. J. D., Taylor‐Rubin, C., Taylor, B., Harding, E., Gonzalez, A. S., Jiang, J., Thompson, L. M., Kingma, R. M., Chokesuwattanaskul, A., Walker, F., et al. (2023) · medRxiv · doi:10.1101/2023.03.13.23286972 · Cited by 10 · see citing works
Kumfor, F., Wei, G., Ries, N. M., Bennett, H. P., D’Mello, M., Kaizik, C., Piguet, O., & Hodges, J. R. (2024) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12577 · Cited by 9 · see citing works
Fieldhouse, J. L. P., van Paassen, D. N., van Engelen, M.-P. E., De Boer, S. C. M., Hartog, W. L., Braak, S., Schoonmade, L. J., Schouws, S. N. T. M., Krudop, W. A., Oudega, M. L., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1382593 · Cited by 8 · see citing works
Cytoarchitectonic gradients of laminar degeneration in behavioural variant frontotemporal dementia
Ohm, D. T., Xie, S. X., Capp, N., Arezoumandan, S., Cousins, K. A. Q., Rascovsky, K., Wolk, D. A., Deerlin, V. M. V., Lee, E. B., McMillan, C. T., et al. (2024) · Brain · doi:10.1093/brain/awae263 · Cited by 14 · see citing works
Healey, M. L., Howard, E., Ungrady, M. B., Olm, C. A., Nevler, N., Irwin, D. J., & Grossman, M. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.598131 · Cited by 8 · see citing works
Samra, K., Peakman, G., MacDougall, A. M., Bouzigues, A., Greaves, C. V., Convery, R. S., Swieten, J. C. V., Jiskoot, L. C., Seelaar, H., Moreno, F., et al. (2024) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12571 · Cited by 8 · see citing works
Gallée, J., Volkmer, A., Whitworth, A., Hersh, D., & Cartwright, J. (2024) · American Journal of Speech-Language Pathology · doi:10.1044/2024_ajslp-24-00085 · Cited by 7 · see citing works
Facets of language performance in early‐onset and late‐onset Alzheimer's disease dementia
Gallée, J., Gibbons, L. E., Choi, S., Lee, M. L., Scollard, P., Trittschuh, E. H., Mez, J. B., Saykin, A. J., Foldi, N. S., Mukherjee, S., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70705 · Cited by 7 · see citing works
Cognitive and neuropsychological examination of the elderly
Pasternak, E., & Smith, G. E. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00006-6 · Cited by 6 · see citing works
Paranhos, T., Lucas, T. O., Salles, A. D., Moll, J., & de Oliveira‐Souza, R. (2022) · Journal of Medical Case Reports · doi:10.1186/s13256-021-03228-z · Cited by 6 · see citing works
Cognitive and Neuroanatomic Accounts of Referential Communication in Focal Dementia
Healey, M. L., Spotorno, N., Olm, C. A., Irwin, D. J., & Grossman, M. (2019) · eNeuro · doi:10.1523/eneuro.0488-18.2019 · Cited by 5 · see citing works
Chatzidimitriou, E., Ntritsos, G., Lagoudaki, R., Poptsi, E., Tsardoulias, E., Symeonidis, A. L., Tsolaki, M., Konstantinopoulou, E., Papadopoulou, K., Charalambous, P., et al. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15100466 · Cited by 7 · see citing works
Chen, T., Ahmed, R. M., Narasimhan, M., Yang, T., Foxe, D., Piguet, O., & Irish, M. (2025) · Human Brain Mapping · doi:10.1002/hbm.70374 · Cited by 5 · see citing works
Cognitive determinants of decisional capacity in neurodegenerative disorders
Portley, M. K., Sherer, C., Wu, T., Farren, J., Danielian, L. E., Scholz, S. W., Traynor, B. J., Ward, M. E., Haselhuhn, T., Snyder, A. G., et al. (2023) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51871 · Cited by 4 · see citing works
Distinct performance profiles on the Brixton test in frontotemporal dementia
Rao, S. P., Nandi, R., Dutt, A., Kapur, N., Harris, J., Thompson, J. C., & Snowden, J. S. (2020) · Journal of Neuropsychology · doi:10.1111/jnp.12228 · Cited by 4 · see citing works
Portuguese version of the CDR plus NACC FTLD: Validation studies
Lima, M., Tábuas‐Pereira, M., Durães, J., Faustino, P., Simões, M. R., Kukull, W. A., Knopman, D. S., & Santana, I. J. (2022) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12355 · Cited by 4 · see citing works
Self-citationTan, J. E., Strauss, E., & Sherman, E. M. S. (2018) · Springer eBooks · doi:10.1007/978-3-319-57111-9_533 · Cited by 4 · see citing works
Clinical Dementia Rating Scale
Schmidt, K. (2021) · Springer eBooks · doi:10.1007/978-3-319-69909-7_690-2 · Cited by 4 · see citing works
Clinical Dementia Rating Scale
Schmidt, K. (2023) · Springer eBooks · doi:10.1007/978-3-031-17299-1_690 · Cited by 4 · see citing works
A Roadmap to Enhance Care for People Living With Primary Progressive Aphasia: What Can Be Done Now?
