The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.
The incidence and prevalence of psychiatric disorders in multiple sclerosis: A systematic review
Open accessAbstract
BACKGROUND: Psychiatric comorbidity is associated with lower quality of life, more fatigue, and reduced adherence to disease-modifying therapy in multiple sclerosis (MS). OBJECTIVES: The objectives of this review are to estimate the incidence and prevalence of selected comorbid psychiatric disorders in MS and evaluate the quality of included studies. METHODS: We searched the PubMed, PsychInfo, SCOPUS, and Web of Knowledge databases and reference lists of retrieved articles. Abstracts were screened for relevance by two independent reviewers, followed by full-text review. Data were abstracted by one reviewer, and verified by a second reviewer. Study quality was evaluated using a standardized tool. For population-based studies we assessed heterogeneity quantitatively using the I² statistic, and conducted meta-analyses. RESULTS: We included 118 studies in this review. Among population-based studies, the prevalence of anxiety was 21.9% (95% CI: 8.76%-35.0%), while it was 14.8% for alcohol abuse, 5.83% for bipolar disorder, 23.7% (95% CI: 17.4%-30.0%) for depression, 2.5% for substance abuse, and 4.3% (95% CI: 0%-10.3%) for psychosis. CONCLUSION: This review confirms that psychiatric comorbidity, particularly depression and anxiety, is common in MS. However, the incidence of psychiatric comorbidity remains understudied. Future comparisons across studies would be enhanced by developing a consistent approach to measuring psychiatric comorbidity, and reporting of age-, sex-, and ethnicity-specific estimates.
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“A comprehensive systematic review of 118 studies on psychiatric comorbidities in MS found that psychiatric comorbidities were common; in particular, the prevalence of diagnosed anxiety and depression were estimated at 21.9 and 23.7%, respectively [53].”
From Functional neurological disorder and multiple sclerosis: a systematic review of misdiagnosis and clinical overlap (2022) · cites this paper as [53]
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“MS patients show increased levels of anxiety and depression compared to healthy participants, and these conditions affect more than 20% of patients [8,21,22,23].”
From Biopsychosocial Correlates of Quality of Life in Multiple Sclerosis Patients (2022) · cites this paper as [23]
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Ferrari, A. J., Charlson, F. J., Norman, R. E., Patten, S. B., Freedman, G., Murray, C. J. L., Vos, T., & Whiteford, H. A. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001547 · Cited by 3,115
A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: Overview
Marrie, R., Cohen, J., Stüve, O., Trojano, M., Sørensen, P., Reingold, S., Cutter, G., & Reider, N. (2015) · Multiple Sclerosis · doi:10.1177/1352458514564491 · Cited by 762
Self-citationNeyeloff, J. L., Fuchs, S. C. P. C., & Moreira, L. B. (2012) · BMC Research Notes · doi:10.1186/1756-0500-5-52 · Cited by 731
Depressive disorders and immunity: 20 years of progress and discovery
Irwin, M. R., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.01.010 · Cited by 676
Chwastiak, L., Ehde, D. M., Gibbons, L. E., Sullivan, M., Bowen, J. D., & Kraft, G. H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1862 · Cited by 555
Depression and multiple sclerosis
Sadovnick, A. D., Remick, R. A., Allen, J. B., Swartz, E. S., Yee, I. M. L., Eisen, K., Farquhar, R., Hashimoto, S. A., Hooge, J. P., Kastrukoff, L. F., et al. (1996) · Neurology · doi:10.1212/wnl.46.3.628 · Cited by 536
Quality of life in multiple sclerosis: the impact of depression, fatigue and disability
Amato, M. P., Ponziani, G., Rossi, F., Liedl, C. L., Stefanile, C., & Rossi, L. (2001) · Multiple Sclerosis Journal · doi:10.1177/135245850100700511 · Cited by 506
Quality of life in patients with multiple sclerosis
Janardhan, V., & Bakshi, R. (2002) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(02)00312-x · Cited by 489
Lobentanz, I. S., Asenbaum, S., Vass, K., Sauter, C., Klosch, G., Kollegger, H., Kristoferitsch, W., & Zeitlhofer, J. (2004) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2004.00257.x · Cited by 439
Anxiety disorders and their clinical correlates in multiple sclerosis patients
Korostil, M., & Feinstein, A. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458506071161 · Cited by 424
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Filippi, M., Bar-Or, A., Piehl, F., Preziosa, P., Solari, A., Vukusic, S., & Rocca, M. A. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0041-4 · Cited by 1,562
A systematic review of reviews on the prevalence of anxiety disorders in adult populations
Remes, O., Brayne, C., van der Linde, R., & Lafortune, L. (2016) · Brain and Behavior · doi:10.1002/brb3.497 · Cited by 802
Prevalence of depression and anxiety in Multiple Sclerosis: A systematic review and meta-analysis
Boeschoten, R. E., Braamse, A. M. J., Beekman, A. T. F., Cuijpers, P., van Oppen, P., Dekker, J., & Uitdehaag, B. M. J. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.11.067 · Cited by 713
Depression and anxiety in patients with Inflammatory Bowel Disease: a systematic review
Neuendorf, R., Harding, A., Stello, N., Hanes, D., & Wahbeh, H. (2016) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2016.06.001 · Cited by 561
A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: Overview
Marrie, R., Cohen, J., Stüve, O., Trojano, M., Sørensen, P., Reingold, S., Cutter, G., & Reider, N. (2015) · Multiple Sclerosis · doi:10.1177/1352458514564491 · Cited by 762
Self-citation
Metadata
- Authors
- Marrie, R. A., Reingold, S., Cohen, J., Stuve, O., Trojano, M., Sorensen, P. S., Cutter, G., & Reider, N.
- Affiliations
- University of Manitoba (CA)
- Scientific and Clinical Review Associates, LLC, USA
- Cleveland Clinic (US)
- Department of Neurology and Neurotherapeutics, University of Texas Southwestern, USA
- Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Italy
- Department of Neurology, Copenhagen University Hospital Rigshospitalet, Denmark
- University of Alabama at Birmingham (US)
- Corresponding author
- Marrie, Ruth Ann
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2015-01-12
- Volume
- 21
- Issue
- 3
- Pages
- 305-317
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- PMC
- PMC4429164
- OpenAlex
- W2105913548
- Cited by
- 519
- References
- 136
- Citations by year
- 2026: 42 · 2025: 31 · 2024: 45 · 2023: 46 · 2022: 52 · 2021: 68 · 2020: 48 · 2019: 38 · 2018: 43 · 2017: 47 · 2016: 43 · 2015: 16
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Multiple Sclerosis Journal (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- mediaTUM (Technical University of Munich) (submittedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Funders
- U.S. Department of Defense
- National Multiple Sclerosis Society
- Pfizer
- GlaxoSmithKline
- Sanofi
- Gilead Sciences
- Biogen
- Teva Pharmaceutical Industries
- Cleveland Clinic
- Multiple Sclerosis Society of Canada
- Multiple Sclerosis Society
- MedDay Pharmaceuticals
- National Institutes of Health
- Genentech
- EMD Serono
- National Heart, Lung, and Blood Institute
- National Institute of Neurological Disorders and Stroke
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- multiple sclerosis, psychiatric comorbidity, depression, anxiety, alcohol abuse, bipolar disorder, substance abuse, psychosis, incidence, prevalence, quality of life, fatigue
- MeSH terms
- Mental Disorders, Humans, Multiple Sclerosis, Comorbidity, Incidence, Prevalence
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