AMP-Activated Protein Kinase (AMPK) Molecular Crossroad for Metabolic Control and Survival of Neurons

The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis

Liang, J., Shao, S. H., Xu, Z.-X., Hennessy, B. T., Ding, Z., Larrea, M. D., Kondo, S., Dumont, D. J., Gutterman, J. U., Walker, C. L., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1537 · Cited by 868 · see citing works

Resveratrol stimulates AMP kinase activity in neurons

Dasgupta, B., & Milbrandt, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610068104 · Cited by 723 · see citing works

Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy

Vı́lchez, D., R�os, S., Cifuentes, D., Pujadas, L., Vallès, J., García-Fojeda, B., Criado‐García, O., Fernández-Sánchez, E., Medraño-Fernández, I., Domínguez, J. E., et al. (2007) · Nature Neuroscience · doi:10.1038/nn1998 · Cited by 374 · see citing works

AMP-Activated Protein Kinase is Highly Expressed in Neurons in the Developing Rat Brain and Promotes Neuronal Survival Following Glucose Deprivation

Culmsee, C., monnig, J., Kemp, B. E., & Mattson, M. P. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:1:45 · Cited by 340 · see citing works

AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues

Xue, B., & Kahn, B. B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.113217 · Cited by 338 · see citing works

Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke

McCullough, L. D., Zeng, Z., Li, H., Landree, L. E., McFadden, J., & Ronnett, G. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409985200 · Cited by 333 · see citing works

Cellular Distribution and Developmental Expression of AMP‐Activated Protein Kinase Isoforms in Mouse Central Nervous System

Turnley, A. M., Stapleton, D., Mann, R. J., Witters, L. A., Kemp, B. E., & Bartlett, P. F. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.721707.x · Cited by 262 · see citing works

AMP‐activated protein kinase: role in metabolism and therapeutic implications

Schimmack, G., DeFronzo, R. A., & Musi, N. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2005.00561.x · Cited by 229 · see citing works

Neuroprotective Effects of Adenosine Monophosphate- Activated Protein Kinase Inhibition and Gene Deletion in Stroke

Li, J., Zeng, Z., Viollet, B., Ronnett, G. V., & McCullough, L. D. (2007) · Stroke · doi:10.1161/strokeaha.107.490904 · Cited by 216 · see citing works

Sustained activation of AMP‐activated protein kinase induces c‐Jun N‐terminal kinase activation and apoptosis in liver cells

Meisse, D., de Casteele, M. V., Beauloye, C., Hainault, I., Kefas, B. A., Rider, M. H., Foufelle, F., & Hue, L. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03110-1 · Cited by 205 · see citing works

Phospho-Dependent Functional Modulation of GABAB Receptors by the Metabolic Sensor AMP-Dependent Protein Kinase

Kuramoto, N., Wilkins, M. E., Fairfax, B. P., Revilla-Sanchez, R., Terunuma, M., Tamaki, K., Takarada‐Iemata, M., Warren, N. A., Couve, A., Calver, A. R., et al. (2007) · Neuron · doi:10.1016/j.neuron.2006.12.015 · Cited by 184 · see citing works

Omega-3 Fatty Acids Supplementation Restores Mechanisms that Maintain Brain Homeostasis in Traumatic Brain Injury

Wu, A., Ying, Z., & Gómez‐Pinilla, F. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2007.0313 · Cited by 178 · see citing works

Exercise affects energy metabolism and neural plasticity-related proteins in the hippocampus as revealed by proteomic analysis

Ding, Q., Vaynman, S., Souda, P., Whitelegge, J. P., & Gomez‐Pinilla, F. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05026.x · Cited by 174 · see citing works

The AMP‐activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes

Blázquez, C., Geelen, M. J. H., Velasco, G., & Guzmán, M. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02089-0 · Cited by 163 · see citing works

AICA riboside both activates AMP‐activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus

Gadalla, A. E., Pearson, T., Currie, A. J., Dale, N., Hawley, S. A., Sheehan, M., Hirst, W. D., Michel, A. D., Randall, A. D., Hardie, D. G., et al. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02253.x · Cited by 145 · see citing works

The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing

Tschäpe, J., Hammerschmied, C., Mühlig‐Versen, M., Athenstaedt, K., Daum, G., & Kretzschmar, D. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf636 · Cited by 128 · see citing works

Nutritional Status, Cognition, and Survival

Dagon, Y., Avraham, Y., Magen, I., Gertler, A., Ben‐Hur, T., & Berry, E. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507607200 · Cited by 113 · see citing works

