Atomoxetine Treatment of ADHD in Children With Comorbid Tourette Syndrome
Abstract
Objective: This study examines changes in severity of tics and ADHD during atomoxetine treatment in ADHD patients with Tourette syndrome (TS). Method: Subjects (7-17 years old) with ADHD ( Diagnostic and Statistical Manual of Mental Disorders, DSM-IV) and TS were randomly assigned to double-blind treatment with placebo ( n = 56) or atomoxetine (0.5-1.5 mg/kg/day, n = 61) for approximately 18 weeks. Results: Atomoxetine subjects showed significantly greater improvement on ADHD symptom measures. Treatment was also associated with significantly greater reduction of tic severity on two of three measures. Significant increases were seen in mean pulse rate and rates of treatment-emergent nausea, decreased appetite, and decreased body weight. No other clinically relevant treatment differences were observed in any other vital sign, adverse event, laboratory parameter, or electrocardiographic measure. Conclusion: Atomoxetine is efficacious for treatment of ADHD and its use appears well tolerated in ADHD patients with comorbid TS. (J. of Att. Dis. 2008; 11(4) 470-481)
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In controlled studies of atomoxetine, its impact on tics was either not different from placebo or even showed some positive effect on tic frequency.
“In the controlled studies of atomoxetine, its impact on tics was either not different from placebo or even showed some positive effect on tic frequency [8, 110, 135].”
From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [135]
Cites
KAUFMAN, J., BIRMAHER, B., BRENT, D., RAO, U., FLYNN, C., MORECI, P., WILLIAMSON, D., & RYAN, N. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199707000-00021 · Cited by 10,148 · see citing works
The yale global tic severity scale: initial testing of a clinician-rated scale of tic severity
LECKMAN, J. F., RIDDLE, M. A., HARDIN, M. T., ORT, S. I., SWARTZ, K. L., STEVENSON, J., & COHEN, D. J. (1989) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198907000-00015 · Cited by 2,146 · see citing works
Children's Yale-Brown Obsessive Compulsive Scale: Reliability and Validity
SCAHILL, L., RIDDLE, M. A., McSWIGGIN-HARDIN, M., ORT, S. I., KING, R. A., GOODMAN, W. K., CICCHETTI, D., & LECKMAN, J. F. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199706000-00023 · Cited by 2,045 · see citing works
(1998) · Cited by 2,026 · see citing works
Bymaster, F. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00346-9 · Cited by 1,123 · see citing works
Michelson, D., Faries, D., Wernicke, J., Kelsey, D., Kendrick, K., Sallee, F. R., Spencer, T., & the Atomoxetine ADHD Study Group (2001) · Pediatrics · doi:10.1542/peds.108.5.e83 · Cited by 666 · see citing works
Self-citationMichelson, D., Allen, A. J., Busner, J., Casat, C., Dunn, D., Kratochvil, C., Newcorn, J., Sallee, F. R., Sangal, R. B., Saylor, K., et al. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1896 · Cited by 599 · see citing works
Self-citationScahill, L., Chappell, P. B., Kim, Y. S., Schultz, R. T., Katsovich, L., Shepherd, E., Arnsten, A. F. T., Cohen, D. J., & Leckman, J. F. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.7.1067 · Cited by 588 · see citing works
Treatment of ADHD in children with tics: A randomized controlled trial
The Tourette’s Syndrome Study Group (2002) · Neurology · doi:10.1212/wnl.58.4.527 · Cited by 504 · see citing works
Kelsey, D. K., Sumner, C. R., Casat, C. D., Coury, D. L., Quintana, H., Saylor, K. E., Sutton, V. K., Gonzales, J., Malcolm, S. K., Schuh, K. J., et al. (2004) · Pediatrics · doi:10.1542/peds.114.1.e1 · Cited by 464 · see citing works
Self-citationRelative pre- and postsynaptic potencies of ?-adrenoceptor agonists in the rabbit pulmonary artery
Starke, K., Endo, T., & Taube, H. D. (1975) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00510821 · Cited by 455 · see citing works
Children’s Depression Rating Scale – Revised (CDRS-R)
Keller, F., Grieb, J., Ernst, M., Spröber, N., Fegert, J. M., & Kölch, M. G. (2011) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917/a000090 · Cited by 453 · see citing works
A placebo-controlled trial of risperidone in Tourette syndrome
Scahill, L., Leckman, J. F., Schultz, R. T., Katsovich, L., & Peterson, B. S. (2003) · Neurology · doi:10.1212/01.wnl.0000055434.39968.67 · Cited by 362 · see citing works
Clonidine Treatment of Gilles de la Tourette's Syndrome
Leckman, J. F. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810280040006 · Cited by 334 · see citing works
Spencer, T., Heiligenstein, J. H., Biederman, J., Faries, D. E., Kratochvil, C. J., Conners, C. K., & Potter, W. Z. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n1209 · Cited by 333 · cited 6× · see citing works
“…has been reported following treatment with tricyclic reuptake inhibitors with varying selectivity for noradrenergic reuptake, such as desipramine (Spencer et al., 1993a; Spencer et al., 2002a), imipramine (Messiha & Knopp, 1976; Sandyk & Bamford, 1988), or nortriptyline (Spencer et al., 1993b).”
