Cited by 114Epigenetics and DNA MethylationToxic Organic Pollutants ImpactPesticide Exposure and Toxicity

The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.

Effects of Mixtures of Polychlorinated Biphenyls, Methylmercury, and Organochlorine Pesticides on Hepatic DNA Methylation in Prepubertal Female Sprague-Dawley Rats

Desaulniers, Daniel, Xiao, Gong-hua, Lian, Hong, Feng, Yong-Lai, Zhu, Jiping, Nakai, Jamie, Bowers, Wayne J.·2009·International Journal of Toxicology

DOI 10.1177/1091581809337918

Open this paper in CoChat — free account

Abstract

DNA methylation is one of the epigenetic mechanisms that regulates gene expression, chromosome structure, and stability. Our objective was to determine whether the DNA methylation system could be a target following in utero and postnatal exposure to human blood contaminants. Pregnant rats were dosed daily from gestation day 1 until postnatal day 21 with 2 dose levels of either organochlorine pesticides (OCP; 0.019 or 1.9 mg/kg/day), methylmercury chloride (MeHg; 0.02 or 2 mg/kg/day), polychlorinated biphenyls (PCBs; 0.011 or 1.1 mg/kg/day), or a mixture (Mix; 0.05, or 5 mg/kg/day) including all 3 groups of chemicals. Livers from 1 female offspring per litter were collected at postnatal day 29. Hepatic analysis revealed that the mRNA abundance for DNA methyltransferase (DNMT)-1, -3a, and -3b were significantly reduced by the high dose of PCB, that the high dose of MeHg also reduced mRNA levels for DNMT-1, and -3b, but that OCP had no significant effects compared with control. The high dose of PCB and Mix reduced the abundance of the universal methyl donor S-adenosylmethionine, and Mix also reduced global genome DNA methylation (5-methyl-deoxycytidine/5-methyl-deoxycytidine + deoxycytidine). The latter is consistent with pyrosequencing methylation analysis, revealing that the high-dose groups (except OCP) generally decreased the methylation of CpG sites (position -63 to -29) in the promoter of the tumor suppressor gene p16 INK4a . Overall, these hepatic results suggest that the DNA methylation system can be affected by exposure to high doses of blood contaminants, and that OCP is the least potent chemical group from the investigated mixtures.

