Treatment of Anxiety and Depression in Adolescents and Young Adults With Cancer
Abstract
Adolescents and young adults (AYAs) with cancer are a unique population of patients who experience a period of intense and dramatic life changes when they are diagnosed. Overall, AYAs with cancer are resilient; however, their psychosocial needs are often underestimated or unmet. Currently, there are inconsistencies in how AYAs are screened and treated for anxiety and depression. Barriers to treatment include clinicians’ lack of confidence in distinguishing between side effects of treatment and depression/anxiety. Additional barriers include the black box warning for prescribing antidepressants and difficulty partnering with mental health professionals. This article seeks to provide recommendations for pediatric oncology clinicians on how to identify and address anxiety and depression in AYAs and how to partner with mental health professionals in their treatment, and it suggests directions for future research.
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Anxiety is common among young people with cancer, with effective treatments either not available in the settings in which adolescents and young adults with cancer receive treatment or not offered by referring clinicians.
“Anxiety is also common among young people with cancer, with effective treatments either not available in the settings in which adolescents and young adults with cancer receive treatment or not offered by referring clinicians. [31].”
Depression is common among young people with cancer.
“Depression is common among young people with cancer [31]”
Cites
Erikson, E. H. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.18614668 · Cited by 13,081 · see citing works
Bellizzi, K. M., Smith, A. W., Schmidt, S. D., Keegan, T. H. M., Zebrack, B., Lynch, C. F., Deapen, D., Shnorhavorian, M., Tompkins, B. J., Simon, M. W., et al. (2012) · Cancer · doi:10.1002/cncr.27512 · Cited by 362 · see citing works
Smith, A. W., Bellizzi, K. M., Keegan, T. H. M., Zebrack, B., Chen, V. W., Neale, A. V., Hamilton, A. S., Shnorhavorian, M., & Lynch, C. F. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.47.3173 · Cited by 337 · see citing works
Psychosocial issues in adolescents with cancer
Abrams, A. N., Hazen, E. P., & Penson, R. T. (2007) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2006.12.006 · Cited by 285 · see citing works
Decline in Treatment of Pediatric Depression After FDA Advisory on Risk of Suicidality With SSRIs
Libby, A. M., Brent, D. A., Morrato, E. H., Orton, H. D., Allen, R. R., & Valuck, R. J. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.6.884 · Cited by 280 · see citing works
Zebrack, B. J., Block, R., Hayes‐Lattin, B., Embry, L., Aguilar, C., Meeske, K. A., Li, Y., Butler, M., & Cole, S. (2013) · Cancer · doi:10.1002/cncr.27713 · Cited by 268 · see citing works
Sex, Drugs, and Rock ‘n’ Roll: Caring for Adolescents and Young Adults With Cancer
Morgan, S., Davies, S., Palmer, S., & Plaster, M. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.5474 · Cited by 226 · see citing works
Adolescent and Young Adult Oncology
Coccia, P. F., Altman, J., Bhatia, S., Borinstein, S. C., Flynn, J., George, S., Goldsby, R., Hayashi, R., Huang, M. S., Johnson, R. H., et al. (2012) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2012.0117 · Cited by 211 · see citing works
The relationship between unmet needs and distress amongst young people with cancer
Dyson, G., Thompson, K., Palmer, S., Thomas, D. M., & Schofield, P. E. (2011) · Supportive Care in Cancer · doi:10.1007/s00520-010-1059-7 · Cited by 154 · see citing works
Myers, R. M., Balsamo, L. M., Lu, X., Devidas, M., Hunger, S. P., Carroll, W. L., Winick, N. J., Maloney, K. W., & Kadan‐Lottick, N. S. (2014) · Cancer · doi:10.1002/cncr.28578 · Cited by 148 · see citing works
Treatment of Depression in Cancer
Fisch, M. J. (2004) · JNCI Monographs · doi:10.1093/jncimonographs/lgh011 · Cited by 109 · see citing works
The Adolescent and Young Adult With Cancer: State of the Art - Psychosocial Aspects
