The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus
Open accessAbstract
Eosinophils are recruited to the lungs in response to respiratory syncytial virus (RSV) infection; however, their role in promoting antiviral host defense remains unclear. Here, we demonstrate that eosinophils express TLRs that recognize viral nucleic acids, are activated and degranulate after single-stranded RNA (ssRNA) stimulation of the TLR-7–MyD88 pathway, and provide host defense against RSV that is MyD88 dependent. In contrast to wild-type mice, virus clearance from lung tissue was more rapid in hypereosinophilic (interleukin-5 transgenic) mice. Transfer of wild-type but not MyD88-deficient eosinophils to the lungs of RSV-infected wild-type mice accelerated virus clearance and inhibited the development of airways hyperreactivity. Similar responses were observed when infected recipient mice were MyD88 deficient. Eosinophils isolated from infected hypereosinophilic MyD88-sufficient but not MyD88-deficient mice expressed greater amounts of IFN regulatory factor (IRF)–7 and eosinophil-associated ribonucleases EAR-1 and EAR-2. Hypereosinophilia in the airways of infected mice also correlated with increased expression of IRF-7, IFN-β, and NOS-2, and inhibition of NO production with the NOS-2 inhibitor L-NMA partially reversed the accelerated virus clearance promoted by eosinophils. Collectively, our results demonstrate that eosinophils can protect against RSV in vivo, as they promote virus clearance and may thus limit virus-induced lung dysfunction.
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Cites
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Cited by
Eosinophils: changing perspectives in health and disease
Rosenberg, H. F., Dyer, K. D., & Foster, P. S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3341 · Cited by 989
Self-citationEosinophils: Biological Properties and Role in Health and Disease
HOGAN, S. P., ROSENBERG, H. F., MOQBEL, R., PHIPPS, S., FOSTER, P. S., LACY, P., KAY, A. B., & ROTHENBERG, M. E. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.02958.x · Cited by 834
Self-citationThe role of viruses in acute exacerbations of asthma
Jackson, D. J., & Johnston, S. L. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.04.021 · Cited by 351
Eosinophils from Physiology to Disease: A Comprehensive Review
Ramirez, G. A., Yacoub, M.-R., Ripa, M., Mannina, D., Cariddi, A., Saporiti, N., Ciceri, F., Castagna, A., Colombo, G., & Dagna, L. (2018) · BioMed Research International · doi:10.1155/2018/9095275 · Cited by 316
Graham, B. S. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00972.x · Cited by 239
Metadata
- Authors
- Phipps, S., Lam, C. E., Mahalingam, S., Newhouse, M., Ramirez, R., Rosenberg, H. F., Foster, P. S., & Matthaei, K. I.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2007-09-01
- Volume
- 110
- Issue
- 5
- Pages
- 1578-1586
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2136561766
- Cited by
- 305
- References
- 55
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Phipps, S., Lam, C. E., Mahalingam, S., Newhouse, M., Ramirez, R., Rosenberg, H. F., Foster, P. S., & Matthaei, K. I. (2007). Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus. Blood. https://doi.org/10.1182/blood-2007-01-071340
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