Gallée, J. (2023) · Perspectives of the ASHA Special Interest Groups · doi:10.1044/2023_persp-23-00025 · Cited by 3 · see citing works
Toller, G., Cobigo, Y., Ljubenkov, P. A., Appleby, B. S., Dickerson, B. C., Domoto‐Reilly, K., Fong, J. C., Forsberg, L. K., Gavrilova, R. H., Ghoshal, N., et al. (2022) · Neurology · doi:10.1212/wnl.0000000000200582 · Cited by 3 · see citing works
Self-citationCytoarchitectonic gradients of laminar degeneration in behavioral variant frontotemporal dementiaPreprint
Ohm, D. T., Xie, S. X., Capp, N., Arezoumandan, S., Cousins, K. A. Q., Rascovsky, K., Wolk, D. A., Deerlin, V. M. V., Lee, E. B., McMillan, C. T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.05.588259 · Cited by 3 · see citing works
Doğdu, C., Upadhyay, N., Frommann, I., Kleineidam, L., Johnen, A., Stark, M., Roeske, S., Spottke, A. E., Gamez, A., Petzold, G. C., et al. (2025) · Journal of Neuropsychology · doi:10.1111/jnp.70000 · Cited by 2 · see citing works
Taomoto, D., Sato, S., Kanemoto, H., Suzuki, M., Hirakawa, N., Takasaki, A., Akimoto, M., Satake, Y., Koizumi, F., Yoshiyama, K., et al. (2023) · Psychogeriatrics · doi:10.1111/psyg.13072 · Cited by 2 · see citing works
Self-citationZhao, A. T., Nair, R. M., Lee, E. B., Cousins, K. A. Q., Irwin, D. J., & Kim, B. J. (2025) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2024-335723 · Cited by 2 · see citing works
Tan, J. E., Strauss, E., & Sherman, E. M. S. (2018) · Springer eBooks · doi:10.1007/978-3-319-56782-2_533-2 · Cited by 2 · see citing works
A Literature Review of Language Characteristics in Patients with Vascular Dementia
Kwon, S. M., Lee, H. S., & Yoon, J. H. (2024) · Audiology and Speech Research · doi:10.21848/asr.240138 · Cited by 1 · see citing works
Psychotropic medication usage in sporadic versus genetic behavioral‐variant frontotemporal dementia
Vargas‐González, J., Dimal, N. P. M., Cortez, K., Heuer, H. W., Forsberg, L. K., Appleby, B. S., Barmada, S. J., Bozoki, A., Clark, D. G., Cobigo, Y., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14448 · Cited by 1 · see citing works
Locus coeruleus TDP-43 pathology in a community-based cohort: Clinical and pathological correlates
Neltner, A. M., Shahidehpour, R. K., Hall, M. E., Ning, X., Fister, S. X., Kang, H., Anderson, S., Jicha, G. A., Lee, T., Abner, E. L., et al. (2026) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlag035 · Cited by 1 · see citing works
Quantitative assessment of brain atrophy in bvFTD: Implications for diagnostic conversion
Beydoun, C., Quang, H., Matis, S., Hazelton, J. L., Carrick, J., Fumagalli, G., Piguet, O., & Landín-Romero, R. (2026) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.70307 · Cited by 1 · see citing works
Corriveau‐Lecavalier, N., Falgàs, N., Putcha, D., Graff‐Radford, J., Yong, K. X. X., Boon, B. D. C., Mohanty, R., Westman, E., Groot, C., Jones, D. T., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71521 · Cited by 1 · see citing works
Chatzidimitriou, E., Ntritsos, G., Poptsi, E., Tsardoulias, E., Symeonidis, A. L., Tsolaki, M., Charalambous, P., Sioka, C., Aretouli, E., Iakovou, I. P., et al. (2026) · Journal of Personalized Medicine · doi:10.3390/jpm16080415 · Cited by 1 · see citing works
Cortical & Subcortical Dementias: A Psychoneurolinguistic Perspective
