The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Blood Lactate Measurements and Analysis during Exercise: A Guide for Clinicians
Open accessAbstract
Blood lactate concentration ([La−]b) is one of the most often measured parameters during clinical exercise testing as well as during performance testing of athletes. While an elevated [Lai may be indicative of ischemia or hypoxemia, it may also be a “normal” physiological response to exertion. In response to “all-out” maximal exertion lasting 30–120 seconds, peak [La−]b values of =15–25 mM may be observed 3–8 minutes postexercise. In response to progressive, incremental exercise, [La−]b increases gradually at first and then more rapidly as the exercise becomes more intense. The work rate beyond which [La−]b increases exponentially [the lactate threshold (LT)] is a better predictor of performance than VO 2max and is a better indicator of exercise intensity than heart rate; thus LT (and other valid methods of describing this curvilinear [La−]b response with a single point) is useful in prescribing exercise intensities for most diseased and nondiseased patients alike. H+-monocarboxylate cotransporters provide the primary of three routes by which La− transport proceeds across the sarcolemma and red blood cell membrane. At rest and during most exercise conditions, whole blood [La−] values are on average 70% of the corresponding plasma [La−] values; thus when analyzing [La−]b, care should be taken to both (1) validate the [LaT-measuring instrument with the criterion/reference enzymatic method and (2) interpret the results correctly based on what is being measured (plasma or whole blood). Overall, it is advantageous for clinicians to have a thorough understanding of [La−] responses, blood La− transport and distribution, and [La−] analysis.
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Cites
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A lung/liver-on-a-chip platform for acute and chronic toxicity studies
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Metadata
- Authors
- Goodwin, M. L., Harris, J. E., Hernández, A., & Gladden, L. B.
- Venue
- Journal of Diabetes Science and Technology
- Publisher
- SAGE Publications
- Published
- 2007-07
- Volume
- 1
- Issue
- 4
- Pages
- 558-569
- ISSN
- 1932-2968 (ISSN-L)
- OpenAlex
- W2133943332
- Cited by
- 554
- References
- 4
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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