BackgroundResultInfluentialSelf-citationReynolds, C. R. (2008) · Encyclopedia of Special Education · doi:10.1002/9780470373699.speced1606 · Cited by 307 · see citing works
KRATOCHVIL, C. J., HEILIGENSTEIN, J. H., DITTMANN, R., SPENCER, T. J., BIEDERMAN, J., WERNICKE, J., NEWCORN, J. H., CASAT, C., MILTON, D., & MICHELSON, D. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200207000-00008 · Cited by 292 · see citing works
Self-citationStimulant Medications Precipitate Tourette's Syndrome
Lowe, T. L. (1982) · JAMA · doi:10.1001/jama.1982.03320370043028 · Cited by 251 · see citing works
CHAPPELL, P. B., RIDDLE, M. A., SCAHILL, L., LYNCH, K. A., SCHULTZ, R., ARNSTEN, A., LECKMAN, J. F., & COHEN, D. J. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199509000-00010 · Cited by 250 · see citing works
Castellanos, F. X., Giedd, J. N., Elia, J., Marsh, W., Ritchie, G. F., Hamburger, S. D., & Rapoport, J. L. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199705000-00008 · Cited by 239 · see citing works
Gadow, K. D., Sverd, J., Sprafkin, J. N., Nolan, E. E., & Grossman, S. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.4.330 · Cited by 234 · see citing works
Atomoxetine treatment in children and adolescents with ADHD and comorbid tic disorders
Allen, A. J., Kurlan, R. M., Gilbert, D. L., Coffey, B. J., Linder, S. L., Lewis, D. W., Winner, P. K., Dunn, D. W., Dure, L. S., Sallee, F. R., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000188869.58300.a7 · Cited by 225 · see citing works
Self-citationRisperidone Versus Clonidine in the Treatment of Children and Adolescents With Tourette's Syndrome
Gaffney, G., Perry, P. J., Lund, B. C., Bever‐Stille, K. A., Arndt, S. V., & Samuel Kuperman, C. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200203000-00013 · Cited by 223 · see citing works
Dittmann, R., Fouche, D. S., Kratochvil, C. J., Heiligenstein, J. H., Spencer, T. J., & Biederman, J. (2001) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(01)80448-x · Cited by 223 · see citing works
Self-citationHeil, S. H., Holmes, H., Bickel, W. K., Higgins, S. T., Badger, G. J., Laws, H. F., & Faries, D. E. (2002) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(02)00053-4 · Cited by 198 · see citing works
Comings, D. E., & Comings, B. G. (1984) · Journal of the American Academy of Child Psychiatry · doi:10.1097/00004583-198403000-00004 · Cited by 195 · see citing works
Clinical and Molecular Genetics of ADHD and Tourette Syndrome
Comings, D. E. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05773.x · Cited by 151 · see citing works
Tic Reduction With Risperidone Versus Pimozide in a Randomized, Double-Blind, Crossover Trial
Gilbert, D. L., Batterson, J. R., Sethuraman, G., & Sallee, F. R. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200402000-00017 · Cited by 150 · see citing works
Self-citationLaw, S., & Schachar, R. J. (1999) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199908000-00009 · Cited by 130 · see citing works
Spencer, T. J., Biederman, J., Coffey, B. J., GELLER, D. A., CRAWFORD, M. H., Bearman, S. K., Tarazi, R. A., & Faraone, S. V. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.7.649 · Cited by 129 · see citing works
Self-citationNeuropsychiatric Effects of Guanfacine in Children With Mild Tourette Syndrome: A Pilot Study
Cummings, D. D., Singer, H. S., Krieger, M., Miller, T., & Mahone, E. M. (2002) · Clinical Neuropharmacology · doi:10.1097/00002826-200211000-00009 · Cited by 120 · see citing works
Spencer, T. J., Biederman, J., Wilens, T. E., Steingard, R. J., & Geist, D. E. (1993) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199301000-00029 · Cited by 109 · see citing works
