Cited by 216Hematopoietic Stem Cell TransplantationT-cell and B-cell ImmunologyDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.

Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells

Open access

Rossi, Simona W., Jeker, Lukas T., Ueno, Tomoo, Kuse, Sachiyo, Keller, Marcel P., Zuklys, Saulius, Gudkov, Andrei V., Takahama, Yousuke, Krenger, Werner, Blazar, Bruce R., Holländer, Georg A.·2007·Blood

DOI 10.1182/blood-2006-10-049767PMC PMC1874572

Open this paper in CoChat — free account Open PDF

Abstract

The systemic administration of keratinocyte growth factor (KGF) enhances T-cell lymphopoiesis in normal mice and mice that received a bone marrow transplant. KGF exerts protection to thymic stromal cells from cytoablative conditioning and graft-versus-host disease–induced injury. However, little is known regarding KGF's molecular and cellular mechanisms of action on thymic stromal cells. Here, we report that KGF induces in vivo a transient expansion of both mature and immature thymic epithelial cells (TECs) and promotes the differentiation of the latter type of cells. The increased TEC numbers return within 2 weeks to normal values and the microenvironment displays a normal architectural organization. Stromal changes initiate an expansion of immature thymocytes and permit regular T-cell development at an increased rate and for an extended period of time. KGF signaling in TECs activates both the p53 and NF-κB pathways and results in the transcription of several target genes necessary for TEC function and T-cell development, including bone morphogenetic protein 2 (BMP2), BMP4, Wnt5b, and Wnt10b. Signaling via the canonical BMP pathway is critical for the KGF effects. Taken together, these data provide new insights into the mechanism(s) of action of exogenous KGF on TEC function and thymopoiesis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1182/blood-2006-10-049767

Cites

78 of 78 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The p53 pathway: positive and negative feedback loops
Harris, S. L., & Levine, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208615 · Cited by 1,967
Cellular signaling by fibroblast growth factor receptors
Eswarakumar, V. P., Lax, I., & Schlessinger, J. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.01.001 · Cited by 1,923
Bone Morphogenetic Proteins
Chen, D., Zhao, M., & Mundy, G. R. (2004) · Growth Factors · doi:10.1080/08977190412331279890 · Cited by 1,921
Changes in thymic function with age and during the treatment of HIV infection
Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature · doi:10.1038/25374 · Cited by 1,893
Fibroblast growth factors, their receptors and signaling
Powers, C. J., McLeskey, S. W., & Wellstein, A. (2000) · Endocrine-related cancer · doi:10.1677/erc.0.0070165 · Cited by 1,332
A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy
Komarov, P. G., Komarova, E. A., Kondratov, R. V., Christov-Tselkov, K., Coon, J. S., Chernov, M. V., & Gudkov, A. V. (1999) · Science · doi:10.1126/science.285.5434.1733 · Cited by 1,270
Self-citation
Age, Thymopoiesis, and CD4+ T-Lymphocyte Regeneration after Intensive Chemotherapy
Mackall, C. L., Fleisher, T. A., Brown, M. R., Andrich, M. P., Chen, C. C., Feuerstein, I. M., Horowitz, M. E., Magrath, I. T., Shad, A. T., Steinberg, S. M., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199501193320303 · Cited by 1,026
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.
Kouhara, H., Hadari, Y., Spivak-Kroizman, T., Schilling, J., Bar-Sagi, D., Lax, I., & Schlessinger, J. (1997) · Cell · doi:10.1016/s0092-8674(00)80252-4 · Cited by 908
NF-κB as a Therapeutic Target in Multiple Myeloma
Hideshima, T., Chauhan, D., Richardson, P. G. G., Mitsiades, C. S., Mitsiades, N., Hayashi, T., Munshi, N. C., Dang, L., Castro, A. C., Palombella, V. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200360200 · Cited by 899
Assessment of thymic output in adults after haematopoietic stemcell transplantation and prediction of T-cell reconstitution
Douek, D. C., Vescio, R. A., Betts, M. R., Brenchley, J. M., Hill, B. J., Zhang, L., Berenson, J. R., Collins, R. H., & Koup, R. A. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02293-5 · Cited by 579

