Effect of Lisdexamfetamine Dimesylate on Sleep in Children With ADHD
Abstract
Objective: This study evaluated the potential effects of short-term treatment with lisdexamfetamine dimesylate (LDX) on both subjective and objective sleep characteristics in children aged 6 to12 years ( n = 24) with ADHD. Method: Polysomnography (PSG) and actigraph measures as well as assessments of subjective sleep parameters were examined in children before and after treatment with either LDX or placebo in a randomized, double-blind, single-center, parallel-group study. Results: There was no statistically significant increase in the primary endpoint of latency to persistent sleep (LPS) for the LDX-treated group compared to the placebo group. Secondary PSG or actigraph results generally supported primary endpoint results. Subjective sleep measure results indicated the possibility that responses are influenced by sleep hygiene counseling before and throughout the study. Conclusions: In this pilot sleep study in children with ADHD, LDX did not appear to contribute to any sleep disturbances as measured by both objective and subjective sleep parameters. The sample used in this study was small, and the multifarious nature of findings in this study warranted that the study conclusions be interpreted cautiously and that further study is required focusing on the influence of LDX on sleep in larger samples of ADHD children.
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In Giblin et al study of 24 children with ADHD aged 6-12 years, lisdexamfetamine was not associated with sleep disturbances on either subjective or objective measures, and sleep efficiency was slightly improved compared with placebo.
“Lisdexamfetamine was not associated with sleep disturbances on either subjective or objective measures, and sleep efficiency was reported as being slightly improved compared with the placebo group.24”
From Update on optimal use of lisdexamfetamine in the treatment of ADHD (2013) · cites this paper as [24]
LDX treatment is not associated with impairments in sleep quality or quantity in clinical trials using objective sleep measures in adults with ADHD and children with ADHD.
“LDX treatment was not associated with impairments in sleep quality or quantity in clinical trials using objective sleep measures in adults with ADHD (Adler et al. 2009a; Surman and Roth 2011) and children with ADHD (Giblin and Strobel 2011) (Fig. 2).”
From Associations of sleep disturbance with ADHD: implications for treatment (2015) · cites this paper as Giblin and Strobel 2011
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Lisdexamfetamine Dimesylate: A New Therapeutic Option for Attention-Deficit Hyperactivity Disorder
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“Lisdexamfetamine was not associated with sleep disturbances on either subjective or objective measures, and sleep efficiency was reported as being slightly improved compared with the placebo group.(24) Another common concern with stimulant medications in children is growth retardation.”
Result
- Authors
- Giblin, J. M., & Strobel, A. L.
- Affiliations
- Clinical Study Centers LLC, Little Rock, AR
- Corresponding author
- Giblin, John M.
- Venue
- Journal of Attention Disorders
- Publisher
- SAGE Publications
- Published
- 2010-06-23
- Volume
- 15
- Issue
- 6
- Pages
- 491-498
- ISSN
- 1087-0547 (ISSN-L)
- 1557-1246
- OpenAlex
- W2107371099
- Cited by
- 38
- References
- 29
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 3 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 6
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Attention Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Keywords
- lisdexamfetamine dimesylate, attention deficit hyperactivity disorder, children, sleep, sleep disorders, polysomnography, actigraphy, subjective sleep, stimulant medication
- MeSH terms
- Lisdexamfetamine Dimesylate, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Dextroamphetamine, Double-Blind Method, Female, Humans, Male, Sleep, Treatment Outcome, Polysomnography
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