Integrity signals

Registry

Crossref · 10.1177/1091581809337918

Cites

80 of 80 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
Irizarry, R. A., Ladd-Acosta, C., Wen, B., Wu, Z., Montano, C., Onyango, P., Cui, H., Gabo, K., Rongione, M., Webster, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.298 · Cited by 2,177
Minamata Disease: Methylmercury Poisoning in Japan Caused by Environmental Pollution
Harada, M. (1995) · Critical Reviews in Toxicology · doi:10.3109/10408449509089885 · Cited by 2,085
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L.-V. F., Kolettas, E., Niforou, K., Zoumpourlis, V. C., et al. (2006) · Nature · doi:10.1038/nature05268 · Cited by 1,986
Cognitive Deficit in 7-Year-Old Children with Prenatal Exposure to Methylmercury
Grandjean, P., Weihe, P., White, R. F., Debes, F., Araki, S., Yokoyama, K., Murata, K., Sørensen, N., Dahl, R., & Jørgensen, P. J. (1997) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(97)00097-4 · Cited by 1,738
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
Fabbri, M., Garzon, R., Cimmino, A., Liu, Z., Zanesi, N., Callegari, E., Liu, S., Alder, H., Costinean, S., Fernandez-Cymering, C., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707628104 · Cited by 1,705
Analysis of polychlorinated biphenyls (PCB) by glass capillary gas chromatography
Ballschmiter, K., & Zell, M. (1980) · Fresenius Zeitschrift für Analytische Chemie · doi:10.1007/bf00469758 · Cited by 1,441
Organohalogen compounds
(1995) · Environmental Science and Pollution Research · doi:10.1007/bf02986737 · Cited by 1,126
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
Rhee, I., Bachman, K. E., Park, B. H., Jair, K.-W., Yen, R.-W. C., Schuebel, K. E., Cui, H., Feinberg, A. P., Lengauer, C., Kinzler, K. W., et al. (2002) · Nature · doi:10.1038/416552a · Cited by 1,039
Genetic and Epigenetic Mechanisms in Metal Carcinogenesis and Cocarcinogenesis: Nickel, Arsenic, and Chromium
Salnikow, K., & Zhitkovich, A. (2007) · Chemical Research in Toxicology · doi:10.1021/tx700198a · Cited by 934
Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all
Gil, J., & Peters, G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1987 · Cited by 843
Rapid DNA methylation changes after exposure to traffic particles
Baccarelli, A., Wright, R. O., Bollati, V., Tarantini, L., Litonjua, A. A., Suh, H. H., Zanobetti, A., Sparrow, D., Vokonas, P. S., & Schwartz, J. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200807-1097oc · Cited by 653
Changes in DNA Methylation Patterns in Subjects Exposed to Low-Dose Benzene
Bollati, V., Baccarelli, A., Hou, L., Bonzini, M., Fustinoni, S., Cavallo, D. M., Byun, H., Jiang, J., Marinelli, B., Pesatori, A. C., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2995 · Cited by 612
DNMT3L Stimulates the DNA Methylation Activity of Dnmt3a and Dnmt3b through a Direct Interaction
Suetake, I., Shinozaki, F., Miyagawa, J., Takeshima, H., & Tajima, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400181200 · Cited by 550
What is an epigenetic transgenerational phenotype?
Skinner, M. K. (2008) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.09.001 · Cited by 485
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases
Benetti, R., Gonzalo, S., Jaco, I., Muñoz, P., González, S., Schoeftner, S., Murchison, E. P., Andl, T., Chen, T., Klatt, P., et al. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1399 · Cited by 439
Persistent organic pollutants and mercury in marine biota of the Canadian Arctic: An overview of spatial and temporal trends
Braune, B. M., Outridge, P. M., Fisk, A. T., Muir, D. C. G., Helm, P. A., Hobbs, K. E., Hoekstra, P. F., Kuzyk, Z. Z. A., Kwan, M., Letcher, R. J., et al. (2005) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2004.10.034 · Cited by 429
Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene
Bachman, K. E., Park, B. H., Rhee, I. P., Rajagopalan, H., Herman, J. G., Baylin, S. B., Kinzler, K. W., & Vogelstein, B. (2003) · Cancer Cell · doi:10.1016/s1535-6108(02)00234-9 · Cited by 419
