The DOI matches its Crossref record; 53 of the 54 references it cites were found in a registry or an index.
Autocrine formation of hepcidin induces iron retention in human monocytes
Abstract
Hepcidin, a master regulator of iron homeostasis, is produced in small amounts by inflammatory monocytes/macrophages. Chronic immune activation leads to iron retention within monocytes/macrophages and the development of anemia of chronic disease (ACD). We questioned whether monocyte-derived hepcidin exerts autocrine regulation toward cellular iron metabolism. Monocyte hepcidin mRNA expression was significantly induced within 3 hours after stimulation with LPS or IL-6, and hepcidin mRNA expression was significantly higher in monocytes of ACD patients than in controls. In ACD patients, monocyte hepcidin mRNA levels were significantly correlated to serum IL-6 concentrations, and increased monocyte hepcidin mRNA levels were associated with decreased expression of the iron exporter ferroportin and iron retention in these cells. Transient transfection experiments using a ferroportin/EmGFP fusion protein construct demonstrated that LPS inducible hepcidin expression in THP-1 monocytes resulted in internalization and degradation of ferroportin. Transfection of monocytes with siRNA directed against hepcidin almost fully reversed this lipopolysaccharide-mediated effect. Using ferroportin mutation constructs, we found that ferroportin is mainly targeted by hepcidin when expressed on the cell surface. Our results suggest that ferroportin expression in inflammatory monocytes is negatively affected by autocrine formation of hepcidin, thus contributing to iron sequestration within monocytes as found in ACD.
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“Moreover, macrophages produce minute amounts of hepcidin in response to inflammatory stimuli such as IL-6 or LPS thereby blocking iron export in an autocrine fashion (Peyssonnaux et al., 2006; Theurl et al., 2008), which is meant to result from a nutritional immune strategy of the body to reduce the availability of iron for extracellular pathogens (Figure 1).”
From Iron at the interface of immunity and infection (2014) · cites this paper as Theurl et al., 2008
In the citing paper
“LPS stimulates macrophages to produce HAMP themselves, which reduces FPN1-mediated iron export as autocrine regulator (Peyssonnaux et al., 2006;Theurl et al., 2008).”
From Iron in infection and immunity (2020) · cites this paper as Theurl et al., 2008
In the citing paper
“exposure of macrophages to bacteria (53), the bacterial wall constituent LPS, and Toll-like receptor agonists (54), all occurring in CVUs (55, 56), result in the induction of hepcidin (57), the major inhibitor of iron export from macrophages.”
From An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice (2011) · cites this paper as [54]
In the citing paper
“Interleukin-6 in acute and chronic inflammation increases hepcidin levels, causing iron-restricted erythropoiesis and ane-mia of inflammation in the presence of iron-replete macrophages.”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [55]
In the citing paper
“Macrophages produce hepcidin in inflammation, potentiating the systemic effect on iron sequestration.55”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [55]
In the citing paper
“Moreover, MΦs produce minute amounts of hepcidin in response to challenge with LPS or IL-6, which targets in an autocrine fashion ferroportin exposed on the cell surface, thereby resulting in blockage of iron egress to rapidly limit iron access to extracellular microbes (195, 196).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [195]
In the citing paper
“Activated Mø can produce minute amounts of hepcidin in response to bacterial lipopolysaccharide (LPS) or cytokines, targeting FPN for proteolytic degradation [109,110].”
From The Iron age of host–microbe interactions (2015) · cites this paper as [110]
In the citing paper
“This is also in a line with the observation of autocrine formation of hepcidin by macrophage which is an immediate mechanism to down-regulate FPN1 expression at sites of infection and to prevent cellular iron egress to feed pathogens [170,171].”
