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Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection
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Regulated by histone acetyltransferases and deacetylases (HDACs), histone acetylation is a key epigenetic mechanism controlling chromatin structure, DNA accessibility, and gene expression. HDAC inhibitors induce growth arrest, differentiation, and apoptosis of tumor cells and are used as anticancer agents. Here we describe the effects of HDAC inhibitors on microbial sensing by macrophages and dendritic cells in vitro and host defenses against infection in vivo. HDAC inhibitors down-regulated the expression of numerous host defense genes, including pattern recognition receptors, kinases, transcription regulators, cytokines, chemokines, growth factors, and costimulatory molecules as assessed by genome-wide microarray analyses or innate immune responses of macrophages and dendritic cells stimulated with Toll-like receptor agonists. HDAC inhibitors induced the expression of Mi-2β and enhanced the DNA-binding activity of the Mi-2/NuRD complex that acts as a transcriptional repressor of macrophage cytokine production. In vivo, HDAC inhibitors increased the susceptibility to bacterial and fungal infections but conferred protection against toxic and septic shock. Thus, these data identify an essential role for HDAC inhibitors in the regulation of the expression of innate immune genes and host defenses against microbial pathogens.
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“As drug inhibition of cellular deacetylases strongly attenuates pathogen-and immunogen-induced immune responses (139–141), it is tempting to speculate that acetylation plays a key role in modulating immune signaling pathways.”
From The Impact of Mass Spectrometry–Based Proteomics on Fundamental Discoveries in Virology (2014) · cites this paper as [140]
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Metadata
- Authors
- Roger, T., Lugrin, J., Le Roy, D., Goy, G., Mombelli, M., Koessler, T., Ding, X. C., Chanson, A.-L., Reymond, M. K., Miconnet, I., Schrenzel, J., François, P., & Calandra, T.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland;
- University Hospital of Geneva (CH)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2011-01-27
- Volume
- 117
- Issue
- 4
- Pages
- 1205-1217
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2066887945
- Cited by
- 341
- References
- 51
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 13 · 2023: 17 · 2022: 23 · 2021: 23 · 2020: 26 · 2019: 18 · 2018: 24 · 2017: 23 · 2016: 38 · 2015: 23 · 2014: 28 · 2013: 28 · 2012: 24
- FWCI
- 8.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- histone deacetylase inhibitors, innate immunity, TLR agonists, macrophages, dendritic cells, histone acetylation, epigenetic regulation, NuRD complex, host defense genes, cytokine production, bacterial infection susceptibility, fungal infection susceptibility, septic shock, pattern recognition receptors
- MeSH terms
- Animals, Cells, Cultured, Disease Models, Animal, Drug Evaluation, Preclinical, Female, Gene Expression Regulation, Humans, Immunity, Innate, Infections, Macrophages, Mice, Inbred BALB C, Down-Regulation, Gene Expression Profiling, Microarray Analysis, Toll-Like Receptors, Mice, Histone Deacetylase Inhibitors
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