5′-aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells

Garcia‐Gil, M., Pesi, R., Perna, S., Allegrini, S., Giannecchini, M., Camici, M., & Tozzi, M. G. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00836-9 · Cited by 112 · see citing works

Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain

Mukherjee, P., Mulrooney, T. J., Marsh, J., Blair, D., Chiles, T. C., & Seyfried, T. N. (2008) · Molecular Cancer · doi:10.1186/1476-4598-7-37 · Cited by 101 · see citing works

5-Aminoimidazole-4-carboxamide-ribonucleoside enhances oxidative stress-induced apoptosis through activation of nuclear factor-κB in mouse Neuro 2a neuroblastoma cells

Jung, J. E., Lee, J., Ha, J., Kim, S. S., Cho, Y. H., Baik, H. H., & Kang, I. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.10.012 · Cited by 86 · see citing works

Role of hypothalamic 5′-AMP-activated protein kinase in the regulation of food intake and energy homeostasis

Kim, M., & Lee, K. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0659-z · Cited by 71 · see citing works

5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved

López, J. M., Santidrián, A. F., Campàs, C., & Gil, J. (2003) · Biochemical Journal · doi:10.1042/bj20021053 · Cited by 66 · see citing works

AICAR Induces Astroglial Differentiation of Neural Stem Cells via Activating the JAK/STAT3 Pathway Independently of AMP-activated Protein Kinase

Zang, Y., Yu, L.-F., Pang, T., Fang, L., Xu, F., Wen, T., Nan, F., Feng, L., & Li, J. X. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708619200 · Cited by 65 · see citing works

Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro

Kleman, A. M., Yuan, J., Aja, S. M., Ronnett, G. V., & Landree, L. E. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.08.028 · Cited by 58 · see citing works

Drosophila alicorn Is a Neuronal Maintenance Factor Protecting against Activity-Induced Retinal Degeneration

Spasić, M. R., Callaerts, P., & Norga, K. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1646-08.2008 · Cited by 56 · see citing works

Activation of AMP-activated protein kinase by tributyltin induces neuronal cell death

Nakatsu, Y., Kotake, Y., Hino, A., & Ohta, S. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.03.021 · Cited by 48 · see citing works

Activation of AMP-activated protein kinase by kainic acid mediates brain-derived neurotrophic factor expression through a NF-kappaB dependent mechanism in C6 glioma cells

Yoon, H., Oh, Y. T., Lee, J. Y., Choi, J. H., Lee, J. H., Baik, H. H., Kim, S. S., Choe, W., Yoon, K., Ha, J., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.04.102 · Cited by 38 · see citing works

Ethanol alters lipid profiles and phosphorylation status of AMP‐activated protein kinase in the neonatal mouse brain

Saito, M., Chakraborty, G., Mao, R., Wang, R., Cooper, T. B., Vadasz, C., & Saito, M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04836.x · Cited by 34 · see citing works

Timely administration of AICA riboside reduces reperfusion injury in rabbits

Kingma, J. G., Simard, D., & Rouleau, J. R. (1994) · Cardiovascular Research · doi:10.1093/cvr/28.7.1003 · Cited by 33 · see citing works

New Candidate Targets of AMP-Activated Protein Kinase in Murine Brain Revealed by a Novel Multidimensional Substrate-Screen for Protein Kinases

Tuerk, R. D., Thali, R. F., Auchli, Y., Rechsteiner, H., Brunisholz, R., Schlattner, U., Wallimann, T., & Neumann, D. (2007) · Journal of Proteome Research · doi:10.1021/pr070160a · Cited by 32 · see citing works

Appetite and Metabolic Effects of Ghrelin and Cannabinoids: Involvement of AMP-Activated Protein Kinase

van Thuijl, H., Kola, B., & Korbonits, M. (2007) · Vitamins and hormones · doi:10.1016/s0083-6729(06)77006-6 · Cited by 31 · see citing works

Lithium blocks ethanol-induced modulation of protein kinases in the developing brain

Chakraborty, G., Saito, M., Mao, R., Wang, R., Vadász, C., & Saito, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.01.004 · Cited by 28 · see citing works

Metformin: An Old But Still the Best Treatment for Type 2 Diabetes

Rojas, L. B. A., & Gomes, M. B. (2013) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-5-6 · Cited by 567 · see citing works

How does adenosine control neuronal dysfunction and neurodegeneration?