Environmental pollutants and breast cancer: Epidemiologic studies
Brody, J. G., Moysich, K. B., Humblet, O., Attfield, K. R., Beehler, G. P., & Rudel, R. A. (2007) · Cancer · doi:10.1002/cncr.22655 · Cited by 375
Elevation in S-Adenosylhomocysteine and DNA Hypomethylation: Potential Epigenetic Mechanism for Homocysteine-Related Pathology
James, S. J., Melnyk, S., Pogribna, M., Pogribny, I. P., & Caudill, M. A. (2002) · Journal of Nutrition · doi:10.1093/jn/132.8.2361s · Cited by 367
PCBs: Recent Advances in Environmental Toxicology and Health Effects
Burgin, D. E. (2002) · International Journal of Toxicology · doi:10.1177/109158180202100610 · Cited by 366
Global DNA Hypomethylation Is Associated with High Serum-Persistent Organic Pollutants in Greenlandic Inuit
Rusiecki, J. A., Baccarelli, A., Bollati, V., Tarantini, L., Moore, L. E., & Bonefeld-Jorgensen, E. C. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11338 · Cited by 352
Environmental epigenomics in human health and disease
Dolinoy, D. C., & Jirtle, R. L. (2008) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20366 · Cited by 332
Transport of toxic metals by molecular mimicry.
Ballatori, N. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110s5689 · Cited by 285
DNA Hypermethylation of Promoter of Gene p53 and p16 in Arsenic-Exposed People with and without Malignancy
Chanda, S., Dasgupta, U. B., GuhaMazumder, D., Gupta, M., Chaudhuri, U., Lahiri, S., Das, S., Ghosh, N., & Chatterjee, D. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfj030 · Cited by 285
Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage
Suzuki, K., Suzuki, I., Leodolter, A., Alonso, S., Horiuchi, S., Yamashita, K., & Perucho, M. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.02.016 · Cited by 272
Prenatal Exposures to Persistent and Non‐Persistent Organic Compounds and Effects on Immune System Development
Hertz‐Picciotto, I., Park, H., Dostal, M., Kocan, A., Trnovec, T., & Sram, R. (2008) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2007.00190.x · Cited by 253
Optimization of Quantitative MGMT Promoter Methylation Analysis Using Pyrosequencing and Combined Bisulfite Restriction Analysis
Mikeska, T., Bock, C., El‐Maarri, O., Hübner, A., Ehrentraut, D., Schramm, J., Felsberg, J., Kahl, P., Büttner, R., Pietsch, T., et al. (2007) · Journal of Molecular Diagnostics · doi:10.2353/jmoldx.2007.060167 · Cited by 241
Nickel Ions Increase Histone H3 Lysine 9 Dimethylation and Induce Transgene Silencing
Chen, H., Ke, Q., Kluz, T., Yan, Y., & Costa, M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.10.3728-3737.2006 · Cited by 229
Environmental Chemicals Impacting the Thyroid: Targets and Consequences
Zoeller, R. T. (2007) · Thyroid · doi:10.1089/thy.2007.0107 · Cited by 228
The Dynamic Epigenome and its Implications in Toxicology
Szyf, M. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm177 · Cited by 227
Inuit exposure to organochlorines through the aquatic food chain in arctic québec.
Dewailly, É., Ayotte, P., Bruneau, S., Laliberté, C., Muir, D. C. G., & Norstrom, R. J. (1993) · Environmental Health Perspectives · doi:10.1289/ehp.93101618 · Cited by 222
Prenatal exposure to polychlorinated biphenyls and attention at school age
Jacobson, J. L., & Jacobson, S. W. (2003) · The Journal of Pediatrics · doi:10.1067/s0022-3476(03)00577-8 · Cited by 219
Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo
Koturbash, I., Rugo, R. E., Hendricks, C. A., Loree, J. M., Thibault, B. J., Kutanzi, K. R., Pogribny, I. P., Yanch, J. C., Engelward, B. P., & Kovalchuk, O. (2006) · Oncogene · doi:10.1038/sj.onc.1209467 · Cited by 217
Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas
Kondo, Y., Shen, L., Suzuki, S., Kurokawa, T., Masuko, K., Tanaka, Y., Kato, H., Mizuno, Y., Yokoe, M., Sugauchi, F., et al. (2007) · Hepatology Research · doi:10.1111/j.1872-034x.2007.00141.x · Cited by 213