Epelman, C. L. (2013) · Current Oncology Reports · doi:10.1007/s11912-013-0324-6 · Cited by 83 · see citing works
Thompson, K., Dyson, G., Holland, L., & Joubert, L. (2013) · Social Work in Health Care · doi:10.1080/00981389.2012.737898 · Cited by 79 · see citing works
Screening for Psychosocial Risk at Pediatric Cancer Diagnosis
Kazak, A. E., Barakat, L. P., DiTaranto, S., Biros, D., Hwang, W., Beele, D., Kersun, L. S., Alderfer, M. A., Mougianis, I. D., Hocking, M. C., et al. (2011) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0b013e31820c3b52 · Cited by 70 · see citing works
Hedström, M., Kreuger, A., Ljungman, G., Nygren, P., & von Essén, L. (2005) · Pediatric Blood & Cancer · doi:10.1002/pbc.20693 · Cited by 56 · see citing works
Psychiatric aspects of pediatric cancer
Apter, A., Farbstein, I., & Yaniv, I. (2003) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/s1056-4993(03)00026-9 · Cited by 48 · see citing works
The Prevalence and Use of Antidepressant Medication in Pediatric Cancer Patients
Portteus, A., Ahmad, N., Tobey, D., & Leavey, P. J. (2006) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2006.16.467 · Cited by 41 · see citing works
Screening for Depression and Anxiety in Adolescent Cancer Patients
Kersun, L. S., Rourke, M. T., Mickley, M., & Kazak, A. E. (2009) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0b013e3181b8704c · Cited by 37 · see citing works
Psychotropic Medication Use in Pediatric Patients With Cancer
Pao, M., Ballard, E. D., Rosenstein, D. L., Wiener, L. S., & Wayne, A. S. (2006) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.160.8.818 · Cited by 34 · see citing works
Kersun, L. S., & Kazak, A. E. (2005) · Pediatric Blood & Cancer · doi:10.1002/pbc.20484 · Cited by 31 · see citing works
Phipps, S., Buckholdt, K. E., Fernandez, L., Wiener, L. S., Kupst, M. J., Madan‐Swain, A., Mullins, L. L., Robert, R. S., Sahler, O. J. Z., Vincent, N., et al. (2011) · Pediatric Blood & Cancer · doi:10.1002/pbc.22788 · Cited by 24 · see citing works
Psychiatric Aspects of Pediatric Cancer
Kurtz, B. P., & Abrams, A. N. (2011) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2011.06.009 · Cited by 18 · see citing works
Exploratory Analyses of Substance Use in Adolescents With and Without Cancer
Szalda, D. E., Brumley, L. D., Danielson, C. K., & Schwartz, L. A. (2013) · Journal of Adolescent and Young Adult Oncology · doi:10.1089/jayao.2012.0023 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Greer, S., Ramo, D., Chang, Y.-J., Fu, M., Moskowitz, J., & Haritatos, J. (2019) · JMIR mHealth and uHealth · doi:10.2196/15018 · Cited by 265 · see citing works
The Adolescent and Young Adult with Cancer: A Developmental Life Course Perspective
Docherty, S. L., Kayle, M., Maslow, G., & Santacroce, S. J. (2015) · Seminars in Oncology Nursing · doi:10.1016/j.soncn.2015.05.006 · Cited by 118 · see citing works
Wiener, L. S., Battles, H. B., Zadeh, S., Widemann, B. C., & Pao, M. (2015) · Psycho-Oncology · doi:10.1002/pon.4038 · Cited by 69 · see citing works
Ma, J., Yang, Y., Chen, D. W., Chen, M., Wang, H., Wang, X., Sun, L., Wang, F.-Z., & Wang, D. (2016) · Oncology Reports · doi:10.3892/or.2016.4860 · Cited by 68 · see citing works
Chan, A., Poon, E. Y. L., Goh, W. L., Gan, Y., Tan, C. J., Yeo, K., Chua, A., Chee, M., Law, Y. C., Somasundaram, N., et al. (2018) · Supportive Care in Cancer · doi:10.1007/s00520-018-4189-y · Cited by 50 · see citing works
Lazor, T., Tigelaar, L., Pole, J. D., De Souza, C., Tomlinson, D., & Sung, L. (2017) · Supportive Care in Cancer · doi:10.1007/s00520-017-3743-3 · Cited by 42 · see citing works
Soanes, L., & Gibson, F. (2018) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2018.01.010 · Cited by 37 · see citing works
Psychosocial Distress Due to Interference of Normal Developmental Milestones in AYAs with Cancer
Itzep, N. P., & Roth, M. E. (2022) · Children · doi:10.3390/children9030309 · Cited by 34 · see citing works
Dhikr Therapy for Reducing Anxiety in Cancer Patients