Self-citationThe effect of central nervous system stimulants on tourette syndrome
Golden, G. S. (1977) · Annals of Neurology · doi:10.1002/ana.410020113 · Cited by 103 · see citing works
Journal of Child and Adolescent Psychiatric Nursing
Kasem, A. A., Khatatbeh, H., Eid, H. M. M., & Al-Dwaikat, T. (2010) · Journal of Child and Adolescent Psychiatric Nursing · doi:10.1111/(issn)1744-6171 · Cited by 82 · see citing works
Gilles de la Tourette's Syndrome
Pollack, M. A. (1977) · Archives of Neurology · doi:10.1001/archneur.1977.00500220064011 · Cited by 74 · see citing works
Spencer, T. J., Biederman, J., Kerman, K. L., Steingard, R. J., & Wilens, T. E. (1993) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199303000-00017 · Cited by 60 · see citing works
Self-citationStimulant Medications Precipitate Tourette's Syndrome
Lowe, T. L. (1982) · JAMA · doi:10.1001/jama.1982.03320330064029 · Cited by 43 · see citing works
Atomoxetine Use Associated with Onset of a Motor Tic
Ledbetter, M. (2005) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2005.15.331 · Cited by 40 · see citing works
Meyerhoff, J. L., & Snyder, S. H. (1973) · Psychopharmacology · doi:10.1007/bf00414035 · Cited by 38 · see citing works
Lee, T.-S. W., Lee, T. D., Lombroso, P. J., & King, R. A. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000132833.12842.4e · Cited by 35 · see citing works
Riddle, M. A., Lynch, K. A., Scahill, L. D., deVRIES, A., Cohen, D. J., & Leckman, J. F. (1995) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.1995.5.205 · Cited by 31 · see citing works
2.1.14. Diseases of the Nervous System
(2015) · KARGER eBooks · doi:10.1159/000409362 · Cited by 29 · see citing works
A study of endogenous dopamine metabolism in Gilles de la Tourette's disease.
Messiha, F. S., & Knopp, W. (1976) · PubMed · Cited by 20 · see citing works
Beneficial Effects of Imipramine on Tourette's Syndrome
Sandyk, R., & Bamford, C. R. (1988) · International Journal of Neuroscience · doi:10.3109/00207458808985689 · Cited by 9 · see citing works
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Attention‐Deficit‐Hyperactivity Disorder: An Update
Dopheide, J. A., & Pliszka, S. R. (2009) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.29.6.656 · Cited by 645 · see citing works
the ESSTS Guidelines Group, Roessner, V., Plessen, K. J., Rothenberger, A., Ludolph, A. G., Rizzo, R., Skov, L., Strand, G., Stern, J. S., Termine, C., et al. (2011) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-011-0163-7 · Cited by 461 · see citing works
European guidelines on managing adverse effects of medication for ADHD
(for the European Guidelines Group), Graham, J., Banaschewski, T., Buitelaar, J., Coghill, D., Danckaerts, M., Dittmann, R. W., Döpfner, M., Hamilton, R., Hollis, C., et al. (2011) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-010-0140-6 · Cited by 374 · see citing works
Bloch, M. H., Panza, K. E., Landeros-Weisenberger, A., & Leckman, J. F. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181b26e9f · Cited by 270 · see citing works
Evidence-based pharmacological treatment options for ADHD in children and adolescents
Mechler, K., Banaschewski, T., Hohmann, S., & Häge, A. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107940 · Cited by 293 · see citing works
Practice Parameter for the Assessment and Treatment of Children and Adolescents With Tic Disorders
Murphy, T. K., Lewin, A. B., Storch, E. A., & Stock, S. L. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.09.015 · Cited by 252 · see citing works