Tumor Suppressor Gene Inactivation during Cadmium-Induced Malignant Transformation of Human Prostate Cells Correlates with Overexpression of de Novo DNA Methyltransferase
Benbrahim‐Tallaa, L., Waterland, R. A., Dill, A. L., Webber, M. M., & Waalkes, M. P. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10207 · Cited by 208
A Folate- and Methyl-Deficient Diet Alters the Expression of DNA Methyltransferases and Methyl CpG Binding Proteins Involved in Epigenetic Gene Silencing in Livers of F344 Rats
Ghoshal, K., Li, X., Datta, J., Bai, S., Pogribny, I. P., Pogribny, M., Huang, Y., Young, D., & Jacob, S. T. (2006) · Journal of Nutrition · doi:10.1093/jn/136.6.1522 · Cited by 200
Aberrant DNA methylation and gene expression in livers of newborn mice transplacentally exposed to a hepatocarcinogenic dose of inorganic arsenic
Xie, Y., Liu, J., Benbrahim‐Tallaa, L., Ward, J. M., Logsdon, D. L., Diwan, B. A., & Waalkes, M. P. (2007) · Toxicology · doi:10.1016/j.tox.2007.03.021 · Cited by 165
Endocrine Disruptors and Abnormalities of Pubertal Development
Schoeters, G. E. R., Hond, E. D., Dhooge, W., Larebeke, N. V., & Leijs, M. M. (2008) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2007.00180.x · Cited by 159
Alteration of the Methylation Status of Tumor-Promoting Genes Decreases Prostate Cancer Cell Invasiveness and Tumorigenesis In vitro and In vivo
Shukeir, N., Pakneshan, P., Chen, G., Moshe Szyf, A., & Rabbani, S. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1954 · Cited by 155
The reduced expression and aberrant methylation of p16INK4a in chromate workers with lung cancer
Kondo, K., Takahashi, Y., Hirose, Y., Nagao, T., Tsuyuguchi, M., Hashimoto, M., Ochiai, A., Monden, Y., & Tangoku, A. (2006) · Lung Cancer · doi:10.1016/j.lungcan.2006.05.022 · Cited by 152
Carcinogenicity of “Non-Dioxinlike” Polychlorinated Biphenyls
Knerr, S., & Schrenk, D. (2006) · Critical Reviews in Toxicology · doi:10.1080/10408440600845304 · Cited by 147
Epigenetic changes and nontargeted radiation effects—Is there a link?
Kovalchuk, O., & Baulch, J. E. (2008) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20361 · Cited by 144
Chronic Oral Exposure to Inorganic Arsenate Interferes with Methylation Status of p16INK4a and RASSF1A and Induces Lung Cancer in A/J Mice
Cui, X., Wakai, T., Shirai, Y., Hatakeyama, K., & Hirano, S. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj159 · Cited by 144
Organochlorine levels in maternal and umbilical cord blood plasma in Arctic Canada
Butler-Walker, J., Seddon, L., McMullen, E., Houseman, J., Tofflemire, K. M., Corriveau, A., WEBER, J., MILLS, C., SMITH, S., & VANOOSTDAM, J. (2003) · The Science of The Total Environment · doi:10.1016/s0048-9697(02)00319-4 · Cited by 142
Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells.
Cui, X., Wakai, T., Shirai, Y., Yokoyama, N., Hatakeyama, K., & Hirano, S. (2006) · Human Pathology · doi:10.1016/j.humpath.2005.10.013 · Cited by 140
Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low-dose X-ray-irradiation
Kovalchuk, O., Burke, P., Besplug, J., Slovack, M., Filkowski, J. N., & Pogribny, I. P. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.12.016 · Cited by 138
DNA Methyltransferase Inhibitors for Cancer Therapy
Brueckner, B., Kuck, D., & Lyko, F. (2007) · The Cancer Journal · doi:10.1097/ppo.0b013e31803c7245 · Cited by 132
Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung
Licchesi, J. D. F., Westra, W. H., Hooker, C. M., Machida, E. O., Baylin, S. B., & Herman, J. G. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn017 · Cited by 129
Alterations of visual evoked potentials in preschool Inuit children exposed to methylmercury and polychlorinated biphenyls from a marine diet☆
Saint‐Amour, D., Roy, M., Bastien, C., Ayotte, P., Dewailly, É., DESPRES, C., Gingras, S., & Muckle, G. (2006) · NeuroToxicology · doi:10.1016/j.neuro.2006.02.008 · Cited by 128
