Efficacy of a single, brief alcohol reduction intervention among men and women living with HIV/AIDS and using alcohol in Kampala, Uganda: a randomized trial
Open accessAbstract
We evaluated the efficacy of a brief motivational intervention (MI) counseling in reducing alcohol consumption among persons living with HIV/AIDS in Kampala, Uganda. Persons living with HIV/AIDS with Alcohol Use Disorders Identification Tool (AUDIT) score ≥3 points were randomized to either standardized positive prevention counseling alone or in combination with alcohol brief MI counseling. The mean change in AUDIT-C scores over 6 months was compared by treatment arm. The mean (standard deviation [SD]) AUDIT-C scores were 6.3 (2.3) and 6.8 (2.3) for control and MI arms ( P = .1) at baseline, respectively, and change in mean AUDIT-C score was not statistically different between arms over the 6 months ( P = .8). However, there was a statistically significant decrease in mean AUDIT-C score (−1.10; 95% confidence interval: −2.19 to −0.02, P = .046) among women in the MI arm. There was a nondifferential reduction in alcohol consumption overall, but MI appeared effective among women only. Studies with more than 1 counseling session and evaluation of gender differences in treatment response are needed.
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Some studies found no effect on total ASSIST scores.
“Some studies found no effect on total Alcohol Smoking and Substance Involvement Screening Test (ASSIST) scores [62,68], while others reported a statistically significant reduction in total ASSIST scores [49,69].”
From A scoping review of substance use brief interventions in Africa (2024) · cites this paper as [68]
The Results (Change in alcohol consumption over time; page unavailable) report no significant difference between arms in mean AUDIT-C change over six months. The paper measured AUDIT-C, not total ASSIST scores, so it supports the no-between-arm-difference finding but not the stated outcome measure. (LLM, conf=0.84)
Experimental — accuracy not yet measuredSome studies reported no intervention effect on alcohol use at month 6.
“Other studies reported no intervention effect on alcohol use at month 3 [44], month 5 [58], month 6 [59,64,68] and month 12 [58,64].”
From A scoping review of substance use brief interventions in Africa (2024) · cites this paper as [68]
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Self-citation
- Authors
- Wandera, B., Tumwesigye, N. M., Nankabirwa, J. I., Mafigiri, D. K., Parkes-Ratanshi, R. M., Kapiga, S., Hahn, J., & Sethi, A. K.
- Affiliations
- Infectious Diseases Institute (UG)
- Makerere University (UG)
- London School of Hygiene & Tropical Medicine (GB)
- University of California, San Francisco (US)
- University of Wisconsin–Madison (US)
- Corresponding author
- Wandera, Bonnie
- ORCID
- Venue
- Journal of the International Association of Providers of AIDS Care (JIAPAC)
- Publisher
- SAGE Publications
- Published
- 2016-05-23
- Volume
- 16
- Issue
- 3
- Pages
- 276-285
- ISSN
- 2325-9574 (ISSN-L)
- 2325-9582
- PMC
- PMC5121104
- OpenAlex
- W2397194214
- Semantic Scholar
- 11ce84e9f96f9914b8b634667e436b4fd2578db9
- Cited by
- 61
- References
- 41
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 6 · 2023: 16 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 7 · 2018: 3 · 2017: 3 · 2016: 1
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of the International Association of Providers of AIDS Care (JIAPAC) (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Wellcome Trust (087540)
- Medical Research Council (MR/R00255X/1)
- National Institute on Alcohol Abuse and Alcoholism (K24AA022586)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- alcohol consumption reduction, brief motivational interviewing, HIV/AIDS, people living with HIV, brief alcohol intervention, gender differences, women, AUDIT-C, alcoholism, Kampala, Uganda
- MeSH terms
- Acquired Immunodeficiency Syndrome, Adult, Alcohol Drinking, Counseling, Female, Humans, Male, Middle Aged, Uganda, HIV Infections, Motivational Interviewing
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