European clinical guidelines for Tourette Syndrome and other tic disorders
Roessner, V., Rothenberger, A., Rickards, H. E., & Hoekstra, P. J. (2011) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-011-0165-5 · Cited by 171 · see citing works
Wigal, S. B. (2009) · CNS Drugs · doi:10.2165/00023210-200923000-00004 · Cited by 166 · see citing works
Pringsheim, T. M., & Steeves, T. D. L. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007990.pub2 · Cited by 160 · see citing works
Hollis, C. P., Pennant, M. E., Cuenca, J., Glazebrook, C., Kendall, T., Whittington, C. J., Stockton, S., Larsson, L., Bunton, P., Dobson, S., et al. (2016) · Health Technology Assessment · doi:10.3310/hta20040 · Cited by 155 · see citing works
Pharmacological treatment of tic disorders and Tourette Syndrome
Roessner, V., Schoenefeld, K., Buse, J., Bender, S., Ehrlich, S., & Münchau, A. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.05.043 · Cited by 138 · see citing works
Singer, H. S. (2019) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000752 · Cited by 122 · see citing works
Osland, S., Steeves, T. D. L., & Pringsheim, T. M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007990.pub3 · Cited by 113 · see citing works
van de Loo-Neus, G. H. H., Rommelse, N., & Buitelaar, J. K. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.03.008 · Cited by 98 · see citing works
Tourette Syndrome and comorbid ADHD: Current pharmacological treatment options
Rizzo, R., Gulisano, M., Calì, P. V., & Curatolo, P. (2013) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2013.01.005 · Cited by 76 · see citing works
Reed, V. A., Buitelaar, J. K., Anand, E., Day, K. A., Treuer, T., Upadhyaya, H. P., Coghill, D. R., Kryzhanovskaya, L. A., & Savill, N. C. (2016) · CNS Drugs · doi:10.1007/s40263-016-0349-0 · Cited by 113 · see citing works
Core ADHD Symptom Improvement With Atomoxetine Versus Methylphenidate
Hazell, P., Kohn, M. R., Dickson, R. A., Walton, R., Granger, R. E., & van Wyk, G. W. (2010) · Journal of Attention Disorders · doi:10.1177/1087054710379737 · Cited by 65 · see citing works
Shier, A. C., Reichenbacher, T., Ghuman, H. S., & GHUMAN, J. K. (2012) · Journal of Central Nervous System Disease · doi:10.4137/jcnsd.s6691 · Cited by 69 · see citing works
Tourette disorder and other tic disorders
Deeb, W., Malaty, I. A., & Mathews, C. A. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64012-3.00008-3 · Cited by 65 · see citing works
Attention-Deficit Hyperactivity Disorder
MAY, D. E., & Kratochvil, C. J. (2009) · Drugs · doi:10.2165/11530540-000000000-00000 · Cited by 62 · see citing works
A critical appraisal of atomoxetine in the management of ADHD
Childress, A. C. (2015) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s59270 · Cited by 62 · see citing works
Tourette’s syndrome and its borderland
Stern, J. S. (2018) · Practical Neurology · doi:10.1136/practneurol-2017-001755 · Cited by 60 · see citing works
Fu, D., Wu, D.-D., Guo, H.-L., Hu, Y.-H., Xia, Y., Ji, X., Fang, W.-R., Li, Y.-M., Xu, J., Chen, F., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.780921 · Cited by 66 · see citing works
Clemow, D. B., Bushe, C., Mancini, M., Ossipov, M. H., & Upadhyaya, H. P. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s115707 · Cited by 59 · see citing works
Savill, N. C., Buitelaar, J. K., Anand, E., Day, K. A., Treuer, T., Upadhyaya, H. P., & Coghill, D. (2015) · CNS Drugs · doi:10.1007/s40263-014-0224-9 · Cited by 57 · see citing works
Update on atomoxetine in the treatment of attention-deficit/hyperactivity disorder
Vaughan, B. S., Fegert, J. M., & Kratochvil, C. J. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560902762873 · Cited by 49 · see citing works