Active cytosine demethylation triggered by a nuclear receptor involves DNA strand breaks
Kress, C., Thomassin, H., & Grange, T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601793103 · Cited by 122
Polychlorinated biphenyls, organochlorine pesticides and neurodevelopment
Korrick, S. A., & Sagiv, S. K. (2008) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e3282f6a4e9 · Cited by 115
DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma
Park, H. J., Yu, E., & Shim, Y. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.03.017 · Cited by 114
Uterine Responsiveness to Estradiol and DNA Methylation Are Altered by Fetal Exposure to Diethylstilbestrol and Methoxychlor in CD-1 Mice: Effects of Low versus High Doses
Alworth, L. C., Howdeshell, K. L., Ruhlen, R. L., Day, J. K., Lubahn, D. B., Huang, T. H. ‐., Besch-Williford, C. L., & Saal, F. S. V. (2002) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2002.9459 · Cited by 110
Chemoprevention of hepatocarcinogenesis
Pascale, R. M., Simile, M. M., Miglio, M. R. D., & Feo, F. (2002) · Alcohol · doi:10.1016/s0741-8329(02)00227-6 · Cited by 96
Molecular Analysis of a Multistep Lung Cancer Model Induced by Chronic Inflammation Reveals Epigenetic Regulation of p16, Activation of the DNA Damage Response Pathway
Blanco, D., Vicent, S., Fraga, M. F., Fernandez‐Garcia, I., Freire, J., Lujambio, A., Esteller, M., Ortíz-de-Solórzano, C., Pı́o, R., Lecanda, F., et al. (2007) · Neoplasia · doi:10.1593/neo.07517 · Cited by 92
Declining risk of methylmercury exposure to infants during lactation
Sakamoto, M., Kubota, M., Matsumoto, S., Nakano, A., & Akagi, H. (2002) · Environmental Research · doi:10.1016/s0013-9351(02)00011-7 · Cited by 88
p16INK4a as a Second Effector of the Telomere Damage Pathway
Jacobs, J. J. L., & de Lange, T. (2005) · Cell Cycle · doi:10.4161/cc.4.10.2104 · Cited by 87
The Effects of Diet, Genetics and Chemicals on Toxicity and Aberrant DNA Methylation: an Introduction
Poirier, L. A. (2002) · Journal of Nutrition · doi:10.1093/jn/132.8.2336s · Cited by 86
Transcriptional regulation of the human DNA methyltransferase 3A and 3B genes by Sp3 and Sp1 zinc finger proteins
Jinawath, A., Miyaké, S., Yanagisawa, Y., Akiyama, Y., & Yuasa, Y. (2005) · Biochemical Journal · doi:10.1042/bj20040684 · Cited by 81
Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene
Bagnyukova, T., Tryndyak, V., Montgomery, B. A., Churchwell, M. I., Karpf, A. R., James, S. R., Muskhelishvili, L., Beland, F. A., & Pogribny, I. P. (2008) · Carcinogenesis · doi:10.1093/carcin/bgm303 · Cited by 67
ΔDNMT3B Variants Regulate DNA Methylation in a Promoter-Specific Manner
Wang, J., Bhutani, M., Pathak, A. K., Lang, W., Ren, H., Jelı́nek, J., He, R. L., Shen, L., Issa, J. J., & Mao, L. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1337 · Cited by 54
Some evidence of effects of environmental chemicals on the endocrine system in children
Rogan, W. J., & Ragan, N. B. (2007) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2007.07.005 · Cited by 53
Maternal-to-fetus transfer of mercury in metallothionein-null pregnant mice after exposure to mercury vapor
Yoshida, M., Satoh, M., Shimada, A., Yamamoto, E., Yasutake, A., & Tohyama, C. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00084-7 · Cited by 50
Comparisons of Brain, Uterus, and Liver mRNA Expression for Cytochrome P450s, DNA Methyltransferase-1, and Catechol-O-Methyltransferase in Prepubertal Female Sprague-Dawley Rats Exposed to a Mixture of Aryl Hydrocarbon Receptor Agonists
Desaulniers, D., Xiao, G.-H., Leingartner, K., Chu, I., Musicki, B., & Tsang, B. K. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi178 · Cited by 50
Self-citation
DNA Hypomethylation Induced by Drinking Water Disinfection By-Products in Mouse and Rat Kidney
Tao, L., Wang, W., Li, L., Kramer, P. M., & Pereira, M. A. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi257 · Cited by 47
Epigenetic reprogramming of liver cells in tamoxifen‐induced rat hepatocarcinogenesis
