Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection

IL-17 and th17 cells

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Interleukin-12 and the regulation of innate resistance and adaptive immunity

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Anticancer activities of histone deacetylase inhibitors

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Recognition of microorganisms and activation of the immune response

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The many roles of histone deacetylases in development and physiology: implications for disease and therapy

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Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

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Macrophage migration inhibitory factor: a regulator of innate immunity

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Histone deacetylase inhibitors: molecular mechanisms of action

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Extracellular histones are major mediators of death in sepsis

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Sulforaphane inhibits angiotensin II-induced cardiomyocyte apoptosis by acetylation modification of Nrf2

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Valproic Acid Increases Susceptibility to Endotoxin Shock Through Enhanced Release of High-Mobility Group Box 1

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The Novel HDAC8 Inhibitor WK2-16 Attenuates Lipopolysaccharide-Activated Matrix Metalloproteinase-9 Expression in Human Monocytic Cells and Improves Hypercytokinemia In Vivo

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SWATH‐based proteomics reveals processes associated with immune evasion and metastasis in poor prognosis colorectal tumours

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HDAC inhibitors block innate immunity

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The Roles of Histone H3K18 Lactylation, Acetylation, and Lactylation/Acetylation Ratio as Potential Biomarkers in the Diagnosis and Severity Assessment of Sepsis and Septic Shock

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Epigenetic regulation of Thy‐1 gene expression by histone modification is involved in lipopolysaccharide‐induced lung fibroblast proliferation

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Time-dependent effects of histone deacetylase inhibition in sepsis-associated acute kidney injury

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Chromatin Structure and Drug Resistance in Candida spp.

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Patho-epigenetics: histone deacetylases as targets of pathogens and therapeutics

Schator, D., Gómez-Valero, L., Buchrieser, C., & Rolando, M. (2021) · microLife · doi:10.1093/femsml/uqab013 · Cited by 20

The development of immune-modulating compounds to disrupt HIV latency

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SCFAs’ pleiotropic role in pathogenesis and salutogenesis: mechanisms in exacerbation and regulation of inflammation and fibrosis from gut to host

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Mechanoimmunology: Are inflammatory epigenetic states of macrophages tuned by biophysical factors?

Jain, N., Lord, J. M., & Viola Vogel, B. (2022) · APL Bioengineering · doi:10.1063/5.0087699 · Cited by 17

Increased HDAC3 and decreased miRNA-130a expression in PBMCs through recruitment HDAC3 in patients with spinal cord injuries.

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IRF5 is elevated in childhood-onset SLE and regulated by histone acetyltransferase and histone deacetylase inhibitors

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Lack of impact of type and extent of prior therapy on outcomes of mogamulizumab therapy in patients with cutaneous T cell lymphoma in the MAVORIC trial

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Noncoding RNAs Involved in the Pathogenesis of Ankylosing Spondylitis

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Histone deacetylase inhibitor valproic acid affects plasmacytoid dendritic cells phenotype and function

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The epigenetic regulation of Dicer and microRNA biogenesis by Panobinostat

Hoffend, N. C., Magner, W. J., & Tomasi, T. B. (2016) · Epigenetics · doi:10.1080/15592294.2016.1267886 · Cited by 15

The histone deacetylase inhibitor valproic acid attenuates phospholipase Cγ2 and IgE-mediated mast cell activation

Rodríguez-López, G. M., Soria-Castro, R., Campillo-Navarro, M., Pérez‐Tapia, S. M., Flores‐Borja, F., Wong‐Baeza, I., Muñoz-Cruz, S., López‐Santiago, R., Estrada-Parra, S. A., Estrada‐García, I., et al. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ab0320-547rr · Cited by 15

Genetic-and-Epigenetic Interspecies Networks for Cross-Talk Mechanisms in Human Macrophages and Dendritic Cells during MTB Infection

Li, C., Lee, Y., & Chen, B. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00124 · Cited by 15

Targeting Histone Deacetylases to Modulate Graft-Versus-Host Disease and Graft-Versus-Leukemia

Kim, S., Santhanam, S., Lim, S., & Choi, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124281 · Cited by 14

Histone Deacetylase Inhibition Protects Mice Against Lethal Postinfluenza Pneumococcal Infection

Yagi, K., Ishii, M., Namkoong, H., Fujii, H., Asami, T., Suzuki, S., Asakura, T., Mizoguchi, K., Kamo, T., Tasaka, S., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001821 · Cited by 14

