The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease
Open accessAbstract
Despite major advances in our understanding of the initiating factors that trigger many neurodegenerative disorders, to date, no novel disease-modifying therapies have been shown to provide significant benefit for patients who suffer from these devastating disorders. As most neurodegenerative disorders are late-onset, slowly progressive, and appear to have long relatively asymptomatic prodromal phases, it is possible that therapies optimally targeting the triggers of these disorders may have limited benefit when treatment is initiated in the symptomatic patient. Such therapies may work in the prodromal phase, or when given prophylactically, but in the symptomatic patient there simply may be too much damage to the neuronal networks to restore functionality by reducing or even eliminating the primary stressor. As functional neuronal demise and overt neuronal death are almost certainly the key factors that mediate the functional impairment, it is clear that preventing neuronal death and dysfunction will have a huge clinical benefit. Unfortunately, we lack a detailed understanding of neuronal death pathways in almost all neurodegenerative disorders. To rationally develop new disease modifying therapies that target steps in the degenerative cascade downstream of the disease trigger will require a number of factors. First, we need to refocus our basic research efforts on identifying the precise steps in the pathological cascade that lead to neuronal death in each neurodegenerative disease and, if possible, determine the relative placement of those events within a potentially very complex cascade. Second, we will need to determine which of these steps are potentially targetable. Finally, we will need to develop novel therapies that interfere with these steps and demonstrate that such therapies alone, or in combination with therapies that target the trigger of these devastating diseases, have clinical benefit.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AD is a neurodegenerative disorder marked by neuronal loss, especially in the hippocampus and cerebral cortex.
“AD is a neurodegenerative disorder marked by neuronal loss, especially in the hippocampus and cerebral cortex (49, 50).”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [49]
The Introduction identifies AD as a neurodegenerative disease, and the section on the natural history of neurodegenerative diseases describes neuronal loss as part of its progression (Figure 1). The passages do not identify the hippocampus or cerebral cortex as sites of especially marked loss, so that anatomical detail is unsupported by our copy. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works
SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565 · see citing works
Protein aggregation and neurodegenerative disease
Ross, C. A., & Poirier, M. A. (2004) · Nature Medicine · doi:10.1038/nm1066 · Cited by 3,454 · see citing works
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
SantaCruz, K., Lewis, J., Spires, T., Paulson, J., Kotilinek, L., Ingelsson, M., Guimaraes, A., DeTure, M., Ramsden, M., McGowan, E., et al. (2005) · Science · doi:10.1126/science.1113694 · Cited by 2,014 · see citing works
Aggresomes, inclusion bodies and protein aggregation
Kopito, R. R. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01852-3 · Cited by 1,906 · see citing works
Oxidative stress in neurodegeneration: Cause or consequence?
Andersen, J. K. (2004) · Nature Medicine · doi:10.1038/nrn1434 · Cited by 1,869 · see citing works
Aromatic amino acids and modification of parkinsonism.
