Cited by 36Celiac Disease Research and ManagementEosinophilic EsophagitisGastrointestinal disorders and treatments

Long‐term health and treatment outcomes in adult coeliac disease patients diagnosed by screening in childhood

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Kivelä, Laura, Popp, Alina, Arvola, Taina, Huhtala, Heini, Kaukinen, Katri, Kurppa, Kalle·2018·United European Gastroenterology Journal

Abstract

Background: The diagnostic yield of coeliac disease could be improved by screening in at‐risk groups, but long‐term benefits of this approach are obscure. Objective: To investigate health, quality of life and dietary adherence in adult coeliac patients diagnosed in childhood by screening. Methods: After thorough evaluation of medical history, follow‐up questionnaires were sent to 559 adults with a childhood coeliac disease diagnosis. The results were compared between screen‐detected and clinically‐detected patients, and also between originally asymptomatic and symptomatic screen‐detected patients. Results: In total, 236 (42%) patients completed the questionnaires a median of 18.5 years after childhood diagnosis. Screen‐detected patients ( n = 48) had coeliac disease in the family and type 1 diabetes more often, and were less often smokers and members of coeliac societies compared to clinically‐detected patients, whereas the groups did not differ in current self‐experienced health or health concerns, quality of life or dietary adherence. Screen‐detected, originally asymptomatic patients had more anxiety than those presenting with symptoms, whereas the subgroups were comparable in other current characteristics. Conclusion: Comparable long‐term outcomes between screen‐detected and clinically‐detected patients support risk‐group screening for coeliac disease. However, asymptomatic patients may require special attention.

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  • The long-term outcome of celiac disease in type 1 diabetes patients is similar to that in celiac disease without type 1 diabetes in terms of compliance with the gluten-free diet and achieving remission of celiac disease.

    “The long-term outcome of CD in T1D patients is similar to the one in CD without T1D in terms of compliance with the GFD and achieving remission of CD (129, 130).”

    From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [130]

    The Results and Discussion report similar long-term dietary adherence in screen-detected and clinically diagnosed coeliac disease patients. They do not compare adherence in patients with versus without type 1 diabetes, and they do not report remission rates for those groups. The Discussion says a gluten-free diet is necessary for remission, but that does not establish the claimed similarity in remission. (LLM, conf=0.84)

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Authors
Kivelä, L., Popp, A., Arvola, T., Huhtala, H., Kaukinen, K., & Kurppa, K.
Affiliations
  • Tampere University Hospital (FI)
  • Carol Davila University of Medicine and Pharmacy (RO)
  • Kanta-Hämeen Keskussairaala (FI)
  • Tampere University (FI)
Corresponding author
Kurppa, Kalle
Venue
United European Gastroenterology Journal
Publisher
Wiley
Published
2018-08
Volume
6
Issue
7
Pages
1022-1031
ISSN
  • 2050-6406 (ISSN-L)
  • 2050-6414
OpenAlex
W2804470574
Cited by
36
References
35
Citations by year
2026: 3 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 2 · 2018: 3
FWCI
4.76
Type
journal article
Language
en
Open access
Locations
  • United European Gastroenterology Journal (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Tampere University Institutional Repository (Tampere University) (acceptedVersion)
  • Tampere University Institutional Repository (Tampere University) (submittedVersion)
Funders
  • Lastentautien Tutkimussäätiö
  • Maud Kuistilan Muistosäätiö
  • Suomen Lääketieteen Säätiö
  • Yrjö Jahnssonin Säätiö
  • Mary and Georg C. Ehrnrooth Foundation
  • Competitive State Research Financing of the Expert Area of Tampere University Hospital
  • Foundation for Pediatric Research
  • Maire Rossi Foundation
Topics
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Health Sciences › Medicine › Surgery › Eosinophilic Esophagitis
  • Health Sciences › Medicine › Surgery › Gastrointestinal disorders and treatments
Keywords
celiac disease, childhood screening, long-term health effects, quality of life, dietary adherence, anxiety, type 1 diabetes

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