Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A
Open accessAbstract
Neuropilin-1 (NRP1) and NRP2 are cell surface receptors shared by class 3 semaphorins and vascular endothelial growth factor (VEGF). Ligand interaction with NRPs selects the specific signal transducer, plexins for semaphorins or VEGF receptors for VEGF, and promotes NRP internalization, which effectively shuts down receptor-mediated signaling by a second ligand. Here, we show that the sulfated polysaccharides dextran sulfate and fucoidan, but not others, reduce endothelial cell-surface levels of NRP1, NRP2, and to a lesser extent VEGFR-1 and VEGFR-2, and block the binding and in vitro function of semaphorin3A and VEGF(165). Administration of fucoidan to mice reduces VEGF(165)-induced angiogenesis and tumor neovascularization in vivo. We find that dextran sulfate and fucoidan can bridge the extracellular domain of NRP1 to that of the scavenger receptor expressed by endothelial cells I (SREC-I), and induce NRP1 and SREC-I coordinate internalization and trafficking to the lysosomes. Overexpression of SREC-I in SREC-I-negative cells specifically reduces cell-surface levels of NRP1, indicating that SREC-I mediates NRP1 internalization. These results demonstrate that engineered receptor internalization is an effective strategy for reducing levels and function of cell-surface receptors, and identify certain sulfated polysaccharides as "internalization inducers."
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Growth of two types of murine tumor cells inoculated into footpads of mice was suppressed by administration of natural and oversulfated fucoidans.
“In addition, the growth of two types of murine tumor cells inoculated into the footpads of mice was suppressed by administration of natural and oversulfated fucoidans.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [49]
Fucoidans may suppress tumor growth by inhibiting tumor-induced angiogenesis.
“Fucoidans may suppress tumor growth by inhibiting tumor-induced angiogenesis.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [49]
Natural and oversulfated fucoidans suppressed VEGF165-induced proliferation and migration of HUVEC by preventing VEGF165 binding to its receptor and inhibiting VEGF-mediated signaling.
“Natural and oversulfated fucoidans suppressed the VEGF165 induced proliferation and the migration of human umbilical vein endothelial cells (HUVEC) by preventing the binding of VEGF165 to its cell surface receptor and inhibiting the VEGF-mediated signaling transduction [49].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [49]
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- Authors
- Narazaki, M., Segarra, M., & Tosato, G.
- Affiliations
- National Institutes of Health (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-04-15
- Volume
- 111
- Issue
- 8
- Pages
- 4126-4136
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC2288723
- OpenAlex
- W1974007852
- Cited by
- 59
- References
- 61
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 5 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 5 · 2015: 1 · 2014: 7 · 2013: 2 · 2012: 2
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- neuropilin-1, neuropilin-2, sulfated polysaccharides, dextran sulfate, fucoidan, receptor internalization, semaphorin 3A, VEGF165, VEGFR1, VEGFR2, angiogenesis inhibition, tumor angiogenesis, lysosomal trafficking, endothelial cells
- MeSH terms
- Animals, Cell Line, Endocytosis, Humans, Polysaccharides, Protein Binding, Dextran Sulfate, Protein Structure, Tertiary, Neovascularization, Physiologic, Neuropilin-1, Semaphorin-3A, Vascular Endothelial Growth Factor A, Endothelial Cells, Scavenger Receptors, Class F, Lysosomal Membrane Proteins, Lysosomal-Associated Membrane Protein 1
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