Cunha, R. A. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13724 · Cited by 442 · see citing works

Life or death: Neuroprotective and anticancer effects of quercetin

Dajas, F. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.07.005 · Cited by 379 · see citing works

Copper signaling in the mammalian nervous system: Synaptic effects

Gaier, E. D., Eipper, B. A., & Mains, R. E. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23143 · Cited by 210 · see citing works

Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion

Liu, Y., Tang, G., Li, Y., Wang, Y., Chen, X., Gu, X., Zhang, Z., Wang, Y., & Yang, G. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0177-4 · Cited by 186 · see citing works

AMP Kinase Activation Mitigates Dopaminergic Dysfunction and Mitochondrial Abnormalities inDrosophilaModels of Parkinson's Disease

Ng, C.-H., Guan, M. S. H., Koh, C., Ouyang, X., Yu, F., Tan, E., O’Neill, S., Zhang, X., Chung, J., & Lim, K. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0499-12.2012 · Cited by 177 · see citing works

Resveratrol neuroprotection in stroke and traumatic CNS injury

Lopez, M. S., Dempsey, R. J., & Vemuganti, R. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.08.009 · Cited by 171 · see citing works

Total Synthesis and Biological Evaluation of the Resveratrol-Derived Polyphenol Natural Products Hopeanol and Hopeahainol A

Nicolaou, K. C., Kang, Q., Wu, T., Lim, C. S., & Chen, D. Y. ‐. (2010) · Journal of the American Chemical Society · doi:10.1021/ja102623j · Cited by 154 · see citing works

Adiponectin is Protective against Oxidative Stress Induced Cytotoxicity in Amyloid-Beta Neurotoxicity

Chan, K., Lam, K. S. L., Cheng, O.-Y., Kwan, J., Ho, P. W., Cheng, K. K. Y., Chung, S. K., Ho, J. W.-M., Guo, V. Y., & Xu, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052354 · Cited by 140 · see citing works

The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro

Dulović, M., Jovanović, M., Xilouri, M., Stefanis, L., Harhaji-Trajkovic, L. M., Kravic‐Stevovic, T., Paunović, V., Ardah, M. T., El‐Agnaf, O. M. A., Kostić, V., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.11.002 · Cited by 123 · see citing works

Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: Interference of AMPK/PGC-1α pathway

Ashabi, G., Khodagholi, F., Khalaj, L., Goudarzvand, M., & Nasiri, M. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-013-9475-2 · Cited by 120 · see citing works

Metabolic features and regulation in cell senescence

Kwon, S. M., Hong, S. M., Lee, Y.-K., Min, S., & Yoon, G. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.1.291 · Cited by 111 · see citing works

Chronic stress-induced memory deficits are reversed by regular exercise via AMPK-mediated BDNF induction

Kim, D.-M., & Leem, Y. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.03.019 · Cited by 104 · see citing works

AMPK/PPAR-γ/NF-κB axis participates in ROS-mediated apoptosis and autophagy caused by cadmium in pig liver

Wang, H., Wang, A., Wang, X., Zeng, X., & Xing, H. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.118659 · Cited by 104 · see citing works

Revisiting the Relationship Between Autism and Schizophrenia: Toward an Integrated Neurobiology

de Lacy, N., & King, B. H. (2013) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185627 · Cited by 98 · see citing works

Mitochondrial dysfunction and Parkinson disease: a Parkin–AMPK alliance in neuroprotection

Hang, L., Thundyil, J., & Lim, K. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12820 · Cited by 101 · see citing works

Unpredictable chronic mild stress induces anxiety and depression-like behaviors and inactivates AMP-activated protein kinase in mice

Zhu, S., Wang, J., Zhang, Y., Li, V., Kong, J., He, J., & Li, X. (2014) · Brain Research · doi:10.1016/j.brainres.2014.06.002 · Cited by 100 · see citing works

Regulation of bile canalicular network formation and maintenance by AMP-activated protein kinase and LKB1

Fu, D., Wakabayashi, Y., Ido, Y., Lippincott‐Schwartz, J., & Arias, I. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.068098 · Cited by 98 · see citing works

AMPK: An emerging target for modification of injury-induced pain plasticity

Price, T. J., & Dussor, G. O. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.06.060 · Cited by 96 · see citing works

Wild jujube polysaccharides protect against experimental inflammatory bowel disease by enabling enhanced intestinal barrier function

Yue, Y., Wu, S., Li, Z., Li, J., Li, X., Xiang, J., & Ding, H. (2015) · Food & Function · doi:10.1039/c5fo00378d · Cited by 94 · see citing works

Sestrin2 protects dopaminergic cells against rotenone toxicity through AMPK-Dependent autophagy activation

Hou, Y.-S., Guan, J.-J., Xu, H.-D., Wu, F., Sheng, R., & Qin, Z.-H. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00285-15 · Cited by 87 · see citing works

Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots

Yang, S.-H., Li, W., Sumien, N., Forster, M. J., Simpkins, J. W., & Liu, R. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.10.005 · Cited by 86 · see citing works

Adiponectin attenuates neuronal apoptosis induced by hypoxia-ischemia via the activation of AdipoR1/APPL1/LKB1/AMPK pathway in neonatal rats

Xu, N., Zhang, Y., Doycheva, D. M., Ding, Y. P., Zhang, Y., Tang, J., Guo, H., & Zhang, J. H. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.02.024 · Cited by 82 · see citing works

Role of 5′-Adenosine Monophosphate-Activated Protein Kinase in Cell Survival and Death Responses in Neurons

Weisová, P., Dávila, D., Tuffy, L. P., Ward, M. W., Concannon, C. G., & Prehn, J. H. M. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3544 · Cited by 83 · see citing works

AMP-activated protein kinase mediates activity-dependent regulation of peroxisome proliferator-activated receptor γ coactivator-1α and nuclear respiratory factor 1 expression in rat visual cortical neurons

Yu, L., & Yang, S. J. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.04.063 · Cited by 76 · see citing works

Nutraceuticals in Parkinson’s Disease

Hang, L., Basil, A. H., & Lim, K. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8398-6 · Cited by 69 · see citing works

Metformin Improves Neurologic Outcome Via AMP‐Activated Protein Kinase–Mediated Autophagy Activation in a Rat Model of Cardiac Arrest and Resuscitation

Zhu, J., Liu, K., Huang, K., Gu, Y., Hu, Y., Pan, S., & Ji, Z. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.008389 · Cited by 66 · see citing works

Activation of Adenosine Monophosphate–activated Protein Kinase Suppresses Neuroinflammation and Ameliorates Bone Cancer Pain

Song, H., Han, Y., Pan, C., Deng, X., Dai, W., Hu, L., Jiang, C., Yang, Y., Cheng, Z., Li, F. Y., et al. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000856 · Cited by 57 · see citing works

Targeting AMPK for the Alleviation of Pathological Pain

Asiedu, M. N., Dussor, G. O., & Price, T. J. (2016) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-319-43589-3_11 · Cited by 56 · see citing works

Epigallocatechin-3-Gallate, a Promising Molecule for Parkinson's Disease?

Renaud, J., Nabavi, S. F., Daglia, M., Nabavi, S. M., & Martinoli, M. (2015) · Rejuvenation Research · doi:10.1089/rej.2014.1639 · Cited by 53 · see citing works

Low on energy? An energy supply-demand perspective on stress and depression

Østergaard, L., Jørgensen, M. B., & Knudsen, G. M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.08.007 · Cited by 52 · see citing works

Altered energy status of primary cerebellar granule neuronal cultures from rats exposed to lead in the pre- and neonatal period

Baranowska‐Bosiacka, I., Gutowska, I., Marchetti, C., Rutkowska, M., Marchlewicz, M., Kolasa, A., Prokopowicz, A., Wiernicki, I., Piotrowska, K., Baskiewicz, M., et al. (2010) · Toxicology · doi:10.1016/j.tox.2010.11.004 · Cited by 52 · see citing works

P2X7 Receptor is Involved in Mitochondrial Dysfunction Induced by Extracellular Alpha Synuclein in Neuroblastoma SH-SY5Y Cells

Wilkaniec, A., Cieślik, M., Murawska, E., Babiec, L., Gąssowska-Dobrowolska, M., Pałasz, E., Jęśko, H. M., & Adamczyk, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113959 · Cited by 50 · see citing works

Functional modulation of GABAB receptors by protein kinases and receptor trafficking

Terunuma, M., Pangalos, M. N., & Moss, S. J. (2010) · Advances in Pharmacology · doi:10.1016/s1054-3589(10)58005-0 · Cited by 49 · see citing works

Effects of Dietary Energy Level on Performance, Plasma Parameters, and Central AMPK Levels in Stressed Broilers

Hu, X., Li, X., Xiao, C., Kong, L., Zhu, Q., & Song, Z. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.681858 · Cited by 49 · see citing works

Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography

Mayor, E. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1161814 · Cited by 46 · see citing works

Cadmium induces mitophagy via AMP‐activated protein kinases activation in a PINK1/Parkin‐dependent manner in PC12 cells

Wang, T., Zhu, Q., Cao, B., Yuan, Y., Wen, S., & Liu, Z. (2020) · Cell Proliferation · doi:10.1111/cpr.12817 · Cited by 46 · see citing works

AMPK-associated signaling to bridge the gap between fuel metabolism and hepatocyte viability

Yang, Y. M. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i30.3731 · Cited by 45 · see citing works