Sulistyawati, R. A., Probosuseno, P., & Setiyarini, S. (2019) · Asia-Pacific Journal of Oncology Nursing · doi:10.4103/apjon.apjon_33_19 · Cited by 32 · see citing works
Adolescents and Young Adults with Cancer: A Biopsychosocial Approach
Zebrack, B., Santacroce, S. J., Patterson, P., & Gubin, A. (2015) · Springer eBooks · doi:10.1007/978-3-319-21374-3_12 · Cited by 28 · see citing works
Shain, L. M., Pao, M., Tipton, M. V., Bedoya, S. Z., Kang, S. J., Horowitz, L. M., & Wiener, L. S. (2019) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-019-09631-5 · Cited by 23 · see citing works
Zhang, A., Kamat, A., Acquati, C., Aratow, M., Kim, J. S., DuVall, A. S., & Walling, E. (2022) · Cancers · doi:10.3390/cancers14040914 · Cited by 21 · see citing works
Ogland-Hand, C., Ciesielski, T. H., Daunov, K., Bean, M. K., & Nock, N. L. (2023) · Nutrients · doi:10.3390/nu15071731 · Cited by 20 · see citing works
Lazor, T., Pole, J. D., Souza, C. M. D., Schechter, T., Grant, R. M., Davis, H., Duong, N., Stein, E., Cook, S., Tigelaar, L., et al. (2019) · Psycho-Oncology · doi:10.1002/pon.5004 · Cited by 20 · see citing works
Gupta, S., Li, Q., Nathan, P. C., D’Agostino, N. M., Baxter, N. N., Fox, C. J., Chalifour, K., Coburn, N. G., & Sutradhar, R. (2023) · Cancer Medicine · doi:10.1002/cam4.5837 · Cited by 19 · see citing works
Zhang, A. (2021) · Research on Social Work Practice · doi:10.1177/10497315211062508 · Cited by 17 · see citing works
Alrubai, T., Khalil, A. M., Zaki, R., Sinno, L., & Tabbah, S. A. A. A. (2021) · Psycho-Oncology · doi:10.1002/pon.5851 · Cited by 14 · see citing works
Sender, A., Friedrich, M., Leuteritz, K., Stuckenberg, E., Richter, D., Stöbel‐Richter, Y., Lordick, F., & Geue, K. (2021) · Psycho-Oncology · doi:10.1002/pon.5678 · Cited by 17 · see citing works
Exploring Adolescents' Cancer Journey Through Photovoice: A Narrative Synthesis
Niepage, M., Georgievski, G., Shama, W., & Lucchetta, S. A. (2017) · Journal of Adolescent and Young Adult Oncology · doi:10.1089/jayao.2017.0073 · Cited by 13 · see citing works
Lazor, T., Souza, C. M. D., Urquhart, R., Serhal, E., & Gagliardi, A. R. (2020) · Supportive Care in Cancer · doi:10.1007/s00520-020-05845-8 · Cited by 11 · see citing works
Hyslop, S., Tomlinson, D., Baggott, C., Dix, D. B., Gibson, P. J., Johnston, D. L., Orsey, A. D., Portwine, C., Price, V., Vanan, M., et al. (2020) · Supportive Care in Cancer · doi:10.1007/s00520-020-05818-x · Cited by 10 · see citing works
Horwood, M., Loades, M. E., Košir, U., & Davis, C. (2023) · Journal of Pediatric Hematology/Oncology Nursing · doi:10.1177/27527530231190378 · Cited by 8 · see citing works
Chan, A., Ports, K. D., Ng, D. Q., Nasr, R., Hsu, S., Armenian, S. H., Baca, N. M., Freyer, D. R., Kuo, D. J., Lin, C. H., et al. (2023) · Journal of Adolescent and Young Adult Oncology · doi:10.1089/jayao.2022.0086 · Cited by 8 · see citing works
McCann, L., Hewitt, C., & McMillan, K. A. (2023) · JMIR Cancer · doi:10.2196/41441 · Cited by 8 · see citing works
Merz, S., Friedrich, M., Brock, H., Leuteritz, K., Geue, K., Richter, D., Mehnert, A., & Sender, A. (2024) · Psycho-Oncology · doi:10.1002/pon.6282 · Cited by 6 · see citing works
Sarvan, S., Bekar, P., Erkul, M., & Efe, E. (2024) · Cancer Nursing · doi:10.1097/ncc.0000000000001369 · Cited by 6 · see citing works
Chao, C., Zhou, H. C., Shalman, D. M., Pak, K. J., Armenian, S. H., Xu, L., Gu, Z., & Hechter, R. C. (2025) · Cancer · doi:10.1002/cncr.35866 · Cited by 5 · see citing works
Malaval, C., Stanchi, K. M. C., Werle, D., Thiel, S., Gansel, M., Lang, P., Handgretinger, R., Svaldi, J., & Döring, M. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05300-1 · Cited by 4 · see citing works
Morrison, C. F., Drake, S., Basile, N. L., Horn, M. J., Lambert, J., Myers, K. C., & Pai, A. L. H. (2022) · Journal of Pediatric Hematology/Oncology Nursing · doi:10.1177/27527530211068746 · Cited by 3 · see citing works
Bibliometric analysis of research on digestive system tumors and depression
Qu, Y., Nie, D., Song, Y., Cai, X., Gong, Y., Chen, S., Ye, J., & Li, J. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1414528 · Cited by 3 · see citing works