From Iron in immune cell function and host defense (2021) · cites this paper as [171]
Citations
Cites
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
Weiss, G., & Goodnough, L. T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041809 · Cited by 3,800
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168
Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., & Loréal, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008923200 · Cited by 1,697
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature · doi:10.1038/35001596 · Cited by 1,667
McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., & Ganz, T. (2003) · Blood · doi:10.1182/blood-2002-10-3235 · Cited by 1,417
A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism
Abboud, S., & Haile, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000713200 · Cited by 1,267
Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215686 · Cited by 1,214
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Differential regulation of iron homeostasis during human macrophage polarized activation
Recalcati, S., Locati, M., Marini, A., Santambrogio, P., Zaninotto, F., De Pizzol, M., Zammataro, L., Girelli, D., & Cairo, G. (2010) · European Journal of Immunology · doi:10.1002/eji.200939889 · Cited by 438
Theurl, I., Aigner, E., Theurl, M., Nairz, M., Seifert, M., Schroll, A., Sonnweber, T., Eberwein, L., Witcher, D. R., Murphy, A. T., et al. (2009) · Blood · doi:10.1182/blood-2008-12-195651 · Cited by 421
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Brüne, B., Dehne, N., Grossmann, N., Jung, M., Namgaladze, D., Schmid, T., von Knethen, A., & Weigert, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4785 · Cited by 377
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Self-citationIron in fatty liver and in the metabolic syndrome: A promising therapeutic target
Dongiovanni, P., Fracanzani, A. L., Fargion, S. R., & Valenti, L. V. C. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.05.008 · Cited by 364
Iron at the interface of immunity and infection
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“…of hepcidin in response to inflammatory stimuli such as IL-6 or LPS thereby blocking iron export in an autocrine fashion (Peyssonnaux et al., 2006; Theurl et al., 2008), which is meant to result from a nutritional immune strategy of the body to reduce the availability of iron for extracellular…”
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Weiss, G. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.08.006 · Cited by 322
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Corna, G., Campana, L., Pignatti, E., Castiglioni, A., Tagliafico, E., Bosurgi, L., Campanella, A., Brunelli, S., Manfredi, A. A., Apostoli, P., et al. (2010) · Haematologica · doi:10.3324/haematol.2010.023879 · Cited by 304
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Hepcidin in Human Iron Disorders: Diagnostic Implications
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Harada, N., Kanayama, M., Maruyama, A., Yoshida, A., Tazumi, K., Hosoya, T., Mimura, J., Toki, T., Maher, J. M., Yamamoto, M. P., et al. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.02.001 · Cited by 236
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Mu, Q., Chen, L., Gao, X., Shen, S., Sheng, W., Min, J., & Wang, F. (2021) · 中国科学通报：英文版 · doi:10.1016/j.scib.2021.02.010 · Cited by 232
Nairz, M., Schleicher, U., Schroll, A., Sonnweber, T., Theurl, I., Ludwiczek, S., Talasz, H., Brandacher, G., Moser, P. L., Muckenthaler, M. U., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20121946 · Cited by 204
Self-citationIron Regulation: Macrophages in Control
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Hepcidin Regulation of Iron Transport
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Ramey, G., Deschemin, J., Durel, B., Canonne‐Hergaux, F., Nicolas, G., & Vaulont, S. (2009) · Haematologica · doi:10.3324/haematol.2009.014399 · Cited by 201
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Lanser, L., Fuchs, D., Kurz, K., & Weiß, G. (2021) · Nutrients · doi:10.3390/nu13113732 · Cited by 179
Interferon‐γ limits the availability of iron for intramacrophage Salmonella typhimurium
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Self-citationIron levels in polarized macrophages: regulation of immunity and autoimmunity
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Anaemia in inflammatory rheumatic diseases
Weiss, G., & Schett, G. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.183 · Cited by 146
Nairz, M., Theurl, I., Schroll, A., Theurl, M., Fritsche, G., Lindner, E., Seifert, M., Crouch, M.-L. V., Hantke, K., Akira, S., et al. (2009) · Blood · doi:10.1182/blood-2009-05-223354 · Cited by 146
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Hepcidin modulation in human diseases: From research to clinic