Effect of Metformin on Different Non-Diabetes Related Conditions, a Special Focus on Malignant Conditions: Review of Literature

Abdelgadir, E., Ali, R., Rashid, F., & Bashier, A. M. (2017) · Journal of Clinical Medicine Research · doi:10.14740/jocmr2922e · Cited by 44 · see citing works

Novel Neuroprotective Effects of Melanin-Concentrating Hormone in Parkinson’s Disease

Park, J.-Y., Kim, S., Yoo, J., Jang, J., Lee, A., Oh, J., Kim, H., Oh, S. T., Park, S.-U., Kim, J., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0258-8 · Cited by 43 · see citing works

Current evidence for AMPK activation involvement on resveratrol-induced neuroprotection in cerebral ischemia

Pineda-Ramírez, N., Aguilar, G. F. G., Espinoza-Rojo, M., & Aguilera, P. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1284361 · Cited by 42 · see citing works

‘Mild mitochondrial uncoupling’ induced protection against neuronal excitotoxicity requires AMPK activity

Weisová, P., Anilkumar, U., Ryan, C., Concannon, C. G., Prehn, J. H. M., & Ward, M. W. (2012) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.01.016 · Cited by 42 · see citing works

The activation of adenosine monophosphate-activated protein kinase in rat hippocampus contributes to the rapid antidepressant effect of ketamine

Xu, S., Zhou, Z. Q., Li, X. M., Ji, M. H., Zhang, G. F., & Yang, J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.07.032 · Cited by 40 · see citing works

Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes

Castellano‐González, G., Pichaud, N., Ballard, J. W. O., Bessede, A., Marçal, H., & Guillemin, G. J. (2016) · Oncotarget · doi:10.18632/oncotarget.6863 · Cited by 41 · see citing works

Copper induces mitochondria-mediated apoptosis via AMPK-mTOR pathway in hypothalamus of Pigs

Lei, C., Liao, J., Li, Q., Shi, J., Zhang, H., Guo, J., Han, Q., Hu, L., Li, Y., Pan, J., et al. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112395 · Cited by 40 · see citing works

Arsenic induces autophagy-dependent apoptosis via Akt inactivation and AMPK activation signaling pathways leading to neuronal cell death

Fu, S.-C., Lin, J.-W., Liu, J., Liu, S., Fang, K., Su, C., Hsu, R., Wu, C.-C., Huang, C.-F., Lee, K.-I., et al. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.05.008 · Cited by 39 · see citing works

Minireview: Hey U(PS): Metabolic and Proteolytic Homeostasis Linked via AMPK and the Ubiquitin Proteasome System

Ronnebaum, S. M., Patterson, C., & Schisler, J. C. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1180 · Cited by 37 · see citing works

Electroacupuncture improves cognitive deficits associated with AMPK activation in SAMP8 mice

Dong, W., Guo, W.-Q., Zheng, X., Wang, F., Chen, Y., Zhang, W., & Shi, H. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9641-1 · Cited by 37 · see citing works

Resveratrol as a Protective Molecule for Neuroinflammation: A Review of Mechanisms

Renaud, J., & Martinoli, M. (2014) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201015666140617101332 · Cited by 36 · see citing works

Dexmedetomidine pretreatment inhibits cerebral ischemia/reperfusion‑induced neuroinflammation via activation of AMPK

Wang, Z., Zhou, W., Dong, H., Ma, X., & He, Z. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9349 · Cited by 36 · see citing works

Autophagy, autophagy-associated adaptive immune responses and its role in hematologic malignancies

You, L., Jin, S., Zhu, L., & Qian, W. (2016) · Oncotarget · doi:10.18632/oncotarget.13583 · Cited by 35 · see citing works

AMPK Mediates Glucocorticoids Stress-Induced Downregulation of the Glucocorticoid Receptor in Cultured Rat Prefrontal Cortical Astrocytes

Yuan, S., Liu, J., Zhou, J., Lü, W., Zhou, H.-Y., Long, L., Hu, Z., Ni, L., Wang, Y., Chen, J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159513 · Cited by 34 · see citing works

Potentiation of neuronal insulin signaling and glucose uptake by resveratrol: the involvement of AMPK

Patel, M. I., Gupta, A. K., & Dey, C. S. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70635-1 · Cited by 32 · see citing works

Effects and mechanism of epigallocatechin-3-gallate on apoptosis and mTOR/AKT/GSK-3β pathway in substantia nigra neurons in Parkinson rats

Zhou, W., Chen, L., Hu, X., Cao, S., & Yang, J. (2018) · Neuroreport · doi:10.1097/wnr.0000000000001149 · Cited by 32 · see citing works

The Effects of Hispidulin on Bupivacaine-Induced Neurotoxicity: Role of AMPK Signaling Pathway

Niu, X., Chen, J., Wang, P., Zhou, H., Li, S., & Zhang, M. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-014-9888-5 · Cited by 31 · see citing works

AMPK γ2 subunit gene PRKAG2 polymorphism associated with cognitive impairment as well as diabetes in old age

Kim, E., Lee, S. H., Lee, K. S., Cheong, H., Namkoong, K., Hong, C. H., & Oh, B. H. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.005 · Cited by 31 · see citing works

Effects of metformin on recognition memory and hippocampal neuroplasticity in rats with metabolic syndrome

Muñoz‐Arenas, G., Pulido, G., Treviño, S., Vázquez‐Roque, R. A., Flores, G., Morán, C., Handal‐Silva, A., Guevara, J., Venegas, B., & Díaz, A. (2020) · Synapse · doi:10.1002/syn.22153 · Cited by 29 · see citing works

Activation of AMPK/aPKCζ/CREB pathway by metformin is associated with upregulation of GDNF and dopamine

Katila, N., Bhurtel, S., Park, P., Hong, J. T., & Choi, D. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114193 · Cited by 29 · see citing works

The Effects of Hispidulin on Bupivacaine-Induced Neurotoxicity: Role of AMPK Signaling Pathway

NiuJie, X., Wang, C., ZhouSong, H., & Zhang, L. (2014) · Cited by 27 · see citing works

Metabolic Stress Modulates Motor Patterning via AMP-Activated Protein Kinase

Rodgers, C. I., Armstrong, G. A. B., & Robertson, R. M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5215-10.2011 · Cited by 26 · see citing works

Short-term starvation is a strategy to unravel the cellular capacity of oxidizing specific exogenous/endogenous substrates in mitochondria

Zeidler, J. D., Fernandes-Siqueira, L. O., Carvalho, A. S., Lopes, E. C., Dias, M. H., Ketzer, L. A., Galina, A., & Poian, A. T. D. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.786582 · Cited by 25 · see citing works

Neuroprotective Effects of AMP-Activated Protein Kinase on Scopolamine Induced Memory Impairment

Kim, S., Lee, J., Chung, H.-S., Song, J.-H., Ha, J., & Bae, H. (2013) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2013.17.4.331 · Cited by 24 · see citing works

Activation of AMP-Activated Protein Kinase Alleviates Homocysteine-Mediated Neurotoxicity in SH-SY5Y Cells

Park, Y., Ko, J., Jang, Y., & Kwon, Y. H. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1057-5 · Cited by 22 · see citing works

Activation of AMP-activated Protein Kinase Regulates Hippocampal Neuronal pH by Recruiting Na+/H+ Exchanger NHE5 to the Cell Surface

Jinadasa, T., Szabó, E. Z., Numata, M., & Orlowski, J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.555284 · Cited by 22 · see citing works

Chronological changes and effects of AMP-activated kinase in the hippocampal CA1 region after transient forebrain ischemia in gerbils

Nam, H. G. W., Kim, W., Yoo, D. Y., Choi, J. H., Won, M., Hwang, I. K., Jeong, J. H., Hwang, H. S., & Moon, S. M. (2013) · Neurological Research · doi:10.1179/1743132813y.0000000158 · Cited by 22 · see citing works

Hypoxic stabilization of mRNA is HIF-independent but requires mtROS

Fortenbery, G. W., Sarathy, B., Carraway, K., & Mansfield, K. D. (2018) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-018-0112-2 · Cited by 21 · see citing works

Eukaryote-like Ser/Thr protein kinase PrkA modulates sporulation via regulating the transcriptional factor σK in Bacillus subtilis

Yan, J., Zou, W., Fang, J., Huang, X., Gao, F., He, Z., Zhang, K., & Zhao, N. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00382 · Cited by 20 · see citing works

Nicotinamide Mononucleotide Adenylyltransferase 1 Protects Neural Cells Against Ischemic Injury in Primary Cultured Neuronal Cells and Mouse Brain with Ischemic Stroke Through AMP-Activated Protein Kinase Activation

Liang, J., Wang, P., Jia, W. P., Bao, C., & Han, D. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1569-2 · Cited by 20 · see citing works

Resveratrol promotes cellular glucose utilization in primary cultured cortical neurons via calcium-dependent signaling pathway

Zhang, J., Wu, P., Long, L., Chen, Y., Hu, Z., Ni, L., Wang, F., & Chen, J. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.02.015 · Cited by 19 · see citing works

HFS ‐Triggered AMPK Activation Phosphorylates GSK 3β and Induces E‐ LTP in Rat Hippocampus In Vivo

Yu, D., Shen, Z., Wu, P., Guan, X., Chen, T., Jin, Y., Hu, Z., Ni, L., Wang, F., Chen, J., et al. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12532 · Cited by 18 · see citing works

The biguanide metformin alters phosphoproteomic profiling in mouse brain

Khang, R., Park, C., & Shin, J. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.07.029 · Cited by 18 · see citing works

Hypoxia and Hypoglycemia synergistically regulate mRNA stability

Carraway, K., Johnson, E. M., Kauffmann, T. C., Fry, N. J., & Mansfield, K. D. (2017) · RNA Biology · doi:10.1080/15476286.2017.1311456 · Cited by 18 · see citing works

Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress

Vink, E. I., Smiley, J. R., & Mohr, I. (2017) · Journal of Virology · doi:10.1128/jvi.00295-17 · Cited by 18 · see citing works

AICAR induced AMPK activation potentiates neuronal insulin signaling and glucose uptake

Shah, A. K., Gupta, A. K., & Dey, C. S. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.03.005 · Cited by 17 · see citing works

Reduction in Neural Performance following Recovery from Anoxic Stress Is Mimicked by AMPK Pathway Activation

Money, T. G. A., Sproule, M. K. J., Hamour, A. F., & Robertson, R. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088570 · Cited by 16 · see citing works

Neuroprotective Effects of Rhodiola Sacra on Transient Global Cerebral Ischemia Through Activating AMPK/Nrf2 Pathway in Rats

Li, K., Jiang, J., Shi, Z., Zhan, L., Peng, L., Sun, W., Tang, Y., Zuo, X., & Xu, E. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8224 · Cited by 15 · see citing works

Blunted response of hippocampal AMPK associated with reduced neurogenesis in older versus younger mice

Jang, S., Kim, H., Jeong, J., Lee, S. K., Kim, E. W., Park, M., Kim, C. H., Lee, J. E., Namkoong, K., & Kim, E. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.06.011 · Cited by 14 · see citing works

Targeting AMPK for Therapeutic Intervention in Type 2 Diabetes

Kodiha, M., & Stochaj, U. (2011) · InTech eBooks · doi:10.5772/20930 · Cited by 14 · see citing works

SARM1 Deficiency Induced Depressive-like Behavior via AMPKα/p-eEF2 axis to Synapse Dysfunction.

Li, W.-F., Zhu, W., Chen, J.-H., Ali, T., & Li, S.-P. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110206 · Cited by 13 · see citing works

Role of The Purinergic Neuromodulation System in Epilepsy

Tomé, Â. R., Silva, H. B. L., & Cunha, R. A. (2010) · The Open Neuroscience Journal · doi:10.2174/1874082001004010064 · Cited by 12 · see citing works

Increased Actin Polymerization and Stabilization Interferes with Neuronal Function and Survival in the AMPKγ Mutant Loechrig

Cook, M., Bolkan, B. J., & Kretzschmar, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089847 · Cited by 11 · see citing works

Transcriptional insights on the regenerative mechanics of axotomized neurons in vitro

Ng, J. M. J., Chen, M. J., Leung, J. Y. K., Peng, Z. F., Manikandan, J., Qi, R. Z., Chuah, M. I., West, A. K., Vickers, J. C., Lu, J., et al. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01361.x · Cited by 9 · see citing works

Activators of AMPK: Not Just for Type II Diabetes

Zaks, I., Getter, T., & Gruzman, A. (2014) · Future Medicinal Chemistry · doi:10.4155/fmc.14.74 · Cited by 9 · see citing works

Partial Rescue of Retinal Function in Chronically Hypoglycemic Mice

Umino, Y., Cuenca, N., Everhart, D., Fernández‐Sánchez, L., Barlow, R. B., & Solessio, E. C. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8787 · Cited by 6 · see citing works

Exendin-4 protects the dopaminergic neurons by attenuating inflammatory responses of microglial cells via activation of AMPK

Rimal, N., Khanal, S., Bohara, G., & Choi, D. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110643 · Cited by 5 · see citing works

Neuroprotective mode of action of resveratrol in central nervous system

Dasgupta, S., & Bandyopadhyay, M. (2013) · PharmaNutrition · doi:10.1016/j.phanu.2013.05.006 · Cited by 5 · see citing works

Food restriction does not relieve PTSD-like anxiety

Hendriksen, H., Bink, D. I., Vergoossen, D. L. E., van Slobbe, E. S., Olivier, B., & Oosting, R. S. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.10.060 · Cited by 5 · see citing works