The surviving sepsis campaign: basic/translational science research priorities

Deutschman, C. S., Hellman, J., Ferrer, R., Backer, D. D., Coopersmith, C. M., Coopersmith, C. M., Backer, D. D., Antonelli, M. M., Deutschman, C. S., Evans, L., et al. (2020) · Intensive Care Medicine Experimental · doi:10.1186/s40635-020-00312-4 · Cited by 13

Frontline Science: ATF3 is responsible for the inhibition of TNF-α release and the impaired migration of acute ethanol-exposed monocytes and macrophages

Hu, C., Meng, X., Huang, C., Shen, C., & Li, J. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.2hi1115-491r · Cited by 13

Screening the Impact of Sirtuin Inhibitors on Inflammatory and Innate Immune Responses of Macrophages and in a Mouse Model of Endotoxic Shock

Ciarlo, E., & Roger, T. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3667-0_21 · Cited by 13

Mass spectrometry-based metabolomics approaches to interrogate host–microbiome interactions in mammalian systems

Kulkarni, A. S., Paiva, G. C. M., Jin, J., Laro, J. A., Peramuna, T., McCall, L., & Garg, N. (2025) · Natural Product Reports · doi:10.1039/d5np00021a · Cited by 12

Restoring Histone Acetylation Accelerates Diabetic Wound Repair by Improving the Spatiotemporal Dynamics of Macrophages

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Epigenetic regulation of RNA sensors: Sentinels of immune response

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SARS-CoV-2 Infection, Sex-Related Differences, and a Possible Personalized Treatment Approach with Valproic Acid: A Review

Stakišaitis, D., Kapočius, L., Valančiūtė, A., Balnytė, I., Tamošuitis, T., Vaitkevičius, A., Sužiedėlis, K., Urbonienė, D., Tatarūnas, V., Kilimaitė, E., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10050962 · Cited by 12

Histone deacetylase inhibitors impair the host immune response against Mycobacterium tuberculosis infection

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Immunology of Cryptosporidiosis

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HDACs and their inhibitors in immunology: teaching anticancer drugs new tricks

Fairlie, D. P., & Sweet, M. J. (2012) · Immunology and Cell Biology · doi:10.1038/icb.2011.105 · Cited by 11

Epigenetic Modulation of TLR4 Expression by Sulforaphane Increases Anti-Inflammatory Capacity in Porcine Monocyte-Derived Dendritic Cells

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Inhibition of Class I Histone Deacetylase Activity Blocks the Induction of TNFAIP3 Both Directly and Indirectly via the Suppression of Endogenous TNF-α

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Innate Immune Sensing ofFusarium culmorumby Mouse Dendritic Cells

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Macrophage activation in the lung during the progression of nitrogen mustard induced injury is associated with histone modifications and altered miRNA expression

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HDAC1 fine-tunes Th17 polarization in vivo to restrain tissue damage in fungal infections

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Roles of HDACs in the Responses of Innate Immune Cells and as Targets in Inflammatory Diseases

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A Gene Cluster That Encodes Histone Deacetylase Inhibitors Contributes to Bacterial Persistence and Antibiotic Tolerance in Burkholderia thailandensis

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Fungal Lysine Deacetylases in Virulence, Resistance, and Production of Small Bioactive Compounds

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Cyclic Tetrapeptides with Synergistic Antifungal Activity from the Fungus Aspergillus westerdijkiae Using LC-MS/MS-Based Molecular Networking

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Microarray gene expression profiling reveals potential mechanisms of tumor suppression by the class I HDAC-selective benzoylhydrazide inhibitors

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Valproic acid attenuates the expression of pro-inflammatory cytokines lipopolysaccharide-treated canine peripheral blood mononuclear cells (in vitro) and in a canine endotoxemia model (in vivo)

Song, R., Yu, D., Yoon, J.-S., & Park, J. (2015) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2015.06.012 · Cited by 10

Histone deacetylase inhibitor sodium butyrate regulates the activation of toll-like receptor 4/interferon regulatory factor-3 signaling pathways in prostate cancer cells

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From Gut to Brain: The Impact of Short-Chain Fatty Acids on Brain Cancer

Saadh, M. J., Allela, O. Q. B., Kareem, R. A., Sanghvi, G. V., Menon, S. V., Sharma, P., Tomar, B. S., Sharma, A., Sameer, H. N., Hamad, A. K., et al. (2025) · NeuroMolecular Medicine · doi:10.1007/s12017-025-08830-8 · Cited by 9

Histone deacetylase activity and recurrent bacterial bronchitis in severe eosinophilic asthma

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Epigenetic Regulation of Toll-Like Receptor Signaling: Implications for Cancer Development

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HDAC inhibitors and IBD: Charting new approaches in disease management