Cotzias, G., van Woert, M. H., & Schiffer, L. (1967) · New England Journal of Medicine · doi:10.1056/nejm196702162760703 · Cited by 1,501 · see citing works
Modification of Parkinsonism — Chronic Treatment with L-Dopa
Cotzias, G. C., Papavasiliou, P. S., & Gellene, R. A. (1969) · New England Journal of Medicine · doi:10.1056/nejm196902132800701 · Cited by 1,287 · see citing works
Toxic Proteins in Neurodegenerative Disease
Taylor, J. P., Hardy, J., & Fischbeck, K. H. (2002) · Science · doi:10.1126/science.1067122 · Cited by 1,251 · see citing works
Mitochondria take center stage in aging and neurodegeneration
Beal, M. F. (2005) · Annals of Neurology · doi:10.1002/ana.20624 · Cited by 957 · see citing works
Mattson, M. P. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00275.x · Cited by 751 · see citing works
Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs
Forman, M. S., Trojanowski, J. Q., & Lee, V. M.-Y. (2004) · Nature Medicine · doi:10.1038/nm1113 · Cited by 715 · see citing works
Oxidative stress, cell cycle, and neurodegeneration
Klein, J. A., & Ackerman, S. L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18182 · Cited by 584 · see citing works
Autophagy and neurodegeneration: when the cleaning crew goes on strike
Martínez‐Vicente, M., & Cuervo, A. M. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70076-5 · Cited by 472 · see citing works
Axonal transport defects: a common theme in neurodegenerative diseases
Roy, S., Zhang, B., Lee, V. M. ‐., & Trojanowski, J. Q. (2005) · Acta Neuropathologica · doi:10.1007/s00401-004-0952-x · Cited by 372 · see citing works
Kopito, R. R., & Ron, D. (2000) · Nature Cell Biology · doi:10.1038/35041139 · Cited by 318 · see citing works
Neurodegeneration and neuroprotection in Parkinson disease
Fahn, S., & Sulzer, D. L. (2004) · Neurotherapeutics · doi:10.1602/neurorx.1.1.139 · Cited by 266 · see citing works
Genetic Neurodegenerative Diseases: The Human Illness and Transgenic Models
Price, D. L., Sisodia, S. S., & Borchelt, D. (1998) · Science · doi:10.1126/science.282.5391.1079 · Cited by 259 · see citing works
Berke, S. J. S., & Paulson, H. L. (2003) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(03)00053-4 · Cited by 178 · see citing works
Cell division in the CNS: Protective response or lethal event in post-mitotic neurons?
Yang, Y., & Herrup, K. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.10.002 · Cited by 156 · see citing works
The interplay between inflammation and neurodegeneration in CNS disease
Esiri, M. M. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.013 · Cited by 87 · see citing works
Modification of Parkinsonism???Chronic Treatment with L-Dopa
Cotzias, G. C., Papvasiliou, P. S., & Gellene, R. A. (1969) · Journal of Occupational and Environmental Medicine · doi:10.1097/00043764-196912000-00037 · Cited by 68 · see citing works
Contributions of PET and SPECT to the understanding of the pathophysiology of Parkinson’s disease
Thobois, S., Guillouet, S., & Broussolle, E. (2001) · Neurophysiologie Clinique · doi:10.1016/s0987-7053(01)00273-8 · Cited by 67 · see citing works
Value of genetic models in understanding the cause and mechanisms of Parkinson’s disease
Moore, D. J., & Dawson, T. M. (2008) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-008-0045-7 · Cited by 50 · see citing works
Laihinen, A., Ruottinen, H., Rinne, J. O., Haaparanta‐Solin, M., Bergman, J., Solin, O. H., Koskenvuo, M., Marttila, R. J., & Rinne, U. K. (2000) · Journal of Neurology · doi:10.1007/pl00022911 · Cited by 43 · see citing works
The neurochemistry of Alzheimer's disease and senile dementia
Davies, P. (1983) · Medicinal Research Reviews · doi:10.1002/med.2610030302 · Cited by 22 · see citing works
An update on the neurochemistry of Alzheimer disease.
