Systemic activation of the complement system in patients with advanced age-related macular degeneration
Abstract
Purpose To examine the role of systemic activation of the complement system (assessed by levels of circulating C3a, Ba, and sC5b-9) in patients (n = 122) with advanced age-related macular degeneration, geographic atrophy, and neovascular age-related macular degeneration, compared with cataract controls (n = 27). Methods Plasma complement factors were measured using enzyme-linked immunosorbent assays. Statistical analysis included univariate and multivariate logistic regression (p Results Adjusted for age, the odds ratios of C3a and sC5b-9 for any advanced age-related macular degeneration were 1.78 (95% confidence interval = 1.16-2.73, p Conclusion We suggest a role for elevated plasma levels of C3a and sC5b-9 in patients with neovascular age-related macular degeneration. The study's results reinforce the need for more investigation to assess the impact of therapeutic interventions targeted at the complement signaling pathways in age-related macular degeneration.
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Levels of circulating complement activation products may be associated with the severity of AMD.
“There is evidence suggesting that levels of circulating complement activation products may be associated with the severity of AMD”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [217]
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Hammadi, S., Tzoumas, N., Ferrara, M., Meschede, I. P., Lo, K., Harris, C., Lako, M., & Steel, D. H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082870 · Cited by 44 · see citing works
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- Authors
- Lynch, A. M., Mandava, N., Patnaik, J. L., Frazer-Abel, A. A., Wagner, B. D., Palestine, A. G., Mathias, M. T., Siringo, F. S., Cathcart, J. N., & Holers, V. M.
- Affiliations
- University of Colorado Anschutz (US)
- Exsera BioLabs, University of Colorado School of Medicine, Aurora, CO, USA
- Colorado School of Public Health (US)
- Corresponding author
- Lynch, Anne M
- ORCID
- Venue
- European Journal of Ophthalmology
- Publisher
- SAGE Publications
- Published
- 2019-06-17
- Volume
- 30
- Issue
- 5
- Pages
- 1061-1068
- ISSN
- 1120-6721 (ISSN-L)
- 1724-6016
- OpenAlex
- W2949424847
- Cited by
- 44
- References
- 48
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 7 · 2022: 12 · 2021: 9 · 2020: 5 · 2019: 2
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- age-related macular degeneration, complement activation, C3a, C3b, sC5b-9, geographic atrophy, neovascular age-related macular degeneration
- MeSH terms
- Aged, Aged, 80 and over, Complement Activation, Enzyme-Linked Immunosorbent Assay, Female, Fluorescein Angiography, Humans, Male, Complement Factor B, Complement C3a, Complement Membrane Attack Complex, Odds Ratio, Choroidal Neovascularization, Tomography, Optical Coherence, Geographic Atrophy, Wet Macular Degeneration
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