Aagaard, L., & Hansen, E. H. (2011) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s26403 · Cited by 47 · see citing works
Cao, P., Wang, L., Cheng, Q., Sun, X., Kang, Q., Dai, L., Zhou, X., & Song, Z.-X. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.02.037 · Cited by 45 · see citing works
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Ghanizadeh, A. (2013) · Journal of Attention Disorders · doi:10.1177/1087054712443154 · Cited by 43 · see citing works
Masi, G., Gagliano, A., Siracusano, R., Berloffa, S., Calarese, T., Ilardo, G., Pfanner, C., Magazù, A., & Cedro, C. (2012) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2011.0081 · Cited by 41 · see citing works
Hutchison, S. L., GHUMAN, J. K., Ghuman, H. S., Karpov, I. O., & Schuster, J. M. (2016) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125316647686 · Cited by 41 · see citing works
Serajee, F., & Huq, A. H. M. M. (2015) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2015.03.007 · Cited by 40 · see citing works
Simpson, H. A., Jung, L., & Murphy, T. K. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0223-1 · Cited by 39 · see citing works
Pharmacotherapeutics of Tourette Syndrome and Stereotypies in Autism
Rajapakse, T., & Pringsheim, T. M. (2010) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2010.10.008 · Cited by 36 · see citing works
Emerging Treatment Strategies in Tourette Syndrome
Termine, C., Selvini, C., Rossi, G., & Balottin, U. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-411546-0.00015-9 · Cited by 35 · see citing works
Updates in Medical and Surgical Therapies for Tourette Syndrome
Malaty, I. A., & Akbar, U. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0458-4 · Cited by 31 · see citing works
Clinical Pharmacology of Comorbid Attention Deficit Hyperactivity Disorder in Tourette Syndrome
Rizzo, R., & Gulisano, M. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-411546-0.00014-7 · Cited by 29 · see citing works
Neurodevelopmental Disabilities
Patel, D. R., Merrick, J., Omar, H. Α., & Greydanus, D. E. (2011) · Springer eBooks · doi:10.1007/978-94-007-0627-9 · Cited by 29 · see citing works
Complexities for Assessment and Treatment of Co-Occurring ADHD and Tics
Coffey, B. J. (2015) · Current Developmental Disorders Reports · doi:10.1007/s40474-015-0061-7 · Cited by 28 · see citing works
Self-citationPredictors of Polypharmacy and Off-Label Prescribing of Psychotropic Medications
Kearns, M. A., & Hawley, K. M. (2014) · Journal of Psychiatric Practice · doi:10.1097/01.pra.0000456592.20622.45 · Cited by 26 · see citing works
Gilbert, D. L., Zhang, J., Lipps, T. D., Natarajan, N., Brandyberry, J., Wang, Z., Sallee, F. R., & Wassermann, E. M. (2007) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.05.065 · Cited by 25 · see citing works
Self-citationDell’Agnello, G., Zuddas, A., Masi, G., Curatolo, P., Besana, D., & Rossi, A. (2009) · CNS Drugs · doi:10.2165/11314350-000000000-00000 · Cited by 25 · see citing works
Tic Suppression: The Medical Model
Wu, S. W., Harris, E., & Gilbert, D. L. (2010) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2010.0015 · Cited by 16 · see citing works
Self-citationWhalen, C. K., Henker, B., Ishikawa, S. S., Emmerson, N. A., Swindle, R., & Johnston, J. A. (2010) · Journal of Attention Disorders · doi:10.1177/1087054708325118 · Cited by 15 · see citing works
Shahed, J. J. (2009) · Neurologic Clinics · doi:10.1016/j.ncl.2009.04.011 · Cited by 15 · see citing works
Optimizing clinical outcomes across domains of life in adolescents and adults with ADHD.