Al-Yaari, S. A. S., Hammadi, F. S. A., & Alyami, S. (2013) · International Journal of English Language Education · doi:10.5296/ijele.v1i2.3065 · Cited by 1 · see citing works
Psychometrics - New Insights in the Diagnosis of Mental Disorders
Misciagna, S. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.100655 · Cited by 1 · see citing works
Early diagnosis of behavioral variant of frontotemporal dementia – a clinical perspective
Barczak, A. K., & Hintze, B. (2022) · Neuropsychiatria i Neuropsychologia · doi:10.5114/nan.2022.117952 · Cited by 1 · see citing works
Misciagna, S. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.110883 · Cited by 1 · see citing works
Morrow, C. B., Onyike, C. U., Pantelyat, A. Y., Smith, G. S., Leoutsakos, J., Faria, A. V., Graff‐Radford, N. R., Darby, R. R., Ghoshal, N., Staffaroni, A. M., et al. (2024) · medRxiv · doi:10.1101/2024.02.19.24302699 · Cited by 1 · see citing works
Considerations in Subtyping and Monitoring of Symptom Progression in Primary Progressive Aphasia
Sapolsky, D., Domoto‐Reilly, K., & Dickerson, B. C. (2014) · Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders · doi:10.1044/nnsld24.4.122
Cecchini, M. A. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2018.tde-20022018-101250
Validação da escala de estadiamento e progressão da demência frontotemporal (FTD-FRS)
da Silva, T. B. L. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2018.tde-09052018-111153
Faculty Opinions recommendation of Assessment of Individuals with Primary Progressive Aphasia.
Tippett, D. C. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733496220.793569913
Advances in Primary Progressive Aphasia
Matías‐Guiu, J. A., Laforce, R. J., & Utianski, R. L. (2022) · MDPI eBooks · doi:10.3390/books978-3-0365-4407-6
Park, J., Sung, J. E., & Kim, Y. T. (2023) · Eon'eo cheong'gag jang'ae yeon'gu/Communication sciences & disorders · doi:10.12963/csd.22919
- Authors
- Knopman, D. S., Weintraub, S., & Pankratz, V. S.
- Affiliations
- Mayo Clinic (US)
- Departments of Psychiatry and Neurology, Cognitive Neurology and Alzheimer's Disease Center Northwestern Feinberg School of Medicine, Northwestern University Chicago IL USA
- Corresponding author
- Knopman, David S.
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2011-05
- Volume
- 7
- Issue
- 3
- Pages
- 293-299
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC3096831
- OpenAlex
- W2118116363
- Cited by
- 105
- References
- 30
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 14 · 2023: 15 · 2022: 9 · 2021: 11 · 2020: 10 · 2019: 9 · 2018: 11 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 4 · 2012: 1
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Mayo Alzheimer Disease Research Center (R01-AG023195, P50-AG016574, P30-AG013854)
- Northwestern Alzheimer's Disease Center (U01 AG016976)
- National Alzheimer Coordinating Center
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Clinical Dementia Rating, language disorders
- MeSH terms
- Aged, Aged, 80 and over, Mental Disorders, Cross-Sectional Studies, Dementia, Diagnosis, Differential, Female, Humans, Language Disorders, Language Tests, Male, Neuropsychological Tests, Predictive Value of Tests
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
