Effects of exercise training on HbA 1c and VO 2peak in patients with type 2 diabetes and coronary artery disease: A randomised clinical trial
Open accessAbstract
Objective: Few exercise trials have focused on patients with both type 2 diabetes and coronary artery disease. We investigated the effects of 1 year of exercise training on HbA 1c and VO 2peak in these patients. Methods: Patients with type 2 diabetes and coronary artery disease ( n = 137) were randomised to combined exercise training or control group. HbA 1c was measured at the beginning and end of the study. Changes in VO 2peak , and also ventilatory threshold and time to exhaustion, were assessed by cardiopulmonary exercise testing. Results: No differences in changes between the randomised groups were observed in HbA 1c and VO 2peak , whereas ventilatory threshold and time to exhaustion increased significantly in the exercise group compared with the controls ( p = 0.046 and p = 0.034). In patients without previous acute myocardial infarction and diabetes microvascular complications ( n = 46), the exercise group did improve HbA 1c and VO 2peak compared with the controls ( p = 0.052 and p = 0.035). Conclusion: No significant effects of exercise training on HbA 1c or VO 2peak were observed in patients with type 2 diabetes and coronary artery disease, although improvements were seen in patients without vascular complications beyond coronary artery disease, implying that the degree of vascular disease may influence exercise responses. Ventilatory threshold and time to exhaustion did increase significantly, indicating improved exercise performance despite the minor change in VO 2peak .
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Other studies of exercise-based interventions in patients with type 2 diabetes and coronary artery disease have shown no significant improvements in HbA1c or exercise capacity and poor adherence.
“others have shown no significant improvements in HbA1c or exercise capacity and poor adherence to the intervention”
From Clinical management of stable coronary artery disease in patients with type 2 diabetes mellitus: a scientific statement from the American Heart Association (2020) · cites this paper as [166]
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- Authors
- Byrkjeland, R., Njerve, I. U., Anderssen, S., Arnesen, H., Seljeflot, I., & Solheim, S.
- Affiliations
- Oslo University Hospital (NO)
- Norwegian School of Sport Sciences (NO)
- ORCID
- Venue
- Diabetes and Vascular Disease Research
- Publisher
- SAGE Publications
- Published
- 2015-06-19
- Volume
- 12
- Issue
- 5
- Pages
- 325-333
- ISSN
- 1479-1641 (ISSN-L)
- 1752-8984
- OpenAlex
- W1957769650
- Cited by
- 52
- References
- 31
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 12 · 2016: 3
- FWCI
- 11.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes and Vascular Disease Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- exercise training, type 2 diabetes, coronary artery disease, HbA1c, peak oxygen uptake, ventilatory threshold, time to exhaustion, exercise performance, diabetic microvascular complications, cardiopulmonary exercise testing
- MeSH terms
- Aged, Coronary Artery Disease, Diabetes Mellitus, Type 2, Exercise Test, Exercise Therapy, Female, Glycated Hemoglobin, Humans, Male, Middle Aged, Oxygen, Oxygen Consumption, Exercise
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