Tryndyak, V., Kovalchuk, O., Muskhelishvili, L., Montgomery, B. A., Rodriguez‐Juarez, R., Melnyk, S., Ross, S. A., Beland, F. A., & Pogribny, I. P. (2007) · Molecular Carcinogenesis · doi:10.1002/mc.20263 · Cited by 46
Reproductive Toxicology of Environmental Toxicants: Emerging Issues and Concerns
Younglai, E. V., Wu, Y., & Foster, W. G. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207782110499 · Cited by 45
Allele-specific germ cell epimutation in the spacer promoter of the gene after Cr(III) exposure
Shiao, Y., CRAWFORD, E., Anderson, L. G., PATEL, P., & KO, K. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.10.017 · Cited by 44
Gene expression profiling in rat cerebellum following in utero and lactational exposure to mixtures of methylmercury, polychlorinated biphenyls and organochlorine pesticides
Padhi, B. K., Pelletier, G., Williams, A., Berndt-Weis, L., Yauk, C. L., Bowers, W. J., & Chu, I. (2007) · Toxicology Letters · doi:10.1016/j.toxlet.2007.08.016 · Cited by 44
Self-citation
Epigenetic changes in the rat livers induced by pyrazinamide treatment☆
Kovalenko, V. M., Bagnyukova, T., Сергиенко, О. В., Bondarenko, L. B., Shayakhmetova, G. M., Matvienko, A. V., & Pogribny, I. P. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.08.011 · Cited by 40
Identification of Genes that May Play Critical Roles in Phenobarbital (PB)-Induced Liver Tumorigenesis due to Altered DNA Methylation
Phillips, J. M., & Goodman, J. I. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn063 · Cited by 39
Molecular analysis of the Ink4a/Rb1–Arf/Tp53 pathways in radon-induced rat lung tumors
Bastide, K., Guilly, M., Bernaudin, J., Joubert, C., Lectard, B., Levalois, C., Malfoy, B., & Chevillard, S. (2008) · Lung Cancer · doi:10.1016/j.lungcan.2008.06.007 · Cited by 38
Induction of metallothionein in the livers of female Sprague-Dawley rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin
Nishimura, N., Miyabara, Y., Suzuki, J. S., Sato, M., Aoki, Y., Satoh, M., Yonemoto, J., & Tohyama, C. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01212-7 · Cited by 38
Methylmercury exposure during lactation: Milk concentration and tissue uptake of mercury in the neonatal rat
Sundberg, J., Oskarsson, A., & Albanus, L. (1991) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/bf01691946 · Cited by 37
Toxicological Effects of In Utero and Lactational Exposure of Rats to a Mixture of Environmental Contaminants Detected in Canadian Arctic Human Populations
Chu, I., Bowers, W. J., Caldwell, D., Nakai, J. S., Wade, M. G., Yagminas, A. P., Li, N., Moir, D., Elabbas, L. E., Håkansson, H., et al. (2007) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390701612811 · Cited by 34
Self-citation
Methylation and inhibition of expression of uPA by the RAS oncogene: divergence of growth control and invasion in breast cancer cells
Pakneshan, P. (2004) · Carcinogenesis · doi:10.1093/carcin/bgi009 · Cited by 34
Diethanolamine and Phenobarbital Produce an Altered Pattern of Methylation in GC-Rich Regions of DNA in B6C3F1 Mouse Hepatocytes Similar to That Resulting from Choline Deficiency
Bachman, A. N., Kamendulis, L. M., & Goodman, J. I. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj091 · Cited by 34
Transplacental effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the temporal modulation of Sp1 DNA binding in the developing cerebral cortex and cerebellum
Nayyar, T., Zawia, N. H., & Hood, D. B. (2002) · Experimental and Toxicologic Pathology · doi:10.1078/0940-2993-00219 · Cited by 32
DNA methylation analysis using CpG microarrays is impaired in benzopyrene exposed cells
Sadiković, B., Andrews, J. D., & Rodenhiser, D. I. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.08.013 · Cited by 27
Ah Receptor Binding to its Cognate Response Element is Required for Dioxin-Mediated Toxicity
Perdew, G. H. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn220 · Cited by 15