Activation of kinase phosphorylation by heat-shift and mild heat-shock

Passeri, P. P., Quaresima, S., Mongiardi, M. P., Severini, C., & Possenti, R. (2010) · Cell Biology International Reports · doi:10.1042/cbr20100002 · Cited by 5 · see citing works

The ameliorating effect of exercise on long-term memory impairment and dendritic retraction via the mild activation of AMP-activated protein kinase in chronically stressed hippocampal CA1 neurons

Leem, Y., & Chang, H. (2018) · Physical Activity and Nutrition · doi:10.20463/jenb.2018.0022 · Cited by 4 · see citing works

The Involvement of Nitric Oxide in Antidepressant-Like Effect of Metformin after Bile-Duct Ligation in NMRI Mice

Ostadhadi, S., Jahanabadi, S., Javadi, S., Saadaei, H., Zolfaghari, S., & Dehpour, A. R. (2015) · Caspian Journal of Neurological Sciences · doi:10.18869/acadpub.cjns.1.3.1 · Cited by 4 · see citing works

Increased frequency of AMP‐activated protein kinase‐positive spinal motor neurons after sciatic nerve injury in a mouse model

Bao, Q., Cao, G., Li, Q., Chen, G., Liang, X., Wang, Y., & Meng, C. (2018) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/j.kjms.2017.12.007 · Cited by 2 · see citing works

From non-pharmacological interventions to therapeutic targets for the treatment of PTSD

Hendriksen, H. M. A. (2012) · Utrecht University Repository (Utrecht University) · Cited by 2 · see citing works

Contributions of AMP kinase to the Pathogenesis of Type 2 Diabetes and Neurodegenerative Diseases

Kodiha, M., Mahboubi, H., & Stochaj, U. (2013) · Wiley eBooks · doi:10.1002/9781118395318.ch22 · Cited by 2 · see citing works

Role of AMPK in aging and age-related loss of behavioral plasticity in C. elegans

Escoubas, C. C. (2018) · HAL · doi:10.70675/1c8dd62ez2561z4581zaa55z169311331b91 · Cited by 2 · see citing works

Neuropatia sensorial periférica induzida pela cisplatina: estudo dos mecanismos de neurotoxicidade da cisplatina e do efeito protetor do éster fenetil do ácido cafeico (CAPE) em células PC12

Ferreira, R. S. (2018) · doi:10.11606/t.60.2018.tde-17102018-104638 · Cited by 1 · see citing works

Angefertigt mit Genehmigung der Mathematisch-Naturwissenschaftlichen Fakultät der

Bonn, R. F.-W.-U. (2012)

AMP‐Activated Protein Kinase (AMPK) as a Cellular Energy Sensor and Therapeutic Target for Neuroprotection

Weisová, P., Pfeiffer, S. L., & Prehn, J. H. M. (2015) · Wiley eBooks · doi:10.1002/9781119017127.ch5

The role of adenosine monophosphate-activated protein kinase (AMPK) in the action of modified recombinant extracellular wt (wild-type) ASYN in vitro

Jeremić, M., Radeta, R., & Jovanović, M. (2016) · Medicinski podmladak · doi:10.5937/medpodm1601051j

The effect manipulating AMPK activity has on ouabain-induced spreading depression in fed and starved Locusta migratoria.

Mangulins, R. (2015) · QSpace (Queen's University Library)

Expanding roles for AMP‐activated protein kinase in neuronal survival and autophagy

Poels, J., Spasić, M. R., Callaerts, P., & Norga, K. (2009) · BioEssays · doi:10.1002/bies.200900003 · Cited by 130 · see citing works

AMPK in the brain: its roles in glucose and neural metabolism

Muraleedharan, R., & Dasgupta, B. (2021) · FEBS Journal · doi:10.1111/febs.16151 · Cited by 164 · see citing works

Role of 5′-Adenosine Monophosphate-Activated Protein Kinase in Cell Survival and Death Responses in Neurons

Weisová, P., Dávila, D., Tuffy, L. P., Ward, M. W., Concannon, C. G., & Prehn, J. H. M. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3544 · Cited by 83 · see citing works

AMP-Activated Protein Kinase is Highly Expressed in Neurons in the Developing Rat Brain and Promotes Neuronal Survival Following Glucose Deprivation

Culmsee, C., monnig, J., Kemp, B. E., & Mattson, M. P. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:1:45 · Cited by 340 · see citing works

AMP-Activated Protein Kinase (AMPK) Activation and Signalling Following Neuronal Excitotoxicity

Connolly, N. M. C. (2013) · doi:10.25419/rcsi.10806233