The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Activation of influenza virus–specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunity
Open accessAbstract
Plasmacytoid dendritic cells (pDCs) contribute to innate antiviral immune responses by producing type I interferons (IFNs) upon exposure to enveloped viruses. However, their role in adaptive immune responses, such as the initiation of antiviral T-cell responses, is not known. In this study, we examined interactions between blood pDCs and influenza virus with special attention to the capacity of pDCs to activate influenza-specific T cells. pDCs were compared with CD11c+ DCs, the most potent antigen-presenting cells (APCs), for their capacity to activate T-cell responses. We found that like CD11c+ DCs, pDCs mature following exposure to influenza virus, express CCR7, and produce proinflammatory chemokines, but differ in that they produce type I IFN and are resistant to the cytopathic effect of the infection. After influenza virus exposure, both DC types exhibited an equivalent efficiency to expand anti–influenza virus cytotoxic T lymphocytes (CTLs) and T helper 1 (TH1) CD4+ T cells. Our results pinpoint a new role of pDCs in the induction of antiviral T-cell responses and suggest that these DCs play a prominent role in the adaptive immune response against viruses.
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Cites
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Self-citationReciprocal Control of T Helper Cell and Dendritic Cell Differentiation
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Self-citationMouse type I IFN-producing cells are immature APCs with plasmacytoid morphology
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Mapping the human DC lineage through the integration of high-dimensional techniques
See, P., Dutertre, C.-A., Chen, J., Günther, P., McGovern, N., Irac, S. E., Gunawan, M., Beyer, M., Händler, K., Duan, K., et al. (2017) · Science · doi:10.1126/science.aag3009 · Cited by 574
Regulation of immunological homeostasis in the respiratory tract
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Critical review on the presence of phthalates in food and evidence of their biological impact
Giuliani, A., Zuccarini, M., Cichelli, A., Khan, H., & Reale, M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17165655 · Cited by 420
Metadata
- Authors
- Fonteneau, J.-F., Gilliet, M., Larsson, M., Dasilva, I., Münz, C., Liu, Y.-J., & Bhardwaj, N.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2003-05-01
- Volume
- 101
- Issue
- 9
- Pages
- 3520-3526
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2137594178
- Cited by
- 346
- References
- 32
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fonteneau, J.-F., Gilliet, M., Larsson, M., Dasilva, I., Münz, C., Liu, Y.-J., & Bhardwaj, N. (2003). Activation of influenza virus–specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunity. Blood. https://doi.org/10.1182/blood-2002-10-3063
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