Show all 78 references

Sorted by citations

Items 101–200 of 216

A Proposed Link Between Acute Thymic Involution and Late Adverse Effects of Chemotherapy
Lagou, M. K., Anastasiadou, D. P., & Karagiannis, G. S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.933547 · Cited by 22
Enhanced paracrine action of FGF21 in stromal cells delays thymic aging
Youm, Y., Gliniak, C. M., Zhang, Y., Dlugos, T., Scherer, P. E., & Dixit, V. D. (2025) · Nature Aging · doi:10.1038/s43587-025-00813-5 · Cited by 23
Greater than the sum of their parts: Combination strategies for immune regeneration following allogeneic hematopoietic stem cell transplantation
Dudakov, J. A., & van den Brink, M. R. M. (2011) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2011.05.003 · Cited by 20
Thymic Engraftment by in vitro-Derived Progenitor T Cells in Young and Aged Mice
Singh, J., Mohtashami, M., Anderson, G., & Zúñiga‐Pflücker, J. C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01850 · Cited by 21
Redox regulation of age-associated defects in generation and maintenance of T cell self-tolerance and immunity to foreign antigens
Hester, A. K., Semwal, M. K., Cepeda, S., Xiao, Y., Rueda, M., Wimberly, K., Venables, T., Dileepan, T., Kraig, E., & Griffith, A. V. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110363 · Cited by 21
Peritransplant palifermin use and lymphocyte recovery after T‐cell replete, matched related allogeneic hematopoietic cell transplantation
Romee, R., Levine, J. E., DeFor, T. E., Ferrara, J. L. M., Weisdorf, D. J., Blazar, B. R., & Verneris, M. R. (2011) · American Journal of Hematology · doi:10.1002/ajh.22136 · Cited by 20
Self-citation
Thymic cysts originate from Foxn1 positive thymic medullary epithelium
Vroegindeweij, E. M., Crobach, S., Itoi, M., Satoh, R., Žuklys, S., Happe, C., Germeraad, W. T. V., Cornelissen, J. J., Cupedo, T., Holländer, G. A., et al. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.10.034 · Cited by 20
The Thymus and the Immune System: Layered Levels of Control
Lee, D. K., Hakim, F. T., & Gress, R. E. (2010) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181f20474 · Cited by 19
Knockdown of receptor-interacting serine/threonine protein kinase-2 (RIPK2) affects EMT-associated gene expression in human hepatoma cells.
Wu, S., Kanda, T., Nakamoto, S., Imazeki, F., & Yokosuka, O. (2012) · PubMed · Cited by 19
Fetal thymus graft prevents age-related hearing loss and up regulation of the IL-1 receptor type II gene in CD4+ T cells
Iwai, H., & Inaba, M. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.05.007 · Cited by 19
FGF7 secreted from dermal papillae cell regulates the proliferation and differentiation of hair follicle stem cell
Wang, N., Zhang, W., Zhong, Z., Zhou, X., Shi, X., & Wang, X. (2023) · Journal of Integrative Agriculture · doi:10.1016/j.jia.2023.10.012 · Cited by 18
FGF7 supports hematopoietic stem and progenitor cells and niche-dependent myeloblastoma cells via autocrine action on bone marrow stromal cells in vitro
Ishino, R., Minami, K., Tanaka, S., Nagai, M., Matsui, K., Hasegawa, N., Roeder, R. G., Asano, S., & Ito, M. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.09.044 · Cited by 18
Thymus-derived hormonal and cellular control of cancer
Savino, W., & Lepletier, A. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1168186 · Cited by 17
Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging
Sonar, S. A., Watanabe, M., & Nikolich‐Žugich, J. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101835 · Cited by 19
Acute irradiation causes a long-term disturbance in the heterogeneity and gene expression profile of medullary thymic epithelial cells
Horie, K., Namiki, K., Kinoshita, K., Miyauchi, M., Ishikawa, T., Hayama, M., Maruyama, Y., Hagiwara, N., Miyao, T., Murata, S., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1186154 · Cited by 17