Davies, P. (1983) · PubMed · Cited by 13 · see citing works
Flagged first, then by citations
1 of the 28 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Tansey, M. G., & Goldberg, M. S. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.004 · Cited by 1,045 · see citing works
Physiological functions and pathobiology of TDP ‐43 and FUS / TLS proteins
Ratti, A., & Buratti, E. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13625 · Cited by 384 · see citing works
Pahuja, R., Seth, K., Shukla, A., Shukla, R. K., Bhatnagar, P., Chauhan, L. K. S., Saxena, P. N., Arun, J., Chaudhari, B. P., Patel, D. K., et al. (2015) · ACS Nano · doi:10.1021/nn506408v · Cited by 261 · see citing works
Neuroinflammation in Parkinson’s Disease
Lee, J., Tran, T. A. T., & Tansey, M. G. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9176-0 · Cited by 174 · see citing works
Nilson, A. N., English, K. C., Gerson, J. E., Whittle, T. B., Crain, C. N., Xue, J. J., Sengupta, U., Castillo‐Carranza, D. L., Zhang, W., Gupta, P. K., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160912 · Cited by 170 · see citing works
Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases
Kim, S., Jung, U. J., & Kim, S. R. (2024) · Antioxidants · doi:10.3390/antiox13121462 · Cited by 173 · see citing works
Pre-MCI and MCI: Neuropsychological, Clinical, and Imaging Features and Progression Rates
Duara, R., Loewenstein, D., Potter, E., Barker, W., Raj, A., Schoenberg, M. R., Wu, Y., Banko, J. L., Potter, H., Greig, M. T., et al. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3182107c69 · Cited by 137 · see citing works
Identification of early neurodegenerative pathways in progressive multiple sclerosis
Kaufmann, M., Schaupp, A.-L., Sun, R., Coscia, F., Dendrou, C. A., Cortés, A., Kaur, G., Evans, H. G., Mollbrink, A., Navarro, J. F., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01097-3 · Cited by 128 · see citing works
Targeting the “hallmarks of aging” to slow aging and treat age-related disease: fact or fiction?
Keshavarz, M., Xie, K., Schaaf, K., Bano, D., & Ehninger, D. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01680-x · Cited by 122 · see citing works
Golde, T. E., & Miller, V. M. (2009) · Alzheimer's Research & Therapy · doi:10.1186/alzrt5 · Cited by 98 · see citing works
Self-citationTargeting Aβ and tau in Alzheimer's disease, an early interim report
Golde, T. E., Petrucelli, L., & Lewis, J. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2009.07.035 · Cited by 89 · see citing works
Self-citationModeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming
Sun, Z., Kwon, J.-S., Ren, Y., Chen, S., Walker, C. K., Lu, X., Cates, K., Karahan, H., Sviben, S., Fitzpatrick, J. A. J., et al. (2024) · Science · doi:10.1126/science.adl2992 · Cited by 77 · see citing works
“AD is a neurodegenerative disorder marked by neuronal loss, especially in the hippocampus and cerebral cortex (49, 50).”
Unique biology of gliomas: challenges and opportunities
Watkins, S., & Sontheimer, H. W. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.05.001 · Cited by 76 · see citing works
Shen, Q., Loewenstein, D., Potter, E., Zhao, W., Appel, J., Greig, M. T., Raj, A., Acevedo, A., Schofield, E., Barker, W., et al. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.07.002 · Cited by 68 · see citing works
The Bad, the Good, and the Ugly about Oxidative Stress
Jiménez-Del-Río, M., & Velez‐Pardo, C. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/163913 · Cited by 64 · see citing works
