The DOI matches its Crossref record; 39 of the 41 references it cites were found in a registry or an index.
Prevalence and concurrence of anxiety, depression and fatigue over time in multiple sclerosis
Open accessAbstract
Background: Anxiety, depression and fatigue are commonly reported by persons with multiple sclerosis (PwMS). Objectives: We estimated the prevalence of each factor in a representative sample of PwMS, and in subgroups defined by age, sex and disease duration, at cohort entry and over time. We further examined whether and how these factors clustered together. Methods: A population-based longitudinal cohort of 198 PwMS was followed 6-monthly for 2.5 years. The Hospital Anxiety and Depression Scale (HADS) was used to measure anxiety (cut-point >7) and depression (>7) and the Fatigue Severity Scale (FSS) to measure fatigue (≥5). Results: At cohort entry, prevalence of anxiety was 44.5% (95%CI 37–51%), depression 18.5% (95%CI 12.6–23.4%), and fatigue 53.7% (95%CI 47–61%). Fatigue was more common in males than females (RR 1.29, p =0.01), with attenuation of the effect after adjustment for Expanded Disability Status Scale (adjusted RR 1.18, p =0.13). Prevalence of anxiety (but not depression or fatigue) decreased by 8.1% per year of cohort observation (RR 0.92, 95%CI 0.86–0.98, p =0.009), with the effect more pronounced in women (14.6%, RR 0.85, 95%CI 0.79–0.93, –<0.001) than men (2.6%, RR 1.03, 95%CI 0.90–1.17, p =0.77). There was no apparent seasonal variation in the prevalence of any of the three factors ( p >0.05). All three factors occurred contemporaneously at cohort entry in a higher proportion of the cohort than expected by chance ( p <0.001). Conclusions: Anxiety, depression and fatigue are common in PwMS and tend to cluster together. The findings are important for clinical management of PwMS and to the exploration of possible shared causal biological pathways.
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“The lifetime prevalence of anxiety disorders ranges from 20% to 45% throughout the course of MS,1”
From EMDR treatment for anxiety in MS patients: A pilot study (2020) · cites this paper as [1]
In the citing paper
“Multiple sclerosis (MS) patients suffer from high levels of anxiety.”
From EMDR treatment for anxiety in MS patients: A pilot study (2020) · cites this paper as [1]
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“directly questioned (19), it is likely that only those with the very highest levels of fatigue have this”
BackgroundDepression and Anxiety Symptoms Are Associated with Mean Platelet Volume in Autoimmune Disorders
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“This is consistent with research in which depressive states and feelings of fatigue tended to persist, while the level of anxiety initially co-occurred but nevertheless decreased over time and as the disease progressed [82].”
ResultPaucke, M., Kern, S., & Ziemssen, T. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2017.00703 · Cited by 10
Reen, G., Silber, E., & Langdon, D. W. (2018) · Value in Health · doi:10.1016/j.jval.2017.12.015 · Cited by 10
“Other commonly experienced MS symptoms, such as depression, anxiety and fatigue [17] may also influence understanding, but have not been previously assessed.”
BackgroundJerković, A., Proroković, A., Matijaca, M., Katić, A. Ć., Košta, V., Mihalj, M., Dolić, K., Đogaš, Z., & Vidaković, M. R. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.103397 · Cited by 10
The Multiple Sclerosis-Fatigue Self– Efficacy (MS-FSE) scale: initial validation
Thomas, S., Kersten, P., & Thomas, P. (2014) · Clinical Rehabilitation · doi:10.1177/0269215514543702 · Cited by 15
“28 Participants were excluded if they: (1) were non-English speaking, (2) had had a relapse requiring corticosteroids within the past 3 months, (3) had started a disease modifying drug or anti-depressant within the past 3 months, (4) were judged by the clinical team to have cognitive deficits such that they could not…”
BackgroundSaul, A., Taylor, B., Simpson, S., Ponsonby, A.-L., Blizzard, L., Dwyer, T., McMorran, B., Wood, B., & van der Mei, I. A. (2019) · Multiple Sclerosis Journal · doi:10.1177/1352458518770021 · Cited by 9
Self-citationMaguire, R., Deane-King, J., Fahy, A., Larkin, A., & Coote, S. B. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2022.104419 · Cited by 9
Abou, L., Whibley, D., Clauw, D. J., & Kratz, A. L. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.09.005 · Cited by 10
Neuropsychiatric Status of Patients With Multiple Sclerosis Across Disease Duration Intervals
Freedman, D., Oh, J., & Feinstein, A. (2023) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.20220124 · Cited by 15
Al-Hussain, F., Al-Salloum, N., Alazwary, N., Saeedi, J., Howaidi, S., & Daif, A. (2017) · Journal of Comparative Effectiveness Research · doi:10.2217/cer-2016-0087 · Cited by 9
Walker, L. A. S., Gardner, C. M., Freedman, M. S., MacLean, H. J., Rush, C., & Bowman, M. (2018) · International Journal of MS Care · doi:10.7224/1537-2073.2017-090 · Cited by 9
Cárdenas‐Robledo, S., Otero‐Romero, S., Passarell‐Bacardit, M. A., Carbonell‐Mirabent, P., Sastre‐Garriga, J., Montalbán, X., & Tintoré, M. (2021) · European Journal of Neurology · doi:10.1111/ene.15030 · Cited by 10
Andreeva, M. T., & Караваева, Т. А. (2020) · V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY · doi:10.31363/2313-7053-2019-4-2-19-28 · Cited by 11
Palotai, M., Small, C., Makris, N., et al. (2021) · Journal of Neuroimaging · doi:10.1111/jon.12832 · Cited by 9
“Time between MFIS assessments and MRI scan (months) 2 (0-12) 2 (1-12) 2 (0-12) 6 (0-12) N/A”
Multiple sclerosis experiences of couples: Examination of patient and partner perspectives
Demirtepe-Saygılı, D. (2021) · Journal of Health Psychology · doi:10.1177/13591053211017192 · Cited by 8
“Higher levels of depressive and anxiety symptoms were reported by people with MS (Wood et al., 2013).”