Adler, L., Mattingly, G., Montano, C. B., & Newcorn, J. (2011) · Journal of Clinical Psychiatry · doi:10.4088/jcp.10063ah1 · Cited by 9 · see citing works
Jaffe, R. J., & Coffey, B. J. (2022) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2022.03.004 · Cited by 10 · see citing works
Self-citationOff-label use of atomoxetine in adults: is it safe?
Dadashova, R., & Silverstone, P. H. (2012) · Mental Illness · doi:10.4081/mi.2012.e19 · Cited by 10 · see citing works
Stern, J. S. (2014) · Paediatrics and Child Health · doi:10.1016/j.paed.2014.03.003 · Cited by 10 · see citing works
Clinical Rating Instruments in Tourette Syndrome
Cavanna, A. E., & Piedad, J. C. P. (2013) · Oxford University Press eBooks · doi:10.1093/med/9780199796267.003.0019 · Cited by 9 · see citing works
Tic Symptoms Induced by Atomoxetine in Treatment of ADHD: A Case Report and Literature Review
Yang, R., Li, R., Gao, W., & Zhao, Z. (2016) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0000000000000371 · Cited by 9 · see citing works
Treatment of psychiatric disturbances in common hyperkinetic movement disorders
Berardelli, I., Pasquini, M., Conte, A., Bologna, M., Berardelli, A., & Fabbrini, G. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1555475 · Cited by 8 · see citing works
Drug Class Review: Pharmacologic Treatments for Attention Deficit Hyperactivity Disorder
McDonagh, M. S., & Peterson, K. (2011) · Cited by 7 · see citing works
Drug treatments for attention-deficit hyperactivity disorder in young people
Bates, G. D. L. (2009) · Advances in Psychiatric Treatment · doi:10.1192/apt.bp.108.005561 · Cited by 7 · see citing works
Suzuki, Y., Tajiri, M., Sugimoto, A., Orime, N., Hayashi, T., Egawa, J., Sugai, T., Inoue, Y., & Someya, T. (2016) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000630 · Cited by 6 · see citing works
Pediatric ADHD Medication Errors Reported to United States Poison Centers, 2000 to 2021
DeCoster, M., Spiller, H. A., Badeti, J., Casavant, M. J., Rine, N. I., Michaels, N. L., Zhu, M., & Smith, G. A. (2023) · PEDIATRICS · doi:10.1542/peds.2023-061942 · Cited by 6 · see citing works
Treatment of Psychiatric Comorbidities in Tourette Syndromes
Cardona, F., & Rizzo, R. (2013) · Oxford University Press eBooks · doi:10.1093/med/9780199796267.003.0025 · Cited by 6 · see citing works
The role of adrenergic neurotransmitter reuptake inhibitors in the ADHD armamentarium
Ilipilla, G. S., & Arnold, L. E. (2024) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2024.2369197 · Cited by 5 · see citing works
Samar, S. M., Moyano, M. B., Braña-Berríos, M., Irazoqui, G., Matos, A., Kichic, R., Gellatly, R., Ibanez-Gomez, L., Zwilling, A. L., Petkova, E., et al. (2013) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-013-0406-x · Cited by 5 · see citing works
Self-citationMethylphenidate-induced Exacerbation of Chorea in a Child Resolved with Switching to Atomoxetine
Ekıncı, O., Yaşöz, C., Baş, S. A. İ., Ekinci, N., & Doğan, Ö. İ. (2020) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2020.18.2.327 · Cited by 5 · see citing works
Toward a New Understanding of Attention-Deficit Hyperactivity Disorder
Spencer, T. J. (2009) · CNS Drugs · doi:10.2165/00023210-200923000-00002 · Cited by 5 · see citing works
Self-citationPharmacotherapies to tics: a systematic review
Zhang, Z., Yang, C., Zhang, L., Yi, Q., Liu, B., Zeng, J., & Yu, D. (2018) · Oncotarget · doi:10.18632/oncotarget.25080 · Cited by 5 · see citing works
Brandt, V. C., Perroud, N. A., & Plessen, K. J. (2026) · Handbook of clinical neurology · doi:10.1016/b978-0-443-13554-5.00003-1 · Cited by 4 · see citing works
