Cited by 90Natural Antidiabetic Agents StudiesPhytochemicals and Antioxidant ActivitiesNitric Oxide and Endothelin Effects

Antioxidant Phytochemicals as Potential Therapy for Diabetic Complications

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Akpoveso, Oke-Oghene Philomena, Ubah, Emeka Emmanuel, Obasanmi, Gideon·2023·Antioxidants

Abstract

The global prevalence of diabetes continues to increase partly due to rapid urbanization and an increase in the aging population. Consequently, this is associated with a parallel increase in the prevalence of diabetic vascular complications which significantly worsen the burden of diabetes. For these diabetic vascular complications, there is still an unmet need for safe and effective alternative/adjuvant therapeutic interventions. There is also an increasing urge for therapeutic options to come from natural products such as plants. Hyperglycemia-induced oxidative stress is central to the development of diabetes and diabetic complications. Furthermore, oxidative stress-induced inflammation and insulin resistance are central to endothelial damage and the progression of diabetic complications. Human and animal studies have shown that polyphenols could reduce oxidative stress, hyperglycemia, and prevent diabetic complications including diabetic retinopathy, diabetic nephropathy, and diabetic peripheral neuropathy. Part of the therapeutic effects of polyphenols is attributed to their modulatory effect on endogenous antioxidant systems. This review attempts to summarize the established effects of polyphenols on endogenous antioxidant systems from the literature. Moreover, potential therapeutic strategies for harnessing the potential benefits of polyphenols for diabetic vascular complications are also discussed.

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Crossref · 10.3390/antiox12010123

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  • Chronic hyperglycemia results in suppressed activity of mTOR associated with AMPK-induced increase in ROS formation and enhanced expression of TXNIP.

    “Chronic hyperglycemia results in the suppressed activity of mTOR associated with AMP-activated protein kinase-induced increase in ROS formation and enhanced expression of thioredoxin interacting protein (TXNIP) a potential sensor of glucose and oxidative stress (Akpoveso et al. 2023).”

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  1. [13]Bharadwaj K.C. Gupta T. Singh R.M. Chapter 9—Alkaloid Group of Cinchona Officinalis: Structural, Synthetic, and Medicinal Aspects Synthesis of Medicinal Agents from Plants Tewari A. Tiwari S. Elsevier Amsterdam, The Netherlands 2018 205 227 978-0-08-102071-5

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Authors
Akpoveso, O.-O. P., Ubah, E. E., & Obasanmi, G.
Affiliations
  • School of Basic Sciences, All American Institute of Medical Sciences, Black River, Saint Elizabeth Parish JMDEH03, Jamaica
  • Michael Okpara University of Agriculture (NG)
  • University of British Columbia (CA)
Corresponding author
  • Akpoveso, Oke-Oghene Philomena
  • Obasanmi, Gideon
Venue
Antioxidants
Publisher
MDPI AG
Published
2023-01-04
Volume
12
Issue
1
Pages
123
ISSN
2076-3921 (ISSN-L)
OpenAlex
W4313494619
Cited by
90
References
254
Citations by year
2026: 18 · 2025: 30 · 2024: 28 · 2023: 14
FWCI
3.23
Type
journal article
Language
en
Open access
Locations
  • Antioxidants (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • cIRcle (University of British Columbia) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Open Collections
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
polyphenols, antioxidant phytochemicals, diabetic vascular complications, oxidative stress, hyperglycemia, insulin resistance, endothelial injury, diabetic retinopathy, diabetic nephropathy, diabetic peripheral neuropathy, endogenous antioxidant system, natural products, plant-derived drugs

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