Inflammation and Thymus Ageing
Lepletier, A., Al‐Sharif, A., & Chidgey, A. P. (2017) · Frontiers of hormone research · doi:10.1159/000452903 · Cited by 17
Intrathymic adeno-associated virus gene transfer rapidly restores thymic function and long-term persistence of gene-corrected T cells
Pouzolles, M., Machado, A., Guilbaud, M., Irla, M., Gailhac, S., Barennes, P., Cesana, D., Calabria, A., Benedicenti, F., Sergé, A., et al. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.08.029 · Cited by 17
The potential role of the thymus in immunotherapies for acute myeloid leukemia
Hino, C., Xu, Y., Xiao, J., Baylink, D. J., Reeves, M. E., & Cao, H. L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1102517 · Cited by 18
The role of the thymus in allogeneic haematopoietic stem cell transplantation
Krenger, W., & Holländer, G. A. (2010) · Swiss Medical Weekly · doi:10.4414/smw.2010.13051 · Cited by 17
Self-citation
Age-related thymic involution: Mechanistic insights and rejuvenating approaches to restore immune function
Santamaria, J. C., & Irla, M. (2026) · Science Advances · doi:10.1126/sciadv.aeb2970 · Cited by 20
Generation and repair of thymic epithelial cells
Anderson, G., Cosway, E. J., James, K. D., Ohigashi, I., & Takahama, Y. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20230894 · Cited by 16
Self-citation
Meis1 Is Required for the Maintenance of Postnatal Thymic Epithelial Cells
Hirayama, T., Asano, Y., Iida, H., Watanabe, T., Nakamura, T., & Goitsuka, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089885 · Cited by 16
Generation of pro-T cells in vitro: potential for immune reconstitution
Awong, G., Motte-Mohs, R. N. L., & Zúñiga‐Pflücker, J. C. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.005 · Cited by 16
The immunosenescence clock: A new method for evaluating biological age and predicting mortality risk
Li, S., Wang, K., Wu, J., & Zhu, Y. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102653 · Cited by 18
Keratinocyte growth factor enhanced immune reconstitution in murine allogeneic umbilical cord blood cell transplant
Wang, Y., Chen, G., Qiao, S.-M., Ma, X., Tang, X., Sun, A., & Wu, D. (2011) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2011.573037 · Cited by 15
Co‑transplantation of tonsil‑derived mesenchymal stromal cells in bone marrow transplantation promotes thymus regeneration and T cell diversity following cytotoxic conditioning
Choi, D., Cho, K., Lee, H., Kim, Y., Woo, K.-J., Park, J., Ryu, K., & Woo, S. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4657 · Cited by 15
The proliferative and anti-apoptosis functions of KGF/KGFR contributes to bronchial epithelial repair in asthma
Wang, J., Sun, H., & Liu, Y. (2020) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2020.101931 · Cited by 15
T cells fail to develop in the human skin-cell explants system; an inconvenient truth
Meek, B., van Elssen, C. H. M. J., Huijskens, M. J. A. J., van der Stegen, S. J. C., Tonnaer, S., Lumeij, S. B., Vanderlocht, J., Kirkland, M. A., Hesselink, R. P., Germeraad, W. T. V., et al. (2011) · BMC Immunology · doi:10.1186/1471-2172-12-17 · Cited by 15
Fgf21 regulates T-cell development in the neonatal and juvenile thymus
Nakayama, Y., Masuda, Y., Ohta, H., Tanaka, T., Washida, M., Nabeshima, Y., Miyake, A., Itoh, N., & Konishi, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-00349-8 · Cited by 15
Immune Reconstitution Following Hematopoietic Cell Transplantation
Dudakov, J. A., Perales, M., & van den Brink, M. R. M. (2015) · Wiley eBooks · doi:10.1002/9781118416426.ch15 · Cited by 13
Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan
Wedemeyer, S. A., Jones, N. E., Raza, I. G. A., Green, F. M., Xiao, Y., Semwal, M. K., Garza, A., Archuleta, K. S., Wimberly, K., Venables, T., et al. (2025) · Nature Aging · doi:10.1038/s43587-024-00801-1 · Cited by 17