Pharmacological treatment of Tourette’s syndrome: from the past to the future
Gong, H., Du, X., Su, A., & Du, Y.-W. (2023) · Neurological Sciences · doi:10.1007/s10072-023-07172-2 · Cited by 4 · see citing works
Fahn, S., Jankovic, J. J., & Hallett, M. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-2369-4.00016-0 · Cited by 4 · see citing works
Update on tic disorders and Tourette syndrome
Stern, J. S. (2010) · Paediatrics and Child Health · doi:10.1016/j.paed.2010.03.013 · Cited by 4 · see citing works
Lv, X., Shu, Z., Zhang, Y., Wu, S., & Zhan, S.-Y. (2012) · PubMed Central · doi:10.3978/j.issn.2224-4336.2012.04.04 · Cited by 3 · see citing works
Sood, R., & Coffey, B. J. (2013) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2013.2392 · Cited by 3 · see citing works
Self-citationPringsheim, T. M., & Steeves, T. D. L. (2012) · Evidence-Based Child Health A Cochrane Review Journal · doi:10.1002/ebch.1861 · Cited by 3 · see citing works
Jummani, R. R., & Coffey, B. J. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139035491.028 · Cited by 3 · see citing works
Self-citationAttention Deficit Hyperactivity Disorder
Greydanus, D. E. (2011) · Springer eBooks · doi:10.1007/978-94-007-0627-9_8 · Cited by 3 · see citing works
Non-stimulant treatment of ADHD
Pedraza, J. D., & Newcorn, J. H. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139035491.022 · Cited by 2 · see citing works
Psychiatric Treatment and Management of Psychiatric Comorbidities of Movement Disorders
Walsh, K. H., Soe, K. C., & Sarawgi, S. (2017) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2017.12.002 · Cited by 2 · see citing works
Rostain, A. L. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1364-7_14 · Cited by 2 · see citing works
Psychische Störungen und umschriebene Entwicklungsstörungen im Kindes- und Jugendalter
Blank, R., Fricke-Oerkermann, L., Lehmkuhl, G., Lehmkuhl, U., Mitschke, A., Roessner, V., Röhling, D., Rothenberger, A., Salbach‐Andrae, H., Sinzig, J., et al. (2014) · Elsevier eBooks · doi:10.1016/b978-3-437-23076-9.00019-x · Cited by 1 · see citing works
Attention Deficit Hyperactivity Disorder Through The Life Cycle
Rostain, A. L. (2012) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.10.3.266 · Cited by 1 · see citing works
Jankovic, J. J., Hallett, M., Okun, M. S., Comella, C., Fahn, S., & Goldman, J. G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-31071-0.00015-9 · Cited by 1 · see citing works
Clinical Rating Instruments in Tourette Syndrome
Cavanna, A. E. (2022) · Oxford University Press eBooks · doi:10.1093/med/9780197543214.003.0021 · Cited by 1 · see citing works
Atomoksetin Kullanımına Bağlı Motor Tikler: Olgu Sunumu
Küçükköse, M., Özbaran, N. B., & Köse, S. (2011) · Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology · doi:10.5455/bcp.20110429040705 · Cited by 1 · see citing works
Pharmakologische Behandlung von Tics
Roessner, V., & Beste, C. (2020) · Nervenheilkunde · doi:10.1055/a-1096-9918 · Cited by 1 · see citing works
Movement Disorders: Tics and Tourette's Disorder
Lam, K., & Coffey, B. J. (2012) · Wiley eBooks · doi:10.1002/9781119962229.ch23 · Cited by 1 · see citing works
Self-citationIntervention, Treatment, and Management of ADHD
Vloet, T. D., von Polier, G. G., & Herpertz‐Dahlmann, B. (2020) · doi:10.1002/9781119159322.ch33 · Cited by 1 · see citing works
InforMatrix for attention deficit hyperactivity disorder
Janknegt, R., Faber, A., Pereira, R. R., & Kalverdijk, L. J. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560902765769 · Cited by 1 · see citing works
