The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Ameliorative effect of kaempferol, a flavonoid, on oxidative stress in streptozotocin-induced diabetic rats
Open accessAbstract
OBJECTIVE: The aim of the present study was to evaluate the protective effect of kaempferol against oxidative stress in streptozotocin (STZ)-induced diabetic rats. METHODS: Diabetes was induced in male, adult albino rats of the Wistar strain, by intraperitoneal administration of STZ (40 mg/kg body weight (BW)). Kaempferol (100 mg/kg BW) or glibenclamide (600 µg/kg BW) was administered orally once daily for 45 days to normal and STZ-induced diabetic rats. RESULTS: The STZ-induced diabetic rats showed significantly increased levels of plasma glucose, thiobarbituric acid reactive substances, lipid hydroperoxides, and conjugated dienes in plasma, liver, kidney, and heart whereas they showed significantly decreased level of plasma insulin. The levels of non-enzymic antioxidants (vitamin C, vitamin E, reduced glutathione) in plasma, liver, kidney, and heart and the activities of enzymatic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase) in liver, kidney, and heart were significantly decreased in diabetic rats. Administration of kaempferol to diabetic rats was showed brought back in plasma glucose, insulin, lipid peroxidation products, enzymatic, and non-enzymatic antioxidants to near normal. CONCLUSION: The present study indicates that kaempferol has a good antioxidant property, as evidenced by its increase of antioxidant status and decrease of lipid peroxidation markers, thus providing protection from the risks of diabetic complications.
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Oxidative stress and diabetic complications
Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461
Genet, S., Kale, R. K., & Baquer, N. Z. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1016103131408 · Cited by 258
Ramesh, B., Karuna, R., Sreenivasa, R. S., Haritha, K., Sai, M. D., Sasis, B. R. B., & Saralakumari, D. (2012) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(12)60249-4 · Cited by 85
Cited by
Antidiabetic Properties of Dietary Flavonoids: A Cellular Mechanism Review
Vinayagam, R., & Xu, B. (2015) · Nutrition & Metabolism · doi:10.1186/s12986-015-0057-7 · Cited by 597
Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids
Kawser Hossain, M., Abdal Dayem, A., Han, J., Yin, Y., Kim, K., Kumar Saha, S., Yang, G.-M., Choi, H., & Cho, S.-G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040569 · Cited by 495
Chemo‐preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
Imran, M., Rauf, A., Shah, Z. A., Saeed, F., Imran, A., Arshad, M. U., Ahmad, B., Bawazeer, S., Atif, M., Peters, D. G., et al. (2019) · Phytotherapy Research · doi:10.1002/ptr.6227 · Cited by 339
Antioxidant Phytochemicals as Potential Therapy for Diabetic Complications
Akpoveso, O.-O. P., Ubah, E. E., & Obasanmi, G. (2023) · Antioxidants · doi:10.3390/antiox12010123 · Cited by 90
Therapeutic Potentials of Microalgae and Their Bioactive Compounds on Diabetes Mellitus
Tamel Selvan, K., Goon, J. A., Makpol, S., & Tan, J. K. (2023) · Marine Drugs · doi:10.3390/md21090462 · Cited by 32
Metadata
- Authors
- Al-Numair, K. S., Chandramohan, G., Veeramani, C., & Alsaif, M. A.
- Venue
- Redox Report
- Publisher
- Informa UK Limited
- Published
- 2014-12-12
- Volume
- 20
- Issue
- 5
- Pages
- 198-209
- ISSN
- 1351-0002 (ISSN-L)
- 1743-2928
- OpenAlex
- W1968064903
- Cited by
- 193
- References
- 3
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Al-Numair, K. S., Chandramohan, G., Veeramani, C., & Alsaif, M. A. (2015). Ameliorative effect of kaempferol, a flavonoid, on oxidative stress in streptozotocin-induced diabetic rats. Redox Report. https://doi.org/10.1179/1351000214y.0000000117
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