BackgroundFatigue is associated with worse cognitive and everyday functioning in older persons with HIV
Campbell, L. M., Sun-Suslow, N., Heaton, A., Heaton, R. K., Ellis, R. J., Moore, D. J., & Moore, R. C. (2022) · AIDS · doi:10.1097/qad.0000000000003162 · Cited by 8
“Research has repeatedly suggested fatigue’s association with a wide-range of psychosocial factors, including depression [8], anxiety [9], poor sleep quality [10], less social support [11], and overall poorer quality of”
BackgroundHerbert, R., Taylor, J. L., Lord, S. R., & Gandevia, S. C. (2020) · BMC Public Health · doi:10.1186/s12889-020-09443-5 · Cited by 9
Safi, S. Z. (2015) · Iranian Journal of Psychiatry and Behavioral Sciences · doi:10.17795/ijpbs340 · Cited by 8
“Previous studies have indicated that depression is prevalent in MS patients and affects treatment adherence and is associated with neurological damage that results from MS (24-42).”
BackgroundNogales-Gaete, J., Rodrigo Aracena, C., Sergio Cepeda, Z., Claudio Eloiza, C., Paula Agurto, M., Díaz, V., Labbé, S., Martínez, S., Flores, J., & Araya, C. (2014) · Revista médica de Chile · doi:10.4067/s0034-98872014000500002 · Cited by 8
1-year course of fatigue in patients on chronic hemodialysis
Bossola, M., Stasio, E. D., Antocicco, M., Pepe, G., Marzetti, E., & Vulpio, C. (2017) · International Urology and Nephrology · doi:10.1007/s11255-016-1496-4 · Cited by 8
Naderi, A., Rezvani, M. H., Aminianfar, A., & Hamood-Ahvazi, S. (2024) · EXPLORE · doi:10.1016/j.explore.2024.103032 · Cited by 10
Assessment of factors associated with depression and anxiety among pwMS in Saudi Arabia
AlSaeed, S., Alkhawajah, N. M., Ayyash, M., Aljarallah, S., Alarieh, R., & Abushaheen, A. (2021) · BMC Neurology · doi:10.1186/s12883-022-02632-2 · Cited by 7
Psychische Störungen bei somatischen Krankheiten
Kapfhammer, H. P. (2011) · Springer eBooks · doi:10.1007/978-3-642-03637-8_76 · Cited by 7
Gromisch, E. S., Neto, L. O., Sloan, J., Tyry, T. M., & Foley, F. W. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.103079 · Cited by 7
Perceived physical and mental fatigability in older adults with and without multiple sclerosis
Luo, D.-H., & Holtzer, R. (2024) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2024.105807 · Cited by 6
Metadata
- Authors
- Wood, B., van der Mei, I., Ponsonby, A.-L., Pittas, F., Quinn, S., Dwyer, T., Lucas, R., & Taylor, B.
- Affiliations
- University of Tasmania (AU)
- Menzies Research Institute Tasmania, University of Tasmania, Tasmania, Australia
- The University of Melbourne (AU)
- Flinders University (AU)
- National Centre for Epidemiology and Public Health, The Australian National University, Canberra, Australia
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2012-06-22
- Volume
- 19
- Issue
- 2
- Pages
- 217-224
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W1973836236
- Cited by
- 294
- References
- 41
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 17 · 2023: 15 · 2022: 24 · 2021: 36 · 2020: 21 · 2019: 19 · 2018: 25 · 2017: 22 · 2016: 24 · 2015: 25 · 2014: 28 · 2013: 19 · 2012: 1
- FWCI
- 16.84
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Locations
- Multiple Sclerosis Journal (publishedVersion)
- PubMed (publishedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- ANU Open Research (Australian National University) (submittedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- multiple sclerosis, anxiety, depression, fatigue, comorbidities, prevalence, longitudinal cohort, sex differences, disease duration, Expanded Disability Status Scale, seasonal variation, Hospital Anxiety and Depression Scale, Fatigue Severity Scale
- MeSH terms
- Adult, Age Factors, Antidepressive Agents, Anxiety, Depression, Disability Evaluation, Educational Status, Fatigue, Female, Humans, Immunologic Factors, Longitudinal Studies, Male, Middle Aged, Multiple Sclerosis, Seasons, Sex Characteristics, Tasmania, Cohort Studies, Disease Progression
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