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Bacterial metabolites and cardiovascular risk in children with chronic kidney disease

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Suppression of IL-12p40-related regulatory cytokines by suberoylanilide hydroxamic acid an inhibitor of histone deacetylases

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Single-Cell Transcriptomic and Targeted Genomic Profiling Adjusted for Inflammation and Therapy Bias Reveal CRTAM and PLCB1 as Novel Hub Genes for Anti-Tumor Necrosis Factor Alpha Therapy Response in Crohn’s Disease

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Modified Suberoylanilide Hydroxamic Acid Reduced Drug-Associated Immune Cell Death and Organ Damage under Lipopolysaccharide Inflammatory Challenge

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Preclinical Study in Mouse Thymus and Thymocytes: Effects of Treatment with a Combination of Sodium Dichloroacetate and Sodium Valproate on Infectious Inflammation Pathways

Stakišaitis, D., Kapočius, L., Kilimaitė, E., Gečys, D., Šlekienė, L., Balnytė, I., Palubinskienė, J., & Lesauskaitė, V. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15122715 · Cited by 7

The Role of Gut-derived Short-Chain Fatty Acids in Multiple Sclerosis

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Transmembrane Amino Acid Transporters in Shaping the Metabolic Profile of Breast Cancer Cell Lines: The Focus on Molecular Biological Subtype

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Cardiovascular risk in COVID-19 infection.

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Nuclear oligo hashing improves differential analysis of single-cell RNA-seq

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Chromatin Remodelling During Host-Bacterial Pathogen Interaction

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Epigenetics in autoimmune connective tissue diseases.

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Editorial: HDAC inhibition begets more MDSCs

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Effects of histone acetyltransferase (HAT) and histone deacetylase (HDAC) inhibitors on proliferative, differentiative, and regenerative functions of Toll-like receptor 2 (TLR-2)-stimulated human dental pulp cells (hDPCs)

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Preclinical and first-in-human of purinostat mesylate, a novel selective HDAC I/IIb inhibitor, in relapsed/refractory multiple myeloma and lymphoma

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Therapy of Infectious Diseases Using Epigenetic Approaches

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Valproic acid inhibits interferon-γ production by NK cells and increases susceptibility to Listeria monocytogenes infection

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Dually Modified Cellulose as a Non-Viral Vector for the Delivery and Uptake of HDAC3 siRNA

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Histone deacetylase inhibitor MS-275 augments expression of a subset of IFN-γ-regulated genes in Toxoplasma gondii-infected macrophages but does not improve parasite control

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siRNA containing a unique 5-nucleotide motif acts as a quencher of IFI16-mediated innate immune response

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Sepsis: neue Erkenntnisse, andere Perspektiven – neue Therapieoptionen?

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The Role of RS Type 2 (High‐Amylose Maize Starch) in the Inhibition of Colon Cancer: A Comprehensive Review of Short‐Chain Fatty Acid (SCFA) Production and Anticancer Mechanisms

Throat, S., & Bhattacharya, S. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70107 · Cited by 6

HDAC Inhibition with Valproate Improves Direct Cytotoxicity of Monocytes against Mesothelioma Tumor Cells

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Tolerogenic Dendritic Cells Generated by in Vitro Treatment with SAHA are not Stable in Vivo

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Role of chromatin modulation in the establishment of protozoan parasite infection for developing targeted chemotherapeutics

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Epigenetic modulation of selected immune response genes and altered functions of T lymphocytes and macrophages collectively contribute to autoimmune diabetes protection

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The Role of an NFκB-STAT3 Signaling Axis in Regulating the Induction and Maintenance of the Pluripotent State

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Aromatic Amino Acid Hydroxylases as Off-Targets of Histone Deacetylase Inhibitors

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Valproic acid restricts mast cell activation by Listeria monocytogenes

Soria-Castro, R., Meneses-Preza, Y. G., Rodríguez-López, G. M., Ibarra-Sánchez, A., González‐Espinosa, C., Pérez‐Tapia, S. M., Flores‐Borja, F., Estrada-Parra, S. A., Chávez-Blanco, A. D., & Chacón‐Salinas, R. (2022) · Scientific Reports · doi:10.1038/s41598-022-20054-5 · Cited by 4

Targeting the Bet-Hedging Strategy with an Inhibitor of Bacterial Efflux Capacity Enhances Antibiotic Efficiency and Ameliorates Bacterial Persistence In Vitro

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Effect of a Histone Deacetylases Inhibitor of IL-18 and TNF-Alpha Secretion in Vitro

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Epigenetic Regulation of Skin Wound Healing

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