JAK-STAT Signaling in Stem Cells

Prospective identification of tumorigenic breast cancer cells

Al‐Hajj, M., Wicha, M. S., Benito‐Hernández, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,388 · see citing works

Identification of human brain tumour initiating cells

Singh, S. K., Hawkins, C. E., Clarke, I. D., Squire, J. A., Bayani, J., Hide, T., Henkelman, R. M., Cusimano, M. D., & Dirks, P. B. (2004) · Nature · doi:10.1038/nature03128 · Cited by 7,388 · see citing works

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

Lapidot, T., Sirard, C., Vormoor, J., Murdoch, B., Hoang, T., Caceres-Cortes, J., Minden, M., Paterson, B., Caligiuri, M. A., & Dick, J. E. (1994) · Nature · doi:10.1038/367645a0 · Cited by 4,783 · see citing works

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

James, C., Ugo, V., Couedic, J. P. L., Staerk, J., Delhommeau, F., Lacout, C., Garçon, L., Raslová, H., Berger, R., Griscelli, A. B., et al. (2005) · Nature · doi:10.1038/nature03546 · Cited by 3,542 · see citing works

A Gain-of-Function Mutation of <i>JAK2</i> in Myeloproliferative Disorders

Kralovics, R., Passamonti, F., Buser, A. S., Teo, S.-S., Tiedt, R., Passweg, J. R., Tichelli, A., Cazzola, M., & Skoda, R. C. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051113 · Cited by 3,470 · see citing works

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

Levine, R. L., Wadleigh, M., Cools, J., Ebert, B. L., Wernig, G., Huntly, B. J. P., Boggon, T. J., Wlodarska, I., Clark, J. J., Moore, S., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.03.023 · Cited by 2,993 · see citing works

Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma

Galli, R., Binda, E., Orfanelli, U., Cipelletti, B., Gritti, A., Vitis, S. D., Fiocco, R., Foroni, C., DiMeco, F., & Vescovi, A. L. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1364 · Cited by 2,570 · see citing works

The Glial Nature of Embryonic and Adult Neural Stem Cells

Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475 · see citing works

The relationship between the spleen colony-forming cell and the haemopoietic stem cell.

Schofield, R. (1978) · PubMed · Cited by 2,319 · see citing works

The JAK/STAT signaling pathway

Rawlings, J. S., Rosler, K. M., & Harrison, D. A. (2004) · Journal of Cell Science · doi:10.1242/jcs.00963 · Cited by 1,858 · see citing works

"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells

Ramalho‐Santos, M., Yoon, S., Matsuzaki, Y., Mulligan, R. C., & Melton, D. A. (2002) · Science · doi:10.1126/science.1072530 · Cited by 1,711 · see citing works

Identification of cells initiating human melanomas

Schatton, T., Murphy, G. F., Frank, N. Y., Yamaura, K., Waaga-Gasser, A. M., Gasser, M., Zhan, Q., Jordan, S., Duncan, L. M., Weishaupt, C., et al. (2008) · Nature · doi:10.1038/nature06489 · Cited by 1,408 · see citing works

IFNα activates dormant haematopoietic stem cells in vivo

Essers, M. A. G., Offner, S., Blanco-Bose, W. E., Waibler, Z., Kalinke, U., Duchosal, M. A., & Trumpp, A. (2009) · Nature · doi:10.1038/nature07815 · Cited by 1,368 · see citing works

JAK-STAT Signaling: From Interferons to Cytokines

Schindler, C., Levy, D. E., & Decker, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r700016200 · Cited by 1,263 · see citing works

Editorial: Some Speculations on the Myeloproliferative Syndromes

Dameshek, W. (1951) · Blood · doi:10.1182/blood.v6.4.372.372 · Cited by 1,089 · see citing works

Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway.

Bonni, A., Sun, Y., Nadal-Vicens, M., Bhatt, A. S., Frank, D., Rozovsky, I., Stahl, N., Yancopouloš, G., & Greenberg, M. (1997) · Science · doi:10.1126/science.278.5337.477 · Cited by 1,050 · see citing works

Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut

Jiang, H., Patel, P. H., Kohlmaier, A., Grenley, M. O., McEwen, D. G., & Edgar, B. A. (2009) · Cell · doi:10.1016/j.cell.2009.05.014 · Cited by 1,017 · see citing works

Cancer stem cells: mirage or reality?

Gupta, P. B., Chaffer, C. L., & Weinberg, R. A. (2009) · Nature Medicine · doi:10.1038/nm0909-1010 · Cited by 982 · see citing works

Hematopoietic stem cell: self‐renewal versus differentiation

Seita, J., & Weissman, I. L. (2010) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.86 · Cited by 925 · see citing works

Synergistic Signaling in Fetal Brain by STAT3-Smad1 Complex Bridged by p300

Nakashima, K., Yanagisawa, M., Arakawa, H., Kimura, N., Hisatsune, T., Kawabata, M., Miyazono, K., & Taga, T. (1999) · Science · doi:10.1126/science.284.5413.479 · Cited by 867 · see citing works

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

Shuai, K., Stark, G. R., Kerr, L. M., & Darnell, J. E. (1993) · Science · doi:10.1126/science.7690989 · Cited by 802 · see citing works

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in DrosophilaPreprint

Buchon, N., Broderick, N. A., Chakrabarti, S., & Lemaître, B. (2009) · Genes & Development · doi:10.1101/gad.1827009 · Cited by 722 · see citing works

Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue

Kiger, A. A., Jones, D. L., Schulz, C., Rogers, M. B., & Fuller, M. T. (2001) · Science · doi:10.1126/science.1066707 · Cited by 698 · see citing works

Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance

Zhou, J., Wulfkuhle, J. D., Zhang, H., Gu, P., Yang, Y., Deng, J., Margolick, J. B., Liotta, L. A., Petricoin, E., & Zhang, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702596104 · Cited by 696 · see citing works

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

Müller, M., Briscoe, J., Laxton, C., Guschin, D., Ziemiecki, A., Silvennoinen, O., Harpur, A., Barbieri, G., Witthuhn, B., Schindler, C., et al. (1993) · Nature · doi:10.1038/366129a0 · Cited by 680 · see citing works

Control of Stem Cell Self-Renewal in Drosophila Spermatogenesis by JAK-STAT Signaling

Tulina, N. M., & Matunis, E. L. (2001) · Science · doi:10.1126/science.1066700 · Cited by 653 · see citing works

Multipotent Drosophila Intestinal Stem Cells Specify Daughter Cell Fates by Differential Notch Signaling

Ohlstein, B., & Spradling, A. C. (2007) · Science · doi:10.1126/science.1136606 · Cited by 651 · see citing works

Polycythemia Vera: Stem-Cell and Probable Clonal Origin of the Disease

Adamson, J. W., Fialkow, P. J., Murphy, S., Prchal, J. F., & Steinmann, L. (1976) · New England Journal of Medicine · doi:10.1056/nejm197610212951702 · Cited by 637 · see citing works

Timing Is Everything: Making Neurons versus Glia in the Developing Cortex

Miller, F. D., & Gauthier, A. S. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.019 · Cited by 588 · see citing works

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway

Watling, D., Guschin, D. Y., Müller, M. M., Silvennoinen, O., Witthuhn, B. A., Quelle, F. W., Rogers, N. C., Schindler, C., Stark, G. R., Ihle, J. N., et al. (1993) · Nature · doi:10.1038/366166a0 · Cited by 533 · see citing works

Two Novel Protein-Tyrosine Kinases, Each with a Second Phosphotransferase-Related Catalytic Domain, Define a New Class of Protein Kinase

Wilks, A. F., Harpur, A. G., Kurban, R. R., Ralph, S. J., Zürcher, G., & Ziemiecki, A. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.4.2057 · Cited by 528 · see citing works

TGF-β Increases Glioma-Initiating Cell Self-Renewal through the Induction of LIF in Human Glioblastoma

Peñuelas, S., Anido, J., Prieto-Sánchez, R. M., Folch, G., Barba, I., Cuartas, I., David Garcia-dorado, A., Poca, M. A., Sahuquillo, J., Baselga, J. M., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.02.011 · Cited by 527 · see citing works

Cancer stem cell niche: the place to be

Borovski, T., De Sousa E Melo, F., Vermeulen, L., & Medema, J. P. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3220 · Cited by 518 · see citing works

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

Shuai, K., Ziemiecki, A., Wilks, A. F., Harpur, A. G., Sadowski, H. B., Gilman, M. Z., & Darnell, J. E., Jr. (1993) · Nature · doi:10.1038/366580a0 · Cited by 509 · see citing works

Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury.

Agaisse, H., Petersen, U., Boutros, M., Mathey-Prevot, B., & Perrimon, N. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00244-2 · Cited by 498 · see citing works

STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells

Sherry, M. M., Reeves, A., Wu, J. K., & Cochran, B. H. (2009) · Stem Cells · doi:10.1002/stem.185 · Cited by 478 · see citing works

Functional Hierarchy and Reversibility Within the Murine Spermatogenic Stem Cell Compartment

Nakagawa, T., Sharma, M., Nabeshima, Y., Braun, R. E., & Yoshida, S. (2010) · Science · doi:10.1126/science.1182868 · Cited by 473 · see citing works

Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.

Harrison, D. A., Binari, R. C., Nahreini, T. S., Gilman, M. Z., & Perrimon, N. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07285.x · Cited by 469 · see citing works

Dpp Signaling Silences bam Transcription Directly to Establish Asymmetric Divisions of Germline Stem Cells

Chen, D., & McKearin, D. (2003) · Current Biology · doi:10.1016/j.cub.2003.09.033 · Cited by 438 · see citing works

Epigenetic-Mediated Dysfunction of the Bone Morphogenetic Protein Pathway Inhibits Differentiation of Glioblastoma-Initiating Cells

Lee, J., Son, M. J., Woolard, K., Donin, N. M., Li, A., Cheng, C. H., Kotliarova, S. E., Kotliarov, Y., Walling, J., Ahn, S. J., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2007.12.005 · Cited by 429 · see citing works

Hes binding to STAT3 mediates crosstalk between Notch and JAK–STAT signalling

Kamakura, S., Oishi, K., Yoshimatsu, T., Nakafuku, M., Masuyama, N., & Gotoh, Y. (2004) · Nature Cell Biology · doi:10.1038/ncb1138 · Cited by 424 · see citing works

Awakening dormant haematopoietic stem cells

Trumpp, A., Essers, M. A. G., & Wilson, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2726 · Cited by 420 · see citing works

DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling

Fan, G., Martinowich, K., Chin, M. H., He, F., Fouse, S. D., Hutnick, L. K., Hattori, D., Ge, W., Shen, Y., Wu, H., et al. (2005) · Development · doi:10.1242/dev.01912 · Cited by 420 · see citing works

Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene,bag of marbles, in germline stem cells in theDrosophilaovary

Song, X., Wong, M. D., Kawase, E., Xi, R., Ding, B. C., McCarthy, J. J., & Xie, T. (2004) · Development · doi:10.1242/dev.01026 · Cited by 415 · see citing works

Regeneration of Male Germline Stem Cells by Spermatogonial Dedifferentiation in Vivo

Brawley, C. M., & Matunis, E. L. (2004) · Science · doi:10.1126/science.1097676 · Cited by 402 · see citing works

A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis

He, F., Ge, W., Martinowich, K., Becker-Catania, S. G., Coskun, V., Zhu, W., Wu, H., Castro, D. S., Guillemot, F., Fan, G., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1440 · Cited by 398 · see citing works

JAK/STAT signalling inDrosophila: insights into conserved regulatory and cellular functions

Arbouzova, N. I., & Zeidler, M. P. (2006) · Development · doi:10.1242/dev.02411 · Cited by 397 · see citing works

Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathwayPreprint

Harrison, D. A., Mccoon, P. E., Binari, R. C., Gilman, M. Z., & Perrimon, N. (1998) · Genes & Development · doi:10.1101/gad.12.20.3252 · Cited by 386 · see citing works

marelle Acts Downstream of the Drosophila HOP/JAK Kinase and Encodes a Protein Similar to the Mammalian STATs

Hou, X. S., Melnick, M. B., & Perrimon, N. (1996) · Cell · doi:10.1016/s0092-8674(00)81286-6 · Cited by 374 · see citing works

Evidence that Embryonic Neurons Regulate the Onset of Cortical Gliogenesis via Cardiotrophin-1

Barnabé‐Heider, F., Wasylnka, J. A., Fernandes, K. J. L., Porsche, C., Sendtner, M., Kaplan, D. R., & Miller, F. D. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.037 · Cited by 362 · see citing works

Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless

Brown, S., Hu, N., & Hombría, J. C. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00524-3 · Cited by 351 · see citing works

Gbb/Bmp signaling is essential for maintaining germline stem cells and for repressingbamtranscription in theDrosophilatestis

Kawase, E., Wong, M. D., Ding, B. C., & Xie, T. (2004) · Development · doi:10.1242/dev.01025 · Cited by 350 · see citing works

Dynamic niches in the origination and differentiation of haematopoietic stem cells

Wang, L. D., & Wagers, A. J. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3184 · Cited by 343 · see citing works

Inflammatory signals regulate hematopoietic stem cells

Baldridge, M. T., King, K., & Goodell, M. (2011) · Trends in immunology · doi:10.1016/j.it.2010.12.003 · Cited by 337 · see citing works

Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre

Krzemień, J., Dubois, L., Makki, R., Meister, M. F., Vincent, A., & Crozatier, M. (2007) · Nature · doi:10.1038/nature05650 · Cited by 331 · see citing works

Untitled work

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Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila.Preprint

Binari, R. C., & Perrimon, N. (1994) · Genes & Development · doi:10.1101/gad.8.3.300 · Cited by 319 · see citing works

Zfh-1 Controls Somatic Stem Cell Self-Renewal in the Drosophila Testis and Nonautonomously Influences Germline Stem Cell Self-Renewal

Leatherman, J. L., & DiNardo, S. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.05.001 · Cited by 316 · see citing works

Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways

Ren, F., Wang, B., Yue, T., Yun, E.-Y., Ip, Y. T., & Jiang, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012759107 · Cited by 316 · see citing works

The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration

Karpowicz, P. A., Perez, J. N., & Perrimon, N. (2010) · Development · doi:10.1242/dev.060483 · Cited by 314 · see citing works

A Hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors

Mandal, L., Martínez-Agosto, J. A., Evans, C. J., Hartenstein, V., & Banerjee, U. K. (2007) · Nature · doi:10.1038/nature05585 · Cited by 310 · see citing works

The Hippo pathway regulates intestinal stem cell proliferation duringDrosophilaadult midgut regeneration

Shaw, R. L., Kohlmaier, A., Polesello, C., Veelken, C., Edgar, B. A., & Tapon, N. (2010) · Development · doi:10.1242/dev.052506 · Cited by 307 · see citing works

The germinal proliferation center in the testis of Drosophila melanogaster

Hardy, R. W., Tokuyasu, K. T., Lindsley, D. L., & Garavito, M. (1979) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(79)90108-4 · Cited by 305 · see citing works

Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera

Královics, R., Guan, Y., & Prchal, J. T. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(01)00789-5 · Cited by 300 · see citing works

Janus kinase inhibitors for the treatment of myeloproliferative neoplasias and beyond

Quintás‐Cardama, A., Kantarjian, H. M., Cortes, J. E., & Verstovšek, S. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3264 · Cited by 292 · see citing works

Canonical and non-canonical JAK–STAT signaling

Li, W. X. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.08.008 · Cited by 290 · see citing works

Germline self-renewal requires cyst stem cells and stat regulates niche adhesion in Drosophila testes

Leatherman, J. L., & DiNardo, S. (2010) · Nature Cell Biology · doi:10.1038/ncb2086 · Cited by 283 · see citing works

hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila

Forbes, A. J., Lin, H., Ingham, P. W., & Spradling, A. C. (1996) · Development · doi:10.1242/dev.122.4.1125 · Cited by 278 · see citing works

Decline in Self-Renewal Factors Contributes to Aging of the Stem Cell Niche in the Drosophila Testis

Boyle, M., Wong, C., Rocha, M., & Jones, D. L. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.002 · Cited by 268 · see citing works

Warts and Yorkie Mediate Intestinal Regeneration by Influencing Stem Cell Proliferation

Kucuk, B., & Irvine, K. D. (2010) · Current Biology · doi:10.1016/j.cub.2010.07.041 · Cited by 266 · see citing works

The stem cell niche: lessons from the Drosophila testis

de Cuevas, M., & Matunis, E. L. (2011) · Development · doi:10.1242/dev.056242 · Cited by 263 · see citing works

Regulation of Stem Cell Maintenance and Transit Amplifying Cell Proliferation by TGF-β Signaling in Drosophila Spermatogenesis

Shivdasani, A. A., & Ingham, P. W. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.063 · Cited by 232 · see citing works

JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage

Beebe, K., Lee, W.-C., & Micchelli, C. A. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.045 · Cited by 228 · see citing works

Radial glia and neural stem cells

Malatesta, P., Appolloni, I., & Calzolari, F. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0481-8 · Cited by 225 · see citing works

The role of STATs in myeloid differentiation and leukemia

Coffer, P. J., Koenderman, L., & de Groot, R. P. (2000) · Oncogene · doi:10.1038/sj.onc.1203479 · Cited by 223 · see citing works

Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions

Birnie, R., Bryce, S. D., Roome, C., Dussupt, V., Droop, A., Lang, S., Berry, P. A., Hyde, C. F., Lewis, J. L., Stower, M. J., et al. (2008) · Genome biology · doi:10.1186/gb-2008-9-5-r83 · Cited by 212 · see citing works

Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocols.

Angelis, P. M. D., Kravik, K., Tunheim, S. H., Haug, T., & Reichelt, W. H. (2004) · Molecular Cancer · doi:10.1186/1476-4598-3-11 · Cited by 205 · see citing works

SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies

Hart, S., Goh, K. C., Novotny‐Diermayr, V., Hu, C. Y., Hentze, H., Tan, Y., Madan, B., Amalini, C., Loh, Y. K., Ong, L. C., et al. (2011) · Leukemia · doi:10.1038/leu.2011.148 · Cited by 204 · see citing works

Intestinal stem cells in the adult Drosophila midgut

Jiang, H., & Edgar, B. A. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.07.020 · Cited by 198 · see citing works

Quantification of Self-Renewal Capacity in Single Hematopoietic Stem Cells from Normal and Lnk-Deficient Mice

Ema, H., Sudo, K., Seita, J., Matsubara, A., Morita, Y., Osawa, M., Takatsu, K., Τακακι, S., & Nakauchi, H. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.019 · Cited by 197 · see citing works

chinmo Is a Functional Effector of the JAK/STAT Pathway that Regulates Eye Development, Tumor Formation, and Stem Cell Self-Renewal in Drosophila

Flaherty, M. S., Salis, P., Evans, C. J., Ekas, L. A., Marouf, A., Zavadil, J., Banerjee, U. K., & Bach, E. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.02.006 · Cited by 195 · see citing works

Drosophila haematopoiesis

Crozatier, M., & Meister, M. F. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.00930.x · Cited by 195 · see citing works

A Misexpression Screen Reveals Effects of bag-of-marbles and TGFβ Class Signaling on the Drosophila Male Germ-Line Stem Cell Lineage

Schulz, C., Kiger, A. A., Tazuke, S. I., Yamashita, Y. M., Pantalena-Filho, L. C., Jones, D. L., Wood, C. G., & Fuller, M. T. (2004) · Genetics · doi:10.1534/genetics.103.023184 · Cited by 186 · see citing works

Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2

Bersenev, A., Wu, C., Balcerek, J., & Tong, W. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35808 · Cited by 183 · see citing works

Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival

Beneklı, M., Xia, Z., Donohue, K. A., Ford, L. A., Pixley, L. A., Baer, M. R., Baumann, H., & Wetzler, M. (2002) · Blood · doi:10.1182/blood.v99.1.252 · Cited by 180 · see citing works

The Adult Drosophila Malpighian Tubules Are Maintained by Multipotent Stem Cells

Singh, S. R., Liu, W., & Hou, S. X. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.07.003 · Cited by 178 · see citing works

Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis

Kato, Y., Iwama, A., Tadokoro, Y., Shimoda, K., Minoguchi, M., Akira, S., Tanaka, M., Miyajima, A., Kitamura, T., & Nakauchi, H. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042541 · Cited by 178 · see citing works

Regulation of self-renewal and differentiation by the intestinal stem cell niche

Yeung, T. M., Chia, L. A., Kosinski, C., & Kuo, C. J. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0687-5 · Cited by 177 · see citing works

JAK-STAT Signal Inhibition Regulates Competition in the Drosophila Testis Stem Cell Niche

Issigonis, M., Tulina, N. M., de Cuevas, M., Brawley, C. M., Sandler, L., & Matunis, E. L. (2009) · Science · doi:10.1126/science.1176817 · Cited by 172 · see citing works

Multiple signaling pathways are involved in erythropoietin-independent differentiation of erythroid progenitors in polycythemia vera

Ugo, V., Marzac, C., Teyssandier, I., Larbret, F., Lécluse, Y., Debili, N., Vainchenker, W., & Casadevall, N. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2003.11.003 · Cited by 166 · see citing works

Hematopoietic progenitors and hemocyte lineages in the Drosophila lymph gland

Krzemień, J., Oyallon, J., Crozatier, M., & Vincent, A. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.08.003 · Cited by 165 · see citing works

Deregulation of a STAT3-Interleukin 8 Signaling Pathway Promotes Human Glioblastoma Cell Proliferation and Invasiveness

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Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis

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