Research works printed but not linked: 4

Allis CD, 2007, Epigenetics
Dewailly E, 1993, Environ Health Perspect, 101, 618
Braune BM, 2005, Sci Total Environ, 351
Leingartner K, 2008, 15th North American Regional Meeting of the International Society for the Study of Xenobiotics

Sorted by citations

Persistent organochlorinated pesticides and mechanisms of their toxicity
Mrema, E. J., Rubino, F. M., Brambilla, G., Moretto, A., Tsatsakis, A. M., & Colosio, C. (2012) · Toxicology · doi:10.1016/j.tox.2012.11.015 · Cited by 511
Epigenetics and pesticides
Collotta, M., Bertazzi, P. A., & Bollati, V. (2013) · Toxicology · doi:10.1016/j.tox.2013.01.017 · Cited by 305
Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence
Ruiz-Hernandez, A., Kuo, C.-C., Rentero-Garrido, P., Tang, W., Redón, J., Ordovás, J. M., Navas‐Acién, A., & Téllez-Plaza, M. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0055-7 · Cited by 215
Endocrine Disruptors Acting on Estrogen and Androgen Pathways Cause Reproductive Disorders through Multiple Mechanisms: A Review
Amir, S., Shah, S. T. A., Mamoulakis, C., Docea, A. O., Kalantzi, O., Zachariou, A., Călina, D. C., Carvalho, F. D., Sofikitis, N., Makrigiannakis, A., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18041464 · Cited by 224
Epigenetic targets of some toxicologically relevant metals: a review of the literature
Cheng, T., Choudhuri, S., & Muldoon‐Jacobs, K. (2012) · Journal of Applied Toxicology · doi:10.1002/jat.2717 · Cited by 194

See all 114

Authors: Desaulniers, D., Xiao, G.-H., Lian, H., Feng, Y.-L., Zhu, J., Nakai, J., & Bowers, W. J.
Affiliations: Health Canada (CA)
Corresponding author: Desaulniers, Daniel
ORCID: Desaulniers, Daniel
Lian, Hong
Feng, Yong-Lai
Zhu, Jiping
Venue: International Journal of Toxicology
Publisher: SAGE Publications
Published: 2009-07
Volume: 28
Issue: 4
Pages: 294-307
ISSN: 1091-5818 (ISSN-L)
1092-874X
DOI: 10.1177/1091581809337918
OpenAlex: W2133372930
Cited by: 114
References: 80
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 11 · 2020: 7 · 2019: 8 · 2018: 8 · 2017: 6 · 2016: 10 · 2015: 11 · 2014: 6 · 2013: 12 · 2012: 14
FWCI: 2.68
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: International Journal of Toxicology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
Keywords: polychlorinated biphenyls, methylmercury, organochlorine pesticides, chemical mixtures, DNA methylation, S-adenosylmethionine, global DNA methylation, CpG methylation, prenatal exposure, liver, epigenetic toxicity
MeSH terms: Animals, Base Sequence, Chromatography, Liquid, Dose-Response Relationship, Drug, Female, Hydrocarbons, Chlorinated, Liver, Methylmercury Compounds, Pesticides, Polychlorinated Biphenyls, Pregnancy, Sexual Maturation, Spectrophotometry, Ultraviolet, DNA Primers, DNA Methylation, Reverse Transcriptase Polymerase Chain Reaction, Spectrometry, Mass, Electrospray Ionization, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effects of Mixtures of Polychlorinated Biphenyls, Methylmercury, and Organochlorine Pesticides on Hepatic DNA Methylation in Prepubertal Female Sprague-Dawley Rats

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks