The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells
Open accessAbstract
The present study was designed to investigate the expression of members of the toll-like receptor (TLR) family in human B cells. High-density, resting, and low-density activated tonsillar B cells expressed TLR9 and TLR10 mRNA transcripts at the highest levels. Expression was higher in activated B cells than in resting cells. Analysis of a range of resting and activated human leukocyte populations revealed that mRNA expression of TLR10 was restricted to B cells. Stimulation of resting B cells with anti-μ and anti-CD40 antibodies or with Staphylococcus aureus Cowan I bacteria (SAC) increased expression of TLR9 and TLR10. TLR1 and TLR4 expression were not significantly induced by B-cell activation. Interestingly, a CpG oligonucleotide, a TLR9 agonist, also stimulated TLR9 expression in B cells. Exposure to anti-μ antibodies augmented TLR9 expression, concomitantly and dramatically increasing the responsiveness of B cells to CpG oligonucleotides in terms of proliferation and chemokine (CC chemokine ligand 3 [CCL3] and CCL22) production. Epstein-Barr virus (EBV)–transformed cell lines and other cell lines representative of mature B-cell neoplasias (Burkitt lymphoma, follicular lymphoma, multiple myeloma) expressed TLR9 and/or TLR10, whereas pre-B cell lines were negative. These results show that normal and neoplastic human B lymphocytes express a distinct TLR repertoire including TLR9 and TLR10 and that expression is increased upon engagement of the antigen receptor complex or TLR9 itself. Regulated expression of selected TLRs in B cells is likely to play an important role in linking innate and adaptive immune responses in normal and pathologic conditions.
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Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
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Self-citationA Toll-like receptor recognizes bacterial DNA
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Self-citationToll-like receptors: critical proteins linking innate and acquired immunity
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Cited by
Hasan, U., Chaffois, C., Gaillard, C., Saulnier, V., Merck, E., Tancredi, S., Guiet, C., Brière, F., Vlach, J., Lebecque, S., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.2942 · Cited by 435
Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity
Suurmond, J., & Diamond, B. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78084 · Cited by 337
Toll-like receptors regulate B cell cytokine production in patients with diabetes
Jagannathan, M., McDonnell, M., Liang, Y., Hasturk, H., Hetzel, J., Rubin, D., Kantarci, A., Van Dyke, T. E., Ganley-Leal, L. M., & Nikolajczyk, B. S. (2010) · Diabetologia · doi:10.1007/s00125-010-1730-z · Cited by 156
Lampropoulou, V., Calderon‐Gomez, E., Roch, T., Neves, P., Shen, P., Stervbo, U., Boudinot, P., Anderton, S. M., & Fillatreau, S. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00855.x · Cited by 130
Concanavalin A induced expression of Toll-like receptors in murine peritoneal macrophages in vitro
Sodhi, A., Tarang, S., & Kesherwani, V. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2006.11.014 · Cited by 67
Metadata
- Authors
- Bourke, E., Bosisio, D., Golay, J., Polentarutti, N., & Mantovani, A.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2003-08-01
- Volume
- 102
- Issue
- 3
- Pages
- 956-963
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2065694999
- Cited by
- 384
- References
- 49
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bourke, E., Bosisio, D., Golay, J., Polentarutti, N., & Mantovani, A. (2003). The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells. Blood. https://doi.org/10.1182/blood-2002-11-3355
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