Brief Intervention Decreases Drinking Frequency in HIV-Infected, Heavy Drinking Women: Results of a Randomized Controlled Trial

Chander, Geetanjali; Hutton, Heidi E.; Lau, Bryan; Xu, Xiaoqiang; McCaul, Mary E.

doi:10.1097/qai.0000000000000679

Cited by 84Substance Abuse Treatment and OutcomesHIV, Drug Use, Sexual RiskHIV/AIDS Research and Interventions

Brief Intervention Decreases Drinking Frequency in HIV-Infected, Heavy Drinking Women: Results of a Randomized Controlled Trial

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Chander, Geetanjali, Hutton, Heidi E., Lau, Bryan, Xu, Xiaoqiang, McCaul, Mary E.·2015·JAIDS Journal of Acquired Immune Deficiency Syndromes

DOI 10.1097/qai.0000000000000679PMC PMC4634011

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Abstract

OBJECTIVE: Hazardous alcohol use by HIV-infected women is associated with poor HIV outcomes and HIV transmission risk behaviors. We examined the effectiveness of brief alcohol intervention (BI) among hazardous drinking women receiving care in an urban HIV clinic. METHODS: Women were randomized to a 2-session BI or usual care. Outcomes assessed at baseline, 3, 6, and 12 months included 90-day frequency of any alcohol use and heavy/binge drinking (≥4 drinks per occasion), and average drinks per drinking episode. Secondary outcomes included HIV medication and appointment adherence, HIV-1 RNA suppression, and days of unprotected vaginal sex. We examined intervention effectiveness using generalized mixed-effect models and quantile regression. RESULTS: Of 148 eligible women, 74 were randomized to each arm. In mixed-effects models, 90-day drinking frequency decreased among intervention group compared with control, with women in the intervention condition less likely to have a drinking day (odds ratio: 0.42; 95% confidence interval: 0.23 to 0.75). Heavy/binge drinking days and drinks per drinking day did not differ significantly between groups. Quantile regression demonstrated a decrease in drinking frequency in the middle to upper ranges of the distribution of drinking days and heavy/binge drinking days that differed significantly between intervention and control conditions. At follow-up, the intervention group had significantly fewer episodes of unprotected vaginal sex. No intervention effects were observed for other outcomes. CONCLUSIONS: BI reduces frequency of alcohol use and unprotected vaginal sex among HIV-infected women. More intensive services may be needed to lower drinks per drinking day and enhance care for more severely affected drinkers.

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The brief format, low training burden, and significant treatment effects have made Chander et al.'s intervention widely adopted in treating unhealthy alcohol use among people with HIV.
“The brief format, low training burden, and significant treatment effects have made Chander et al.’s [16] intervention widely adopted in treating unhealthy alcohol use among PWH.”
From A Randomized Feasibility/Acceptability Trial of Acceptance and Commitment Therapy for People with HIV Who Drink at Unhealthy Levels. (2026) · cites this paper as [16]
The Methods (Intervention; page unavailable) describe two 20-minute sessions and brief booster calls, and the Discussion (page unavailable) reports a significant reduction in drinking frequency among HIV-infected women. The paper does not establish a low training burden or widespread adoption of the intervention. It also cautions that its results may not generalize to men or other settings. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Of trials conducted in the U.S. with adult samples of people with HIV, only three trials have produced significant effects on alcohol-related outcomes different from the control group at 12-month follow-up.
“Of the trials conducted in the U.S. with adult samples of PWH, only three trials [16–18] have produced significant effects on alcohol-related outcomes that were different from the control group at 12-month follow-up.”
From A Randomized Feasibility/Acceptability Trial of Acceptance and Commitment Therapy for People with HIV Who Drink at Unhealthy Levels. (2026) · cites this paper as [16]
The Results section reports a significant reduction in drinking frequency versus control, and the Assessment Visits section confirms follow-up at 3, 6, and 12 months. But the reported effect comes from a model of the follow-up visits, not a separately reported 12-month comparison. This trial also does not establish that only three U.S. trials met that criterion. (LLM, conf=0.84)
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Additional file 2 of Scaling up a brief alcohol intervention to prevent HIV infection in Vietnam: a cluster randomized, implementation trial
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Authors: Chander, G., Hutton, H. E., Lau, B., Xu, X., & McCaul, M. E.
Affiliations: Johns Hopkins University (US)
Corresponding author: Chander, Geetanjali
Lau, Bryan
ORCID: Chander, Geetanjali
Hutton, Heidi E.
Lau, Bryan
Xu, Xiaoqiang
McCaul, Mary E.
Venue: JAIDS Journal of Acquired Immune Deficiency Syndromes
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2015-10-01
Volume: 70
Issue: 2
Pages: 137-145
ISSN: 1525-4135 (ISSN-L)
DOI: 10.1097/qai.0000000000000679
PMC: PMC4634011
OpenAlex: W259468206
Cited by: 83
References: 37
Citations by year: 2026: 4 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 7 · 2020: 11 · 2019: 11 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 1
FWCI: 7.07
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: JAIDS Journal of Acquired Immune Deficiency Syndromes (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (K23AA015313, U01AA020793, R01AA018632, R01AA014500)
National Institute of Allergy and Infectious Diseases (P30AI094189)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords: brief intervention, alcohol consumption, women living with HIV, heavy drinking, binge drinking, drinking frequency, unprotected vaginal sex, HIV treatment adherence, HIV-1 RNA suppression
MeSH terms: Adult, Alcohol Drinking, Counseling, Female, Humans, Middle Aged, Patient Compliance, Risk Factors, HIV Infections, Odds Ratio, Unsafe Sex

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Brief Intervention Decreases Drinking Frequency in HIV-Infected, Heavy Drinking Women: Results of a Randomized Controlled Trial

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