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Cited by 295Multiple Sclerosis Research StudiesCancer survivorship and careAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 39 of the 41 references it cites were found in a registry or an index.

Prevalence and concurrence of anxiety, depression and fatigue over time in multiple sclerosis

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Wood, B, van der Mei, IAF, Ponsonby, A-L, Pittas, F, Quinn, S, Dwyer, T, Lucas, RM, Taylor, BV·2013·Multiple Sclerosis Journal
DOI 10.1177/1352458512450351
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Abstract

Background: Anxiety, depression and fatigue are commonly reported by persons with multiple sclerosis (PwMS). Objectives: We estimated the prevalence of each factor in a representative sample of PwMS, and in subgroups defined by age, sex and disease duration, at cohort entry and over time. We further examined whether and how these factors clustered together. Methods: A population-based longitudinal cohort of 198 PwMS was followed 6-monthly for 2.5 years. The Hospital Anxiety and Depression Scale (HADS) was used to measure anxiety (cut-point >7) and depression (>7) and the Fatigue Severity Scale (FSS) to measure fatigue (≥5). Results: At cohort entry, prevalence of anxiety was 44.5% (95%CI 37–51%), depression 18.5% (95%CI 12.6–23.4%), and fatigue 53.7% (95%CI 47–61%). Fatigue was more common in males than females (RR 1.29, p =0.01), with attenuation of the effect after adjustment for Expanded Disability Status Scale (adjusted RR 1.18, p =0.13). Prevalence of anxiety (but not depression or fatigue) decreased by 8.1% per year of cohort observation (RR 0.92, 95%CI 0.86–0.98, p =0.009), with the effect more pronounced in women (14.6%, RR 0.85, 95%CI 0.79–0.93, –<0.001) than men (2.6%, RR 1.03, 95%CI 0.90–1.17, p =0.77). There was no apparent seasonal variation in the prevalence of any of the three factors ( p >0.05). All three factors occurred contemporaneously at cohort entry in a higher proportion of the cohort than expected by chance ( p <0.001). Conclusions: Anxiety, depression and fatigue are common in PwMS and tend to cluster together. The findings are important for clinical management of PwMS and to the exploration of possible shared causal biological pathways.

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Crossref · 10.1177/1352458512450351

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Metadata

Authors
Wood, B., van der Mei, I., Ponsonby, A.-L., Pittas, F., Quinn, S., Dwyer, T., Lucas, R., & Taylor, B.
Affiliations
  • University of Tasmania (AU)
  • Menzies Research Institute Tasmania, University of Tasmania, Tasmania, Australia
  • The University of Melbourne (AU)
  • Flinders University (AU)
  • National Centre for Epidemiology and Public Health, The Australian National University, Canberra, Australia
ORCID
Venue
Multiple Sclerosis Journal
Publisher
SAGE Publications
Published
2012-06-22
Volume
19
Issue
2
Pages
217-224
ISSN
  • 1352-4585 (ISSN-L)
  • 1477-0970
DOI
10.1177/1352458512450351
OpenAlex
W1973836236
Cited by
294
References
41
Citations by year
2026: 8 · 2025: 9 · 2024: 17 · 2023: 15 · 2022: 24 · 2021: 36 · 2020: 21 · 2019: 19 · 2018: 25 · 2017: 22 · 2016: 24 · 2015: 25 · 2014: 28 · 2013: 19 · 2012: 1
FWCI
16.84
Type
journal article
Language
en
Open access
Licence
Locations
  • Multiple Sclerosis Journal (publishedVersion)
  • PubMed (publishedVersion)
  • eCite Digital Repository (University of Tasmania) (submittedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • ANU Open Research (Australian National University) (submittedVersion)
  • Swinburne figshare (Swinburne University of Technology) (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
multiple sclerosis, anxiety, depression, fatigue, comorbidities, prevalence, longitudinal cohort, sex differences, disease duration, Expanded Disability Status Scale, seasonal variation, Hospital Anxiety and Depression Scale, Fatigue Severity Scale
MeSH terms
Adult, Age Factors, Antidepressive Agents, Anxiety, Depression, Disability Evaluation, Educational Status, Fatigue, Female, Humans, Immunologic Factors, Longitudinal Studies, Male, Middle Aged, Multiple Sclerosis, Seasons, Sex Characteristics, Tasmania, Cohort Studies, Disease Progression

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