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Dysregulation of iron and copper homeostasis in nonalcoholic fatty liver
Aigner, E. S. (2014) · World Journal of Hepatology · doi:10.4254/wjh.v7.i2.177 · Cited by 116
Iron homeostasis in breast cancer
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Role of iron in the pathogenesis of respiratory disease
Ali, M. K., Kim, R., Karim, R., Mayall, J., Martin, K. L., Shahandeh, A., Abbasian, F., Starkey, M. R., Loustaud-Ratti, V., Johnstone, D. M., et al. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.05.003 · Cited by 114
Kell, D. B., & Pretorius, E. (2018) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12407 · Cited by 117
Weiss, G., Theurl, I., Eder, S., Koppelstaetter, C., Kurz, K., Sonnweber, T., Kobold, U., & Mayer, G. J. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2009.02182.x · Cited by 105
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Garrick, M. D., & Garrick, L. M. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.03.018 · Cited by 105
Thomsen, M. S., Andersen, M. V., Christoffersen, P., Jensen, M. D., Lichota, J., & Moos, T. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.013 · Cited by 96
Valenti, L. V. C., Swinkels, D. W., Burdick, L., Dongiovanni, P., Tjalsma, H., Motta, B. M., Bertelli, C., Fatta, E., Bignamini, D., Rametta, R., et al. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.01.003 · Cited by 93
Tazzari, P. L., Tabellini, G., Ricci, F., Papa, V., Bortul, R., Chiarini, F., Evangelisti, C., Martinelli, G., Bontadini, A., Cocco, L., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2815 · Cited by 91
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Self-citationValenti, L. V. C., Dongiovanni, P., Motta, B. M., Swinkels, D. W., Bonara, P., Rametta, R., Burdick, L., Frugoni, C., Fracanzani, A. L., & Fargion, S. R. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.214858 · Cited by 88
Andrews, M., Néstor Soto, I., & Arredondo, M. (2014) · Nutrition · doi:10.1016/j.nut.2014.04.019 · Cited by 91
Schwarz, P., Kübler, J., Strnad, P., Müller, K., Barth, T. F. E., Gerloff, A., Feick, P., Peyssonnaux, C., Vaulont, S., Adler, G., et al. (2011) · Gut · doi:10.1136/gut.2011.241208 · Cited by 86
Li, J. J., Meng, X., Peng, H. S., Zhang, C., Lv, H. X., Zhao, Y. X., Yang, J. M., Dong, M., Zhang, K., Liu, S. X., et al. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.246108 · Cited by 83
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Marques, F., Falcão, A. M., Sousa, J. C., Coppola, G., Geschwind, D. H., Sousa, N., Correia‐Neves, M., & Palha, J. A. (2009) · Endocrinology · doi:10.1210/en.2008-1610 · Cited by 86
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Kaindlstorfer, C., Jellinger, K. A., Eschlböck, S., Stefanova, N., Weiß, G., & Wenning, G. K. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170601 · Cited by 72
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Campanella, A., Santambrogio, P., Fontana, F., Frenquelli, M., Cenci, S., Marcatti, M., Sitia, R., Tonon, G., & Camaschella, C. (2012) · Haematologica · doi:10.3324/haematol.2012.074872 · Cited by 56
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Chung, B., Verdier, F., Matak, P., Deschemin, J., Mayeux, P., & Vaulont, S. (2010) · The FASEB Journal · doi:10.1096/fj.09-152561 · Cited by 51
Xiao, L., Luo, G., Guo, X., Jiang, C., Zeng, H., Zhou, F., Li, Y., Yu, J., & Yao, P. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.158531 · Cited by 50
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Pantopoulos, K. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.6893 · Cited by 49
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Metadata
- Authors
- Theurl, I., Theurl, M., Seifert, M., Mair, S., Nairz, M., Rumpold, H., Zoller, H., Bellmann-Weiler, R., Niederegger, H., Talasz, H., & Weiss, G.
- Affiliations
- Innsbruck Medical University (AT)
- Departments ofGeneral Internal Medicine,
- Hematology and Oncology, and
- Tyrolean Cancer Research Institute (AT)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-02-15
- Volume
- 111
- Issue
- 4
- Pages
- 2392-2399
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1965254560
- Cited by
- 275
- References
- 54
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 15 · 2021: 12 · 2020: 14 · 2019: 14 · 2018: 17 · 2017: 12 · 2016: 13 · 2015: 18 · 2014: 21 · 2013: 17 · 2012: 20
- FWCI
- 12.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- hepcidin, autocrine regulation, iron homeostasis, iron retention, monocytes, ferroportin, anemia of chronic disease, inflammation, lipopolysaccharide, interleukin-6, THP-1 cells, iron export
- MeSH terms
- Anemia, C-Reactive Protein, Chronic Disease, Female, Homeostasis, Humans, Iron, Male, Monocytes, RNA, Messenger, Antimicrobial Cationic Peptides, Hepcidins
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