Dahlmanns, M., Dahlmanns, J. K., Savaskan, N. E., Steiner, H. H., & Yakubov, E. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2803057 · Cited by 52 · see citing works
Maurer, A., Leonov, A., Ryazanov, S., Herfert, K., Kuebler, L., Buss, S., Schmidt, F., Weckbecker, D., Linder, R., Bender, D., et al. (2019) · ChemMedChem · doi:10.1002/cmdc.201900689 · Cited by 50 · see citing works
Katsu-Jiménez, Y., Loría, F., Corona, J. C., & Díaz‐Nido, J. (2016) · Molecular Therapy · doi:10.1038/mt.2016.32 · Cited by 41 · see citing works
Sevastre-Berghian, A., Făgărăşan, V., Toma, V. A., Bâldea, I., Olteanu, D. E., Moldovan, R., Decea, N., Filip, G. A., & Clichici, S. V. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3037876 · Cited by 41 · see citing works
Ham, A., Kim, D. W., Kim, K. H., Lee, S., Oh, K.-B., Shin, J., & Mar, W. (2013) · Brain Research · doi:10.1016/j.brainres.2013.05.036 · Cited by 35 · see citing works
Khalilpour, S., Latifi, S., Behnammanesh, G., Majid, A. M. S. A., Majid, A. S. A., & Tamayol, A. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.12.044 · Cited by 33 · see citing works
Synthesis of Lipoamino Acids and Their Activity against Cerebral Ischemic Injury
Yao, L., Lin, Q. D., Niu, Y.-Y., Deng, K.-M., Zhang, J., & Yang, L. (2009) · Molecules · doi:10.3390/molecules14104051 · Cited by 32 · see citing works
Prevention of age-associated dementia
Mohajeri, M. H., & Leuba, G. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.06.014 · Cited by 29 · see citing works
Implication of matrix metalloproteinases in regulating neuronal disorder
Mukherjee, A., & Swarnakar, S. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3752-y · Cited by 27 · see citing works
Oeckl, P., Steinacker, P., Feneberg, E., & Otto, M. (2014) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2014.12.010 · Cited by 27 · see citing works
Manipulation of the diet–microbiota–brain axis in Alzheimer’s disease
Lee, D. D., Lee, V. M. ‐., & Hur, S. K. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1042865 · Cited by 32 · see citing works
Main plant extracts’active properties effective on scopolamine-induced memory loss
Balmus, I.-M., & Ciobica, A. (2017) · American Journal of Alzheimer's Disease & Other Dementiasr · doi:10.1177/1533317517715906 · Cited by 25 · see citing works
Ham, A., Lee, H. J., Hong, S. S., Lee, D., & Mar, W. (2011) · Phytotherapy Research · doi:10.1002/ptr.3592 · Cited by 24 · see citing works
Alzheimer’s Disease, Drosophila melanogaster and Polyphenols
Jiménez-Del-Río, M., & Velez‐Pardo, C. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-18365-7_2 · Cited by 20 · see citing works
Nhieu, J., Milbauer, L. C., Lerdall, T. A., Najjar, F., Wei, C.-W., Ishida, R., Ma, Y., Kagechika, H., & Wei, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054980 · Cited by 17 · see citing works
Tennakoon, A., Katharesan, V., Musgrave, I., Koblar, S. A., Faull, R. L. M., Curtis, M. A., & Johnson, I. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24996 · Cited by 17 · see citing works
Bjørklund, G., Oliinyk, P., Khavrona, O. P., Lozynska, I., Lysiuk, R., Darmohray, R., Antonyak, H., Dub, N., Zayachuk, V. Y., Antoniv, О., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04321-2 · Cited by 16 · see citing works
Ham, A., Shin, J., Oh, K.-B., Lee, S.-J., Nam, K., Koo, U., Kim, K.-H., & Mar, W. (2011) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2011.19.1.118 · Cited by 16 · see citing works
Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair?
Geribaldi‐Doldán, N., Carrascal, L., Pérez-García, P., Oliva, J. M., Pardillo-Díaz, R., Domínguez‐García, S., Utrera, C. B., Gómez‐Oliva, R., Martínez‐Ortega, S., Verástegui, C., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076587 · Cited by 15 · see citing works
Giraldo-Berrio, D., Mendivil‐Perez, M., Velez‐Pardo, C., & Jiménez-Del-Río, M. (2024) · Neurotoxicity Research · doi:10.1007/s12640-024-00705-3 · Cited by 15 · see citing works
Glycyl-L-Prolyl-L-Glutamate Pseudotripeptides for Treatment of Alzheimer’s Disease
Türkez, H., Cacciatore, I., Marinelli, L., Fornasari, E., Aslan, M. E., Çadırcı, K., Kahraman, Ç. Y., Çağlar, Ö., Tatar, A., Biase, G. D., et al. (2021) · Biomolecules · doi:10.3390/biom11010126 · Cited by 14 · see citing works
Fabrication strategies for chiral self-assembly surface
Niu, X., Yuan, M., Zhao, R., Wang, L., Liu, Y., Zhao, H., Li, H., Yang, X., & Wang, K. (2024) · Microchimica Acta · doi:10.1007/s00604-024-06278-4 · Cited by 13 · see citing works
Negi, N., Ayyannan, S. R., & Tripathi, R. K. P. (2025) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-025-00588-2 · Cited by 11 · see citing works
"Investigation of a Novel Biocompatible Fast-Gelling Hydrogel for Neurodegenerative Diseases"
Jiang, S. (2023) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2023.50.007951 · Cited by 11 · see citing works
You, W., Berendschot, T. T. J. M., Knoops, K., van Zandvoort, M. A. M. J., Webers, C. A. B., Reutelingsperger, C. P. M., & Gorgels, T. G. M. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052650 · Cited by 10 · see citing works
Hu, S., Cui, W., Mak, S., Choi, C., Yuanjia, H., Li, G., Tsim, K. W. K., Pang, Y., & Han, Y. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12401 · Cited by 10 · see citing works
Perspective and Directions for Future Research on Trace Amines and Neurological Disorders
Farooqui, T., & Farooqui, A. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803603-7.00025-2 · Cited by 9 · see citing works
Misawa, K., Kanazawa, T., Mochizuki, D., Imai, A., Mima, M., Yamada, S., Morita, K., Misawa, Y., Shinmura, K., & Mineta, H. (2019) · Cancers · doi:10.3390/cancers11030401 · Cited by 8 · see citing works
Analysis of MRI Data in Diagnostic Neuroradiology
Rathore, S., Abdulkadir, A., & Davatzikos, C. A. (2020) · Annual Review of Biomedical Data Science · doi:10.1146/annurev-biodatasci-022620-015538 · Cited by 8 · see citing works
Optogenetics to biomolecular phase separation in neurodegenerative diseases
Park, K. H., & Kim, K. W. (2025) · Molecules and Cells · doi:10.1016/j.mocell.2025.100247 · Cited by 7 · see citing works
Choi, G. S., Kim, G. H., Choi, J.-H., Hwang, J., Kwon, E., Lee, S. A., Kong, K. A., Kang, H. J., Yoon, B., Kim, B. C., et al. (2018) · Journal of Clinical Neurology · doi:10.3988/jcn.2018.14.3.275 · Cited by 7 · see citing works
Hashemi, M., Asheghabadi, P. S., Moassesfar, M., Mashhadikhan, S., Nasirzade, S., Farahani, A. V., Mehdizadeh, S., Minaei, S., Rahmani, M., Jamshidian, F., et al. (2026) · Molecular Neurobiology · doi:10.1007/s12035-025-05510-3 · Cited by 7 · see citing works
Herpotrichone A Exerts Neuroprotective Effects by Relieving Ferroptosis
Deng, J., Wang, G., Zhai, Y., Feng, X.-Y., Deng, L., Han, W., & Tang, J. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c02418 · Cited by 6 · see citing works
Effects of Curcumin on Neuroinflammation in Animal Models and in Patients with Alzheimer Disease
Farooqui, A. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-15889-1_7 · Cited by 6 · see citing works
Lee, S.-H. (2011) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2011.19.1.001 · Cited by 5 · see citing works
Neuroinflammation as a Potential Mechanism Underlying Parkinsons Disease
Cebrián, C., & Sulzer, D. L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803783-6.00008-0 · Cited by 6 · see citing works
Viegas, C., Fraga, C. A. M., Sousa, M. E., & Tarozzi, A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.609274 · Cited by 5 · see citing works
Suke, S. G., Ghosh, T., Yadav, C., Ahmed, R. S., & Banerjee, B. (2019) · Pharmacognosy Research · doi:10.4103/pr.pr_77_18 · Cited by 4 · see citing works
Bhuvaneshwari, D. S., Pavithra, K., Priyadharshini, R. D., Vennila, K. N., & Elango, K. P. (2025) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2025.141960 · Cited by 3 · see citing works
Kenzelmann, A., Boch, C., Schmidt, R., Richter, M., & Schulz, M. (2024) · Biomedicines · doi:10.3390/biomedicines12122794 · Cited by 3 · see citing works
Neurochemical Aspects of Neurodegenerative Diseases
Farooqui, A. A. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6652-0_8 · Cited by 3 · see citing works
Wiesinger, A., Bigger, B., Giugliani, R., Lampe, C., Scarpa, M., Moser, T., Kampmann, C., Zimmermann, G., & Lagler, F. B. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051565 · Cited by 3 · see citing works
RetractedNeurodegeneration in Neural Trauma, Neurodegenerative Diseases, and Neuropsychiatric Disorders
Farooqui, A. A. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6652-0_1 · Cited by 2 · see citing works
Defining Neurocognitive Disorders
McDonald, W. M. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31823497c7 · Cited by 2 · see citing works
Overview of Mouse Models for Psychiatric and Neurologic Disorders
Lindner, M. D., & McArthur, R. A. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-369497-3.10031-7 · Cited by 1 · see citing works
Exploring the Interaction Between Human Granulin-A (hGrn-A) and Amyloid-β (Aβ) Peptide
Samel, M. A. (2012) · Aquila Digital Community (University of Southern Mississippi)
Summary, Perspective and Direction for Future Research
Farooqui, A. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-15889-1_10
Gene–Environment Interactions in Huntington’s Disease
Bichell, T. J., Uhouse, M. A., Bradley, E. M., & Bowman, A. B. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800228-5.00017-0
Neuroprotective Effects of Sulforaphane and the Involvement of Autophagy
Bednar, S. (2016) · UEA Digital Repository (University of East Anglia)
Neuronal vs Glial Cell Contribution to Adenosine A 2A Receptor-Induced Neurodegeneration
Ferrante, A., Tebano, M. T., Martire, A., Domenici, M. R., & Popoli, P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803724-9.00007-7
Potential Neuroprotective Strategies for Concussion and Chronic Traumatic Encephalopathy
Farooqui, A. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813596-9.00009-2
Suciati, S., Suharyoto, S., Lasman, L., Nurhidayati, N., Islamy, A., & Masruroh, E. (2022) · Lumbung Inovasi Jurnal Pengabdian kepada Masyarakat · doi:10.36312/linov.v7i4.988
Deng, J., Wang, G., Zhai, Y., Feng, X.-Y., Deng, L., Han, W., Tang, J., & Gao, J. (2023) · doi:10.22541/au.169956726.62857132/v1
Exploring innovations in cell death for the study and treatment of non-communicable diseases
Mendes, M. K. D. A., Góes, L. S. B. D. B., Sousa, M. D. S., Carrilho, E., Vieira, E. C., & Júnior, C. A. L. (2025) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2025.06.013
Editorial: The early detection of neurodegenerative diseases: an aging perspective
Abondio, P., Masi, M., & Wang, S. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1765664
- Authors
- Golde, T. E.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Golde, Todd E
- ORCID
- Golde, Todd E
- Venue
- Molecular Neurodegeneration
- Published
- 2009
- Volume
- 4
- Issue
- 1
- Pages
- 8
- ISSN
- 1750-1326 (ISSN-L)
- PMC
- PMC2644308
- OpenAlex
- W2078825616
- Cited by
- 71
- References
- 28
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 8 · 2015: 5 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Molecular Neurodegeneration (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Mayo Foundation for Medical Education and Research
- Coins for Alzheimer's Research Trust
- Fondation pour la Recherche Médicale
- National Institute on Aging (P01AG025531, R01AG018454)
- National Institute of Neurological Disorders and Stroke (NS 39072, R01NS039072)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neuronal cell death, neurodegenerative diseases, disease-modifying therapy, prodromal symptoms, therapeutic target, neuroprotection
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