Meeting the supportive care needs of young adults with cancer
Soanes, L. (2015) · British Journal of Nursing · doi:10.12968/bjon.2015.24.sup16.s30 · Cited by 3 · see citing works
Itzep, N. P., Moore, J., Gallagher, C. M., Roth, M. E., Martin, P., Hernández, M., & Moody, K. M. (2025) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2025.07.036 · Cited by 2 · see citing works
Lavan, O., Peled, O., Avishai-Neumann, M., Weizman, A., Yahel, A., Apter, A. S., Valevski, A., Fennig, S., Stein, J., & Benaroya-Milshtein, N. (2022) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2021.0083 · Cited by 2 · see citing works
A Systematic Review of the Psychosocial Measures Used in Teenage and Young Adult Cancer
Hughes, K., Blackett, L., Jacobson, C. E. H., Henley, S. M. D., & Carr, E. (2023) · Journal of Adolescent and Young Adult Oncology · doi:10.1089/jayao.2023.0051 · Cited by 2 · see citing works
Megari, K., Katsarou, D. V., Mantsos, E., Miliadi, V., Kosmidou, E., Argyriadi, A., Papadopoulou, S. L., Argyriadis, A., Toki, E. I., & Sofologi, M. (2025) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.70040 · Cited by 2 · see citing works
What Adolescents and Young Adults Want Health Professionals to Know
Hawkins, J. (2017) · Springer eBooks · doi:10.1007/978-3-319-66173-5_10 · Cited by 2 · see citing works
Swancy, A. G. (2019) · Professional Psychology Research and Practice · doi:10.1037/pro0000238 · Cited by 2 · see citing works
Transitional-Age Youth With Chronic Medical and Mental Health Conditions
Rahmat, S., O’Connor, R. J., & Qayyum, Z. (2022) · Psychiatric Annals · doi:10.3928/00485713-20220525-01 · Cited by 2 · see citing works
Melesse, T. G., Chau, J. P. C., & Li, W. H. C. (2022) · Trials · doi:10.1186/s13063-022-06768-x · Cited by 1 · see citing works
Psychological Support and Social Care
Holland, L., & Thompson, K. (2017) · Springer eBooks · doi:10.1007/978-3-319-66173-5_4 · Cited by 1 · see citing works
Ansiedade, depressão e qualidade do sono no pós-operatório mediato de cirurgia oncológica
Barbosa, L. K., Silva, J. S. C., de Almeida, A. C. M., Leroy, P. L. A., & Vieira, M. E. B. (2019) · Revista Brasileira de Pesquisa em Saúde/Brazilian Journal of Health Research · doi:10.21722/rbps.v20i4.24600
Malaval, C., Stanchi, K. M. C., Werle, D., Thiel, S., Gansel, M., Lang, P., Handgretinger, R., Svaldi, J., & Döring, M. (2023) · Research Square · doi:10.21203/rs.3.rs-2462213/v1
Marcotulli, D., Salvalaggio, A., Zardini, A., & Vitiello, B. (2025) · Springer eBooks · doi:10.1007/978-3-031-81802-8_12
Melesse, T. G., Chau, J. P. C., & Li, W. H. C. (2022) · Figshare · doi:10.6084/m9.figshare.21211319
Depression and Anxiety Among Adolescents with Cancer: A Saudi Cross-Sectional Study
Alqarni, A. A., Alhabbad, A. A., Alkhawashki, S. H., Batis, H. O., Altbenawi, A. M., AlQumayzi, A. S., Alqarni, B. M., Alajami, M. A., Alturki, R., Almadani, A. H., et al. (2026) · Pediatric Reports · doi:10.3390/pediatric18050140
- Authors
- Lauer, A. L.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Lauer, Amy L.
- Venue
- Journal of Pediatric Oncology Nursing
- Publisher
- SAGE Publications
- Published
- 2015-01-02
- Volume
- 32
- Issue
- 5
- Pages
- 278-283
- ISSN
- 0748-1802 (ISSN-L)
- 1043-4542
- 1532-8457
- OpenAlex
- W2095185125
- Cited by
- 45
- References
- 24
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 7 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 4
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric Oncology Nursing (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Sociology and Political Science › Family Support in Illness
- Keywords
- anxiety, depression, adolescent and young adult cancer, psychosocial needs, screening, barriers to treatment, treatment side effects, clinician confidence
- MeSH terms
- Adolescent, Adult, Communication Barriers, Depressive Disorder, Female, Humans, Male, Neoplasms, Nursing Process, Oncology Nursing, Pediatric Nursing, Adolescent Health Services, Young Adult
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