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Cited by 14Attention Deficit Hyperactivity DisorderDevelopmental and Educational NeuropsychologyReading and Literacy Development

Reading Performance as a Function of Treatment With Lisdexamfetamine Dimesylate in Elementary School Children Diagnosed With ADHD

Wigal, Sharon B., Maltas, Stephanie, Crinella, Francis, Stehli, Annamarie, Steinhoff, Kenneth, Lakes, Kimberley, Schuck, Sabrina·2012·Journal of Attention Disorders
DOI 10.1177/1087054710378008
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Abstract

Background: Medication treatment studies of ADHD have typically not assessed effects on reading performance, although reading difficulties frequently co-occur in children with ADHD. The current study characterizes the effects of lisdexamfetamine dimesylate (LDX; Vyvanse ® , Shire US Inc.), at peak efficacy, on reading performance in children with ADHD. Method: Children (ages 6-12; N = 26) with ADHD enrolled in a modified laboratory school study with an open-label, dose-optimization phase of LDX (30-70 mg/d). The Gray Oral Reading Test-4 (GORT-4) with measures of rate, accuracy, and comprehension was administered at baseline and 3-4 hr postdose, following 4 to 5 weeks of optimal dose titration. Results: Treatment reduced ADHD symptoms. Reading rate was improved, especially among children with higher verbal fluid reasoning without additional symptoms of neurodevelopmental delay. No differences were observed for reading accuracy or comprehension. Conclusion: Endophenotypical profiles may predict drug effects in specific skill areas, such as reading rate.

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Crossref · 10.1177/1087054710378008

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52 of 52 references verified0 citation errors · 0 not checkable

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  • In Wigal et al open-label dose-optimization study of 26 children with ADHD, lisdexamfetamine 30-70 mg produced improvements in rate, accuracy, and comprehension measures on the Gray Oral Reading Test-4 after 4-5 weeks of treatment.

    “Wigal et al34 demonstrated improvements in rate, accuracy, and comprehension measures on the Gray Oral Reading Test-4 performed at baseline and after 4–5 weeks of treatment in a “modified laboratory school” setting.”

    From Update on optimal use of lisdexamfetamine in the treatment of ADHD (2013) · cites this paper as [34]

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Research works printed but not linked: 8

  1. Ashbaker M. H., 1996, Learning Disabilities Research and Practice, 11, 206
  2. National Institutes of Mental Health (NIMH), 1985, Psychopharmacology Bulletin, 21, 839
  3. Perfetti C., 1985, Reading ability
  4. Schuck S. E. B., 2008, Dissertation Abstracts International: Section B: Sciences and Engineering, 69
  5. Wechsler D., 1997, WechslerAdult Intelligence Scale
  6. Wiederholt J., 2001, GORT-4: Gray Oral Reading Tests Examiner’s Manual
  7. Wilkinson G. S., 1993, Wide Range Achievement Test-Revision 3
  8. Woodcock R. W., 2001, Woodcock-Johnson® III

Cited by

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  • Update on optimal use of lisdexamfetamine in the treatment of ADHD

    Madaan, V., Kolli, V., Bestha, D., & Shah, M. (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s34092 · Cited by 19 · see citing works

    “In another open-label, dose-optimization study of lisdexamfetamine 30–70 mg in 26 children with ADHD, Wigal et al 34 demonstrated improvements in rate, accuracy, and comprehension measures on the Gray Oral Reading Test-4 performed at baseline and after 4–5 weeks of treatment in a “modified laboratory school” setting.”
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Related

Authors
Wigal, S. B., Maltas, S., Crinella, F., Stehli, A., Steinhoff, K., Lakes, K., & Schuck, S.
Affiliations
University of California, Irvine (US)
ORCID
Venue
Journal of Attention Disorders
Publisher
SAGE Publications
Published
2010-10-26
Volume
16
Issue
1
Pages
23-33
ISSN
  • 1087-0547 (ISSN-L)
  • 1557-1246
DOI
10.1177/1087054710378008
OpenAlex
W1993113558
Cited by
14
References
52
Citations by year
2020: 1 · 2016: 1 · 2014: 2 · 2013: 3 · 2012: 6
FWCI
1.99
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Journal of Attention Disorders (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health
  • National Institute on Minority Health and Health Disparities (L60 MD002127)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
  • Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
Keywords
lisdexamfetamine dimesylate, attention deficit hyperactivity disorder, reading achievement, reading speed, reading accuracy, reading comprehension, stimulant medication, dose titration, neurodevelopmental delay, elementary school students
MeSH terms
Lisdexamfetamine Dimesylate, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Dextroamphetamine, Female, Humans, Male, Reading, Single-Blind Method, Treatment Outcome

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