Immunologic Resolution of Human Chronic Graft-versus-Host Disease
Mahadeo, K. M., Masinsin, B., Kapoor, N., Shah, A. J., Abdel‐Azim, H., & Parkman, R. (2014) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2014.06.030 · Cited by 14
Stimulatory effect of HGF‐overexpressing adipose tissue‐derived mesenchymal stem cells on thymus regeneration in a rat thymus involution model
Jung, W., Han, S., Kim, S., Kim, M., Lee, J., Seo, K., Youn, H., & Lee, H. (2014) · Cell Biology International · doi:10.1002/cbin.10306 · Cited by 14
Enhancing thymic function improves T-cell reconstitution and immune responses in aged mice
Morales‐Sánchez, A., Lavaert, M., Vacchio, M. S., Martinez‐Ruíz, G. U., Egbase, D., Zhao, Y., Lake, R. G., Ishikawa, M., Braikia, F.-Z., Jankovic, D. L., et al. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003283 · Cited by 13
Primer on fibroblast growth factor 7 (FGF 7)
Zheng, Y., Liu, W.-H., Yang, B., & Krentsis, I. M. (2024) · Differentiation · doi:10.1016/j.diff.2024.100801 · Cited by 13
In Pursuit of Adult Progenitors of Thymic Epithelial Cells
Ishikawa, T., Akiyama, N., & Akiyama, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.621824 · Cited by 13
Epitope-Specific Tolerance Modes Differentially Specify Susceptibility to Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis
Wang, L., Winnewisser, J., Federle, C., Jessberger, G., Nave, K., Werner, H. B., Kyewski, B., Klein, L., & Hinterberger, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01511 · Cited by 13
Stem cells—meet immunity
Heng, T. S. P., Dudakov, J. A., Khong, D., Chidgey, A. P., & Boyd, R. L. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0539-z · Cited by 12
Doxycycline up-regulates the expression of IL-6 and GM-CSF via MAPK/ERK and NF-κB pathways in mouse thymic epithelial cells
Huang, Y., Li, R., Chen, X., Zhuo, Y., Jin, R., Qian, X. P., Jiang, Y. Q., Zeng, Z. H., Zhang, Y., & Shao, Q. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.03.011 · Cited by 12
Concise Review: Hematopoietic Stem Cell Transplantation: Targeting the Thymus
de Barros, S. C., Zimmermann, V. S., & Taylor, N. N. (2013) · Stem Cells · doi:10.1002/stem.1378 · Cited by 11
Twisting immune responses for allogeneic stem cell therapy
Li, S. C. (2009) · World Journal of Stem Cells · doi:10.4252/wjsc.v1.i1.30 · Cited by 10
Transplantation of Donor-Origin Mouse Embryonic Stem Cell-Derived Thymic Epithelial Progenitors Prevents the Development of Chronic Graft-versus-Host Disease in Mice
Hu, R., Liu, Y., Su, M., Song, Y., Rood, D., & Lai, L. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2016-0012 · Cited by 10
The Ins and Outs of Thymic Epithelial Cell Differentiation and Function
Matsumoto, M., Rodrigues, P. M., Sousa, L., Tsuneyama, K., Matsumoto, M., & Alves, N. L. (2019) · Springer eBooks · doi:10.1007/978-3-030-12040-5_3 · Cited by 9
Keratinocyte Growth Factor Improves Allogeneic Bone Marrow Engraftment through a CD4+Foxp3+ Regulatory T Cell-Dependent Mechanism
Bruinsma, M., van Soest, P. L., Leenen, P. J. M., Löwenberg, B., Cornelissen, J. J., & Braakman, E. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803253 · Cited by 9
Role of neuropeptides, hormones, and growth factors in regulating thymopoiesis in middle to old age
Patel, K. G., & Taub, D. D. (2009) · F1000 Biology Reports · doi:10.3410/b1-42 · Cited by 8
Umbilical Cord Blood Transplantation
Grewal, S. S., & Wagner, J. E. (2006) · CRC Press eBooks · doi:10.3109/9780849358807-11 · Cited by 8
Circulating mature dendritic cells homing to the thymus promote thymic epithelial cells involution via the Jagged1/Notch3 axis
Wu, H., Li, X., Zhou, C., Qi-hong, Y., Ge, S., Pan, Z., Zhao, Y., Xia, S., Zhou, X., Liu, X., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00619-5 · Cited by 8
