The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
Abstract
Toll-like receptors (TLRs) are pattern recognition receptors that trigger innate immunity. In this study we investigated the expression of 10 TLRs in human naive and memory B-cell subsets. We report that in human naive B cells most TLRs are expressed at low to undetectable levels, but the expression of TLR9 and TLR10 is rapidly induced following B-cell-receptor (BCR) triggering. In contrast, memory B cells express several TLRs at constitutively high levels. The differential expression of TLR9 correlates with responsiveness to its agonist, CpG DNA. Thus, human memory B cells proliferate and differentiate to immunoglobulin (Ig)–secreting cells in response to CpG, while naive B do so only if simultaneously triggered through the BCR. The BCR-induced expression of TLRs in human naive B cells prevents polyclonal activation in a primary response, because it restricts stimulation to antigen-specific B cells. In contrast, the constitutive expression of TLRs in memory B cells allows polyclonal activation of the entire memory pool. Thus, in human B cells TLRs are downstream of BCR and play a role both in the primary response and in the memory phase.
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Cites
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
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Toll-like receptors: critical proteins linking innate and acquired immunity
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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
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Metadata
- Authors
- Bernasconi, N. L., Onai, N., & Lanzavecchia, A.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2003-06-01
- Volume
- 101
- Issue
- 11
- Pages
- 4500-4504
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2005634587
- Cited by
- 667
- References
- 36
- FWCI
- 12.69
- Type
- journal article
- Language
- en
- Open access
- closed
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