Kearns, M. A. (2011) · MOspace Institutional Repository (University of Missouri) · Cited by 1 · see citing works
Toor, S. S., & Fisher, P. G. (2012) · Journal of Child Neurology · doi:10.1177/0883073812457464
van de Loo-Neus, G. H. H., Rommelse, N. N. J., & Buitelaar, J. K. (2011) · Psiquiatría Biológica · doi:10.1016/j.psiq.2011.10.008
Rostain, A. L., & Culbertson, W. C. (2019) · Springer eBooks · doi:10.1007/978-3-030-14895-9_16
Psychische Störungen im Kindes- und Jugendalter
(2009) · Elsevier eBooks · doi:10.1016/b978-343723075-2.10020-2
Pharmacotherapy profiles of children with tic disorders: A cross-sectional retrospective study (tur)
Dinç, G. Ş., Sekmen, E., Göker, Z., Çöp, E., & Üneri, Ö. Ş. (2020) · Journal of Clinical Psychiatry · doi:10.5505/kpd.2020.69672
Medications Affecting Behavior and Learning
Goldstein, S., Naglieri, J. A., & DeVries, M. L. (2011) · Wiley eBooks · doi:10.1002/9781118093085.ch18
(2010) · Wiley eBooks · doi:10.1002/9781118269954.refs
Brandt, V. C., & Münchau, A. M. (2014) · Neuropsychiatric symptoms of neurological disease · doi:10.1007/978-3-319-09537-0_11
Greydanus, D. E. (2011) · Springer eBooks · doi:10.1007/978-94-007-0627-9_14
Gilles de la Tourette syndrome: the complexities of phenotype and treatment – further information
(2011) · British Journal of Hospital Medicine · doi:10.12968/hmed.2011.72.2.s1
Treatment of Psychiatric Comorbidities in Tourette Syndrome
Cardona, F., & Rizzo, R. (2022) · Oxford University Press eBooks · doi:10.1093/med/9780197543214.003.0027
Walitza, S., Smigielski, L., & Gerlach, M. (2023) · Springer eBooks · doi:10.1007/978-3-662-65267-1_8
Attention deficit hyperactivity disorder: pharmacotherapy in special situations
Zavadenko, N. N. (2025) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202512510159
- Authors
- Spencer, T. J., Sallee, F. R., Gilbert, D. L., Dunn, D. W., McCracken, J. T., Coffey, B. J., Budman, C. L., Ricardi, R. K., Leonard, H. L., Allen, A. J., Milton, D. R., Feldman, P. D., Kelsey, D. K., Geller, D. A., Linder, S. L., Lewis, D. W., Winner, P. K., Kurlan, R. M., & Mintz, M.
- Affiliations
- Massachusetts General Hospital (US)
- Cincinnati Children's Hospital Medical Center (US)
- Indiana University School of Medicine (US)
- Neuropsychiatric Institute, Los Angeles
- New York University (US)
- Northwell Health (US)
- Arizona Family Resource and Counseling Center
- Brown University (US)
- Eli Lilly (United States) (US)
- Lilly Research Laboratories
- Harvard University (US)
- Dallas Pediatric Neurology Associates
- Monarch Research Associates
- Palm Beach Neurology (US)
- University of Rochester Medicine (US)
- Clinical Research Center of New Jersey, The Center for Neurological and Neurodevelopmental Health
- Corresponding author
- Spencer, Thomas J.
- ORCID
- Venue
- Journal of Attention Disorders
- Publisher
- SAGE Publications
- Published
- 2008-01
- Volume
- 11
- Issue
- 4
- Pages
- 470-481
- ISSN
- 1087-0547 (ISSN-L)
- 1557-1246
- OpenAlex
- W1995484354
- Cited by
- 98
- References
- 45
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 7 · 2013: 8 · 2012: 10
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Attention Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- atomoxetine, attention deficit hyperactivity disorder, Tourette syndrome, tic severity, comorbidities, stimulant medication, adverse effects, pulse rate
- MeSH terms
- Atomoxetine Hydrochloride, Attention Deficit Disorder with Hyperactivity, Child, Double-Blind Method, Female, Tourette Syndrome, Humans, Male, Propylamines, Severity of Illness Index, Comorbidity, Adrenergic Uptake Inhibitors
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