Fish Collagen Peptides Enhance Thymopoietic Gene Expression, Cell Proliferation, Thymocyte Adherence, and Cytoprotection in Thymic Epithelial Cells via Activation of the Nuclear Factor-κB Pathway, Leading to Thymus Regeneration after Cyclophosphamide-Induced Injury
Lee, D. Y., Song, W. H., Lim, Y. S., Lee, C., Rajbongshi, L., Hwang, S.-Y., Kim, B. S., Lee, D., Song, Y. J., Kim, H. G., et al. (2023) · Marine Drugs · doi:10.3390/md21100531 · Cited by 7
The role of thymic epithelium in thymus development and age-related thymic involution
Fujimori, S., & Ohigashi, I. (2024) · The Journal of Medical Investigation · doi:10.2152/jmi.71.29 · Cited by 6
Semaphorin 3A Negatively Affects Proliferation of Mouse Thymus Epithelial Cells In Vitro
Rutto, K. V., Ovsyukov, K. S., Kudryavtsev, I. V., & Kiseleva, E. P. (2019) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-019-04346-x · Cited by 6
Disruption of the Thymic Microenvironment Is Associated with Thymic Involution of Transitional Cell Cancer
Song, Y., Yu, R., Wang, C., Chi, F., Guo, Z., & Zhu, X. (2013) · Urologia Internationalis · doi:10.1159/000353350 · Cited by 6
Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor
Guimond, M., Leonard, W. J., Spolski, R. J., Rossi, S. W., Veenstra, R. G., Holländer, G. A., Mackall, C. L., & Blazar, B. R. (2008) · Blood · doi:10.1182/blood-2007-09-113316 · Cited by 6
Self-citation
Clinical Implications of Immune Reconstitution Following Hematopoietic Stem Cell Transplantation
Peggs, K. S., Krauss, A. C., & Mackall, C. L. (2008) · Cancer treatment and research · doi:10.1007/978-0-387-78580-6_6 · Cited by 6
Nitric oxide-dependent immunosuppressive function of thymus-derived mesenchymal stromal/stem cells
Su, X., Li, X., Wang, S., Xue, X., Liu, R., Bai, X., Gong, P., Feng, C., Cao, L., Wang, T., et al. (2023) · Biology Direct · doi:10.1186/s13062-023-00415-4 · Cited by 6
Depletion of Ift88 in thymic epithelial cells affects thymic synapse and T-cell differentiation in aged mice
Kutomi, O., Nonaka, S., Hozumi, K., & Takeda, S. (2022) · Anatomical Science International · doi:10.1007/s12565-022-00663-w · Cited by 5
Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells
Guo, Y., Miyazaki, M., Itoi, M., Satoh, R., Iwama, A., Amagai, T., Kawamoto, H., & Kanno, M. (2011) · European Journal of Immunology · doi:10.1002/eji.201040794 · Cited by 5
Cell Culture Models for Translational Research on Thymomas and Thymic Carcinomas: Current Status and Future Perspectives
Müller, D., Loskutov, J., Küffer, S., Marx, A., Regenbrecht, C. R. A., Ströbel, P., & Regenbrecht, M. (2024) · Cancers · doi:10.3390/cancers16152762 · Cited by 4
The Additive Effect of Mesenchymal Stem Cells and Bone Morphogenetic Protein 2 on γ-Irradiated Bone Marrow in Mice
Liu, S., Hu, P., Hou, Y., Li, P., Li, X., & Tian, Q. (2011) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-011-9236-y · Cited by 4
Loss of Pten Disrupts the Thymic Epithelium and Alters Thymic Function
Garfin, P. M., Nguyen, T. N., & Sage, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149430 · Cited by 5
Adding Insult to Injury: Improving the Regenerative Capacity of the Aged Thymus Following Clinically Induced Damage
Dudakov, J. A., Hun, M. L., Wong, K., Holländer, G. A., & Chidgey, A. P. (2019) · Springer eBooks · doi:10.1007/978-3-030-12040-5_13 · Cited by 4
Keratinocyte growth factor (KGF) delays the onset of collagen-induced arthritis
Yakimchuk, K., Nandakumar, K. S., Chen, L., Holmdahl, R., Okret, S., & Jondal, M. (2012) · Autoimmunity · doi:10.3109/08916934.2012.712169 · Cited by 4
Chemical Castration of Melanoma Patients Does Not Increase the Frequency of Tumor-specific CD4 and CD8 T Cells After Peptide Vaccination
