Adiponectin, T-cadherin and Tumour Necrosis Factor-α in Damaged Cardiomyocytes from Autopsy Specimens
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This study determined the presence of adiponectin, T-cadherin (an adiponectin receptor) and tumour necrosis factor-α (TNF-α) in damaged myocytes from autopsied patients with acute or old myocardial infarction (MI) or dilated cardiomyopathy (DCM), using immunohistochemical staining. The enrolled patients included eight with acute MI, six with old MI and seven with DCM. Four autopsied individuals with no cardiac lesions were also enrolled as controls. Adiponectin and TNF-α were not observed in normal myocytes from control subjects, but T-cadherin was weakly detected. Immunoreactivity for adiponectin and T-cadherin was observed at the periphery of damaged myocytes from MI and DCM patients; intracellular reactivity for TNF-α was also seen. There were no statistically significant differences in the degree of reactivity for each molecule in the myocytes between the MI and DCM patients. These results suggest that the presence of adiponectin and TNF-α in damaged myocytes may contribute to the processes of myocardial injury occurring in MI and DCM.
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In a small number of autopsy specimens, adiponectin was not found in individuals without cardiac lesions, but it was detected in patients who suffered MI or dilated cardiomyopathy.
“Adiponectin was not found in individuals without cardiac lesions, but it was detected in patients who suffered MI or dilated cardiomyopathy (339).”
From Cardiac remodeling in obesity (2008) · cites this paper as [339]
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Self-citation
- Authors
- Takahashi, T., Saegusa, S., Sumino, H., Nakahashi, T., Iwai, K., Morimoto, S., Nojima, T., & Kanda, T.
- Affiliations
- Kanazawa Medical University (JP)
- Gunma University (JP)
- Corresponding author
- Kanda, T
- Venue
- Journal of International Medical Research
- Publisher
- SAGE Publications
- Published
- 2005-03
- Volume
- 33
- Issue
- 2
- Pages
- 236-244
- ISSN
- 0300-0605 (ISSN-L)
- 1473-2300
- OpenAlex
- W2046113543
- Cited by
- 39
- References
- 17
- Citations by year
- 2025: 1 · 2021: 1 · 2018: 3 · 2017: 6 · 2016: 1 · 2015: 1 · 2012: 2
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of International Medical Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kanazawa University
- Kanazawa Medical University (H2004-7)
- Promotion and Mutual Aid Corporation for Private Schools of Japan
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- adiponectin, T-cadherin, TNF-α, cardiomyocyte injury, myocardial infarction, dilated cardiomyopathy, adiponectin receptors, myocardial injury, autopsy specimens
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Autopsy, Cardiomyopathy, Dilated, Female, Humans, Immunohistochemistry, Male, Middle Aged, Cardiomyopathies, Myocardial Infarction, Myocardium, Tumor Necrosis Factor-alpha, Cadherins, Myocytes, Cardiac, Intercellular Signaling Peptides and Proteins, Adiponectin
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