Vence, L. M., Wang, C., Pappu, H., Anson, R. E., Patel, T. A., MILLER, P. W., Bassett, R. L., Lizee, G. A., Overwijk, W. W., Komanduri, K. V., et al. (2013) · Journal of Immunotherapy · doi:10.1097/cji.0b013e31829419f3 · Cited by 4
Regulation of vascular endothelial growth factor production in mouse thymic epithelial cell lines
Rutto, K. V., Lyamina, I. V., Kudryavtsev, I. V., & Kiseleva, E. P. (2016) · Cell and Tissue Biology · doi:10.1134/s1990519x16050126 · Cited by 4
Alteration of long- and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesisPreprint
Nishi, K., Sakamaki, T., Nagasaka, A., Kao, K. S., Sadaoka, K., Asano, M., Yamamoto, N., Takaori‐Kondo, A., & Miyanishi, M. (2024) · eLife · doi:10.7554/elife.95880 · Cited by 6
The Thymus Regeneration Paradox: The Search for Stemness in an Involuting Organ
Ragazzini, R., & Bonfanti, P. (2026) · Immunological Reviews · doi:10.1111/imr.70110 · Cited by 3
Ghrelin Protects the Thymic Epithelium From Conditioning-Regimen-Induced Damage and Promotes the Restoration of CD4+ T Cells in Mice After Bone Marrow Transplantation
Xu, J., Junyu, Z., Tian, X., Qixin, S., Xu, J., Huang, Y., He, Y., Huang, Z., & Wu, B. (2017) · Transplantation · doi:10.1097/tp.0000000000001832 · Cited by 3
A 2-hit model for chronic GVHD
Parkman, R. (2013) · Blood · doi:10.1182/blood-2013-06-507376 · Cited by 3
Disruption of Notch signaling by KGF induces a developmental pause in thymocytes
Teng, R., Flomerfelt, F. A., Xue, P., Chandroth, A., Noguchi, C. T., Svoronos, N., Gress, R. E., & Taylor, N. N. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1675823 · Cited by 2
Alteration of long and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesisPreprint
Nishi, K., Sakamaki, T., Nagasaka, A., Kao, K. S., Sadaoka, K., Asano, M., Yamamoto, N., Takaori‐Kondo, A., & Miyanishi, M. (2024) · eLife · doi:10.7554/elife.95880.2 · Cited by 2
Thymic Senescence
Kvell, K. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.87063 · Cited by 1
Magnetic resonance imaging of radiation-induced thymic atrophy as a model for pathologic changes in acute feline immunodeficiency virus infection
Kuhnt, L. A., Jennings, R. N., Brawner, W. R., Hathcock, J. T., Carreño, A. D., & Johnson, C. M. (2009) · Journal of Feline Medicine and Surgery · doi:10.1016/j.jfms.2009.04.012 · Cited by 1
Thymic Regeneration in Mice and Humans Following Sex Steroid Ablation
Fletcher, A. L., Reiseger, J. J., Vlahos, K., Seach, N., Dudakov, J. A., Chidgey, A. P., & Boyd, R. L. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_74 · Cited by 1
Hematopoietic Stem Cell Transplantation for Primary Immunodeficiency
Gennery, A. R. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405546-9.00058-3 · Cited by 1
Strategies for Thymic Regeneration: Recent Advances Towards Clinical Therapy
Barsanti, M., Hun, M. L., Boyd, R. L., & Chidgey, A. P. (2016) · Springer eBooks · doi:10.1007/978-4-431-56027-2_3 · Cited by 2
DNA Barcoding of Human Stem and Progenitor Cells Reveals Differences in Clonal Dynamics of B and T lymphoid Progeny
Brugman, M., & Staal, F. J. T. (2016) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000408 · Cited by 1
The Additive Effect of Mesenchymal Stem Cells and Bone Morphogenetic Protein 2 on c-Irradiated Bone Marrow in Mice
LiuPeizhen, S., Hou, H., LiXubo, P., & Tian, L. (2011) · Cited by 1
Alteration of long- and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesis
Nishi, K., Sakamaki, T., Nagasaka, A., Kao, K. S., Sadaoka, K., Asano, M., Yamamoto, N., Takaori‐Kondo, A., & Miyanishi, M. (2025) · eLife · doi:10.7554/elife.95880.4 · Cited by 1
Strategies to Improve Posttransplant Immunity
Dudakov, J. A., & van den Brink, M. R. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812630-1.00006-2 · Cited by 1
PREVENTING THYMUS INVOLUTION IN K5.CYCLIN D1 TRANSGENIC MICE SUSTAINS THE NAÏVE T CELL COMPARTMENT WITH AGE
Bolner, M. L. (2015) · Digital Commons-TMC (Texas Medical Center) · Cited by 1
Alteration of long and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesisPreprint
Nishi, K., Sakamaki, T., Nagasaka, A., Kao, K. S., Sadaoka, K., Asano, M., Yamamoto, N., Takaori‐Kondo, A., & Miyanishi, M. (2024) · eLife · doi:10.7554/elife.95880.1 · Cited by 2
Alteration of long and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesisPreprint
Nishi, K., Sakamaki, T., Nagasaka, A., Kao, K. S., Sadaoka, K., Asano, M., Yamamoto, N., Takaori‐Kondo, A., & Miyanishi, M. (2025) · eLife · doi:10.7554/elife.95880.3 · Cited by 1
Chronic Graft Versus Host Disease: Inflammation at the Crossroads of Allo and Auto Immunity
Hakim, F. T. (2010) · Springer eBooks · doi:10.1007/978-1-4419-7219-4_17
Thymic Involution and Thymic Renewal
Hakim, F. T. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_44
Function of Gata-2 in thymic epithelial cells : a transcription factor identified from gene expression analysis of endodermal cells committed to thymic epithelial cell fate
Na, K.-J. (2010) · edoc (University of Basel) · doi:10.5451/unibas-005398236
Rejuvenation of the Thymic Microenvironment by ESC-derived Thymic Epithelial Progenitors
Lai, L. (2011) · InTech eBooks · doi:10.5772/15312
Multiple Multi-Objective Servo Design - Evolutionary Approach
Woźniak, P. (2008) · doi:10.5772/6114
Regulatory T cells and immune tolerance after allogeneic hematopoietic stem cell transplantation
Bruinsma, M. (2010) · RePub (Erasmus University Rotterdam)
Immunosenescence and the 3Rs: Restoration, Replacement and Reprogramming
Mitchell, W. A., Pink, R. C., Lapenna, A., & Aspinall, R. (2011) · Springer eBooks · doi:10.1007/978-3-0346-0219-8_9
Murine Model of Thymic Damage and Recovery Following Sublethal Ionizing Radiation
Kepuska, Z. (2012) · DukeSpace (Duke University)
Autophagy in Thymic Epithelium Shapes the T cell Repertoire and is Essential for Tolerance
der Naturwissenschaften, D. (2009)
predominantly through thymic epithelial cell expansion Exogenous insulin-like growth factor 1 enhances thymopoiesis
Howe, D., Gress, R. E., Chu, Y., Schmitz, S., Choudhury, B., Telford, W. G., & Kapoor, V. (2011)
The Immunogenicity of Stem Cells and Thymus-Based Strategies to Minimise Immune Rejection
Morison, J., Heng, T. S. P., Chidgey, A. P., & Boyd, R. L. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5480-9_11
Consiglio di Amministrazione
di L'Aquila, C. D. C. (2016)
Crossing hla barriers by “megadose” stem cell transplants
Reisner, Y., Martelli, M. P., & Bachar-Lustig, E. (2010) · doi:10.1057/9789814271271_0001
The effects of the transplantation of thymus-derived multipotent stromal cells on the immune system and survival of lethally irradiated mice
Nikolska, K. I. (2018) · Cell and Organ Transplantology · doi:10.22494/cot.v6i2.88
MEKhANIZMY AKTIVATsII TIMUSNOGO EPITELIYa POD DEYSTVIEM ROSTOVYKh FAKTOROV
Rutto, K. V., Kudryavtsev, I. V., & Kiseleva, E. P. (2016) · Medical academic journal · doi:10.17816/maj164166-167
Treatment of Persons with CRS
Akleyev, А. V. (2013) · Springer eBooks · doi:10.1007/978-3-642-45117-1_8
Faculty Opinions recommendation of Epitope-Specific Tolerance Modes Differentially Specify Susceptibility to Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis.
Gray, D. H. D. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732149440.793539185
Thymus Microenvironment: Maintenance, Ageing and Strategies for Thymus Regeneration Following Damage
Alsharif, A., & Chidgey, A. P. (2022) · Wiley eBooks · doi:10.1002/9780470015902.a0029481
Additional file 1 of Nitric oxide-dependent immunosuppressive function of thymus-derived mesenchymal stromal/stem cells
Su, X., Li, X., Wang, S., Xue, X., Liu, R., Bai, X., Gong, P., Feng, C., Cao, L., Wang, T., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24159394

Authors: Rossi, S. W., Jeker, L. T., Ueno, T., Kuse, S., Keller, M. P., Zuklys, S., Gudkov, A. V., Takahama, Y., Krenger, W., Blazar, B. R., & Holländer, G. A.
Affiliations: University of Basel (CH)
Tokushima University (JP)
Laboratory of Pediatric Immunology, Center for Biomedicine, Department of Clinical-Biological Sciences, University of Basel and The University Children's Hospital (UKBB), Basel, Switzerland;
Cleveland Clinic (US)
University of Minnesota (US)
ORCID: Rossi, Simona W.
Jeker, Lukas T.
Keller, Marcel P.
Gudkov, Andrei V.
Takahama, Yousuke
Blazar, Bruce R.
Venue: Blood
Publisher: American Society of Hematology
Published: 2007-01-09
Volume: 109
Issue: 9
Pages: 3803-3811
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2006-10-049767
PMC: PMC1874572
OpenAlex: W2012330112
Cited by: 215
References: 78
Citations by year: 2026: 10 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 8 · 2021: 8 · 2020: 7 · 2019: 12 · 2018: 1 · 2017: 7 · 2016: 14 · 2015: 6 · 2014: 8 · 2013: 15 · 2012: 13
FWCI: 12.62
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
Dana Foundation
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (68310, 3100-68310.02)
National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL073794)
National Institute of Allergy and Infectious Diseases (R01 AI 1057477)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: keratinocyte growth factor, thymic epithelial cells, T cell development, thymopoiesis, thymic stromal cells, bone marrow transplantation, graft-versus-host disease, p53 pathway, NF-κB signaling, BMP signaling, Wnt signaling, thymocyte proliferation
MeSH terms: Animals, Cell Differentiation, Epithelial Cells, Female, T-Lymphocytes, Thymus Gland, Signal Transduction, Tumor Suppressor Protein p53, NF-kappa B, Bone Morphogenetic Proteins, Lymphopoiesis, Cell Proliferation, Mice, Fibroblast Growth Factor 7

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks